37 results on '"Acıcan, Turan"'
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2. Does anticoagulation in combination with immunosuppressive therapy prevent recurrent thrombosis in Behçet's disease?
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Erol, Serhat, Gürün Kaya, Aslıhan, Arslan, Fatma, Hasanzade, Hasan, Daştan, Ahmet Onur, Çiledağ, Aydın, Eriş Gülbay, Banu, Kaya, Akın, Özdemir Kumbasar, Özlem, Çelik, Gökhan, and Acıcan, Turan
- Abstract
Vascular involvement in Behçet's disease (BD) occurs in up to 50% of patients. The main mechanism of thrombosis is inflammation. Thus, immunosuppressants (IS) are the mainstay of therapy, and adding anticoagulation (AC) is controversial. In daily practice, we observed that patients who received AC in combination with IS experienced less recurrent thrombosis and decided to investigate our BD patients retrospectively. We hypothesized that adding AC to immunosuppressive therapy may lower the risk of recurrent thrombosis. Treatment at the time of first or recurrent thrombotic events was recorded. Events under the only IS and IS + AC treatments were compared. There were 40 patients (33 males). The most common types of first vascular events were deep vein thrombosis (77.5%) followed by pulmonary embolism (PE) (52.5%). One patient did not receive any treatment. Among the 39 patients, 32 received glucocorticoid and at least one of the azathioprine, or cyclophosphamide, anti-TNF, 5 received monotherapy with azathioprine, 1 received monotherapy with corticosteroid, and the remaining 1 received monotherapy with cyclophosphamide. In total, 22 patients (55%) experienced 27 recurrent venous thromboembolism (VTE) events. Two (7.4%) events while only on AC, 2 (7.4%) events while on AC + IS, and 15 (55.5%) events occurred while on only IS. Eight (19.6%) patients were not receiving any treatment during relapses. The recurrence rate was statistically significantly lower in the IS + AC treatment group compared to IS alone. In conclusion, IS are the mainstay of treatment for BD, and adding AC may help to lower the recurrence risk of thrombotic events. [ABSTRACT FROM AUTHOR]
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- 2024
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- View/download PDF
3. Clinical and Polysomnographic Differences in Elderly Obstructive Sleep Apnea Patients
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Çiftci, Fatma, primary, Gülbay, Banu, additional, Bulut, Barış, additional, Erdemir Işık, Merda, additional, Önen, Zeynep Pınar, additional, and Acıcan, Turan, additional
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- 2022
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4. Is it important to know the predominant respiratory event in AHI for the management of patients with OSA?
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Gülbay, Banu, primary, Bulut, Barış, additional, Ayöz, Sümeyye, additional, and Acıcan, Turan, additional
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- 2022
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5. Analysis of the factors related to mortality in patients with bronchiectasis
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Onen, Zeynep Pınar, Eris Gulbay, Banu, Sen, Elif, Akkoca Yildiz, Öznur, Saryal, Sevgi, Acican, Turan, and Karabiyikoglu, Gülseren
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- 2007
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6. Side effects due to primary antituberculosis drugs during the initial phase of therapy in 1149 hospitalized patients for tuberculosis
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Gülbay, Banu Eriş, Gürkan, Özlem Ural, Yıldız, Öznur Akkoca, Önen, Zeynep Pınar, Erkekol, Ferda Öner, Baççıoğlu, Ayşe, and Acıcan, Turan
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- 2006
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7. Polysomnographic, demographic and clinic differences between male and female obstructive sleep apnea patients
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Erdemir Işık, Merda, primary, Gülbay, Banu, additional, Çiftci, Fatma, additional, and Acıcan, Turan, additional
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- 2020
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8. Investigation of the Presence of Glaucoma in Patients with Obstructive Sleep Apnea Syndrome Using and Not Using Continuous Positive Airway Pressure Treatment
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Abdullayev, Ahmet, primary, Tekeli, Oya, additional, Yanık, Özge, additional, Acıcan, Turan, additional, and Gülbay, Banu, additional
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- 2019
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9. Clinical and polysomnographic features of hypertension in obstructive sleep apnea: A single-center cross-sectional study.
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Kaya, Aslıhan Gürün, Gülbay, Banu, and Acıcan, Turan
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SLEEP apnea syndromes ,HYPERTENSION ,EPWORTH Sleepiness Scale ,BLOOD pressure ,CROSS-sectional method - Abstract
Objective: Obstructive sleep apnea (OSA) is associated with elevated blood pressure (BP) and increases the risk of developing cardiovascular diseases. This study aimed to determine the clinical and polysomnographic features of OSA that are significantly associated with hypertension (HT). Methods: This is a prospective study that enrolled patients diagnosed with OSA in Ankara University Faculty of Medicine from January 2015 to June 2016. The patients were categorized into normotensives (n=125) and hypertensives (n=141). BP was taken at the evening before and the morning after polysomnography (PSG). The polysomnographic findings of normotensive and hypertensive patients were compared, and independent risk factors that are associated with HT were analyzed. Results: Hypertensive patients exhibited older age and higher Epworth sleepiness scale (ESS), apnea-hypopnea index (AHI), mean apnea duration, arousal index, and oxygen desaturation index (ODI) than normotensive patients. Nocturnal oxygen desaturation (NOD) was more frequent and the percentage of the duration of NOD to total sleep time (TST) was higher in hypertensive than normotensive patients. Multivariate analyses revealed that age (OR: 1.095, 95% CI 1.053 to 1.139, p<0.001), ESS (OR: 1.186, 95% CI 1.071 to 1.313, p=0.001), mean apnea duration (OR: 1.072, 95% CI 1.032 to 1.113, p=0.002), ODI (OR: 1.062, 95% CI 1.025 to 1.101, p=0.001), and NOD (OR: 2.439, 95% CI 1.170 to 5.086, p=0.017) were independent risk factors for HT in OSA. Conclusion: This study suggests that age, ESS, parameters of oxygenation, and apnea duration were associated with HT in patients with OSA. Hence, patients with OSA with these findings should be evaluated for HT. [ABSTRACT FROM AUTHOR]
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- 2020
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10. Predictive Value of STOP-BANG on OSAS-Related Complications Following Coronary Artery Bypass Grafting
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Diken, Özlem Erçen, primary, Diken, Adem İlkay, additional, Yalçınkaya, Adnan, additional, Gülbay, Banu, additional, Acıcan, Turan, additional, Demir, Emre, additional, Özyalçın, Sertan, additional, and Erol, Mehmet Emir, additional
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- 2018
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11. Where do we perform sleep test: In the laboratory or at home?
