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1. Trasplante de páncreas: revisión

Author

Pamela S. Espinoza-Loyola, Luis J. Fernández-López, Paul S. Mogrovejo-Vázquez, Fernando Mondragón-Rodríguez, José A. González-Moreno, Daniel A. Torres-Del Real, Víctor M. Páez-Zayas, Carla A. Escorza-Molina, Abril M. García-Sánchez, Isidoro A. Sánchez-Cedillo, Omar Vásquez-Gómez, Óscar Chapa-Azuela, and Víctor Visag-Castillo

Subjects
Trasplante de páncreas. Diabetes mellitus. Selección de donante de páncreas. Técnica quirúrgica. Resultados., Surgery, RD1-811
Abstract

El trasplante de páncreas es el único tratamiento que estabiliza los niveles normales de glucosa en los pacientes diagnosticados con diabetes tipo 1 o tipo 2. En esta revisión se analizan la supervivencia del injerto, la supervivencia del paciente y el impacto en las complicaciones diabéticas. Se describe la supervivencia del injerto: 82-98% al año para los receptores de trasplante simultáneo de páncreas y riñón, 71% para trasplante páncreas después de riñón y 62% para trasplante de páncreas solitario al año. Supervivencia de los pacientes a 1 año: 96.9% para los receptores de trasplante simultáneo de páncreas y riñón, 96.3% para los receptores de trasplante de páncreas después de riñón y 98.3% para los receptores de páncreas solitario. En general, el trasplante de páncreas mejora y revierte las complicaciones diabéticas. Finalmente, el trasplante de páncreas, un procedimiento mórbido, surge como una alternativa significativa en el manejo de la diabetes, compitiendo directamente con las terapias convencionales de insulina. Hasta ahora, los resultados indican que el modelo de trasplante más efectivo es el simultáneo de páncreas y riñón. Aunque más pacientes podrían beneficiarse de este procedimiento, las complicaciones quirúrgicas y la necesidad de inmunosupresión plantean desafíos significativos.

Published
2024
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2. Estilo de vida en hijos de padres con diabetes mellitus tipo 2

Author

Abril M. Alamo-Romo, Leticia Blanco-Castillo, Enrique Villarreal-Ríos, Liliana Galicia-Rodríguez, and Emma R. Vargas-Daza

Subjects
Estilo de vida. Familiares. Diabetes mellitus tipo 2., Medicine (General), R5-920
Abstract

Antecedentes: El estilo de vida es uno de los factores que influyen en el riesgo de desarrollar enfermedades. Los hábitos y conductas forman parte de un componente psicosocial que se comparte entre los integrantes de una familia, por lo que ciertas conductas de los padres se pueden replicar en los hijos. Objetivo: Determinar la prevalencia del estilo de vida en hijos de padres con diabetes mellitus tipo 2. Material y métodos: Estudio transversal descriptivo en población sin diabetes, de 18 a 45 años de edad, con algún progenitor o ambos con diagnóstico de diabetes mellitus tipo 2. El tamaño de la muestra fue de 375, la técnica muestral fue por casos consecutivos. Las variables incluyeron aspectos sociodemográficos, el estilo de vida se midió con el Cuestionario de Perfil de Estilo de vida PEPS-I Pender; el plan de análisis estadístico incluyó promedios, intervalos de confianza (IC), porcentajes e IC para porcentajes. Resultados: El promedio de edad fue 32.8 años, el 69.8% del sexo femenino, el 64.5% vivía en pareja y el 80.5% con escolaridad preparatoria o menos, el 64.8% eran empleados y el 10.1% tenían hipertensión arterial. Predominó el estilo de vida bueno (60.3%; IC 95%: 55.3-65.3), también en las dimensiones de nutrición y responsabilidad en salud, con 39.7 y 47.5% respectivamente y malo en ejercicio (43.7%), autoactualización (50.4%), soporte interpersonal (51.5%) y manejo del estrés (40.5%). Conclusiones: El estilo de vida en hijos de padres con diabetes fue bueno, aunque se recomienda realizar un enfoque global al momento de su abordaje.

