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2. Evaluation of the performance of Dutch Lipid Clinic Network score in an Italian FH population: The LIPIGEN study

Author

Casula, M. a., B, Be, Olmastroni, E. a., Pirillo, A. c., Catapano, D, A. L. b., D, Jemail, Author, Lipigen, Group, Averna, M. g., Bertolini, S. h., Calandra, S. i., Tarugi, P. i., Pellegatta, F. k., Angelico, F. f., Bartuli, A. l., Biasucci, G. m., Biolo, G. n., Bonanni, L. o., Bonomo, K. p., Borghi, C. q., Bossi, A. C. r., Branchi, A. s., Carubbi, F. t., Cipollone, F. u., Citroni, N. v., Federici, M. w., Ferri, C. x., Fiorenza, A. M. y., Giaccari, A. z., Giorgino, Aa, F., Guardamagna, Ab, O., Iannuzzi, Ac, A., Iughetti, Ad, L., Lupattelli, Ae, G., Lupi, Af, A., Mandraffino, Giuseppe, Ag, G., Marcucci, Ah, R., Maroni, Ai, L., Miccoli, Aj, R., Mombelli, Ak, G., Muntoni, Al, S., Pecchioli, Am, V., Pederiva, An, C., Pipolo, Ao, A., Pisciotta, Ap, L., Pujia, Aq, A., Purrello, Ar, F., Repetti, As, E., Rubba, At, P., Sabbà, Au, C., Sampietro, Av, T., Sarzani, Aw, R., Tagliabue, M. P., Ax, Trenti, Ay, C., Vigna, G. B., Az, Werba, J. P., Ba, Zambon, Bb, S., Zenti, M. G., Bc, Minicocci, I. f., Noto, D. g., Fortunato, Bd, G., Banderali, An, G., Benso, Ax, A., Bigolin, Bb, P., Bonora, Bc, E., Bruzzi, Ad, P., Bucci, M. u., Buonuomo, P. S. l., Capra, M. E. m., Cardolini, I. w., Cefalù, B. g., Cervelli, N. x., Chiariello, Ac, G., Cocci, Aw, G., Colombo, E. y., Cremonini, A. L., Ap, D'Addato, S. q., D'Erasmo, L. f., Dal, Pino, Av, B., Sanctis, De, Ab, L., Vita, De, Ao, E., Del, Ben, M. f., Costanzo, Di, A. f., Taranto, Di, M. D., Bd, Fasano, Ay, T., Gentile, As, L., At, M., Ghirardello, Az, O., Grigore, L. k., Lussu, Al, M., Meregalli, G. r., Moffa, S. z., Montalcini, Aq, T., Morgia, Nascimbeni, F. t., Pasta, A. h., Pavanello, Ak, C., Saitta, Antonino, Ag, A., Scicali, Ar, R., Siepi, Ae, D., Spagnolli, W. v., Spina, R. g., Sticchi, Ah, E., Suppressa, Au, P., Vigo, Ba, L., Vinci, P. n., Manzato, Bf, E., Tragni, Be, E., Zampoleri, Bg, V., Casula, Manuela, Olmastroni, Elena, Pirillo, Angela, Catapano, Alberico Luigi, Arca, Marcello, Averna, Maurizio, Bertolini, Stefano, Calandra, Sebastiano, Tarugi, Patrizia, Pellegatta, Fabio, Angelico, Francesco, Bartuli, Andrea, Biasucci, Giacomo, Biolo, Gianni, Bonanni, Luca, Bonomo, Katia, Borghi, Claudio, Bossi, Antonio Carlo, Branchi, Adriana, Carubbi, Francesca, Cipollone, Francesco, Citroni, Nadia, Federici, Massimo, Ferri, Claudio, Fiorenza, Anna Maria, Giaccari, Andrea, Giorgino, Francesco, Guardamagna, Ornella, Iannuzzi, Arcangelo, Iughetti, Lorenzo, Lupattelli, Graziana, Lupi, Alessandro, Mandraffino, Giuseppe, Marcucci, Rossella, Maroni, Lorenzo, Miccoli, Roberto, Mombelli, Giuliana, Muntoni, Sandro, Pecchioli, Valerio, Pederiva, Cristina, Pipolo, Antonio, Pisciotta, Livia, Pujia, Arturo, Purrello, Francesco, Repetti, Elena, Rubba, Paolo, Sabbà, Carlo, Sampietro, Tiziana, Sarzani, Riccardo, Tagliabue, Milena Paola, Trenti, Chiara, Vigna, Giovanni Battista, Werba, Josè Pablo, Zambon, Sabina, Zenti, Maria Grazia, Minicocci, Ilenia, Noto, Davide, Fortunato, Giuliana, Banderali, Giuseppe, Benso, Andrea, Bigolin, Paola, Bonora, Enzo, Bruzzi, Patrizia, Bucci, Marco, Buonuomo, Paola Sabrina, Capra, Maria Elena, Cardolini, Iri, Cefalù, Baldassarre, Cervelli, Nazzareno, Chiariello, Giuseppe, Cocci, Guido, Colombo, Emanuela, Cremonini, Anna Laura, D'Addato, Sergio, D'Erasmo, Laura, Dal Pino, Beatrice, De Sanctis, Luisa, De Vita, Emanuele, Del Ben, Maria, Di Costanzo, Alessia, Di Taranto, Maria Donata, Fasano, Tommaso, Gentile, Luigi, Gentile, Marco, Ghirardello, Omar, Grigore, Liliana, Lussu, Milena, Meregalli, Giancarla, Moffa, Simona, Montalcini, Tiziana, Morgia, Valeria, Nascimbeni, Fabio, Pasta, Andrea, Pavanello, Chiara, Saitta, Antonino, Scicali, Roberto, Siepi, Donatella, Spagnolli, Walter, Spina, Rossella, Sticchi, Elena, Suppressa, Patrizia, Vigo, Lorenzo, Vinci, Pierandrea, Manzato, Enzo, Tragni, Elena, Zampoleri, Veronica, D'addato, Sergio, D'erasmo, Laura, Casula, M, Olmastroni, E, Pirillo, A, Catapano, A, Averna, M, Noto, D, Cefalu, B, and Spina, R

