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166 results on '"Aceña, Álvaro"'

2. Effect of Diflunisal in Patients with Transthyretin Cardiomyopathy: A Pilot Study.

Author

Camblor Blasco, Andrea, Devesa, Ana, Nieto Roca, Luis, Gómez-Talavera, Sandra, Lumpuy-Castillo, Jairo, Pello Lázaro, Ana María, Llanos Jiménez, Lucía, Sánchez González, Javier, Lorenzo, Óscar, Tuñón, Jose, Ibáñez, Borja, and Aceña, Álvaro

Subjects
TERMINATION of treatment, HEART failure, KIDNEY physiology, TRANSTHYRETIN, MEDICAL protocols
Abstract

Background: ATTR-CM is becoming more prevalent, and disease-modifying therapy has been investigated in recent years with promising results. Diflunisal has shown TTR-stabilizing properties assessed by biomarkers and echocardiography, but there are no trials addressing the evolution of morphological changes with CMR. Methods and Results: AMILCA-DIFLU is an exploratory pilot study prospective, single-center, non-randomized, open-label clinical trial. Patients diagnosed with ATTR-CM underwent clinical, functional, biochemical and imaging assessment before and one year after diflunisal therapy initiation. Of the twelve ATTR-CM patients included, only nine patients completed treatment and study protocol in 12 months. To increase the sample size, we included seven real-world patients with one year of diflunisal treatment. Among the group of patients who completed treatment, diflunisal therapy did not show improvement in cardiac disease status as assessed by many cardiac and inflammatory biomarkers, 6MWT and CMR parameters after one year of treatment. However, a non-significant trend towards stabilization of CMR parameters such as LVEF, ECV and T2 at one year was found. When comparing the group of patients who completed diflunisal therapy and those who did not, a significant decrease in the distance performed in the 6MWT was found in the group of patients who completed treatment at one year (−14 ± 81.8 vs. −173 ± 122.2; p = 0.032). Diflunisal was overall well tolerated, showing only a statistically significant worsening in renal function in the group of diflunisal-treatment patients with no clinical relevance or need for treatment discontinuation. Conclusions: In patients with ATTR-CM, treatment with diflunisal was overall well tolerated and tended to stabilize or slow down amyloid cardiac disease progression assessed by CMR parameters, cardiac and inflammatory biomarkers and functional capacity. [ABSTRACT FROM AUTHOR]

Published
2024
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3. Impact of renal function on the prognostic value of mineral metabolism in patients with chronic ischaemic heart disease patients with chronic ischaemic heart disease

Author

Aceña, Álvaro, Pello-Lázaro, Ana María, Martínez-Milla, Juan, González-Lorenzo, Óscar, Tarín, Nieves, Cristóbal, Carmen, Blanco-Colio, Luis M., Martín-Ventura, José Luis, Huelmos, Ana, López-Castillo, Marta, Alonso, Joaquín, Gutiérrez-Landaluce, Carlos, López Bescós, Lorenzo, Alonso-Pulpón, Luis, González-Parra, Emilio, Egido, Jesús, Mahíllo-Fernández, Ignacio, Lorenzo, Óscar, González-Casaus, María Luisa, and Tuñón, José

Published
2022
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4. Impacto de la función renal en el valor pronóstico del metabolismo mineral en pacientes con cardiopatía isquémica crónica

Author

Aceña, Álvaro, Pello-Lázaro, Ana María, Martínez-Milla, Juan, González-Lorenzo, Óscar, Tarín, Nieves, Cristóbal, Carmen, Blanco-Colio, Luis M., Martín-Ventura, José Luis, Huelmos, Ana, López-Castillo, Marta, Alonso, Joaquín, Gutiérrez-Landaluce, Carlos, López Bescós, Lorenzo, Alonso-Pulpón, Luis, González-Parra, Emilio, Egido, Jesús, Mahíllo-Fernández, Ignacio, Lorenzo, Óscar, González-Casaus, María Luisa, and Tuñón, José

Published
2022
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5. Serum Biomarkers and Their Association with Myocardial Function and Exercise Capacity in Cardiac Transthyretin Amyloidosis

Author

Nieto-Roca, Luis, primary, Camblor Blasco, Andrea, additional, Devesa, Ana, additional, Gómez-Talavera, Sandra, additional, Balaguer-Germán, Jorge, additional, Lumpuy-Castillo, Jairo, additional, Pello, Ana María, additional, Dhier, Luis Martínez, additional, Lapeña, Gregoria, additional, Jiménez, Lucía Llanos, additional, Lorenzo, Óscar, additional, Tuñón, José, additional, Ibáñez, Borja, additional, and Aceña, Álvaro, additional

Published
2024
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6. Cardiac Rehabilitation Increases Plasma Klotho Levels

Author

Pello Lázaro, Ana María, primary, Villelabeitia Jaureguizar, Koldo, additional, Franco Peláez, Juan Antonio, additional, Venegas-Rodriguez, Ana, additional, Aceña, Álvaro, additional, Kallmeyer, Andrea, additional, Cánovas, Ester, additional, González-Casaus, María Luisa, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Gutiérrez-Landaluce, Carlos, additional, Huelmos, Ana, additional, González-Lorenzo, Óscar, additional, Alonso, Joaquín, additional, López-Bescós, Lorenzo, additional, Egido, Jesús, additional, Mahillo-Fernández, Ignacio, additional, Lumpuy-Castillo, Jairo, additional, Lorenzo, Óscar, additional, and Tuñón, José, additional

Published
2024
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9. Fibroblast growth factor 23 independently predicts adverse outcomes after an acute coronary syndrome