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Köseoğlu, Handan İnönü, Kanbay, Asiye, Acıcan, Turan, Gaziosmanpaşa Üniversitesi, and 0-Belirlenecek
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Genel ve Dahili Tıp - Abstract
Obstrüktif uyku apne sendromu (OSAS), erkeklerde %14.3, kadınlarda %5 oranında görülen, başta kardiyovasküler ve serebrovasküler olmak üzere birçok sistemi etkileyen sonuçları nedeniyle morbidite ve mortaliteye yol açabilen önemli bir halk sağlığı problemidir. Toplumda yaygın olmasına rağmen dünyada ve ülkemizde mevcut uyku laboratuvarları bu hastaların teşhisinde yetersiz kalmakta, OSAS'lı olguların %80-90'ına tanı konulamamaktadır. Bu durum, tanıda altın standart yöntem olan polisomnografi incelemesine alternatif olarak, daha pratik, daha az emek ve maliyet gerektiren, teknisyen refakati gerektirmeyen, hastaların evlerinde uygulanabilen portabl monitörizasyon cihazlarının kullanımını gündeme getirmiştir. Bu yazıda OSAS şüphesi olan bir hastaya yapılacak uyku testinin, etkin ve güvenilir olması ve hızlı sonuç vermesi için laboratuvarda mı, yoksa evde mi yapılmasının daha uygun olacağı, bilimsel veriler ışığında tartışılacaktır. Obstructive sleep apnea syndrome (OSAS) is an important public health problem seen in 14.3% of male, and 5% of female population which leads to higher morbidity, and mortality rates because of its outcomes effecting many organ systems including cardiovascular, and cerebrovascular systems. Despite its higher prevalence in community, sleep laboratories both in our country, and in the world remain incapable of diagnosing these patients, and 80-90% of the cases with OSAS can not be diagnosed. As an alternative to gold standard polysomnographic examinations this desperate condition revived the use of more practical, and less expensive portable monitorization devices which can be used at home without the need for help of a technician. In this article we will discuss whether application of sleep test on a patient with suspect OSAS in the laboratory or at home will be more appropriate regarding effectiveness, and reliability of the test in the light of the scientific data.
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- 2016
12. Stabil Kronik Obstriktif Akciğer Hastalarının Vücut Kompozisyonu: Malnutrisyonun Sağlıklı Sigara İçicileri ile Karşılaştırılması
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Baççıoğlu, Ayşe, Eriş, Banu Gülbay, and Acıcan, Turan
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Genel ve Dahili Tıp - Abstract
Amaç: Malnütrisyonun (beden kitle indeksi (BKİ)
- Published
- 2014
13. Health-Related Quality of Life in Patients with Sleep-Related Breathing Disorders: Relationship with Nocturnal Parameters, Daytime Symptoms and Comorbid Diseases
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Gülbay, Banu Eriş, primary, Acıcan, Turan, additional, Önen, Zeynep Pınar, additional, Yıldız, Öznur Akkoca, additional, Baççıoğlu, Ayşe, additional, Arslan, Fatma, additional, and Köse, Kenan, additional
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- 2007
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14. Atopic Status of an Adult Population with Active and Inactive Tuberculosis
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Mungan, Dilşad, primary, Ayşe Sin, Betül, additional, Çelik, Gülfem, additional, Ural Gürkan, Özlem, additional, Acıcan, Turan, additional, and Mısırlıgil, Zeynep, additional
- Published
- 2001
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15. Body Composition in Patients with Stable Chronic Obstructive Pulmonary Disease: Comparison with Malnutrition in Healthy Smokers.
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Baccioglu, Ayse, Gulbay, Banu Eris, and Acıcan, Turan
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MALNUTRITION ,ANALYSIS of variance ,ANTHROPOMETRY ,BODY composition ,CHI-squared test ,COMPARATIVE studies ,FISHER exact test ,LONGITUDINAL method ,OBSTRUCTIVE lung diseases ,SMOKING ,STATISTICS ,T-test (Statistics) ,DATA analysis software ,MANN Whitney U Test - Abstract
Copyright of Eurasian Journal of Medicine is the property of Ataturk University, School of Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2014
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16. The Importance of Symptoms, Symptom Duration and Chest X-Ray in the Diagnosis of Active Pulmonary Tuberculosis.
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Gülbay, Banu Eriş, Erkekol, Ferda Ãner, Ãnen, Zeynep Pınar, Tarakçı, Neslihan, Gürkan, Ãzlem Ural, and Acıcan, Turan
- Abstract
Objective: Isolation of patients with suspected pulmonary active Tuberculosis (TB) to obtain bacteriologic results is an important problem. Material and Method: We investigated the importance of symptoms, duration of symptoms and the radiologic findings in TB diagnosis in 131 active pulmonary TB patients. The symptoms (for TB; typical, compatible with, atypical), period of symptoms (15 days, 16-30 days, >30 days) and chest X-Ray pattern (CXR) (scored as typical, compatible with, atypical) were obtained on admission. Results: 78.6% of patients had a positive smear for acid-fast bacilli (ARB). 95.4% of patients had symptoms typical and/or compatible with TB. Cough, sputum production, and night sweating were the most common symptoms. In 48.1 % of patients, symptom duration was >30 days and symptom duration was 15 days in 22.1%. 80.1% of patients had CXR with typical and/or compatible with TB. 9 of 69 patients (13%) with typical symptoms had atypical CXR and the symptom period was 15 days in 15 (21.7%). 15 of 29 patients (51.7%) with short symptom duration (15 days) had typical CXR for TB. There were no significant relationship between symptoms, symptom duration and radiologic findings. In the smear positive group, symptom duration of patients was longer than in the smear negative group (p=0.007) and there was a statistically significant relationship between smear results and radiologic findings (p=0.006). Conclusion: In conclusion, we showed that TB could be determined in the patients with atypical symptoms, short symptom period, and atypical radiologic findings for TB. For this reason, we thought that microbiologic examination as soon as possible is the most important approach in the diagnosis and isolation of the patients with active pulmonary TB. [ABSTRACT FROM AUTHOR]
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- 2011
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17. Long-term Smoking Cessation Rates and Differences in Outpatients with Chronic Obstructive Pulmonary Disease and Asthma.
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Ãnen, Zeynep Pınar, Şen, Elif, Gülbay, Banu Eriş, Yıldız, Ãznur Akkoca, Acıcan, Turan, Saryal, Sevgi, and Karabıyıkoğlu, Gülseren
- Abstract
Objective: Smoking is an important contributor to respiratory diseases and is the major etiological factor for the development of chronic obstructive pulmonary disease (COPD) and adversely affects control of asthma. For this reason, smoking cessation is the one of the most important ways to improve the prognosis of patients with respiratory disease. Our aim was to determine the characteristics with the long-term smoking cessation rates of outpatients with COPD and asthma and compared the differences between the diseases. Material and Method: 42 smokers with COPD and 28 asthma patients were prospectively evaluated in 2007. All of the patients answered the Fagerstrom test with a regular questionnaire of general characteristics. Baseline spirometry and CO oximetry were performed. The 24 months follow-up results and demographic characteristics were reported. Results: COPD patients were older and the total amount of smoked cigarettes was higher with an evident airway obstruction. In the first year, the smoking cessation rate was less with high tobacco dependence relapses in outpatients with asthma (32% and 18%) compared with COPD (55% and 9%). Asthma patients were predominantly women and cessation rates were quite low with higher relapse rates in women compared with men. At the end of 2 years follow up, smoking cessation rates for COPD was 45%, whereas this was 18% for asthma, which was dramatically low. Conclusion: Results of this analysis confirm that smoking cessation is still a huge problem to be solved in respiratory diseases. Even if smoking is not an etiological factor in asthma, tobacco dependence is more severe and long-term cessation rates are very low with high relapses. [ABSTRACT FROM AUTHOR]
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- 2011
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18. Kronik Obstrktif Akciğer Hastalığı ve Astım Olgularında Uzun Dnem Sigara Bırakma Oranları ve İki Grup Arasındaki Farklılıklar.