Subjects
Male, Settore MED/09 - Medicina Interna, Genetic testing, Predictive Value of Test, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, Decision Support Technique, 0302 clinical medicine, Retrospective Studie, Risk Factors, Cardiovascular Disease, Genetic Marker, Prospective Studies, 030212 general & internal medicine, Age of Onset, Prospective cohort study, education.field_of_study, medicine.diagnostic_test, Middle Aged, Dutch Lipid Clinic Network score, Adult, Biomarkers, Cardiovascular Diseases, Cholesterol, LDL, Female, Genetic Markers, Genetic Predisposition to Disease, Genetic Testing, Humans, Hyperlipoproteinemia Type II, Italy, Phenotype, Predictive Value of Tests, Reproducibility of Results, Retrospective Studies, Risk Assessment, Decision Support Techniques, Mutation, 3. Good health, Cholesterol, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Population, Reproducibility of Result, Physical examination, LDL, 03 medical and health sciences, Internal medicine, medicine, First-degree relatives, education, business.industry, Risk Factor, Settore MED/13 - ENDOCRINOLOGIA, Biomarker, medicine.disease, Missing data, Dutch Lipid Clinic Network score, Familial hypercholesterolemia, Genetic testing, Prospective Studie, Age of onset, business
Abstract

Background and aims Familial hypercholesterolemia (FH) is an inherited disorder characterized by high levels of blood cholesterol from birth and premature coronary heart disease. Thus, the identification of FH patients is crucial to prevent or delay the onset of cardiovascular events, and the availability of a tool helping with the diagnosis in the setting of general medicine is essential to improve FH patient identification. Methods This study evaluated the performance of the Dutch Lipid Clinic Network (DLCN) score in FH patients enrolled in the LIPIGEN study, an Italian integrated network aimed at improving the identification of patients with genetic dyslipidaemias, including FH. Results The DLCN score was applied on a sample of 1377 adults (mean age 42.9 ± 14.2 years) with genetic diagnosis of FH, resulting in 28.5% of the sample classified as probable FH and 37.9% as classified definite FH. Among these subjects, 43.4% had at least one missing data out of 8, and about 10.0% had 4 missing data or more. When analyzed based on the type of missing data, a higher percentage of subjects with at least 1 missing data in the clinical history or physical examination was classified as possible FH (DLCN score 3–5). We also found that using real or estimated pre-treatment LDL-C levels may significantly modify the DLCN score. Conclusions Although the DLCN score is a useful tool for physicians in the diagnosis of FH, it may be limited by the complexity to retrieve all the essential information, suggesting a crucial role of the clinical judgement in the identification of FH subjects.