Author

Kallmeyer, Andrea, primary, Pello, Ana, additional, Cánovas, Ester, additional, Aceña, Álvaro, additional, González‐Casaus, María Luisa, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Gutiérrez‐Landaluce, Carlos, additional, Huelmos, Ana, additional, Rodríguez‐Valer, Aida, additional, González‐Lorenzo, Óscar, additional, Alonso, Joaquín, additional, López‐Bescós, Lorenzo, additional, Egido, Jesús, additional, Mahillo, Ignacio, additional, Lorenzo, Óscar, additional, and Tuñón, José, additional

Published
2023
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10. Short- and Long-Term Prognostic Relevance of Cardiogenic Shock in Takotsubo Syndrome: Results From the RETAKO Registry

Author

Figueras, J., Barrabes, J.A., Andrés, M., Núñez Gil, I.J., Mejía, H.D., Vedia, O., Feltes, Gisela, Worner, F., Bascompte Claret, R., Pereyra, E., Jiménez Candil, J., García Sánchez, M.J., Martín García, A.C., Martín García, A., Bodi, V., Bonanad, C., Bastante, T., Cruz Aguilera, M., Palazuelos, J., Sancho Carmona, D., López Pais, J., Alonso, J.J., Almendro Delia, M., Lobo, M., Rodríguez de Leiras, S., García Rubira, J.C., Corbí-Pascual, M., Córdoba Soriano, J.G., De Mora Martín, M., Pérez, B., Martín Asensio, R., Rueda Sobella, F., Santos Pardo, I., Manzano Nieto, M.C., Escudier Villa, J.M., Fabregat Andrés, O., Ridocci-Soriano, F., Parias Ángel, M.N., Gaebelt, H.P., Aceña, A., Martin Reyes, R., Bergua, C., Sanz Puértolas, P., Echeverria Lucotti, I., Vidal Pérez, R., Sionis, A., Duran Cambra, A., Tómas Ortiz, J., Bosch Genover, X., Guillen Marzo, M., Bardají, R.A., García Acuña, J.M., Sánchez Grande Flecha, A., García González, M.J., García de la Villa Redondo, G., Pérez Castellanos, A., Piqueras-Flores, J., Ruíz Valdepeas Herrero, L., Linares Vicente, J.A., Ruiz Arroyo, J.R., García, J., Giner Caro, J.A., Martínez Selles, M., Martín de Miguel, I., Almendro-Delia, Manuel, Núñez-Gil, Iván J., Lobo, Manuel, Andrés, Mireia, Vedia, Oscar, Sionis, Alessandro, Martin-García, Ana, Cruz Aguilera, María, Pereyra, Eduardo, Martín de Miguel, Irene, Linares Vicente, José A., Corbí-Pascual, Miguel, Bosch, Xavier, Fabregat Andrés, Oscar, Sánchez Grande Flecha, Alejandro, Pérez-Castellanos, Alberto, Pais, Javier López, De Mora Martín, Manuel, Escudier Villa, Juan María, Martín Asenjo, Roberto, Guillen Marzo, Marta, Rueda Sobella, Ferrán, Aceña, Álvaro, García Acuña, José María, and García-Rubira, Juan C.

Published
2018
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11. Fibroblast growth factor 23 independently predicts adverse outcomes after an acute coronary syndrome.

Author

Kallmeyer, Andrea, Pello, Ana, Cánovas, Ester, Aceña, Álvaro, González‐Casaus, María Luisa, Tarín, Nieves, Cristóbal, Carmen, Gutiérrez‐Landaluce, Carlos, Huelmos, Ana, Rodríguez‐Valer, Aida, González‐Lorenzo, Óscar, Alonso, Joaquín, López‐Bescós, Lorenzo, Egido, Jesús, Mahillo, Ignacio, Lorenzo, Óscar, and Tuñón, José

Subjects
FIBROBLAST growth factors, ACUTE coronary syndrome, PEPTIDES, CHRONIC kidney failure, GLOMERULAR filtration rate
Abstract

Aims: Abnormalities of mineral metabolism (MM) have been related to cardiovascular disorders. There are no reports on the prognostic role of MM after an acute coronary syndrome (ACS). We aim to assess the prognostic role of MM after an ACS. Methods and results: Plasma levels of components of MM [fibroblast growth factor 23 (FGF23), calcidiol, parathormone, klotho, and phosphate], high‐sensitivity C‐reactive protein, and N‐terminal‐pro‐brain natriuretic peptide were measured in 1190 patients at discharge from an ACS. The primary outcome was a combination of acute ischaemic events, heart failure (HF) and death. Secondary outcomes were the separate components of the primary outcome. Age was 61.7 ± 12.2 years, and 77.1% were men. Median follow‐up was 5.44 (3.03–7.46) years. Two hundred and ninety‐four patients developed the primary outcome. At multivariable analysis FGF23 (hazard ratio, HR 1.18 [1.08–1.29], P < 0.001), calcidiol (HR 0.86 [0.74–1.00], P = 0.046), previous coronary or cerebrovascular disease, and hypertension were independent predictors of the primary outcome. The predictive power of FGF23 was homogeneous across different subgroups of population. FGF23 (HR 1.45 [1.28–1.65], P < 0.001) and parathormone (HR 1.06 1.01–1.12]; P = 0.032) resulted as independent predictors of HF. FGF23 (HR 1.21 [1.07–1.37], P = 0.002) and calcidiol (HR 0.72 [0.54–0.97), P = 0.028) were independent predictors of death. No biomarker predicted acute ischaemic events. FGF23 predicted independently the primary outcome in patients with estimated glomerular filtration rate > 60 mL/min/1.73 m2. Conclusions: FGF23 and other components of MM are independent predictors of HF and death after an ACS. This effect is homogeneous across different subgroups of population, and it is not limited to patients with chronic kidney disease. [ABSTRACT FROM AUTHOR]

Published
2024
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12. The role of bioimpedance analysis in overweight and obese patients with acute heart failure: a pilot study

