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195 results on '"Abughanimeh, Omar"'

2. Laboratory assays of VWF activity and use of desmopressin trials in the diagnosis of VWD: a systematic review and meta-analysis

Author

Kalot, Mohamad A., Husainat, Nedaa, Abughanimeh, Omar, Diab, Osama, El Alayli, Abdallah, Tayiem, Sammy, Madoukh, Bader, Dimassi, Ahmad, Qureini, Aref, Ameer, Barbara, Eikenboom, Jeroen, Giraud, Nicolas, Haberichter, Sandra, Jacobs-Pratt, Vicky, Konkle, Barbara A., McRae, Simon, Montgomery, Robert, O'Donnell, James S., Brignardello-Petersen, Romina, Flood, Veronica, Connell, Nathan T., James, Paula, and Mustafa, Reem A.

Published
2022
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3. Surgical management of patients with von Willebrand disease: summary of 2 systematic reviews of the literature

Author

Brignardello-Petersen, Romina, El Alayli, Abdallah, Husainat, Nedaa, Kalot, Mohamad, Shahid, Shaneela, Aljabirii, Yazan, Britt, Alec, Alturkmani, Hani, El-Khechen, Hussein, Motaghi, Shahrzad, Roller, John, Dimassi, Ahmad, Abughanimeh, Omar, Madoukh, Bader, Arapshian, Alice, Grow, Jean M., Kouides, Peter, Laffan, Michael, Leebeek, Frank W.G., O'Brien, Sarah H., Tosetto, Alberto, James, Paula D., Connell, Nathan T., Flood, Veronica, and Mustafa, Reem A.

Published
2022
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4. von Willebrand factor levels in the diagnosis of von Willebrand disease: a systematic review and meta-analysis

Author

Kalot, Mohamad A., Husainat, Nedaa, El Alayli, Abdallah, Abughanimeh, Omar, Diab, Osama, Tayiem, Sammy, Madoukh, Bader, Dimassi, Ahmad B., Qureini, Aref, Ameer, Barbara, Eikenboom, Jeroen C.J., Giraud, Nicolas, McLintock, Claire, McRae, Simon, Montgomery, Robert R., O'Donnell, James S., Scappe, Nikole, Sidonio, Robert F., Jr, Brignardello-Petersen, Romina, Flood, Veronica H., Connell, Nathan T., James, Paula D., and Mustafa, Reem A.

Published
2022
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5. Bleeding assessment tools in the diagnosis of VWD in adults and children: a systematic review and meta-analysis of test accuracy

Author

Kalot, Mohamad A., Husainat, Nedaa, Tayiem, Sammy, El Alayli, Abdallah, Dimassi, Ahmad B., Diab, Osama, Abughanimeh, Omar, Madoukh, Bader, Qureini, Aref, Ameer, Barbara, Di Paola, Jorge, Eikenboom, Jeroen C.J., Jacobs-Pratt, Vicky, McLintock, Claire, Montgomery, Robert, O'Donnell, James S., Sidonio, Robert, Jr., Brignardello-Petersen, Romina, Flood, Veronica, Connell, Nathan T., James, Paula D., and Mustafa, Reem A.

Published
2021
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11. Safety Profile of Mutant EGFR-TK Inhibitors in Advanced Non-Small Cell Lung Cancer: A Meta-analysis

Author

Tauseef, Abubakar, Zafar, Maryam, Silberstein, Peter, Nahas, Joseph, Frederickson, Thomas, Hansen, Sean, Abbas, Anum, Alali, Yaman, Buragadda, Avdesh, Abughanimeh, Omar K., Nair, Sunil, Thirumalareddy, Joseph, and Mirza, Mohsin

Subjects
Clinical Review
Abstract

BACKGROUND: Despite the use of platinum-based chemotherapy, lung cancer continues to be the leading cause of cancer-related death in the world. To overcome the rate of lung cancer–related death, scientists discovered advanced therapies, including mutant epidermal growth factor receptor–tyrosine kinase (EGFR-TK) inhibitors. OBSERVATIONS: We conducted a meta-analysis to determine the safety profile of mutant EGFR-TK inhibitors in the management of advanced non–small cell lung cancer (NSCLC). Included in this study are 9 phase 3 randomized controlled trials designed to study the safety profile of mutant EGFR-TK inhibitors in patients with advanced NSCLC. The study showed that mutant EGFR-TK inhibitors have an incidence of adverse effects that is less reported when compared with platinum-based chemotherapy. CONCLUSIONS: We recommend continuing using mutant EGFR-TK inhibitors in patients with advanced NSCLC especially in patients having mutant EGFR receptors. Adverse effects caused by mutant EGFR-TK inhibitors are significant but are usually tolerable and can be avoided by reducing the dosage of it with each cycle or by skipping or delaying the dose until patient is symptomatic.