Published
2018

3. Effects of complete androgen blockade for 12 and 24 weeks on the pathological stage and resection margin status of prostate cancer

Author

Selli, Aag, C., Montironi, R. b, Bono, A. c, Pagano, F. d, Zattoni, F. e, Manganelli, A. f, Selvaggi, F. P. g, Comeri, G. C. h, Fiaccavento, G. i, Guazzieri, S. j, Lembo, A. k, Cosciani, Cunico, S. l, Potenzoni, D. m, Muto, Nac, G., Mazzucchelli, R. b, Santinelli, A. b, Polito, M. n, Muzzonigro, G. n, Minardi, D. n, Palazzo, S. o, Bufo, P. o, Bertoldin, R. p, Doglioni, C. p, Macrì, E. p, Canclini, L. q, Chinagila, D. q, Zambolin, T. r, Tanello, M. r, Tardanico, R. r, Usoi, E. s, Migliari, R. s, Muscas, G. s, Valdes, E. s, Varsi, C. s, Ferretti, S. t, Palladini, P. t, Digregorio, C. t, Conti, G. u, Lunetta, Q. u, Scola, G. u, Signorelli, G. v, Andretta, E. v, Giordano, R. v, Nisi, E. v, Rizzo, M. w, Bartoletti, R. w, Amorosi, A. w, Martini, E. x, Andreassi, P. x, Ventura, T. x, Artibani, W. y, Piazza, R. y, Gaetoni, De, C. y, Fontana, D. z, Tarabuzzi, R. z, Gulbetta, L. z, Bollito, E. z., Prayer, Galetti, Aa, T., Gardiman, Aa, M., Belmonte, Ab, P., Sacchi, Ab, G., Rocco, Rossetti, Ac, S., Terrone, Ac, C., Palestro, Ac, G., Galliano, Ac, D., Bardari, Ac, F., Campobasso, Ac, O., Pisacane, A. M., Ac, Rubertis, De, Ad, G., Del, Vecchio, M. T., Ad, Gregori, Ae, A., Serra, Ae, L., Anselmo, Af, G., Checchin, Af, A., Arrigoni, G. A, Scott, Cathryn Anne, Beltrami, Carlo Alberto, Galassi, Ag, P., Comeri, Ah, G., Bono, A. V., Ah, Fava, Ah, C., Salvadore, Ah, M., Tasca, Ai, A., Meneghini, Meli, S., and Armani, A.

Subjects
Male, medicine.medical_specialty, Surgical margin, Antineoplastic Agents, Hormonal, Biopsy, Pathological staging, medicine.medical_treatment, Drug Administration Schedule, Pathology and Forensic Medicine, Tosyl Compounds, Prostate cancer, Nitriles, medicine, Humans, Anilides, Prospective Studies, Radical surgery, Neoadjuvant therapy, Aged, Neoplasm Staging, Prostatectomy, business.industry, Prostatic Neoplasms, Androgen Antagonists, Original Articles, General Medicine, Middle Aged, medicine.disease, Neoadjuvant Therapy, Surgery, Chemotherapy, Adjuvant, Goserelin, Resection margin, Histopathology, business
Abstract

Aims: To compare the pathological stage and surgical margin status in patients undergoing either immediate radical prostatectomy or 12 and 24 weeks of neoadjuvant hormonal treatment (NHT) in a prospective, randomised study. Methods: Whole mount sections of 393 radical prostatectomy specimens were evaluated: 128 patients had immediate surgery, 143 were treated for 12 weeks and 122 for 24 weeks with complete androgen blockade. Results: Histopathology revealed organ confined tumours in 40.4% of patients with clinical stage B disease in the immediate surgery group, whereas 12 and 24 weeks of NHT increased the number of organ confined tumours to 54.6% and 64.8%, respectively. Among patients with clinical stage C tumours, pathological staging found organ confined disease in 10.4%, 31.4%, and 61.2% in the immediate surgery, 12 weeks of NHT, and 24 weeks of NHT groups, respectively. Preoperative NHT caused a significant decrease in positive margins both in patients with clinical stage B and C disease. The extent of margin involvement was not influenced by preoperative treatment. Conclusions: Neoadjuvant androgenic suppression is effective in reducing both the pathological stage and the positive margin rate in patients with stage B and C prostatic cancer undergoing radical surgery. Some beneficial effects are evident in those patients treated for 24 weeks, and it is reasonable to assume that the optimal duration of NHT is longer than three months.