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Önen, Zeynep Pınar, Şen, Elif, Gülbay, Banu Eriş, Yıldız, Öznur Akkoca, Acıcan, Turan, Saryal, Sevgi, and Karabıyıkoğlu, Gülseren
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ASTHMA diagnosis ,OBSTRUCTIVE lung disease diagnosis ,MEDICAL needs assessment ,OUTPATIENT medical care ,CHRONIC diseases ,LONGITUDINAL method ,PATIENTS ,SMOKING ,SMOKING cessation ,CHEST (Anatomy) - Abstract
Copyright of Turkish Thoracic Journal / Turk Toraks Dergisi is the property of Aves Yayincilik Ltd. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2011
- Full Text
- View/download PDF
19. Aktif Akciğer Tberkloz Tanısında; Semptomlar, Semptom Sresi ve Akciğer Grafisinin Yeri.
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Gülbay, Banu Eriş, Erkekol, Ferda Öner, Önen, Zeynep Pınar, Tarakçı, Neslihan, Gürkan, Özlem Ural, and Acıcan, Turan
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ISOLATION (Hospital care) ,TUBERCULOSIS diagnosis ,CHEST X rays ,TUBERCULOSIS ,LABORATORY test panels ,CHEST (Anatomy) ,SYMPTOMS - Abstract
Copyright of Turkish Thoracic Journal / Turk Toraks Dergisi is the property of Aves Yayincilik Ltd. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2011
- Full Text
- View/download PDF
20. Kardiyopulmoner hastalığı olanlarda sigaranın bırakılması.
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Önen, Zeynep Pınar, Şen, Elif, Gülbay, Banu Eriş, Öztürk, Ayperi, Yıldız, Öznur Akkoca, Acıcan, Turan, Saryal, Sevgi, and Karabıyıkoğlu, Gülseren
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SMOKING cessation ,OUTPATIENT medical care ,CARDIOPULMONARY system ,DISEASES ,CIGARETTE smokers ,TOBACCO - Abstract
Copyright of Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi is the property of KARE Publishing and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Published
- 2011
- Full Text
- View/download PDF
21. CAT Scores May Reflect the Physiological Changes in COPD Patients
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Sen, Elif, Arslan, Fatma, Arkan, Gokcen, Acar, Duygu, Onen, Pinar, Gulbay, Banu, Yildiz, Oznur, Acican, Turan, Saryal, Sevgi, and Karabiyikoglu, Gulseren
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- 2012
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22. Health-Related Quality of Life in Patients with Sleep-Related Breathing Disorders: Relationship with Nocturnal Parameters, Daytime Symptoms and Comorbid Diseases.
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Gülbay, Banu Eriş, Acıcan, Turan, Önen, Zeynep Pınar, Yıldız, Öznur Akkoca, Baççıoğlu, Ayşe, Arslan, Fatma, and Köse, Kenan
- Subjects
- *
QUALITY of life , *DYSPNEA , *COMORBIDITY , *SNORING , *SLEEP apnea syndromes , *DROWSINESS , *ANALYSIS of variance - Abstract
Background: Sleep-related breathing disorders (SRBD) are frequently encountered health problems in the general population. Habitual snoring and obstructive sleep apnea/hypopnea syndrome (OSAHS) constitute most SRBD diagnoses. Although the decrease in quality of life is a well-known entity in SRBD patients, there is not enough data regarding the underlying pathophysiological mechanisms to explain this deterioration. Objectives: The aim of this study was to investigate which parameters were affecting the quality of life in patients with SRBD. Methods: Medical Outcome Survey – Short Form 36 (SF-36) and Epworth Sleepiness Scale were used in 135 patients with SRBD (69 patients with OSAHS and 66 patients with habitual snoring), and Charlson comorbidity index was calculated. Acquired data were compared with leading symptoms and polysomnographic findings in these patients. Results: All SF-36 scores were significantly decreased in SRBD patients. However, there were no significant differences in the SF-36 scores of these patients. Also, no significant correlation was found between the severity of OSAHS and the SF-36 scores. Similarly, none of the polysomnographic parameters was found significantly correlated with SF-36 scores. In contrast, all SF-36 scores were influenced by body mass index, Epworth Sleepiness Scale score, mean nocturnal saturation and the presence of coexisting diseases. Conclusions: According to the results of multiple variance analysis, we concluded that the quality of life depends on a number of collaborative factors such as obesity, mean nocturnal saturation, symptoms related to SRBD and the presence of comorbid diseases, rather than only on one independent parameter in the patients with SRBD. Copyright © 2007 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2008
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23. Uyku bozukluklarında kullanılan polisomnografi dışı tanıyöntemlerinin obstrüktif uyku APNE sendromu tanısını öngörmede etkinliğinin araştırılması
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Güngör, Kübra, Acıcan, Turan, and Göğüs Hastalıkları Anabilim Dalı
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Göğüs Hastalıkları ,Chest Diseases - Abstract
Obstrüktif uyku apne sendromu (OSAS), uyku sırasında oksijen satürasyonunda azalmaya neden olabilen tekrarlayan apne/hipopneler ile karakterize bir hastalıktır. Erkek cinsiyet, ileri yaş, obezite, geniş boyun çevresi (BÇ) ve hipertansiyon (HT) varlığı OSAS'a eğilimi arttırmaktadır. Tanısının konulması hastalığın prognozu ve uygun tedavi seçimi açısından önemlidir. Altın standart tanı yöntemi olan polisomnografi (PSG) pahalı, zaman alıcı ve özel donanım gerektiren bir çalışma olduğundan hasta seçiminde dikkatli davranılması gerekir. Çalışmamızda Berlin, STOP-BANG ve Epworth Uykululuk Anketi'nin PSG ile kıyaslanarak OSAS tanısını ön görmedeki etkinliğinin araştırılması amaçlanmıştır. Çalışmamızda, Ankara Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Uyku Ünitesi'nde PSG yapılmış 136 hasta incelendi ve hastalara başvuru anında uyku anketleri uygulandı. Hastaların AHİ (apne-hipopne indeksi) değerleri ile anketler karşılaştırıldı. Orta-ağır dereceli OSAS grubunun yaş, beden kitle indeksi (BMİ), BÇ ortalaması ve HT sıklığı hafif OSAS/non-OSAS grubuna göre yüksek (33,2 kg/m² vs 29,7 kg/m²;52,4 vs 48,4; 42,9 cm vs 40,1 cm; %50 vs %25) bulundu. Berlin Anketi'nin düşük risk grubuna kıyasla yüksek riskli grupta AHİ ile %88 tutarlılığa sahip olduğu saptandı(p
- Published
- 2020
24. Hipertansiyonu olan ve olmayan obstrüktif uyku apne sendromlu hastalarda polisomnografik değişiklikler
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Gürün Kaya, Aslihan, Acıcan, Turan, and Göğüs Hastalıkları Anabilim Dalı
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Göğüs Hastalıkları ,Polysomnography ,Oxygen saturation ,Hypertension ,Chest Diseases ,Sleep disorders ,Signs and symptoms ,Body mass index ,Sleep apnea syndromes - Abstract