Author

Venegas‐Rodríguez, Ana, primary, Pello, Ana María, additional, López‐Castillo, Marta, additional, Taibo Urquía, Mikel, additional, Balaguer‐Germán, Jorge, additional, Munté, Alicia, additional, González‐Martín, Guillermo, additional, Carriazo‐Julio, Sol María, additional, Martínez‐Milla, Juan, additional, Kallmeyer, Andrea, additional, González Lorenzo, Óscar, additional, Gaebelt Slocker, Hans Paul, additional, Tuñón, José, additional, González‐Parra, Emilio, additional, and Aceña, Álvaro, additional

Published
2023
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13. Fibroblast Growth Factor 23 is a strong independent marker of worse cardiovascular outcomes after an acute coronary syndrome

Author

Kallmeyer, Andrea, primary, Pello, Ana, additional, Cánovas, Ester, additional, Aceña, Álvaro, additional, González-Casaus, María Luisa, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Gutiérrez-Landaluce, Carlos, additional, Huelmos, Ana, additional, Rodríguez-Valer, Aida, additional, González-Lorenzo, Óscar, additional, Alonso, Joaquín, additional, López-Bescós, Lorenzo, additional, Egido, Jesús, additional, Mahillo, Ignacio, additional, Lorenzo, Óscar, additional, and Tuñón, José, additional

Published
2023
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14. Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease

Author

Hageman, Steven H. J., McKay, Ailsa J., Ueda, Peter, Gunn, Laura H., Jernberg, Tomas, Hagström, Emil, Bhatt, Deepak L., Steg, Ph. Gabriel, Läll, Kristi, Mägi, Reedik, Gynnild, Mari Nordbø, Ellekjær, Hanne, Saltvedt, Ingvild, Tuñón, José, Mahíllo, Ignacio, Aceña, Álvaro, Kaminski, Karol, Chlabicz, Malgorzata, Sawicka, Emilia, Tillman, Taavi, McEvoy, John W., di Angelantonio, Emanuele, Graham, Ian, de Bacquer, Dirk, Ray, Kausik K., Dorresteijn, Jannick A. N., Visseren, Frank L. J., Asselbergs, F. W., Nathoe, H. M., de Borst, G. J., Bots, M. L., Geerlings, M. I., Emmelot, M. H., de Jong, P. A., Leiner, T., Lely, A. T., van der Kaaij, N. P., Kappelle, L. J., Ruigrok, Y. M., Verhaar, M. C., Visseren, F. L. J., Westerink, J., Halle, Martin, Timmis, Adam D., Lettino, Maddalena, Vardas, Panos E., McEvoy, John William, Graham, Ian M., and Academic Medical Center

Subjects
Cardiac & Cardiovascular Systems, PREDICTION, Myocardial Infarction, Residual risk, Risk Assessment, ARTERIAL-DISEASE, Recurrent risk, Risk Factors, Medicine and Health Sciences, Humans, Cardiac and Cardiovascular Systems, 1102 Cardiorespiratory Medicine and Haematology, METAANALYSIS, Science & Technology, Kardiologi, Secondary prevention, 1103 Clinical Sciences, ASSOCIATION, Atherosclerosis, Established ASCVD, COMPETING RISKS, PREVENTION, Risk prediction, Stroke, ASPIRIN, Cardiovascular System & Hematology, Cardiovascular Diseases, CLINICAL-PRACTICE, Personalized treatment, Cardiovascular System & Cardiology, Cardiology and Cardiovascular Medicine, OUTPATIENTS, Life Sciences & Biomedicine, Algorithms, Biomarkers, TASK-FORCE
Abstract

Aims The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and may help refine clinical management. To broaden generalizability across regions, we updated the existing tool (SMART2 risk score) and recalibrated it with regional incidence rates and assessed its performance in external populations. Methods and results Individuals with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysms were included from the Utrecht Cardiovascular Cohort-SMART cohort [n = 8355; 1706 ASCVD events during a median follow-up of 8.2 years (interquartile range 4.2-12.5)] to derive a 10-year risk prediction model for recurrent ASCVD events (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular mortality) using a Fine and Gray competing risk-adjusted model. The model was recalibrated to four regions across Europe, and to Asia (excluding Japan), Japan, Australia, North America, and Latin America using contemporary cohort data from each target region. External validation used data from seven cohorts [Clinical Practice Research Datalink, SWEDEHEART, the international REduction of Atherothrombosis for Continued Health (REACH) Registry, Estonian Biobank, Spanish Biomarkers in Acute Coronary Syndrome and Biomarkers in Acute Myocardial Infarction (BACS/BAMI), the Norwegian COgnitive Impairment After STroke, and Bialystok PLUS/Polaspire] and included 369 044 individuals with established ASCVD of whom 62 807 experienced an ASCVD event. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] in BACS/BAMI to 0.772 (95% CI 0.659-0.886) in REACH Europe high-risk region. The clinical utility of the model was demonstrated across a range of clinically relevant treatment thresholds for intensified treatment options. Conclusion The SMART2 risk score provides an updated, validated tool for the prediction of recurrent ASCVD events in patients with established ASCVD across European and non-European populations. The use of this tool could allow for a more personalized approach to secondary prevention based upon quantitative rather than qualitative estimates of residual risk. Key objective To improve upon prediction of 10-year residual atherosclerotic cardiovascular disease (ASCVD) event risk in individuals with established ASCVD, by taking into account competing risks and geographical differences in ASCVD incidence. Key findings Derivation in 8355 individuals with established ASCVD from the Utrecht Cardiovascular Cohort-Secondary Manifestations of ARTerial disease (SMART) cohort. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] to 0.772 (95% CI 0.659-0.886). Clinical utility was demonstrated across a range of treatment thresholds relevant to therapy intensification. Take-home messages The SMART2 risk score can be used to estimate 10-year residual risk of fatal and non-fatal ASCVD in individuals with established ASCVD. Adapted to the CVD incidence in several global regions. Facilitates shared decision-making on Step 2 prevention goals as recommended by the 2021 ESC Guidelines on cardiovascular prevention.

