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148 results on '"Accoto, D."'

1. A soft-lithographed chaotic electrokinetic micromixer for efficient chemical reactions in lab-on-chips

Author

Campisi, M., Accoto, D., Damiani, F., and Dario, P.

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

Mixing is one of the basic functions which automated lab-on-chips require for the effective management of liquid samples. In this paper we report on the working principle, design, fabrication and experimental characterization of a soft-lithographed micromixer for microfluidic applications. The device effectively mixes two liquids by means of chaotic advection obtained as an implementation of a Linked Twisted Map (LTM). In this sense it is chaotic. The liquids are electrokinetically displaced by generating rolls through AC electroosmosis on co-planar electrodes. The device performance has been tested on dyed DI-water for several voltages, frequencies and flow-rates, displaying good mixing properties in the range of $10 \div 100$kHz, at low peak-to-peak voltages ($\sim15 \div 20$ volts). Low voltage supply, small dimensions and possibility of fabrication via standard lithographic techniques make the device highly integrable in lab-on-a-chip platforms., Comment: 8 pages, 6 fihures

Published
2007
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11. A new surgical positioning system for robotic assisted minimally invasive spine surgery and transpedicular approach to the disc

Author

Gianluca Vadalà, Accoto D, Russo F, Portaccio I, Rossini M, Valentini S, Papalia R, and Denaro V

Abstract

Minimally Invasive Spine Surgery (MISS) procedures for the treatment of spinal pathologies have experienced exponential growth due to improved techniques and decreased trauma to the patient. Several MISS procedures that require the use of a trans-pedicular cannula as a guiding tool for pedicle screw placement, delivery of biomaterials to the vertebral body or injection of biologics to the disc space have been described. Although these are clear advantages of MISS, the limited dissection and exposure may reduce the accuracy and stability of operation and make spine surgeons rely heavily on intraoperative fluoroscopy, raising concerns over the level of radiation exposure. Robot-assisted minimal invasive surgery has aroused more attention for its high precision and stability, minimizing risks of damage to neurovascular structures and diminishing harmful exposure to ionizing radiation. The aim of this paper is to describe and characterize a new surgical positioning system for for robotic assisted MISS. The system is conceived to be integrated in a surgical platform capable of supporting the surgeon in a new procedure to treat degenerative intervertebral disc disease. For this purpose, it is necessary to orientate a cannula in order to guide the bone drill along a planned route, to access the intervertebral disc through the pedicle and endplate. In particular, we describe a mechanism that percutaneously guides a cannula towards the intervertebral disc based on the acquisition of few fluoroscopic images. The design of the positioning system, with its features and constrains imposed by the presence of instrumentation and medical staff in the operating room, as well as the software for trajectory planning during surgery, are here described.

Published
2017

26. An implantable neural interface with electromagnetic stimulation capabilities

Author

Accoto, D, Francomano, Mt, Rainer, A, Trombetta, M, Rossini, Paolo Maria, Guglielmelli, E., Rossini, Paolo Maria (ORCID:0000-0003-2665-534X), Accoto, D, Francomano, Mt, Rainer, A, Trombetta, M, Rossini, Paolo Maria, Guglielmelli, E., and Rossini, Paolo Maria (ORCID:0000-0003-2665-534X)

Abstract

Invasive interfaces with the Peripheral Nervous System (PNS), which currently rely on electric means for both nerves stimulation and signals recording, are needed in a number of applications, including prosthetics and assistive technologies. Recent studies showed that the quality of the signal-to-noise ratio of the afferent channel might be negatively affected by physiological reactions, including fibrosis. In this paper we propose a novel approach to the development of implantable neural interfaces, where the PNS is excited electromagnetically and in situ, while electrical means are used only for neural signals recording. Electromagnetic (EM) waves, capable of overcoming fibrotic capsules, are generated by microfabricated coils. Stimulation coils and registration electrodes are deposited on the same flexible substrate, also provided with a bio-absorbable coating, which releases anti-fibrotic drugs and neurons-specific functionalized magnetic nanoparticles (NPs). The NPs are intended to improve the capability of local EM waves to elicit membranes depolarization, thus enhancing selectivity. This paper details the concept of the proposed technology and provides a preliminary in silico feasibility study.

Published
2013

29. Medical Micro-Robotics

Author

Dario, Paolo, Menciassi, Arianna, Accoto, D., Phee, L., and Stefanini, Cesare

Published
2001

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