Obstrüktif uyku apne sendromu (OSAS), uyku sırasında oksijen satürasyonunda azalmaya neden olabilen tekrarlayan apne veya hipopneler ile karakterize bir hastalıktır. OSAS genel popülasyonun yaklaşık %5-15'ini etkileyen bir durumdur. OSAS ve hipertansiyon arasında iki yönlü bir ilişki vardır. Hipertansif hasta popülasyonunda OSAS sıklığı artmakla birlikte, OSAS'lı hastalarda da hipertansiyon görülme sıklığı artmıştır. Bu çalışmada Türkiye'de OSAS ön tanısı ile polisomnografi yapılan hastalarda eşlik eden hipertansiyon varlığının semptomatik, demografik ve polisomnografik etkilerinin araştırılması amaçlanmıştır.Çalışmamıza Ankara Üniversitesi Tıp Fakültesi Göğüs Hastalıkları Uyku Laboratuvarında OSAS tanısı almış 150 hasta dahil edildi. Bu hastaların 75'inin daha önceden hipertansiyon tanısı mevcuttu. Hastaların demografik özellikleri, semptom sorgulamaları ve polisomnografi bulguları prospektif olarak kayıt altına alındı. Hipertansiyonu olan grubun yaş ortalaması, beden kitle indeksi (VKİ) ve Epworth uykululuk ölçeği (ESS) skoru normotansif gruba göre daha yüksek bulundu (yaş: 55.3 vs 46.3; p
- Published
- 2016
25. Obstrüktif Uyku Apne Sendromunda (OUAS) Kalp Hızı Değişkenliği (KHD) ile hastalık şiddeti arasındaki ilişki ve OUAS'lı hastalarda KHD'nin kardiyovasküler hastalık riski açısından önemi
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Buket, Başa Akdoğan, Acıcan, Turan, and Göğüs Hastalıkları Anabilim Dalı
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Cardiovascular system ,Risk factors ,Göğüs Hastalıkları ,Heart rate ,Chest Diseases ,Disease ,Sleep apnea syndromes - Abstract
Amaç; Obstrüktif Uyku Apne Sendromu (OUAS), uyku sırasında üst hava yolunun sürekli olarak tekrarlayan tıkanmaları ile seyreden bir tablodur. Kardiovaskuler sonuçlarıyla ciddi morbidite ve mortalite kaynağıdır. OUAS'da tekrarlayan solunum olaylarının ve arousalların yol açtığı otonom sinir sistemi değişikliklerinin, hipoksi ataklarının ve uyku yoksunluğunun yol açtığı sistemik inflamatuar değişikliklerin, ortaya çıkan kardiyovasküler sonuçlardan sorumlu olduğu düşünülmektedir. Kalp hızı değişkenliği (KHD) ise kardiyak otonomik aktivitenin noninvazif olarak değerlendirilmesini sağlayan bir metottur. Bozulmuş otonomik aktivite, kardiyovasküler hastalıkların önemli bir göstergesidir. Normal uyku sırasında KHD`de artış izlenmektedir. OUAS'lı hastalarda ise artmış sempatik hiperaktivite bulunduğu gösterilmiştir. Artmış sempatik aktivite ile istirahattaki kalp hızı artar, EKG'de R-R interval değişkenliği azalır. KHD'ndeki azalma, ventriküler aritmilerin ve kardiyak ani ölümlerin patogenezi ile yakından ilişkili olan baskılanmış vagal aktivitenin göstergesidir. Kronik sempatik aktivasyonun, OUAS ile kardiyovasküler morbidite arasındaki ilişkide anahtar mekanizmayı oluşturduğu düşünülmektedir. Bu nedenle subklinik otonomik fonksiyon bozukluğunun KHD analizi ile erken dönemde belirlenmesi, hem risk analizi hem de tedavi planı açısından önemlidir. Bu çalışmada; OUAS'lı (AHI >5/sa ) hastalar ile habitüel horlamalı (AHİ 5 olguların, AHI>30 olguların, NOD (+) olguların, gece boyunca saptanan en düşük SaO2 %'si düşük hastaların, ortalama SaO2 %'si düşük olan hastaların, HH'lı ve NOD (-) olgulara göre, KHD özelikle NREM döneminde belirgin olacak şekilde azalma olduğu gösterilmiştir. Olguların ESS skoru, dolayısıyla gündüz aşırı uykuluk halinin şiddeti arttıkça, uyku sırasındaki kalp hızlarının arttığı gösterilmiştir. NOD'u olan olguların olmayan olgulara göre uyku sırasındaki kalp hızlarının istatistiksel olarak anlamlı şekilde yüksek olduğu (p=0,008) ve gündüz EKG'lerindeki kalp hızlarında kalp hızı yüksek saptanmaya devam etmiştir. Ağır OUAS'lı hasta grubu ve HH'lı hastaların PSG'deki EKG kayıtlarının incelenmesinde, Ağır OUAS'lı olgularda sık VPS ler, aritmiler HH' lı hastalara göre daha sık görülmüştürSonuç; AHI ağırlığı kadar NOD, gece boyunca saptanan en düşük SaO2`unun da KHD' de etkili olduğu, kardiyovasküler riskin artması açısından önemli paremetreler olduğu gösterilmiştir. Bu hastaların sadece uyku boyunca değil uyanıklıkta da riskinin artığı söylenebilir. Bu nedenle; AHI yüksek ağır OUAS'lı hastalar dışında GAUH başta olmak üzere semptomları siddetli olan, NOD şiddeti fazla olan, gece boyu saptanan en düşük SaO2 %'si düşük olan, ortalama SaO2 %`si düşük olan hastaların öncelikli tedavisi ve kardiyovasküler açıdan muayenesi, hiperlipidemi ve DM açısından değerlendirilmesi, gerekirse holter yapılmasının önerilmesinin uygun olacağı sonucuna varılmıştır.Anahtar kelimeler; OUAS, NOD, KHD, kardiyovasküler risk Objective ;OSAS is characterised by repeated episodes of upper airway obstruction during sleep. Considering its cardiovascular consequences, OSAS is a serious source of morbiditiy and mortality. It is suggested that; changes of autonomeous nervous system due to arousals and repetitive breathing events in OSAS, hypoxia attacks and systemic inflammatory changes due to lack of sleep are associated with cardiovascular consequences. HRV analysis is a method used to noninvasively evaluate cardiac autonomic functions. Disordered autonomic activity is an important indicator of cardiovascular disease. During normal sleep, an increase at HRV is observed. An elevated symphatetic hyperactivity has shown in patients with OSAS. Due to evelated symphatetic activity, heart rate at rest increases and R-R interval variability reduces. Decrease at HRV is an indicator of restrained vagal activity which is closely associated with ventricular arrythmia and pathogenesis of cardiac sudden deaths. It is suggested that chronic symphatetic activation is the key mechanism of correlation between OSAS and cardiovascular morbidity. Therefore, detection of subclinical autonomic dysfunction by HRV analysis at early period is important both in terms of risk analysis and treatment plan. In this study we aimed to identify the differences between patients with OSAS (AHI>5/h) and patients with habitual snoring (HS) in terms of HRV and to investigate the correlation between HRV and severity of disease and respiratory parameters.Material and Method;60 patients who referred to Ankara University Faculty of Medicine, Sleep Laboratory between March 2008 and June 2009 with symptoms of snoring, witnessed apnoea and excessive daytime somnolence were studied prospectively. Detailed history and physical examination was performed. Whole blood and biochemical tests were performed for all patients and serum, c reactive protein (CRP) and TSH levels were measured, oxygen saturation and/or arterial blood gas analysis and spirometry was performed. Patients? routine wakefulness ECGs and ESS scores were evaluated. Polysomnography (PSG) was performed to all patients and scored. HRV parameters were determined by HRV analysis software found in our PSG device. Patients? data were compared statistically.Findings;The group consisted of 60 patients (39 men, 21 women) with a mean ± SD age of 47,05 ± 9,5 years. 