Published
2002
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6. Recent progress in the assembly of nanodevices and van der Waals heterostructures by deterministic placement of 2D materials

Author

Frisenda R., Navarro-Moratalla E., Gant P., Pérez De Lara D., Jarillo-Herrero P., Gorbachev R.V., Castellanos-Gomez A. and The authors are grateful to Matthew Hamer for a critical reading of our manuscript. AC-G acknowledges funding from the European Commission under the Graphene Flagship, contract CNECTICT-604391. RF acknowledges support from the Netherlands Organisation for Scientific Research (NWO) through the research program Rubicon with project number 680-50-1515. DPdL acknowledges support from MINECO through the program FIS2015-67367-C2-1-p. PJH acknowledges support by the Center for Integrated Quantum Materials under NSF grant DMR-1231319, the Gordon and Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4541, the US DOE, BES Office, Division of Materials Sciences and Engineering under Award DE-SC0001819, and NSF award DMR-1405221.

Published
2018

7. Simultaneous assembly of van der Waals heterostructures into multiple nanodevices

Author

Burzurí E., Vera-Hidalgo M., Giovanelli E., Villalva J., Castellanos-Gomez A., Pérez E.M. and Funding from the European Union (ERC-Starting Grant: 307609 (EMP)), MINECO (Grants: CTQ2014-60541-P (EMP), CTQ2017-86060-P (EMP)) and the Comunidad de Madrid (Grant: MAD2D-CM program S2013/MIT-3007 (EMP)) is gratefully acknowledged. E. B. and E. G. thank the AMAROUT-II fellowship (Marie Curie Action, FP7-PEOPLE-2011-COFUND (PCOFUND-GA-2011-291803)) and MSCA-IF 746579 (EB). IMDEA Nanociencia acknowledges support from the ‘Severo Ochoa’ Programme for Centres of Excellence in R&D (MINECO, Grant SEV-2016-0686). AC-G acknowledges funding from the European Commission under the Graphene Flagship, contract CNECTICT-604391. We thank the National Centre for Electron Microscopy (ICTS-CNME, Universidad Complutense) for electron microscopy facilities.

Published
2018

8. Atomically thin p-n junctions based on two-dimensional materials

Author

Frisenda R., Molina-Mendoza A.J., Mueller T., Castellanos-Gomez A., Van Der Zant H.S.J. and AC-G acknowledges funding from the European Commission under the Graphene Flagship, contract CNECTICT-604391. RF acknowledges support from the Netherlands Organization for Scientific Research (NWO) through the research program Rubicon with project number 680-50-1515. This project further received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 696656 (Graphene Flagship).

Published
2018

9. Micro-reflectance and transmittance spectroscopy: A versatile and powerful tool to characterize 2D materials

Author

Frisenda R., Niu Y., Gant P., Molina-Mendoza A.J., Schmidt R., Bratschitsch R., Liu J., Fu L., Dumcenco D., Kis A., De Lara D.P., Castellanos-Gomez A. and We acknowledge funding from the European Commission under the Graphene Flagship, contract CNECTICT-604391. AC-G acknowledges financial support from the MINECO (Ramon y Cajal 2014 program RYC-2014-01406 and MAT2014-58399-JIN) and from the Comunidad de Madrid (MAD2D-CM Program (S2013/MIT-3007)).

Published
2017

10. Gate tunable photovoltaic effect in MoS2 vertical p-n homostructures

Author

Svatek S.A., Antolin E., Lin D.-Y., Frisenda R., Reuter C., Molina-Mendoza A.J., Muñoz M., Agraït N., Ko T.-S., De Lara D.P., Castellanos-Gomez A. and S. A. S. and N. A. acknowledge funding from the European Commission through the FP7 ITN MOLESCO (Project Number 606728). E. A. gratefully acknowledges financial support from L?Or?al-UNESCO through the Women in Science program. A. J. M.-M. acknowledges the financial support from MICINN (Spain) through the scholarship BES-2012-057346. D. Y. and T. S. acknowledge the support from the Ministry of Science and Technology of the Republic of China under the MOST 104-2112-M-018-004 and 104-2221-E-018-017. D. P. is thankful for funding from the Spanish Ministry of Economy and Competitiveness through FIS2015-67367-C2-1-P. R. F. thanks the Netherlands Organisation for Scientific Research (NWO) for the financial support through the research programme Rubicon with the project number 680-50-1515. AC-G. acknowledges the support from the BBVA Foundation through the fellowship ?I Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales? (?Semiconductores ultradelgados: hacia la optoelectronica flexible?), from the MINECO (Ram?n y Cajal 2014 program, RYC-2014-01406), from the MICINN (MAT2014-58399-JIN) and from the Comunidad de Madrid (MAD2D-CM Program (S2013/MIT-3007)), and the European Commission under the Graphene Flagship, contract CNECTICT-604391.

