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1. Evaluation of LL 37 Lipoprotein As Innate Immunity Marker among Sudanese Patients Cutaneous Leishmania

Author

Ayat H. Bakr, Abugroun E. A., AbdElkarim A. Abdrabo, Omeyma A. Mohamed, Mokhtar M. A., and GadAllah Modawe

Subjects
cathelicidin, LL37, innate immunity, Leishmania, Sudan, Medicine
Abstract

Background: The leishmaniasis is a group of diseases with a broad range of clinical manifestations caused by several species of parasites belonging to the genus Leishmania. LL-37/hCAP18, the only cathelicidin in human, is expressed as an 18-kDa preproprotein. The most prominent function of cathelicidin is their ability to inhibit propagation of a diverse range of microorganisms, which occurs at a micromolar range. Objective: The study was aimed to evaluate the LL37 plasma level in Leishmania Sudanese patients. Methods: In a case-control study, 300 subjects were enrolled (200 as case and 100 controls); 5 ml venous blood was collected in EDTA container, then plasma was obtained and stored frozen at –80°C. LL 37 was estimated using competitive ELISA. The data were analyzed using SPSS version 21. Results: The results revealed that 115 (57%) of Leishimania patients were male and 85 (43%) were female. Plasma LL 37 level was significantly increased in Leishmania patients (1.30 ± 0.71) compared to the control (0.21 ± 0.20) with (p-value 0.000). Conclusion: Leishmania patients had higher levels of plasma LL37, suggesting effective antimicrobial immunity process enhancing healing of cutaneous leishmaniasis.

Published
2019
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2. Cost effectiveness of adopted quality requirements in hospital laboratories

Author

Hamza, A., Eltayib Ahmed-abakur, Abugroun, E., Bakhit, S., and Holi, M.

Subjects
lcsh:Public aspects of medicine, lcsh:RA1-1270, Original Article, Quality management, ISO1518, Cost effectiveness
Abstract

Background: The present study was designed in quasi-experiment to assess adoption of the essential clauses of particular clinical laboratory quality management requirements based on international organization for standardization (ISO 15189) in hospital laboratories and to evaluate the cost effectiveness of compliance to ISO 15189.Methods: The quality management intervention based on ISO 15189 was conceded through three phases; pre –intervention phase, Intervention phase and Post-intervention phase.Results: In pre- intervention phase the compliance to ISO 15189 was 49% for study group vs. 47% for control group with P value 0.48, while the post intervention results displayed 54% vs. 79% for study group and control group respectively in compliance to ISO 15189 and statistically significant difference (P value 0.00) with effect size (Cohen's d) of (0.00) in pre- intervention phase and (0.99) in post – intervention phase. The annual average cost per-test for the study group and control group was 1.80 ± 0.25 vs. 1.97 ± 0.39, respectively with P value 0.39 whereas the post-intervention results showed that the annual average total costs per-test for study group and control group was 1.57 ± 0.23 vs 2.08 ± 0.38, P value 0.019 respectively, with cost-effectiveness ratio of (0.88) in pre -intervention phase and (0.52) in post-intervention phase.Conclusion: The planned adoption of quality management require­ments (QMS) in clinical laboratories had great ef­fect to increase the compliance percent with qual­ity management system requirement, raise the aver­age total cost effectiveness, and improve the analytical process capability of the testing proce­dure.

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