23 patients (%38) were assesed as severe OSAS, 17 patients (%28) HS, 7 patients (%12) moderate OSAS and 13 patients (%22) mild OSAS. Patients with HS were women. Patients with severe OSAS and NOD were men (p5, AHI>30, NOD (+), whose lowest SpO2 percentage detected overnight is low, whose average Sp02 percentage is low have been shown to decrease at HRV, especially significant during NREM stage, compared to patients with HS and NOD (-). It was found that increasing the ESS scores of patients, thereby the severity of the state of excessive daytime somnolence, heart rate during sleep increased. Patients with NOD (+) had statistically significant higher heart rate during sleep compared to patients with NOD (-) (p=0,008) and these patients? heart rate remained high at daytime ECGs. According to ECG recordings, frequent VPS and arrhythmias has been detected more frequent at severe OSAS patients compared to patients with HS.Result;As well as severity of apnoea/hypopnoea index (AHI), nocturnal desaturation (NOD) and the lowest SpO2 overnight is also effective for HRV and have shown that these are important parameters for increased cardiovascular risk. It can be said that, not only during sleep but also during wakefulness these patients? risk rise. Thus, beside patients with high severe OSAS, patients who have severe symptoms especially excessive daytime somnolence, patients whose severity of NOD is excessive, patients whose lowest SpO2 percentage detected overnight is low and patients whose average Sp02 percentage is low should be treated primarily. Also, it?s suggested that these patients should get cardiovascular therapy, should be evaluated in terms of hyperlipidemia and DM and holter should be done if needed.Keywords; OSAS, NOD, HRV, Cardiovascular Risk. 120
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- 2010
26. Kronik obstrüktif akciğer hastalığı stabil dönemde nütrisyonel parametrelerin değerlendirilmesi
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Baççioğlu, Ayşe, Acıcan, Turan, and Göğüs Hastalıkları Anabilim Dalı
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Göğüs Hastalıkları ,Chest Diseases - Abstract
7. ÖZET Malnütrisyon KOAH hastalığının sık görülen bir komplikasyonudur. KOAH'la malnütrisyon prevalansı, nütrisyoncl değerlendirme tekniğine ve çalışılan populasyona göre farklılık göstermektedir. Malnütrisyon, ağır KOAH'lılarda ve kronik hipoksemiklerde daha sık görülmektedir. KOAH hastalarında yağsız vücut kitlesinde azalma düşük ve hatta normal ağırlıklılarda bile görülebilmektedir. Düşük beden kitle indeksi KOAH'da sağkalımı etkileyen, akciğer fonksiyonlarından bağımsız bir prognostik faktördür. Nütrisyonel yetersizlik solunum sistemi fonksiyonlarını farklı yollardan etkilerken, KOAH hastalığı da nütrisyonel durumu olumsuz yönde etkilemektedir. KOAH'ın sistemik hastalık olması, solunum fonksiyonları dışında diğer sistemleri de etkilemesi nedeniyle nütrisyonel durumun tanımlanması KOAH hastalığında klinik değerlendirmenin bir parçası olmalıdır. Nütrisyonel durumun değerlendirmesinde besin alım öyküsü, antropometrik ölçümler ( ÜKÇ, TDKK, el dinamometresi, BKİ) ve biyokimyasal yöntemler ( tam kan sayımı, senim üre, kreatinin, serum elektrolitleri, serum albumin, prealbumin, transferin, CRP) noninvasiv, ucuz, hızlı ve kolay olduğu için rutin olarak kullanılabilir. Malnütrisyon sonucu; Akciğer yapısında amfizematöz değişiklikler oluşmakta, hipoksemiye yanıt bozulmakta, solunum kas kitle ve gücü azalmakta, akut solunum yetmezliği riski artmakta, infeksiyona yatkınlıkda artış sonucu atak sayısı artmakta, hastaneye yatış sayısında, hastanede kalış süresinde ve mekanik ventilatöre bağlanma oranında artış olmakta ve sonuçta KOAH hastalık morbidite ve morlalitesinde artışa yol açmaktadır. Bu nedenle nütrisyonel bozukluğun tanımlanması ve önlenmesi KOAH hastalık seyrinde önemlidir ve KOAH hastalarının değerlendirmesi içinde nütrisyonel değerlendirme yer almalıdır. Kilo kaybı KOAH'da FEVve Pa02 gibi bağımsız bir prognostik faktördür. Malnütrisyonun FEVı ve Pa^'den farkı uygun tedavi ile düzeltilebilir olmasıdır. Uygun nütrisyon desteğiyle vücut ağırlığı arttırılarak solunum parametreleri değişmeksizin prognozun değişmesi mümkündür. Bu nedenle KOAH'lı hastaların klinik değerlendirmesine nütrisyonel durumun da eklenmesi gerekir. 83 8. SUMMARY Malnutrition is a common complication of COPD. The prevalance of malnutrition in patients with COPD is quite variable, according to the method of nutritional assesment and the population studied. Malnutrition is more frequent in patients with advanced disease, especially those with chronic hypoxemia. Reductions in fat free mass can be present in among patients in whom body weight is low and even is normal. Low body weight index is a prognostic factor in survival, independent of lung function in COPD. It is unclear whether malnutrition is the cause of deterioration in pulmonary functions, or whether it is a simply reflect of other processes intrinsic to the disease. Because COPD is a multi-systemic disease, nutritional intervention should be a part of the clinical assesment in COPD. Dietary intake analyse, anthropometric measurements ( including MAMS, TSF, BMI and handgrip dynamamometry) and blood tests (including complete blood count, serum electrolytes, total protein, serum albumin, prealbumin, transferin, CRP, blood urea nitrogen, serum creatinine) are simple, non-invasive, cheap and practical and they can be used in nutritional assesment. Results of malnutrition ; emphysematous changes occure in lung structure, the compansotary to hypoxemia deteriorates, respiratory muscle mass and strength decreases, the risk of acute respiratory failere increases, prevalance of infections and so the exesarbations increases, frequency and duration of hospitalization increases, mechanical vantilation rise increases and at last morbidity and mortalitiy in COPD increases. Becaouse of these reasons searching nutritional depletion and nutritional support is important in the COPD prognosis and nutritional measurements should be taken in account in COPD. Weight loss is a significant predictor of survival, independently of FEVi and Pa`2 in COPD and the difference from the other factors is at least partly reversible. The effect of nutritional support in the management of patients with COPD could change the prognosis without changing the pulmonary functions. All these results indicates the importance of nutritional intervention in COPD and nutritional assesment should be included in the clinical assesment of COPD. 84 97