Published
2021
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4. The CARMENES search for exoplanets around M dwarfs. Guaranteed time observations Data Release 1 (2016-2020)

Author

Ribas, I., Reiners, A., Zechmeister, M., Caballero, J. A., Morales, J. C., Sabotta, S., Baroch, D., Amado, P. J., Quirrenbach, A., Abril, M., Aceituno, J., Anglada-Escudé, G., Azzaro, M., Barrado, D., Béjar, V. J. S., de Haro, D. Benítez, Bergond, G., Bluhm, P., Ortega, R. Calvo, Guillén, C. Cardona, Chaturvedi, P., Cifuentes, C., Colomé, J., Cont, D., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dreizler, S., Duque-Arribas, C., Espinoza, N., Fernández, M., Fuhrmeister, B., Galadí-Enríquez, D., García-López, A., González-Álvarez, E., Hernández, J. I. González, Guenther, E. W., de Guindos, E., Hatzes, A. P., Henning, Th., Herrero, E., Hintz, D., Huelmo, Á. L., Jeffers, S. V., Johnson, E. N., de Juan, E., Kaminski, A., Kemmer, J., Khaimova, J., Khalafinejad, S., Kossakowski, D., Kürster, M., Labarga, F., Lafarga, M., Lalitha, S., Lampón, M., Lillo-Box, J., Lodieu, N., González, M. J. López, López-Puertas, M., Luque, R., Magán, H., Mancini, L., Marfil, E., Martín, E. L., Martín-Ruiz, S., Molaverdikhani, K., Montes, D., Nagel, E., Nortmann, L., Nowak, G., Pallé, E., Passegger, V. M., Pavlov, A., Pedraz, S., Perdelwitz, V., Perger, M., Ramón-Ballesta, A., Reffert, S., Revilla, D., Rodríguez, E., Rodríguez-López, C., Sadegi, S., Carrasco, M. Á. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Schäfer, S., Schlecker, M., Schmitt, J. H. M. M., Schöfer, P., Schweitzer, A., Seifert, W., Shan, Y., Skrzypinski, S. L., Solano, E., Stahl, O., Stangret, M., Stock, S., Stürmer, J., Tabernero, H. M., Tal-Or, L., Trifonov, T., Vanaverbeke, S., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The CARMENES instrument was conceived to deliver high-accuracy radial velocity (RV) measurements with long-term stability to search for temperate rocky planets around a sample of nearby cool stars. The broad wavelength coverage was designed to provide a range of stellar activity indicators to assess the nature of potential RV signals and to provide valuable spectral information to help characterise the stellar targets. The CARMENES Data Release 1 (DR1) makes public all observations obtained during the CARMENES guaranteed time observations, which ran from 2016 to 2020 and collected 19,633 spectra for a sample of 362 targets. The CARMENES survey target selection was aimed at minimising biases, and about 70% of all known M dwarfs within 10 pc and accessible from Calar Alto were included. The data were pipeline-processed, and high-level data products, including 18,642 precise RVs for 345 targets, were derived. Time series data of spectroscopic activity indicators were also obtained. We discuss the characteristics of the CARMENES data, the statistical properties of the stellar sample, and the spectroscopic measurements. We show examples of the use of CARMENES data and provide a contextual view of the exoplanet population revealed by the survey, including 33 new planets, 17 re-analysed planets, and 26 confirmed planets from transiting candidate follow-up. A subsample of 238 targets was used to derive updated planet occurrence rates, yielding an overall average of 1.44+/-0.20 planets with 1 M_Earth < M sin i < 1000 M_Earth and 1 d < P_orb < 1000 d per star, and indicating that nearly every M dwarf hosts at least one planet. CARMENES data have proven very useful for identifying and measuring planetary companions as well as for additional applications, such as the determination of stellar properties, the characterisation of stellar activity, and the study of exoplanet atmospheres., Comment: Published in A&A (https://www.aanda.org/10.1051/0004-6361/202244879), 25 pages, 12 figures, Tables 1 and 2 only available online

Published
2023
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5. HORuS transmission spectroscopy of 55 Cnc e