Published
2022

15. Absence of High Lipoprotein(a) Levels Is an Independent Predictor of Acute Myocardial Infarction without Coronary Lesions

Author

Kallmeyer, Andrea, primary, Pello Lázaro, Ana María, additional, Blanco-Colio, Luis M., additional, Aceña, Álvaro, additional, González-Lorenzo, Óscar, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Gutiérrez-Landaluce, Carlos, additional, Huelmos, Ana, additional, Lumpuy-Castillo, Jairo, additional, López-Castillo, Marta, additional, Montalvo, Juan Manuel, additional, Alonso Martin, Joaquín J., additional, López-Bescós, Lorenzo, additional, Egido, Jesús, additional, Lorenzo, Óscar, additional, and Tuñón, José, additional

Published
2023
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16. Impacto de los niveles plasmáticos de pro-péptido natriurético tipo B aminoterminal, proteína quimiotáctica de monocitos-1 y galectina 3 en la capacidad predictiva de eventos de la escala clínica LIPID en la enfermedad coronaria estable

Author

Higueras, Javier, Martín-Ventura, José Luis, Blanco-Colio, Luis, Cristóbal, Carmen, Tarín, Nieves, Huelmos, Ana, Alonso, Joaquín, Pello, Ana, Aceña, Álvaro, Carda, Rocío, Lorenzo, Óscar, Mahíllo-Fernández, Ignacio, Asensio, Dolores, Almeida, Pedro, Rodríguez-Artalejo, Fernando, Farré, Jerónimo, López Bescós, Lorenzo, Egido, Jesús, and Tuñón, José

Published
2015
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20. Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate

Author

González-Parra, Emilio, Aceña, Álvaro, Lorenzo, Óscar, Tarín, Nieves, González-Casaus, María Luisa, Cristóbal, Carmen, Huelmos, Ana, Mahíllo-Fernández, Ignacio, Pello, Ana María, Carda, Rocío, Hernández-González, Ignacio, Alonso, Joaquín, Rodríguez-Artalejo, Fernando, López-Bescós, Lorenzo, Ortiz, Alberto, Egido, Jesús, and Tuñón, José

Published
2016
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21. NT-proBNP Levels Influence the Prognostic Value of Mineral Metabolism Biomarkers in Coronary Artery Disease

Author

Martínez-Milla, Juan, primary, Aceña, Álvaro, additional, Pello, Ana, additional, López-Castillo, Marta, additional, Gaebelt, Hans Paul, additional, González-Lorenzo, Óscar, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Blanco-Colio, Luis M., additional, Martín-Ventura, José Luis, additional, Huelmos, Ana, additional, Kallmeyer, Andrea, additional, Alonso, Joaquín, additional, Gutiérrez-Landaluce, Carlos, additional, López Bescós, Lorenzo, additional, Egido, Jesús, additional, Mahíllo-Fernández, Ignacio, additional, Lorenzo, Óscar, additional, González-Casaus, María Luisa, additional, and Tuñón, José, additional

Published
2022
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22. Enhancing knowledge and awareness of transthyretin cardiac amyloidosis and shared decision-making among cardiology team members in Colorado, USA via an online educational initiative.

Author

UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Ismailov, Rovshan M, Lerut, Jan, Aceña, Álvaro, Khasanova, Zaytuna D, UCL - SSS/IREC - Institut de recherche expérimentale et clinique, Ismailov, Rovshan M, Lerut, Jan, Aceña, Álvaro, and Khasanova, Zaytuna D

Abstract

Our project aimed to increase knowledge of non-invasive diagnostic modalities (including bone radiotracer scintigraphy), raise suspicion of transthyretin cardiac amyloidosis (ATTR-CA) and improve cardiology team member's awareness and knowledge of shared decision-making (SDM) as well as the quality of SDM communication between cardiology team members and patients. An online educational module and survey was developed and cardiology team members in Colorado, USA were invited to participate. This online educational module included various important topics related to ATTR-CA (e.g., the cause of ATTR-CA, endomyocardial biopsy, and non-invasive methods to diagnose ATTR-CA) and SDM (e.g., benefits of SDM, the role of SDM in the diagnosis of ATTR-CA, implementation SDM in your cardiology practice and the 3-talk model). There were 34 survey respondents, over one-third of whom were cardiologists. Most respondents agreed on the importance of diagnosing ATTR-CA at the early stage, and about three-quarters of the survey takers agreed that bone scintigraphy can reliably diagnose ATTR-CA without the need for endomyocardial biopsy. Concern for increased time commitment was the leading barrier to the implementation of SDM in respondents' clinical practice. The majority of respondents identified the correct answer regarding ATTR-CA and SDM after reading the online educational module. This improvement in scores after exposure to the online educational module was statistically significant. Baseline knowledge and awareness of various issues related to ATTR-CA was relatively low among cardiology team members. Participants' knowledge was enhanced through our effective online educational program. Prospective educational projects focused on various methods of detecting ATTR-CA as well as other amyloid conditions in diverse clinical settings will remain important.