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- 2005
27. Postprimer akciğer tüberkülozunun tanısında semptom süresi, akciğer grafisi ve toraks tomografisinin yeri
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Eriş Gülbay, Banu, Acıcan, Turan, and Göğüs Hastalıkları ve Tüberküloz Anabilim Dalı
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Göğüs Hastalıkları ,Chest Diseases - Abstract
ÖZET Ocak 1998-Kasım 2000 tarihleri arasında kliniğimize başvuran 41 'i erkek, 23'ü idin toplam 64 aktif akciğer tüberkülozlu, 6'sı kadın, 8'i erkek toplam 14 inaktif berkülozlu hasta çalışmaya alındı. Aktif tüberkülozlu hasta grubunda yaş talaması 44.02 ± 16.91 (15-74 arası), inaktif tüberkülozlu hasta grubunda ise 56.57 15.56 (33-74 arası) olarak saptandı. Aktif ve inaktif tüberkülozlu hastaların semptomları incelendi. Aktif tüberkülozlu ısta grubunda en sık görülen semptomlar, öksürük (%78), balgam (%69.3), gece rlemesi (%41.9), hemoptizi (%17.7), ateş (%38.7) ve kilo kaybı (%32) olarak Hirlendi. Yaşlı hasta grubunda semptomlar açısından ise anlamlı bir fark enmezken, inaktif tüberkülozlu olgularda nefes darlığının, hastaları doktora getiren ı önemli ve en sık bulunan semptom olduğu görüldü. Aktif tüberkülozlu hastaların semptom süresi, doktora başvurma zamanlan ve daviye başlangıç zamanları hesaplandı. PA akciğer grafileri ile toraks BT'leri ikildi. Aktif tüberküloz tanısı için sabah üç gün üst üste balgam örnekleri alındı, srekli olan vakalara bronkoskopi ve plevra ponksiyon biyopsisi yapıldı. Aktif tüberkülozlu hastalar semptom sürelerine göre gruplandırıldı, hastaların î'unda semptom süresi 1 ayın atfında {11 'inde
- Published
- 2001
28. Does anticoagulation in combination with immunosuppressive therapy prevent recurrent thrombosis in Behçet's disease?
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Erol S, Gürün Kaya A, Arslan F, Hasanzade H, Daştan AO, Çiledağ A, Eriş Gülbay B, Kaya A, Özdemir Kumbasar Ö, Çelik G, and Acıcan T
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- Male, Humans, Anticoagulants therapeutic use, Azathioprine therapeutic use, Retrospective Studies, Tumor Necrosis Factor Inhibitors therapeutic use, Immunosuppressive Agents therapeutic use, Cyclophosphamide, Immunosuppression Therapy, Behcet Syndrome complications, Behcet Syndrome drug therapy, Behcet Syndrome chemically induced, Venous Thrombosis complications, Venous Thrombosis drug therapy, Thrombosis, Venous Thromboembolism chemically induced
- Abstract
Vascular involvement in Behçet's disease (BD) occurs in up to 50% of patients. The main mechanism of thrombosis is inflammation. Thus, immunosuppressants (IS) are the mainstay of therapy, and adding anticoagulation (AC) is controversial. In daily practice, we observed that patients who received AC in combination with IS experienced less recurrent thrombosis and decided to investigate our BD patients retrospectively. We hypothesized that adding AC to immunosuppressive therapy may lower the risk of recurrent thrombosis. Treatment at the time of first or recurrent thrombotic events was recorded. Events under the only IS and IS + AC treatments were compared. There were 40 patients (33 males). The most common types of first vascular events were deep vein thrombosis (77.5%) followed by pulmonary embolism (PE) (52.5%). One patient did not receive any treatment. Among the 39 patients, 32 received glucocorticoid and at least one of the azathioprine, or cyclophosphamide, anti-TNF, 5 received monotherapy with azathioprine, 1 received monotherapy with corticosteroid, and the remaining 1 received monotherapy with cyclophosphamide. In total, 22 patients (55%) experienced 27 recurrent venous thromboembolism (VTE) events. Two (7.4%) events while only on AC, 2 (7.4%) events while on AC + IS, and 15 (55.5%) events occurred while on only IS. Eight (19.6%) patients were not receiving any treatment during relapses. The recurrence rate was statistically significantly lower in the IS + AC treatment group compared to IS alone. In conclusion, IS are the mainstay of treatment for BD, and adding AC may help to lower the recurrence risk of thrombotic events., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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- 2024
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29. Is it important to know the predominant respiratory event in AHI for the management of patients with OSA?
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Gülbay B, Bulut B, Ayöz S, and Acıcan T
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- Body Mass Index, Humans, Oxygen, Polysomnography, Retrospective Studies, Sleep Apnea, Obstructive complications, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive therapy
- Abstract
Introduction: Obstructive sleep apnea (OSA) is a heterogeneous disorder. The apnea-hypopnea index (AHI) cannot fully reflect this heterogeneity on its own. In this study, the OSA patients were analyzed by grouping them based on the predominant type of respiratory event, and the distinctive findings of each group were evaluated., Materials and Methods: The records of 213 patients with OSA were evaluated retrospectively and the patients were divided into three groups as Group 1 (apnea-predominant OSA; apnea index (AI)≥ 2x hypopnea index (HI) and HI≤ 15/hour), Group 2 (hypopnea-predominant OSA; HI≥ 2xAI and AI≤ 15/ hour), and Group 3 [No Respiratory Event-Predominant OSA (NREP OSA)]., Result: There were 65 patients in Group 1, 58 patients in Group 2, and 90 patients in Group 3. There was no difference between the groups in terms of sex, age, body-mass index, the distribution of symptoms, and concomitant diseases (p> 0.05). Only witnessed apnea was more frequently described by Group 1 patients (p= 0.042). Except for the higher N2 percentage and arousal index (p= 0.009, p= 0.011, respectively) in those with apnea-predominant OSA compared to those with hypopnea-predominant OSA, there was no difference in sleep architecture. In the apnea-predominant group, while the AHI, apnea durations (p= 0.000, 0.000, 0.000, respectively), total oxygen desaturation index (tODI), NREM ODI and REM ODI were higher (p= 0.000, 0.000, 0.047, respectively), nocturnal minimum oxygen saturation (SpO2) was lower (p= 0.001)., Conclusions: This study concluded that apnea-predominant OSA patients had more severe OSA in terms of AHI, respiratory event durations, and problems in oxygenation. These differences may guide the management of OSA.