Author

Tabernero, H. M., Prieto, C. Allende, Osorio, M. R. Zapatero, Hernández, J. I. González, del Burgo, C., López, R. García, Rebolo, R., Abril-Abril, M., Barreto, R., Tovar, J. Calvo, Torres, A. Diaz, Izquierdo, P. Fernández, Gómez-Reñasco, M. F., Gracia-Témich, F., Joven, E., Castro, J. Peñate, Santana-Tschudi, S., Tenegi, F., and Martín, H. D. Viera

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

The High Optical Resolution Spectrograph (HORuS) is a new high-resolution echelle spectrograph available on the 10.4 m Gran Telescopio Canarias (GTC). We report on the first HORuS observations of a transit of the super-Earth planet 55 Cnc e. We investigate the presence of Na I and H$\alpha$ in its transmission spectrum and explore the capabilities of HORuS for planetary transmission spectroscopy. Our methodology leads to residuals in the difference spectrum between the in-transit and out-of-transit spectra for the Na I doublet lines of (3.4 $\pm$ 0.4) $\times$ 10$^{-4}$, which sets an upper limit to the detection of line absorption from the planetary atmosphere that is one order of magnitude more stringent that those reported in the literature. We demonstrate that we are able to reach the photon-noise limit in the residual spectra using HORuS to a degree that we would be able to easily detect giant planets with larger atmospheres. In addition, we modelled the structure, chemistry and transmission spectrum of 55 Cnc e using state-of-the-art open source tools., Comment: Accepted for publication in MNRAS

Published
2020
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6. A giant exoplanet orbiting a very low-mass star challenges planet formation models

Author

Morales, J. C., Mustill, A. J., Ribas, I., Davies, M. B., Reiners, A., Bauer, F. F., Kossakowski, D., Herrero, E., Rodríguez, E., López-González, M. J., Rodríguez-López, C., Béjar, V. J. S., González-Cuesta, L., Luque, R., Pallé, E., Perger, M., Baroch, D., Johansen, A., Klahr, H., Mordasini, C., Anglada-Escudé, G., Caballero, J. A., Cortés-Contreras, M., Dreizler, S., Lafarga, M., Nagel, E., Passegger, V. M., Reffert, S., Rosich, A., Schweitzer, A., Tal-Or, L., Trifonov, T., Zechmeister, M., Quirrenbach, A., Amado, P. J., Guenther, E. W., Hagen, H. -J., Henning, T., Jeffers, S. V., Kaminski, A., Kürster, M., Montes, D., Seifert, W., Abellán, F. J., Abril, M., Aceituno, J., Aceituno, F. J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Arroyo-Torres, B., Azzaro, M., Barrado, D., Becerril-Jarque, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Brinkmöller, M., del Burgo, C., Burn, R., Calvo-Ortega, R., Cano, J., Cárdenas, M. C., Guillén, C. Cardona, Carro, J., Casal, E., Casanova, V., Casasayas-Barris, N., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Dorda, R., Emsenhuber, A., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Cava, I. Gallardo, Vargas, M. L. García, Garcia-Piquer, A., Gesa, L., González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Hermelo, I., Arabi, R. Hernández, Otero, F. Hernández, Hintz, D., Holgado, G., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kehr, M., Kemmer, J., Kim, M., Klüter, J., Klutsch, A., Labarga, F., Labiche, N., Lalitha, S., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lizon, J. -L., Llamas, M., Lodieu, N., del Fresno, M. López, Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Martínez-Rodríguez, H., Marvin, C. J., Mirabet, E., Moya, A., Naranjo, V., Nelson, R. P., Nortmann, L., Nowak, G., Ofir, A., Pascual, J., Pavlov, A., Pedraz, S., Medialdea, D. Pérez, Pérez-Calpena, A., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Sabotta, S., Sadegi, S., Salz, M., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schlecker, M., Schmitt, J. H. M. M., Schöfer, P., Solano, E., Sota, A., Stahl, O., Stock, S., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tulloch, S. M., Veredas, G., Vico-Linares, J. I., Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