Published
2022

23. Prevalence and prognostic value of monoclonal gammopathy in heart failure patients with preserved ejection fraction: A prospective study

Author

Devesa, Ana, primary, Rodríguez Olleros, Celia, additional, Kaçi, Xhorxhi, additional, Askari, Elham, additional, Camblor Blasco, Andrea, additional, Pello Lázaro, Ana María, additional, Gómez Talavera, Sandra, additional, Gómez Octavio, Juan, additional, Lapeña, Gregoria, additional, Navarro, Felipe, additional, Tuñón, José, additional, Ibáñez, Borja, additional, and Aceña, Álvaro, additional

Published
2022
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24. Sustitución de válvula mitral en paciente con dispositivo previo de cierre de orejuela izquierda Amulet Amplatzer

Author

Hernández-Estefanía, Rafael, Aceña, Álvaro, Tomás, Marta, Ibañez, Cristina, García-Vega, María Isabel, and Aldamiz-Echevarria, Gonzalo

Abstract

Presentamos el caso de una paciente en fibrilación auricular y portadora de un dispositivo de cierre de orejuela izquierda Amplatzer Amulet, programada para cirugía de sustitución mitral. El angio-TAC previo a la intervención demuestra la permeabilidad del dispositivo. Antes de la intervención nos preguntamos las siguientes cuestiones: ¿debe retirarse el dispositivo siempre o solo si se demuestra permeabilidad? Si tuviera fugas, ¿hemos de intentar resolver la permeabilidad con sutura, o no tocarlo y centrarnos solo en el recambio de la válvula mitral?

Published
2023
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27. N-Terminal Pro-Brain Natriuretic Peptide Plasma Levels Are Associated with Intermediate-Term Follow-Up Cancer in Coronary Patients

Author

Tuñón, José, primary, Pello, Ana, additional, Aceña, Álvaro, additional, Ramos-Cillán, Sergio, additional, Martínez-Milla, Juan, additional, González-Lorenzo, Óscar, additional, Fuentes-Antras, Jesús, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Blanco-Colio, Luis M., additional, Martín-Ventura, José Luis, additional, Huelmos, Ana, additional, Gutiérrez-Landaluce, Carlos, additional, López-Castillo, Marta, additional, Alonso, Joaquín, additional, Bescós, Lorenzo López, additional, Egido, Jesús, additional, Mahíllo-Fernández, Ignacio, additional, and Lorenzo, Óscar, additional

Published
2021
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29. Takotsubo Cardiomyopathy and Elderly Adults: Still a Benign Condition?

Author

Núñez-Gil, Iván J., Sionis, Alessandro, Andrés, Mireia, Delia, Manuel Almendro, Martin, Ana, Lozano, Álvaro, Córdoba Soriano, Juan Gabriel, Linares Vicente, José A., Sucarrats, Silvia González, Grande Flecha, Alejandro Sánchez, Mejía-Rentería, Hernán D., Biagioni, Corina, Feltes, Gisela, Barrabés, José A., Figueras, Jaume, Andrés, Oscar Fabregat, Ridocci-Soriano, Francisco, Mejía, Hernán D., Feltes Guzmán, Gisela I., Cambra, Alberto Duran, Arroyo, José Ramón Ruiz, Bastante, Teresa, González, Martín Jesús García, Pérez, Beatriz, Martín, Manuel de Mora, Villa, Juan María Escudier, Reyes, Roberto Martin, Aceña, Álvaro, Gaebelt, Hans Paul, Castellanos, Alberto Pérez, Sobella, Ferrán Rueda, Pardo, Irene Santos, Cambeiro, Cristina, Acuña, José María García, Pérez, Milagros Pedreira, Flores, Jesús Piqueras, Arcinegas, Andrea Moreno, Peyrat, Jaime Benítez, Reig, Álvaro-León Moreno, Herrero, Luis Ruiz Valdepeas, Perez, Rafael Vidal, Bodí, Vicente, Picher, Ernesto Valero, Redondo, Bernardo García de la Villa, Peruzzo, Germán Alberto Madoz, Pascual, Miguel Corbí, Vega, Mario Sutil, Sánchez, Pedro Luis, Candil, Javier Jiménez, Bascompte, Ramón, Worner, Fernando, Nieto, María del Carmen Manzano, García, Javier, and Rubira, Juan Carlos García

Published
2015
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31. Prevalence of transthyretin amyloidosis in patients with heart failure and no left ventricular hypertrophy

Author

Devesa, Ana, primary, Camblor Blasco, Andrea, additional, Pello Lázaro, Ana María, additional, Askari, Elham, additional, Lapeña, Gregoria, additional, Gómez Talavera, Sandra, additional, Taibo Urquía, Mikel, additional, Rodríguez Olleros, Celia, additional, Tuñón, José, additional, Ibáñez, Borja, additional, and Aceña, Álvaro, additional

Published
2021
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32. Parathormone levels add prognostic ability to N‐terminal pro‐brain natriuretic peptide in stable coronary patients

Author

Gutiérrez‐Landaluce, Carlos, primary, Aceña, Álvaro, additional, Pello, Ana, additional, Martínez‐Milla, Juan, additional, González‐Lorenzo, Óscar, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Blanco‐Colio, Luis M., additional, Martín‐Ventura, José Luis, additional, Huelmos, Ana, additional, López‐Castillo, Marta, additional, Alonso, Joaquín, additional, López Bescós, Lorenzo, additional, Alonso‐Pulpón, Luis, additional, González‐Parra, Emilio, additional, Egido, Jesús, additional, Mahíllo‐Fernández, Ignacio, additional, Lorenzo, Óscar, additional, González‐Casaus, María Luisa, additional, and Tuñón, José, additional

Published
2021
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33. First and Second Waves of Coronavirus Disease 2019 in Madrid, Spain: Clinical Characteristics and Hematological Risk Factors Associated With Critical/Fatal Illness