Published
2017

11. Strain engineering of Schottky barriers in single- and few-layer MoS2 vertical devices

Author

Quereda J., Palacios J.J., Agräit N., Castellanos-Gomez A., Rubio-Bollinger G. and The authors acknowledge Victor Rubio for kindly providing indium tin oxide samples. GR-B, NA and JQ acknowledge financial support from MICINN/ MINECO through program MAT2014-57915-R, from Comunidad Aut?noma de Madrid through program S2013/MIT-3007 (MAD2D) and from the European Commission under the Graphene Flagship, contract CNECTICT-604391. AC-G acknowledges financial support from the BBVA Foundation through the fellowship ?I Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales?, from the MINECO (Ram?n y Cajal 2014 program, RYC-2014-01406) and from the MICINN (MAT2014- 58399-JIN). JJP acknowledges Spain?s Ministerio de Econom?a y Competitividad for financial support under grant FIS2013-47328-C02-1 and the Generalitat Valenciana under grant no. PROMETEO/2012/011. Note added. During the preparation of this manuscript an article appeared showing mechanically tunable electrical performance in a vertical metal/ semiconductor/metal atomically thin structure [44], where few-layer black phosphorus is used as semiconducting layer instead of the atomically thin MoS2 layer considered in our work. Interestingly, while the I?V characteristics presented in their article almost remain unchanged when the sign of bias voltage is reversed, here we obtain markedly asymmetric I?V characteristics, leading to a strong rectifying behavior.

Published
2017

12. Biaxial strain in atomically thin transition metal dichalcogenides

Author

Frisenda R., Schmidt R., Michaelis De Vasconcellos S., Bratschitsch R., Perez De Lara D., Castellanos-Gomez A. and AC-G acknowledges funding from the European Commission under the Graphene Flagship, contract CNECTICT-??????? RF acknowledges support from tehrela Nndesth Organisation for Scientific Research (NWO) through the research program Rubicon with project number ???????????? DPdL acpkpnoorwt lferdogme st hseu MINECO (program FIS ???????????C ?? ??P).

Published
2017

13. Enhanced superconductivity in atomically thin TaS 2

Author

Navarro-Moratalla E., Island J.O., Manãs-Valero S., Pinilla-Cienfuegos E., Castellanos-Gomez A., Quereda J., Rubio-Bollinger G., Chirolli L., Silva-Guillén J.A., Agraït N., Steele G.A., Guinea F., Van Der Zant H.S.J., Coronado E. and Financial support from the EU (ELFOS project and ERC Advanced Grant SPINMOL), the Spanish MINECO (Excellence Unit ‘‘María de Maeztu’’ MDM-2015-0538, Project Consolider-Ingenio in Molecular Nanoscience and projects MAT2011–25046 and MAT2014–57915-R, co-financed by FEDER), Dutch organization for Fundamental Research on Matter (FOM), NWO/OCW and the Comunidad Autonoma de Madrid (MAD2D-CM -S2013/MIT-3007-and NANOFRONTMAG-CM -S2013/MIT-2850) and the Generalitat Valenciana (Prometeo Program) are gratefully acknowledged. AC-G acknowledges financial support from the BBVA Foundation through the fellowship ‘I Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales’ (‘Semiconductores ultradelgados: hacia la optoelectronica flexible’), from the MINECO (Ramón y Cajal 2014 program, RYC-2014-01406) and from the MICINN (MAT2014-58399-JIN). We are grateful to the Electronic Microscopy team at Central Support Service in Experimental Research (SCSIE, University of Valencia, Spain) for their kind and constant support.

Published
2016

14. Titanium trisulfide (TiS3): A 2D semiconductor with quasi-1D optical and electronic properties

Author

Island J.O., Biele R., Barawi M., Clamagirand J.M., Ares J.R., Sánchez C., Van Der Zant H.S.J., Ferrer I.J., D'Agosta R., Castellanos-Gomez A. and This work was supported by the Dutch Organization for Fundamental Research on Matter (NWO/OCW). R. D’A. and R. B. acknowledge financial support by the DYN-XC-TRANS (Grant No. FIS2013-43130-P), and NanoTHERM (Grant No. CSD2010-00044) of the Ministerio de Economia y Competitividad (MINECO), and Grupo Consolidado UPV/EHU del Gobierno Vasco (Grant No. IT578-13). R. B. acknowledges the financial support of the Ministerio de Educacion, Cultura y Deporte (Grant No. FPU12/01576). AC-G acknowledges financial support from the BBVA Foundation through the fellowship 'I Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales', from the MINECO (Ramón y Cajal 2014 program, RYC-2014-01406) and from the MICINN (MAT2014-58399-JIN). MIRE Group thanks MINECO (MAT2011-22780) for financial support.