Statistical analyses from exoplanet surveys around low-mass stars indicate that super-Earth and Neptune-mass planets are more frequent than gas giants around such stars, in agreement with core accretion theory of planet formation. Using precise radial velocities derived from visual and near-infrared spectra, we report the discovery of a giant planet with a minimum mass of 0.46 Jupiter masses in an eccentric 204-day orbit around the very low-mass star GJ 3512. Dynamical models show that the high eccentricity of the orbit is most likely explained from planet-planet interactions. The reported planetary system challenges current formation theories and puts stringent constraints on the accretion and migration rates of planet formation and evolution models, indicating that disc instability may be more efficient in forming planets than previously thought., Comment: Manuscript author version. 41 pages, 11 figures

Published
2019
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7. The CARMENES search for exoplanets around M dwarfs. Two temperate Earth-mass planet candidates around Teegarden's Star

Author

Zechmeister, M., Dreizler, S., Ribas, I., Reiners, A., Caballero, J. A., Bauer, F. F., Béjar, V. J. S., González-Cuesta, L., Herrero, E., Lalitha, S., López-González, M. J., Luque, R., Morales, J. C., Pallé, E., Rodríguez, E., López, C. Rodríguez, Tal-Or, L., Anglada-Escudé, G., Quirrenbach, A., Amado, P. J., Abril, M., Aceituno, F. J., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Jiménez, R. Antona, Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Bluhm, P., Brinkmöller, M., del Burgo, C., Ortega, R. Calvo, Cano, J., Guillén, C. Cardona, Carro, J., Vázquez, M. C. Cárdenas, Casal, E., Casasayas-Barris, N., Casanova, V., Chaturvedi, P., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dorda, R., Fernández, M., Fernández-Martín, A., Ferro, I. M., Fuhrmeister, B., Fukui, A., Galadí-Enríquez, D., Cava, I. Gallardo, de la Fuente, J. Garcia, Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Rueda, J. Góngora, González-Álvarez, E., Hernández, J. I. González, González-Peinado, R., Grözinger, U., Guàrdia, J., Guijarro, A., de Guindos, E., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, T., Hermelo, I., Arabi, R. Hernández, Castaño, L. Hernández, Otero, F. Hernández, Hintz, D., Huke, P., Huber, A., Jeffers, S. V., Johnson, E. N., de Juan, E., Kaminski, A., Kemmer, J., Kim, M., Klahr, H., Klein, R., Klüter, J., Klutsch, A., Kossakowski, D., Kürster, M., Labarga, F., Lafarga, M., Llamas, M., Lampón, M., Lara, L. M., Launhardt, R., Lázaro, F. J., Lodieu, N., del Fresno, M. López, López-Comazzi, A., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Fernández, P., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Montañés-Rodríguez, P., Montes, D., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Narita, N., Nortmann, L., Nowak, G., Ofir, A., Oshagh, M., Panduro, J., Parviainen, H., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Rabaza, O., Ballesta, A. Ramón, Rebolo, R., Redondo, P., Reffert, S., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Trinidad, A. Rodríguez, Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schöfer, P., Schweitzer, A., Seifert, W., Shulyak, D., Solano, E., Sota, A., Stahl, O., Stock, S., Strachan, J. B. P., Stuber, T., Stürmer, J., Suárez, J. C., Tabernero, H. M., Pinto, M. Tala, Trifonov, T., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context. Teegarden's Star is the brightest and one of the nearest ultra-cool dwarfs in the solar neighbourhood. For its late spectral type (M7.0V), the star shows relatively little activity and is a prime target for near-infrared radial velocity surveys such as CARMENES. Aims. As part of the CARMENES search for exoplanets around M dwarfs, we obtained more than 200 radial-velocity measurements of Teegarden's Star and analysed them for planetary signals. Methods. We find periodic variability in the radial velocities of Teegarden's Star. We also studied photometric measurements to rule out stellar brightness variations mimicking planetary signals. Results. We find evidence for two planet candidates, each with $1.1M_\oplus$ minimum mass, orbiting at periods of 4.91 and 11.4 d, respectively. No evidence for planetary transits could be found in archival and follow-up photometry. Small photometric variability is suggestive of slow rotation and old age. Conclusions. The two planets are among the lowest-mass planets discovered so far, and they are the first Earth-mass planets around an ultra-cool dwarf for which the masses have been determined using radial velocities., Comment: A&A 627, A49. 26 pages, 17 figures, 6 tables. Press release available at http://www.astro.physik.uni-goettingen.de/~zechmeister/teegarden/teegarden.html. v2: two authors and one reference added