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- 2022
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30. Polysomnographic, demographic and clinic differences between male and female obstructive sleep apnea patients.
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Erdemir Işık M, Gülbay B, Çiftci F, and Acıcan T
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- Body Mass Index, Demography, Female, Humans, Male, Middle Aged, Polysomnography, Sex Factors, Sleep Apnea, Obstructive diagnosis, Turkey epidemiology, Sleep Apnea, Obstructive epidemiology
- Abstract
Introduction: The differences between both genders with Obstructive Sleep Apnea Syndrome (OSAS) which is often seen in males can be explained by means of certain polysomnographical parameters and demographical and clinical features. The aim of this research study is to research the gender differences in Turkish population in terms of polysomnographical parameters and demographical and clinical features, and to compare and contrast the results of this research with the results of literature., Materials and Methods: This study has been carried out by including 100 females and 116 males, 216 patients in total, who were diagnosed with OSAS in the Sleep Laboratory of the Medicine Faculty, Ankara University between the years of 2011 and 2014. The demographical information like the ages and the genders of all patients and the figures of the height, weight and body-mass index (BMI) have been recorded. The Epworth Sleepiness Scale (ESS) of patients have also been recorded. Acquired by the polysomnography equipment, the polysomnographical data of all patients having the criteria of this study have been evaluated., Result: The average age of female patients, which is 57.2 ± 9.1 (the lowestthe highest), has been found to be meaningfully high (p<0.05) when compared to the average age of male patients (50.9 ± 11.8). The body-mass index (BMI) averages of female patients, which are 35.4 ± 9.2, have been determined to be high (p<0.05) when compared to the body-mass index (BMI) average of male patients (32.5 ± 6.7). The total Apnea Hypopnea Index (AHI) of male patients have been found to be meaningfully higher than of the female patients (p<0.05). Mild and moderate OSAS in female patients have been observed at a higher rate than males. On the other hand, severe OSAS has been observed at a higher rate than females (p<0.05). Likewise, while the average obstructive apnea time in male patients has been for 17 ± 5.8 seconds, the same figure has been for 14.5 ± 4.4 seconds (p<0.05)., Conclusions: As a result, in this study, we have observed that females suffering from OSAS are older and obese at a more rate and they have lower Apnea Hypopnea Index (AHI) than the males with OSAS. We have also distinguished that the symptoms related to OSAS of both genders are similar despite the lower Apnea Hypopnea Index of females. Meanwhile we want to emphasize that clinicians need to take these factors into consideration while focusing on the diagnosis of OSAS in female patients.
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- 2020
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31. Author`s Reply.
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Gürün Kaya A, Gulbay B, and Acıcan T
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- Humans, Hypertension, Sleep Apnea, Obstructive
- Published
- 2020
32. [Management of obstructive sleep apnea during COVID-19 pandemic].
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Gülbay B, Azap A, Kaya A, and Acıcan T
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- Attitude of Health Personnel, COVID-19, Comorbidity, Coronavirus Infections epidemiology, Global Health, Humans, Pandemics, Pneumonia, Viral epidemiology, Severe Acute Respiratory Syndrome epidemiology, Severe Acute Respiratory Syndrome therapy, Sleep Apnea, Obstructive epidemiology, Coronavirus Infections therapy, Health Personnel statistics & numerical data, Pneumonia, Viral therapy, Sleep Apnea, Obstructive therapy
- Abstract
Coronavirus disease 2019 (COVID-19) is an infectious disease that causes important mortality and morbidity all over the world caused by SARS-CoV-2 (Severe acute respiratory syndrome coronavirus 2), which started in China at the end of 2019. It spreads rapidly, mainly through droplets, and especially for all healthcare workers involved in aerosol producing procedures are at high risk. During COVID-19 pandemic , the health systems worldwide, along with the practice of chest diseases daily were affected. In our article, we aimed to give some clinical suggestions related to sleep practices according to current data.
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- 2020
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33. [The clinical and polysomnographic differences between obese and non-obese patients with obstructive sleep apnea].
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Gülbay B, Acıcan T, Erdemir Işık M, Çiftci F, and Önen ZP
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- Adult, Aged, Anthropometry, Female, Humans, Hypertension complications, Male, Middle Aged, Obesity physiopathology, Polysomnography methods, Retrospective Studies, Risk Factors, Sleep Apnea, Obstructive diagnosis, Body Mass Index, Body Weight physiology, Obesity complications, Sleep Apnea, Obstructive complications
- Abstract
Introduction: Obesity has been considered to be one of the important risk factor for obstructive sleep apnea (OSA). We aimed to investigate the clinical and polysomnographic differences of obese and non-obese OSA patients and how these differences, if any, can be reflected in our daily clinical practice., Materials and Methods: The polysomnographic data of 157 consecutive patients that underwent a sleep study were analyzed. Ninety-nine adult patients with a diagnosis of OSA [apnea-hypopnea index (AHI) ≥ 5/hour] were retrospectively assesed in two groups in respect of obese (BMI ≥ 30 kg/m2) or non-obese (BMI <30 kg/m2) according to body mass index (BMI). The clinical and polysomnographic results of the patients in both groups were compared., Result: Between 2010 and 2011, 99 (31 K/68 M) of 157 patients underwent polysomnography were diagnosed with OSA (AHI ≥ 5/hour). Thirthy six patients with OSA (36.4%) were non-obese and 63 patients (63.6%) were obese. There were no differences in the symptoms related to OSA between two groups (p> 0.05). Although there was no statistical significance, the age of the obese patients (50.5 ± 12.7 years) was lower than those of the non-obese (54.9 ± 10.0 years) in polysomnography their total sleep time was shorter and sleep latency later, and sleep efficiency, arousal index, N3%, and REM% were lower and N1% was higher (p> 0.05). While in the obese OSA patients the AHI and Epworth Sleepiness sclae were higher (respectively; p= 0.028, p= 0.01), average oxygen saturation at sleep was lower (p<0.001). While obese OSA patients had similar ratio of hypertension and atherosclerotic heart disease with non-obese OSA patients, whereas diabetes mellitus was higher in obese OSA group (p= 0.036). The use of antidepressant drug was more common in the non-obese patients than the obese patients (p= 0.011)., Conclusions: Although obese OSA patients have a more severe disease compared to nonobese OSA patients, there were no significant differences in clinical and polysomnographics findings between two groups. Should be noted that OSA may occur in non-obese patients.
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- 2019
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34. Assessment of the risk of obstructive sleep apnoea syndrome among healthcare workers.