Author

Mollinedo-Gajate, Irene, Villar-Álvarez, Felipe, Zambrano-Chacón, María de los Ángeles, Núñez-García, Laura, Dueña-Muñoz, Laura de la, López-Chang, Carlos, Górgolas-Hernández-Mora, Miguel, Cabello, Alfonso, Sánchez-Pernaute, Olga, Romero-Bueno, Fredeswinda, Aceña, Álvaro, González-Mangado, Nicolás, Peces-Barba, Germán, Mollinedo, Faustino, Mollinedo-Gajate, Irene, Villar-Álvarez, Felipe, Zambrano-Chacón, María de los Ángeles, Núñez-García, Laura, Dueña-Muñoz, Laura de la, López-Chang, Carlos, Górgolas-Hernández-Mora, Miguel, Cabello, Alfonso, Sánchez-Pernaute, Olga, Romero-Bueno, Fredeswinda, Aceña, Álvaro, González-Mangado, Nicolás, Peces-Barba, Germán, and Mollinedo, Faustino

Abstract

Objectives: This study aims to determine similarities and differences in clinical characteristics between the patients from two waves of severe acute respiratory syndrome coronavirus-2 infection at the time of hospital admission, as well as to identify risk biomarkers of coronavirus disease 2019 severity. Design: Retrospective observational study. Setting: A single tertiary-care center in Madrid. Patients: Coronavirus disease 2019 adult patients admitted to hospital from March 4, 2020, to March 25, 2020 (first infection wave), and during July 18, 2020, and August 20, 2020 (second infection wave). Interventions: Treatment with a hospital-approved drug cocktail during hospitalization. Measurements and Main Results: Demographic, clinical, and laboratory data were compared between the patients with moderate and critical/fatal illness across both infection waves. The median age of patients with critical/fatal coronavirus disease 2019 was 67.5 years (interquartile range, 56.75–78.25 yr; 64.5% male) in the first wave and 59.0 years (interquartile range, 48.25–80.50 yr; 70.8% male) in the second wave. Hypertension and dyslipidemia were major comorbidities in both waves. Body mass index over 25 and presence of bilateral pneumonia were common findings. Univariate logistic regression analyses revealed an association of a number of blood parameters with the subsequent illness progression and severity in both waves. However, some remarkable differences were detected between both waves that prevented an accurate extrapolation of prediction models from the first wave into the second wave. Interleukin-6 and d-dimer concentrations at the time of hospital admission were remarkably higher in patients who developed a critical/fatal condition only during the first wave (p < 0.001), although both parameters significantly increased with disease worsening in follow-up studies from both waves. Multivariate analyses from wave 1 rendered a predictive signature for critical/fatal illness upon

Published
2021

34. MCP-1 Predicts Recurrent Cardiovascular Events in Patients with Persistent Inflammation

Author

Blanco-Colio, Luis M., primary, Méndez-Barbero, Nerea, additional, Pello Lázaro, Ana María, additional, Aceña, Álvaro, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Martínez-Milla, Juan, additional, González-Lorenzo, Óscar, additional, Martín-Ventura, José Luis, additional, Huelmos, Ana, additional, Gutiérrez-Landaluce, Carlos, additional, López-Castillo, Marta, additional, Kallmeyer, Andrea, additional, Cánovas, Ester, additional, Alonso, Joaquín, additional, López Bescós, Lorenzo, additional, Egido, Jesús, additional, Lorenzo, Óscar, additional, and Tuñón, José, additional

Published
2021
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35. First and Second Waves of Coronavirus Disease 2019 in Madrid, Spain: Clinical Characteristics and Hematological Risk Factors Associated With Critical/Fatal Illness

Author

Mollinedo-Gajate, Irene, primary, Villar-Álvarez, Felipe, additional, Zambrano-Chacón, María de los Ángeles, additional, Núñez-García, Laura, additional, de la Dueña-Muñoz, Laura, additional, López-Chang, Carlos, additional, Górgolas, Miguel, additional, Cabello, Alfonso, additional, Sánchez-Pernaute, Olga, additional, Romero-Bueno, Fredeswinda, additional, Aceña, Álvaro, additional, González-Mangado, Nicolás, additional, Peces-Barba, Germán, additional, and Mollinedo, Faustino, additional

Published
2021
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36. N-terminal Pro-brain Natriuretic Peptide plasma levels are Associated With a Short-Term Diagnosis of Cancer in Patients with Coronary Artery Disease

Author

Tuñón, José, primary, Aceña, Álvaro, additional, Pello, Ana, additional, Ramos-Cillán, Sergio, additional, Martínez-Milla, Juan, additional, González-Lorenzo, Óscar, additional, Fuentes-Antras, Jesús, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Blanco-Colio, Luis Miguel, additional, Martín-Ventura, José Luis, additional, Huelmos, Ana, additional, Gutiérrez-Landaluce, Carlos, additional, López-Castillo, Marta, additional, Alonso, Joaquín, additional, López-Bescós, Lorenzo, additional, Alonso-Pulpón, Luis, additional, Egido, Jesús, additional, Mahíllo-Fernández, Ignacio, additional, and Lorenzo, Óscar, additional

Published
2020
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39. Monocyte Chemoattractant Protein-1 Is an Independent Predictor of Coronary Artery Ectasia in Patients with Acute Coronary Syndrome

Author

Franco-Peláez, Juan Antonio, primary, Martín-Reyes, Roberto, additional, Pello-Lázaro, Ana María, additional, Aceña, Álvaro, additional, Lorenzo, Óscar, additional, Martín-Ventura, José Luis, additional, Blanco-Colio, Luis, additional, González-Casaus, María Luisa, additional, Hernández-González, Ignacio, additional, Carda, Rocío, additional, Martín-Mariscal, María Luisa, additional, Egido, Jesús, additional, and Tuñón, José, additional

Published
2020
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40. Prognostic value of initial QRS analysis in anterior STEMI: Correlation with left ventricular systolic dysfunction, serum biomarkers, and cardiac outcomes