Published
2016

15. Reversible uniaxial strain tuning in atomically thin WSe2

Author

Schmidt R., Niehues I., Schneider R., Drüppel M., Deilmann T., Rohlfing M., De Vasconcellos S.M., Castellanos-Gomez A., Bratschitsch R. and We gratefully acknowledge support by the Deutsche Forschungsgemeinschaft (TRR 61). AC-G acknowledges financial support from the BBVA Foundation through the fellowship 'I Convocatoria de Ayudas Fundacion BBVA a Investigadores, Innovadores y Creadores Culturales' ('Semiconductores ultradelgados: hacia la optoelectronica flexible'), from the MINECO (Ram?n y Cajal 2014 program, RYC-2014-01406), from the MICINN (MAT2014-58399-JIN) and from the Comunidad de Madrid (MAD2D-CM Program (S2013/MIT-3007)). The authors also acknowledge the computing time granted by the John von Neumann Institute for Computing (NIC) and provided on the super-computer JURECA at J?lich Supercomputing Centre (JSC).

Published
2016

16. Hematological profiles of patients with tuberculosis and nontuberculous mycobacteria infections in Bamako, Mali.

Author

Sanogo F, Kodio O, Sarro YS, Diarra B, Coulibaly G, Tolofoudie M, Fofana DB, Maiga A, Somboro AM, Diallo F, G Togo AC, Somboro A, Baya B, Kone B, Sanogo M, Dabitao D, Kone A, Diakite M, Doumbia S, and Mamoudou M

Subjects
Humans, Mali, Cross-Sectional Studies, Pilot Projects, Nontuberculous Mycobacteria genetics, Mycobacterium Infections, Nontuberculous microbiology, Tuberculosis diagnosis, Tuberculosis complications
Abstract

Background: Pulmonary tuberculosis (TB) remains one of the main causes of morbidity and mortality in Mali. Nontuberculous mycobacteria (NTM) infections are very common but are often cofounded with TB because of the similarity of symptoms, which makes the diagnosis difficult. Hematological abnormalities associated with TB have been described, but not with NTM. Therefore, the goal of this study was to compare the hematological parameters of patients infected with TB and NTM infections., Methods: A cross-sectional study enrolling TB and NTM participants was conducted in 2018-2020. Five milliliters of venous blood and sputum samples were collected from each participant to determine the hematological parameters using the RUBY CELL-DYN Ruby Version 2.2 ML. A BACTEC MGIT 960 and multiplex reverse transcription-polymerase chain reaction were used to distinguish Mycobacterium tuberculosis from NTM, respectively., Results: Of the total 90 patients enrolled, there was a decrease in hemoglobin and hematocrit levels in both the groups (P = 0.05). In addition, we found that the percentages of basophil cells (P = 0.01) and mean values of platelets (P = 0.04) were significantly higher in TB patients than those of NTMs. Moreover, the mean of absolute values of eosinophil cells of TB patients was significantly lower than those of NTMs (P = 0.03)., Conclusion: We found significant statistical differences in basophils, platelets, and eosinophils in differentiating TB and NTM in this pilot study. Future studies with patients at different clinical stages are needed to confirm the hematological profiles of TB and NTM patients., Competing Interests: None

Published
2023
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17. Retrospective Cohort Study of COVID-19 in Patients of the Brazilian Public Health System with SARS-CoV-2 Omicron Variant Infection.

Author

Murari TB, Fonseca LMDS, Pereira HBB, Nascimento Filho AS, Saba H, Scorza FA, G de Almeida AC, Maciel ELN, Mendes JFF, Rocha Filho TM, David JR, Badaró R, Machado BAS, and Moret MA

Abstract

Several vaccines against COVID-19 are now available, based on different techniques and made by different laboratories spread around the world. With the roll out of the vaccination process in an advanced stage in many countries, the reduced risk of hospitalization due to the Omicron variant relative to the Delta variant infection, despite the higher transmission risk of Omicron, may lead to a misinterpretation of the results, as infection by Omicron is associated with a significant reduction in severe outcomes and shorter hospitalization time than the Delta variant. We compared the in-hospital mortality due to the Omicron (Jan-Mar 2022) with Gamma (Jan 2021) and Delta (Oct-Dec 2021) variants of patients in the Brazilian public health system. This study also discusses the decrease in booster vaccine effectiveness in patients hospitalized due to the Omicron variant compared with the Delta variant. Without a remodeling of vaccines for new variants, booster doses may be necessary with a shorter time interval.

Published
2022
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18. Coumarin-benzimidazole hybrids: A review of developments in medicinal chemistry.