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Aydın Güçlü Ö, Karadağ M, İntepe YS, Acıcan T, Arslan S, and Sertoğullarından B
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- Adult, Aged, Aged, 80 and over, Body Weight, Comorbidity, Cross-Sectional Studies, Female, Humans, Hypertension epidemiology, Male, Middle Aged, Prevalence, Prospective Studies, Sleep Apnea Syndromes diagnosis, Surveys and Questionnaires, Turkey epidemiology, Young Adult, Health Personnel statistics & numerical data, Quality of Life, Risk Assessment methods, Sleep Apnea Syndromes epidemiology
- Abstract
Introduction: Sleep deprivation is known to increase the risks for workplace accidents, neuro-behavioural symptoms and reduced quality of life. Shift work leads to sleep related problems, such as sleep deprivation, poor sleep quality and daytime sleepiness. The purpose of our study is to assess snoring prevalence and obstructive sleep apnoea risk among healthcare workers (HCWs) by using the Berlin Questionnaire., Materials and Methods: HCWs employed at different centres that agreed to take part in this study were enrolled. Employing the Berlin Questionnaire, demographic characteristics, smoking histories, comorbidities, on-call shifts, number of on-call shifts and sleep durations of the participants were surveyed., Result: 604 HCWs including specialist, nurse, junior doctor, medical student, clinical academic, health technician and hospital staff were enrolled in this study. In terms of sleep apnoea, 92 (15.1%) participants were identified as high-risk and 512 (84.8%) as low-risk according to the findings of the questionnaire. When the two groups identified as high and low risk for sleep apnoea according to the Berlin Questionnaire were compared, significant differences were found between the two groups in terms of age, sex, height, weight, BMI value and hypertension (p< 0.001 for all variables). Multivariate logistic regression analysis has shown that on-call shifts (OR= 0.199, CI= 0.053-0.747, p= 0.017) are negative associated with sleep apnoea risk., Conclusions: With extended working hours and on-call shifts increasing the risk of sleep disorders among HCWs, surveys designed for screening can be used to identify the prospective cases in this population for further examination.
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- 2019
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35. The factors affecting survival in patients with bronchiectasis.
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Çiftçi F, Şen E, Saryal SB, Önen ZP, Gülbay B, Yıldız Ö, Acıcan T, and Karabıyıkoğlu G
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- Humans, Pseudomonas Infections, Pseudomonas aeruginosa, Respiratory Function Tests, Sputum, Bronchiectasis
- Abstract
Background/aim: There is limited information about the rate and modifiers of mortality in noncystic fibrosis bronchiectasis., Materials and Methods: This study enrolled a total of 56 bronchiectasis patients. Patients' body mass index, smoking habit, previous therapies, comorbid disorders, history of vaccination, bronchiectasis type and radiological extent, arterial blood gas analysis, respiratory function tests, and laboratory results were recorded., Results: After a follow-up of 65.38 ± 18.62 months the overall mortality rate was 35.7%. The mean survival duration was 46.42 ± 8.25 months. Advanced age significantly increased mortality (HR: 2.031; CI: 0.991-4.072, P = 0.035). A significant correlation was found between mortality rate and the partial oxygen pressure level (HR: 0.886 (CI: 0.817-0.960); P = 0.039). Pulmonary artery pressure was directly proportional to mortality rate (HR: 9.015 (CI: 3.272-94.036); P = 0.03). There was also a significant correlation between Pseudomonas aeruginosa proliferation in sputum and mortality (HR: 7.014 (CI: 2.812-17.962); P = 0.00). Comorbidities increased mortality (HR: 1.984 (CI: 0.972-2.996); P = 0.04)., Conclusion: Bronchiectasis is a disease with high mortality. Advanced age, comorbid conditions, reduced partial oxygen pressure, pulmonary hypertension, and Pseudomonas aeruginosa proliferation in sputum increase its mortality rate.
- Published
- 2016
- Full Text
- View/download PDF
36. [Where do we perform sleep test: In the laboratory or at home?]
- Author
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İnönü Köseoğlu H, Kanbay A, and Acıcan T
- Subjects
- Female, Humans, Male, Reproducibility of Results, Monitoring, Ambulatory methods, Polysomnography methods, Sleep Apnea, Obstructive diagnosis
- Abstract
Obstructive sleep apnea syndrome (OSAS) is an important public health problem seen in 14.3% of male, and 5% of female population which leads to higher morbidity, and mortality rates because of its outcomes effecting many organ systems including cardiovascular, and cerebrovascular systems. Despite its higher prevalence in community, sleep laboratories both in our country, and in the world remain incapable of diagnosing these patients, and 80-90% of the cases with OSAS can not be diagnosed. As an alternative to gold standard polysomnographic examinations this desperate condition revived the use of more practical, and less expensive portable monitorization devices which can be used at home without the need for help of a technician. In this article we will discuss whether application of sleep test on a patient with suspect OSAS in the laboratory or at home will be more appropriate regarding effectiveness, and reliability of the test in the light of the scientific data.
- Published
- 2016
- Full Text
- View/download PDF
37. [Comparing the effectiveness of different treatment modalities on the smoking cessation rates].
- Author
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Onen ZP, Sen E, Eriş Gülbay B, Oztürk A, Akkoca Yıldız O, Acıcan T, Saryal S, and Karabıyıkoğlu G
- Subjects
- Adult, Combined Modality Therapy, Female, Humans, Male, Nicotine administration & dosage, Treatment Outcome, Bupropion therapeutic use, Nicotine therapeutic use, Psychotherapy, Group, Smoking Cessation methods, Tobacco Use Disorder therapy
- Abstract
The social patterns of smoking have changed significantly in the past two decades but smoking is still as prevalent in the lowest socioeconomic groups as it was widespread. For the solution of this enormous problem many kinds of treatment modalities have been proposed but there is no single successful method for quitting. To determine the smoking cessation rates with behavioural treatment, behavioural + pharmacological treatments and compare the differences between each approaches. 371 smokers were prospectively evaluated between 2004 and 2008. At the beginning subjects were classified into two groups: behavioral treatment group (I) and pharmacological + behavioural treatment group (II). Numbers of patients per group were 88 and 283 respectively. According to pharmacological therapy group II was also divided into three subgroups: nicotine replacement treatment (NRT) (regardless of the type and dosage) (IIa), bupropion (IIb) and combination treatment modalities group (IIc). Numbers of patients per subgroups were 185, 70 and 28 respectively. All of the patients were attended the one year follow up visits. According to the baseline characteristics there was no significant difference between the groups and subgroups. At the end of the fist year, in group I smoking cessation rate was 41% and in group II 51% and this was not statistically significant (p< 0.05). In the sub group analysis the success rates for group IIa, IIb and IIc; 44.8%, 62.8% and 64% respectively and bupropion is significantly superior to the NRT (p= 0.01). In study subjects, smoking cessation rates were less with comorbid diseases (p= 0.004), baseline airway obstruction (p= 0.04) and high CO levels (p= 0.008). Results of this analysis confirm that, there is a significant difference between pharmacological treatment and behavioral treatments. Additionally, in the pharmacological approaches, bupropion seems to be superior. Besides, comorbid conditions have been a huge problem to solve.
- Published
- 2010
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