Author

López‐Castillo, Marta, primary, Aceña, Álvaro, additional, Pello‐Lázaro, Ana M., additional, Viegas, Vanessa, additional, Merchán Muñoz, Beatriz, additional, Carda, Rocío, additional, Franco‐Peláez, Juan, additional, Martín‐Mariscal, Maria Luisa, additional, Briongos‐Figuero, Sem, additional, and Tuñón, Jose, additional

Published
2020
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41. PCSK9 and HS-CRP Predict Progression of Aortic Stenosis in Patients with Stable Coronary Artery Disease

Author

Aceña, Álvaro, primary, Franco Peláez, Juan Antonio, additional, Pello Lázaro, Ana María, additional, Gonzalez Parra, Emilio, additional, Gonzalez Lorenzo, Óscar, additional, Martínez-Milla, Juan, additional, Hernandez, Ignacio, additional, Martín-Mariscal, María Luisa, additional, Lopez Castillo, Marta, additional, Kallmeyer, Andrea, additional, Lorenzo, Oscar, additional, González-Casaus, María Luisa, additional, Egido, Jesús, additional, and Tuñón, José, additional

Published
2020
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42. Galectin-3 is Associated with Cardiovascular Events in Post-Acute Coronary Syndrome Patients with Type-2 Diabetes

Author

Lorenzo-Almorós, Ana, primary, Pello, Ana, additional, Aceña, Álvaro, additional, Martínez-Milla, Juan, additional, González-Lorenzo, Óscar, additional, Tarín, Nieves, additional, Cristóbal, Carmen, additional, Blanco-Colio, Luis M, additional, Martín-Ventura, José Luis, additional, Huelmos, Ana, additional, Gutiérrez-Landaluce, Carlos, additional, López-Castillo, Marta, additional, Kallmeyer, Andrea, additional, Cánovas, Ester, additional, Alonso, Joaquín, additional, López Bescós, Lorenzo, additional, Egido, Jesús, additional, Lorenzo, Óscar, additional, and Tuñón, Jose, additional

Published
2020
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43. Advanced interatrial block: An electrocardiographic marker for stroke recurrence

Author

García-Talavera, Camila S., primary, Aceña, Álvaro, additional, Andrés López, Alberto, additional, García Torres, María Araceli, additional, Olivié García, Laura, additional, de la Cruz Berlanga, Elena, additional, de los Reyes Oliva Encabo, María, additional, Franco-Peláez, Juan, additional, Tuñón, José, additional, and Rubio, José Manuel, additional

Published
2019
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44. Short- and Long-Term Prognostic Relevance of Cardiogenic Shock in Takotsubo Syndrome: Results From the RETAKO Registry

Author

Almendro-Delia, Manuel, Núñez-Gil, Iván J, Lobo, Manuel, Andrés, Mireia, Vedia, Oscar, Sionis, Alessandro, Martin-García, Ana, Cruz Aguilera, María, Pereyra, Eduardo, Martín de Miguel, Irene, Linares Vicente, José A, Corbí-Pascual, Miguel, Bosch, Xavier, Fabregat Andrés, Oscar, Sánchez Grande Flecha, Alejandro, Pérez-Castellanos, Alberto, Pais, Javier López, De Mora Martín, Manuel, Escudier Villa, Juan María, Martín Asenjo, Roberto, Guillen Marzo, Marta, Rueda Sobella, Ferrán, Aceña, Álvaro, García Acuña, José María, García-Rubira, Juan C, and RETAKO Investigators

Subjects
Male, beta blockers, cardiogenic shock, Shock, Cardiogenic, Prognosis, stress, Risk Factors, Takotsubo Cardiomyopathy, Takotsubo syndrome, beta blockers, cardiogenic shock, stress, Humans, Female, Registries, Takotsubo syndrome, Aged, Proportional Hazards Models
Abstract

OBJECTIVES This study sought to describe the incidence, determinants, and prognostic impact of cardiogenic shock (CS) in takotsubo syndrome (TTS). BACKGROUND TTS can be associated with severe hemodynamic instability. The prognostic implication of CS has not been well characterized in large studies of TTS. METHODS We analyzed patients with a definitive TTS diagnosis (modified Mayo criteria) who were recruited for the National RETAKO (Registry on Takotsubo Syndrome) trial from 2003 to 2016. Cox and competing risk regression models were used to identify factors associated with mortality and recurrences. RESULTS A total of 711 patients were included, 81 (11.4%) of whom developed CS. Mate sex, QTc interval prolongation, tower left ventricular ejection fraction at admission, physical triggers, and presence of "a significant" left intraventricular pressure gradient, were associated with CS (C index 0.85). In-hospital complication rates, including mortality, were significantly higher in patients with CS. Over a median follow-up of 284 days (interquartile range: 94 to 929 days), CS was the strongest independent predictor of tong-term, all-cause mortality (hazard ratio (HR]: 5.38; 95% confidence interval (CI): 2.60 to 8.38); cardiovascular (CV) death (sub-HR: 4.29; 95% CI: 2.40 to 21.2), and non-CV death (sub-HR: 3.34; 95% CI: 1.70 to 6.53), whereas no significant difference in the recurrence rate was observed between groups (sub-HR: 0.76; 95% CI: 0.10 to 5.95). Among patients with CS, those who received beta-blockers at hospital discharge experienced lower 1-year mortality compared with those who did not receive a beta-blocker (HR: 0.52; 95% 0: 0.44 to 0.79; p(interaction) = 0.043). CONCLUSIONS CS is not uncommon and is associated with worse short- and long-term prognosis in TTS. CS complicating TTS may constitute a marker of underlying disease severity and could identify a masked heart failure phenotype with increased vulnerability to catecholamine-mediated myocardial stunning. (C) 2018 by the American College of Cardiology Foundation.