Published
2022

13. Surgical management of patients with von Willebrand disease:summary of 2 systematic reviews of the literature

Author

Brignardello-Petersen, Romina, Alayli, Abdallah El, Husainat, Nedaa, Kalot, Mohamad, Shahid, Shaneela, Aljabirii, Yazan, Britt, Alec, Alturkmani, Hani, El-Khechen, Hussein, Motaghi, Shahrzad, Roller, John, Dimassi, Ahmad, Abughanimeh, Omar, Madoukh, Bader, Arapshian, Alice, Grow, Jean M., Kouides, Peter, Laffan, Michael, Leebeek, Frank W.G., O’Brien, Sarah H., Tosetto, Alberto, James, Paula D., Connell, Nathan T., Flood, Veronica, Mustafa, Reem A., Brignardello-Petersen, Romina, Alayli, Abdallah El, Husainat, Nedaa, Kalot, Mohamad, Shahid, Shaneela, Aljabirii, Yazan, Britt, Alec, Alturkmani, Hani, El-Khechen, Hussein, Motaghi, Shahrzad, Roller, John, Dimassi, Ahmad, Abughanimeh, Omar, Madoukh, Bader, Arapshian, Alice, Grow, Jean M., Kouides, Peter, Laffan, Michael, Leebeek, Frank W.G., O’Brien, Sarah H., Tosetto, Alberto, James, Paula D., Connell, Nathan T., Flood, Veronica, and Mustafa, Reem A.

Abstract

von Willebrand disease (VWD) is the most common inherited bleeding disorder. The management of patients with VWD who are undergoing surgeries is crucial to prevent bleeding complications. We systematically summarized the evidence on the management of patients with VWD who are undergoing major and minor surgeries to support the development of practice guidelines. We searched Medline and EMBASE from inception through October 2019 for randomized clinical trials (RCTs), comparative observational studies, and case series that compared maintaining factor VIII (FVIII) levels or von Willebrand factor (VWF) levels at .0.50 IU/mL for at least 3 days in patients undergoing major surgery, and those with options for perioperative management of patients undergoing minor surgery. Two authors screened and abstracted data and assessed the risk of bias. We conducted meta-analyses when possible. We evaluated the certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. We included 7 case series for major surgeries and 2 RCTs and 12 case series for minor surgeries. Very-low-certainty evidence showed that maintaining FVIII levels or VWF levels of .0.50 IU/mL for at least 3 consecutive days showed excellent hemostatic efficacy (as labeled by the researchers) after 74% to 100% of major surgeries. Low- to very-low-certainty evidence showed that prescribing tranexamic acid and increasing VWF levels to 0.50 IU/mL resulted in fewer bleeding complications after minor procedures compared with increasing VWF levels to 0.50 IU/mL alone. Given the low-quality evidence for guiding management decisions, a shared-decision model leading to individualized therapy plans will be important in patients with VWD who are undergoing surgical and invasive procedures.

Published
2022

15. von Willebrand factor levels in the diagnosis of von Willebrand disease: a systematic review and meta-analysis

Author

Kalot, Mohamad A., primary, Husainat, Nedaa, additional, El Alayli, Abdallah, additional, Abughanimeh, Omar, additional, Diab, Osama, additional, Tayiem, Sammy, additional, Madoukh, Bader, additional, Dimassi, Ahmad B., additional, Qureini, Aref, additional, Ameer, Barbara, additional, Eikenboom, Jeroen C.J., additional, Giraud, Nicolas, additional, McLintock, Claire, additional, McRae, Simon, additional, Montgomery, Robert R., additional, O’Donnell, James S., additional, Scappe, Nikole, additional, Sidonio, Robert F., additional, Brignardello-Petersen, Romina, additional, Flood, Veronica H., additional, Connell, Nathan T., additional, James, Paula D., additional, and Mustafa, Reem A., additional

Published
2021
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17. Five-Year Outcomes of Chronic Red Blood Cell Exchange Transfusion Program for Patients with Sickle Cell Disease, the Experience of University of Nebraska Medical Center

Author

Abughanimeh, Omar, primary, Ebers, Steven, additional, Khan Suheb, Mahammed, additional, Eclov, Julie, additional, High, Robin, additional, Bobr, Aleh, additional, Koepsell, Scott A, additional, Harper, James, additional, Gundabolu, Krishna, additional, Nester, Alex, additional, and Buddharaju, Laxmi Narayana, additional

Published
2021
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25. Establishing a Comprehensive Database for Patients with Sickle Cell Disease in the State of Nebraska, the First Step of Improving Their Care

Author

Abughanimeh, Omar, primary, Khan Suheb, Mahammed, additional, Ebers, Steven, additional, Eclov, Julie, additional, High, Robin, additional, Nester, Alex, additional, Bobr, Aleh, additional, Koepsell, Scott A, additional, Harper, James, additional, Gundabolu, Krishna, additional, and Buddharaju, Laxmi Narayana, additional