Author

G AC, Gondru R, Li Y, and Banothu J

Subjects
Anti-Infective Agents chemical synthesis, Anti-Infective Agents chemistry, Anti-Inflammatory Agents chemical synthesis, Anti-Inflammatory Agents chemistry, Antineoplastic Agents chemical synthesis, Antineoplastic Agents chemistry, Antioxidants chemical synthesis, Antioxidants chemistry, Benzimidazoles chemistry, Chemistry, Pharmaceutical, Coumarins chemistry, Drug Development, Humans, Molecular Structure, Anti-Infective Agents pharmacology, Anti-Inflammatory Agents pharmacology, Antineoplastic Agents pharmacology, Antioxidants pharmacology, Benzimidazoles pharmacology, Coumarins pharmacology
Abstract

Coumarin and benzimidazole are privileged structures in medicinal chemistry and are widely used in drug discovery and development due to their vast biological properties. The pharmacokinetic and pharmacodynamic properties of the individual scaffolds can be improved by developing coumarin-benzimidazole chimeric molecules via molecular hybridization approach. The three major classes of coumarin-benzimidazole hybrids are merged, fused and spacer-linked hybrids. Depending on the substitution position, fused hybrids and spacer-linked hybrids can be further classified as coumarin-C3 hybrids, coumarin-C4 hybrids and coumarin-C5/6/7/8 hybrids. Most of the coumarin-benzimidazole hybrid molecules exhibited potent anticancer, antiviral, antimicrobial, antitubercular, anthelmintic, anti-inflammatory, antioxidant, anticonvulsant and carbonic anhydrase inhibitory activities. The fused coumarin-C3 hybrid (2), thiomethylene-linked coumarin-C3 hybrid (45), N-glucoside substituted thiomethylene-linked coumarin-C3 hybrid (37c), amide-linked coumarin-C3 hybrid (50a), and sulfonylmethylene-linked coumarin-C4 hybrid (63) were identified as the representative potent anticancer, antimicrobial, antiviral, antioxidant and antitubercular agents respectively. The biological properties of the different classes of coumarin-benzimidazole hybrids with their structure-activity relationship studies and the mechanism of action studies were presented in this review, aiming to help the researchers across the globe to generate future hybrid molecules as potential drug candidates., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2021 Elsevier Masson SAS. All rights reserved.)

Published
2022
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19. 2020 vision: New insights on hypoxia imaging to assess cardiac and extra-cardiac active inflammatory sarcoidosis.

Author

Schwartz RG and Vidula H

Subjects
Fluorodeoxyglucose F18 administration & dosage, Fluorodeoxyglucose F18 therapeutic use, Heart diagnostic imaging, Heart physiopathology, Humans, Hypoxia etiology, Positron Emission Tomography Computed Tomography methods, Positron Emission Tomography Computed Tomography statistics & numerical data, Radiopharmaceuticals administration & dosage, Radiopharmaceuticals therapeutic use, Sarcoidosis diagnostic imaging, Hypoxia diagnostic imaging, Positron Emission Tomography Computed Tomography standards, Sarcoidosis complications
Published
2021
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21. Performance of Mali's biosafety level 3 laboratory in the external quality assessment in preparedness of laboratory accreditation and support to clinical trials.

Author

Coulibaly N, Kone B, Sanogo M, G Togo AC, Diarra B, Sarro YS, Cisse AB, Kodio O, Coulibaly G, Kone M, Baya B, Maiga M, Dabitao D, Belson M, Dao S, Diallo S, Diakite M, Babana AH, and Doumbia S

Subjects
Cross-Sectional Studies, Humans, Mali, Microbiological Techniques methods, Microbiological Techniques standards, Mycobacterium growth & development, Mycobacterium isolation & purification, Quality Assurance, Health Care standards, Retrospective Studies, Staining and Labeling, Tuberculosis diagnosis, Tuberculosis microbiology, Accreditation, Clinical Trials as Topic, Containment of Biohazards standards, Laboratories standards
Abstract

Background: The external quality assessment (EQA) or external quality control is an evaluation conducted by a certified external organization to inquire about the quality of the results provided by a laboratory. The primary role of EQA is to verify the accuracy of laboratory results. This is essential in research because research data should be published in international peer-reviewed journals, and laboratory results must be repeatable. In 2007, the University Clinical Research Center (UCRC's) biosafety level 3 (BSL-3) laboratory joined the EQA program with the College of American Pathologists in acid-fast staining and culture and identification of mycobacteria as per laboratory accreditation preparedness. Thus, after 11 years of participation, the goal of our study was to evaluate the performance of our laboratory during the different interlaboratory surveys., Methods: We conducted a descriptive retrospective study to evaluate the results of UCRC mycobacteriology laboratory from surveys conducted during 2007 and 2017., Results: Of the 22 evaluations, the laboratory had satisfactory (100% of concordance results) in 18 (81.8%) and good (80% of concordance results) in 4 (18.2%). Overall, the laboratory was above the commended/accepted limits of 75%., Conclusion: So far, UCRC's BSL-3 performed well during the first 11 years of survey participation, and efforts should be deployed to maintain this high quality in the preparedness for laboratory accreditation and support to clinical trials., Competing Interests: None