Published
2018

45. Enhancing knowledge and awareness of transthyretin cardiac amyloidosis and shared decision-making among cardiology team members in Colorado, USA via an online educational initiative

Author

Ismailov, Rovshan M, Lerut, Jan, Aceña, Álvaro, and Khasanova, Zaytuna D

Abstract

ABSTRACTObjectivesOur project aimed to increase knowledge of noninvasive diagnostic modalities (including bone radiotracer scintigraphy), raise suspicion of transthyretin cardiac amyloidosis (ATTR-CA), and improve cardiology team member’s awareness and knowledge of shared decision-making (SDM), as well as the quality of SDM communication between cardiology team members and patients.MethodsAn online educational module and survey was developed and cardiology team members in Colorado, USA, were invited to participate. This online educational module included various important topics related to ATTR-CA (e.g., the cause of ATTR-CA, endomyocardial biopsy, and noninvasive methods to diagnose ATTR-CA) and SDM (e.g., benefits of SDM, the role of SDM in the diagnosis of ATTR-CA, implementation of SDM in cardiology practice, and the 3-talk model).ResultsThere were 34 survey respondents, over one-third of whom were cardiologists. Most respondents agreed on the importance of diagnosing ATTR-CA at an early stage, and about three-quarters of the survey takers agreed that bone scintigraphy can reliably diagnose ATTR-CA without the need for endomyocardial biopsy. Concern over increased time commitment was the leading barrier to the implementation of SDM in respondents’ clinical practice. The majority of respondents identified the correct answer regarding ATTR-CA and SDM after reading the online educational module. This improvement in scores after exposure to the online educational module was statistically significant.ConclusionBaseline knowledge and awareness of various issues related to ATTR-CA was relatively low among cardiology team members. Participants’ knowledge was enhanced through our effective online educational program. Prospective educational projects focused on various methods of detecting ATTR-CA as well as other amyloid conditions in diverse clinical settings will remain important.

Published
2022
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46. Prognostic value of initial QRS analysis in anterior STEMI: Correlation with left ventricular systolic dysfunction, serum biomarkers, and cardiac outcomes.

Author

López‐Castillo, Marta, Aceña, Álvaro, Pello‐Lázaro, Ana M., Viegas, Vanessa, Merchán Muñoz, Beatriz, Carda, Rocío, Franco‐Peláez, Juan, Martín‐Mariscal, Maria Luisa, Briongos‐Figuero, Sem, and Tuñón, Jose

Abstract

Background: The presence of pathologic Q waves on admission electrocardiogram (ECG) in patients with anterior ST‐elevated myocardial infarction (STEMI) has been related to adverse cardiac outcomes. Our study evaluates the prognostic value of QRS complex and Q waves in patients with STEMI undergoing percutaneous coronary intervention. Methods: We prospectively analyzed the specific characteristics of QRS complex and pathologic Q waves on admission and on discharge ECG in 144 patients hospitalized for anterior STEMI. We correlated these findings with the development of left ventricular systolic dysfunction (LVSD), appearance of heart failure (HF) or death during follow‐up, and levels of several biomarkers obtained 6 months after the index event. Results: Multivariate logistic regression analysis showed that QRS width (odds ratios [OR] 1.05, p =.001) on admission ECG and the sum of Q‐wave depth (OR 1.06, p =.002) on discharge ECG were independent predictors of LVSD development. Moreover, QRS width on admission ECG was related to an increased risk of HF or death (OR 1.03, p =.026). Regarding biomarkers, QRS width on admission ECG revealed a statistically significant relationship with the levels of NT‐pro‐BNP at 6 months (0.29, p =.004); the sum of Q‐wave depth (0.27, p =.012) and width (0.25, p =.021) on admission ECG was related to the higher levels of hs‐cTnI; the sum of the voltages in precordial leads both on admission ECG (−0.26, p =.011) and discharge ECG (0.24, p =.046) was related to the lower levels of parathormone. Conclusions: Assessment of QRS complex width and pathologic Q waves on admission and discharge ECGs aids in predicting long‐term prognosis in patients with STEMI. [ABSTRACT FROM AUTHOR]

Published
2021
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47. PROGNOSTIC VALUE OF HIGH SENSITIVE TROPONIN IN STABLE CORONARY ARTERY DISEASE

Author

Carda, Rocío, primary, Lorenzo, Oscar, additional, Pello, Ana Maria, additional, Aceña, Álvaro, additional, Landaluce, Carlos Gutierrez, additional, Cristobal, Carmen, additional, Tarín, Nieves, additional, Huelmos, Ana, additional, Fuentes-Antras, Jesús, additional, Mariscal, María Martín, additional, Gonzalez, Ignacio Hernandez, additional, Bescos, Lorenzo Lopez, additional, and Tunon, José, additional

Published
2018
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49. Use of Proton-Pump Inhibitors Predicts Heart Failure and Death in Patients with Coronary Artery Disease

Author

Pello Lázaro, Ana María, primary, Cristóbal, Carmen, additional, Franco-Peláez, Juan Antonio, additional, Tarín, Nieves, additional, Aceña, Álvaro, additional, Carda, Rocío, additional, Huelmos, Ana, additional, Martín-Mariscal, María Luisa, additional, Fuentes-Antras, Jesús, additional, Martínez-Millá, Juan, additional, Alonso, Joaquín, additional, Lorenzo, Óscar, additional, Egido, Jesús, additional, López-Bescós, Lorenzo, additional, and Tuñón, José, additional

Published
2017
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50. Prevalencia y consecuencias de las alteraciones del metabolismo mineral en cardiopatía isquémica

Author

Aceña, Álvaro, Tuñón Fernández, José, Egido de los Ríos, Jesús, and UAM. Departamento de Medicina

Subjects
Metabolismo mineral - Tesis doctorales, Medicina, Corazón - Enfermedades - Tesis doctorales
Abstract

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 27-11-2015

Published
2015

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