Published
2020
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29. Intrahepatic Cholangiocarcinoma Masquerading as Acute Fatty Liver of Pregnancy: A Case Report and Review of the Literature

Author

Qasrawi, Ayman, Abughanimeh, Omar, Abu Ghanimeh, Mouhanna, Arora-Elder, Simran, Yousef, Osama, and Tamimi, Tarek

Subjects
Article Subject
Abstract

Cholangiocarcinoma (CCA) is an uncommon cancer and accounts only for 3% of all gastrointestinal malignancies. In this report, we present a case of an intrahepatic cholangiocarcinoma masquerading as acute fatty liver of pregnancy (AFLP). A 38-year-old female who is 36-week pregnant presented with a 1-week history of headache, nausea, vomiting, and right upper abdominal pain, along with hepatomegaly. Laboratory investigations were remarkable for mild leukocytosis, hyperbilirubinemia, proteinuria, and elevated transaminases and prothrombin time. Ultrasound of the liver revealed hepatomegaly, fatty infiltration, and a right hepatic lobe mass. Based on the overall picture, AFLP was suspected, and the patient underwent delivery by Cesarean section. However, bilirubin and liver enzyme levels gradually increased after delivery. MRI revealed a large dominant hepatic mass along with multiple satellite lesions in both lobes. Biopsy revealed the presence of intrahepatic CCA. CCA presenting during pregnancy is extremely rare with only 9 other cases reported in the literature. Therefore, the signs and symptoms can be easily confused with other more common disorders that occur during pregnancy.

Published
2018
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30. Colopancreatic Fistula: An Uncommon Complication of Recurrent Acute Pancreatitis

Author

Abu Ghanimeh, Mouhanna, Abughanimeh, Omar, Abuamr, Khalil, Yousef, Osama, and Sadeddin, Esmat

Subjects
Article Subject
Abstract

Colonic complications, including colopancreatic fistulas (CPFs), are uncommon after acute and chronic pancreatitis. However, they have been reported and are serious. CPFs are less likely to close spontaneously and are associated with a higher risk of complications. Therefore, more definitive treatment is required that includes surgical and endoscopic options. We present a case of a 62-year-old male patient with a history of heavy alcohol intake and recurrent acute pancreatitis who presented with a 6-month history of watery diarrhea and abdominal pain. His abdominal imaging showed a possible connection between the colon and the pancreas. A further multidisciplinary workup by the gastroenterology and surgery teams, including endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, and colonoscopy, resulted in a diagnosis of CPF. A distal pancreatectomy and left hemicolectomy were performed, and the diagnosis of CPF was confirmed intraoperatively. The patient showed improvement afterward.

Published
2018
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31. Dental Impaction in the Cecum: Case Report and Review of Gastrointestinal Foreign Body Impactions

Author

Abu Ghanimeh, Mouhanna, Abughanimeh, Omar, Albadarin, Sakher, Kaddourah, Osama, and Helzberg, John H.

Subjects
Article Subject
Abstract

Approximately 20% of the adult population in the United States wears dentures. Foreign body ingestions, including dentures, are not uncommon. Although the majority of all ingested foreign bodies pass spontaneously through the gastrointestinal tract, impaction may occur, especially with physiologic constrictions, angulations, or stenosis. The esophagus is the most common site of impaction, whereas colonic impaction is extremely uncommon. We present a case of an 84-year-old male who was referred to the gastroenterology clinic for denture impaction, which lasted for two weeks. The patient had already failed to pass the denture following conservative treatment with laxatives, and repeated abdominal imaging showed the dental plate in the cecum. Colonoscopy was performed three weeks after the ingestion of his dentures, and tripod forceps were used to dislodge the end of the dental plate and ultimately remove it. The patient was asymptomatic for the entire period.

Published
2018
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43. Gastric Metastasis from Renal Cell Carcinoma, Clear Cell Type, Presenting with Gastrointestinal Bleeding

Author

Abu Ghanimeh, Mouhanna, Qasrawi, Ayman, Abughanimeh, Omar, Albadarin, Sakher, and Helzberg, John H.

Subjects
Article Subject, urologic and male genital diseases, neoplasms, female genital diseases and pregnancy complications
Abstract

Renal cell carcinoma (RCC) accounts for 80–85% of all primary renal neoplasms. Although RCC can metastasize to any organ, gastric metastases from RCC are exceedingly rare. A 67-year-old male presented with melena and acute blood loss anemia. The patient had a history of RCC that had been treated with a radical nephrectomy. He had a recent myocardial infarction and was receiving double antiplatelet therapy. After hemodynamic stabilization, esophagogastroduodenoscopy showed a polypoid mass in the gastric fundus. The mass was excised. Histological and immunohistochemical evaluation were consistent with clear cell RCC. The polypoid lesion is consistent with a late solitary metastasis.

Published
2017
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