Published
2020
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22. Uptake and Documentation of the Use of an Encounter Decision Aid in Usual Practice: A Retrospective Analysis of the Use of the Statin/Aspirin Choice Decision Aid.

Author

Inselman J, Branda M, Castaneda-Guarderas A, Gionfriddo MR, Zeballos-Palacios CL, Morris MM, Shah ND, Montori VM, and LeBlanc A

Subjects
Adult, Aged, Aspirin administration & dosage, Choice Behavior, Electronic Health Records, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors administration & dosage, Male, Middle Aged, Retrospective Studies, Risk Assessment, Socioeconomic Factors, Aspirin therapeutic use, Decision Making, Decision Support Techniques, Hydroxymethylglutaryl-CoA Reductase Inhibitors therapeutic use, Patient Participation methods
Published
2016
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24. An iridoid and a flavonoid from Sideritis lanata L.

Author

Alipieva KI, Kostadinova EP, Evstatieva LN, Stefova M, and Bankova VS

Subjects
Flavones chemistry, Glucosides chemistry, Iridoid Glucosides, Iridoids chemistry, Molecular Structure, Plant Components, Aerial chemistry, Flavones isolation & purification, Glucosides isolation & purification, Iridoids isolation & purification, Sideritis chemistry
Abstract

A new iridoid diglucoside, 10-O-(E)-p-coumaroylmelittoside (1) and a new flavone glucoside, O-(6''-O-Acetyl-)-beta-glucopyranosylchrysoeriol (2), together with four known flavone glycosides, were isolated from the aerial parts of Sideritis lanata. The structures of the new compounds were elucidated by spectroscopic methods, 2D NMR and MS.

Published
2009
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25. [Invariants of spatial summation for S (short wavelength) cone vision].

Author

Vasilev A, Anderson RS, and Zlatkova M

Subjects
Adult, Humans, Male, Middle Aged, Retinal Ganglion Cells cytology, Retinal Ganglion Cells physiology, Sensory Thresholds, Vision Disparity physiology, Visual Pathways physiology, Depth Perception physiology, Retina physiology, Retinal Cone Photoreceptor Cells physiology, Vision, Ocular physiology
Abstract

Spatial summation in the human visual system was studied as a function of retinal eccentricity upon selective stimulation of the short-wavelength sensitive cones. The area of complete spatial summation (Ricco's area) was found to increase with retinal eccentricity while the threshold of stimuli equal in size with Ricco's area remained constant. Comparisons with known morphology of the small bistratified retinal ganglion cells, the only cells known to be excited by S-one ON stimulation, showed that Ricco's area included 2-4 such cells and is up to 1.5 times larger than the dendritic field of a single cell. These relationships were relatively constant within the eccentricity range tested (5-20 deg along the temporal horizontal meridian) and might be the source of threshold invariance of stimuli matching Ricco's area.

Published
2003

26. [Temporal summation and reaction time for grid detection].

Author

Mitov DL and Totev TsT

Subjects
Humans, Sensory Thresholds physiology, Contrast Sensitivity, Pattern Recognition, Visual physiology, Reaction Time physiology
Abstract

We studied the stimulus-duration effect on the reaction time (RT) to gratings with different spatial frequencies. At each duration value, the product of the contrast and the duration, i.e. the contrast "energy" was kept constant. We found that at near-threshold "energy" levels the RT was constant for up to 15 ms at lower spatial frequencies and up to 30 ms at higher spatial frequencies. At higher "energy" levels, this critical interval was the same (up to 15 ms) for both lower and higher spatial frequencies. The effect of the duration of gradual onset of the stimulus on RT was also studied. An increase of onset duration (up to 60 ms) at low spatial frequencies substantially delayed reaction time for the contrasts under study. Conversely, at high spatial frequencies, this effect was present only for gratings with a high contrast. These results suggest that reaction time is determined by two types of mechanisms (transient and sustained) at a near threshold contrast, and by one type (transient) mechanism at higher contrasts.

Published
2003

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