Published
2019
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8. Modeling Dengue Vector Population Using Remotely Sensed Data and Machine Learning

Author

Scavuzzo, J. M., Trucco, F., Espinosa, M., Tauro, C. B., Abril, M., Scavuzzo, C. M., and Frery, A. C.

Subjects
Statistics - Machine Learning, Computer Science - Learning
Abstract

Mosquitoes are vectors of many human diseases. In particular, Aedes \ae gypti (Linnaeus) is the main vector for Chikungunya, Dengue, and Zika viruses in Latin America and it represents a global threat. Public health policies that aim at combating this vector require dependable and timely information, which is usually expensive to obtain with field campaigns. For this reason, several efforts have been done to use remote sensing due to its reduced cost. The present work includes the temporal modeling of the oviposition activity (measured weekly on 50 ovitraps in a north Argentinean city) of Aedes \ae gypti (Linnaeus), based on time series of data extracted from operational earth observation satellite images. We use are NDVI, NDWI, LST night, LST day and TRMM-GPM rain from 2012 to 2016 as predictive variables. In contrast to previous works which use linear models, we employ Machine Learning techniques using completely accessible open source toolkits. These models have the advantages of being non-parametric and capable of describing nonlinear relationships between variables. Specifically, in addition to two linear approaches, we assess a Support Vector Machine, an Artificial Neural Networks, a K-nearest neighbors and a Decision Tree Regressor. Considerations are made on parameter tuning and the validation and training approach. The results are compared to linear models used in previous works with similar data sets for generating temporal predictive models. These new tools perform better than linear approaches, in particular Nearest Neighbor Regression (KNNR) performs the best. These results provide better alternatives to be implemented operatively on the Argentine geospatial Risk system that is running since 2012., Comment: Accepted for publication in Acta Tropica

Published
2018

9. The CARMENES search for exoplanets around M dwarfs - HD 147379b: A nearby Neptune in the temperate zone of an early-M dwarf

Author

Reiners, A., Ribas, I., Zechmeister, M., Caballero, J. A., Trifonov, T., Dreizler, S., Morales, J. C., Tal-Or, L., Lafarga, M., Quirrenbach, A., Amado, P. J., Kaminski, A., Jeffers, S. V., Aceituno, J., Béjar, V. J. S., Guàrdia, J., Guenther, E. W., Hagen, H. -J., Montes, D., Passegger, V. M., Seifert, W., Schweitzer, A., Cortés-Contreras, M., Abril, M., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E. N., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Labarga, F., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, M. J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schöfer, P., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Ulbrich, R. -G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Solar and Stellar Astrophysics
Abstract

We report on the first star discovered to host a planet detected by radial velocity (RV) observations obtained within the CARMENES survey for exoplanets around M dwarfs. HD 147379 ($V = 8.9$ mag, $M = 0.58 \pm 0.08$ M$_{\odot}$), a bright M0.0V star at a distance of 10.7 pc, is found to undergo periodic RV variations with a semi-amplitude of $K = 5.1\pm0.4$ m s$^{-1}$ and a period of $P = 86.54\pm0.06$ d. The RV signal is found in our CARMENES data, which were taken between 2016 and 2017, and is supported by HIRES/Keck observations that were obtained since 2000. The RV variations are interpreted as resulting from a planet of minimum mass $m_{\rm p}\sin{i} = 25 \pm 2$ M$_{\oplus}$, 1.5 times the mass of Neptune, with an orbital semi-major axis $a = 0.32$ au and low eccentricity ($e < 0.13$). HD 147379b is orbiting inside the temperate zone around the star, where water could exist in liquid form. The RV time-series and various spectroscopic indicators show additional hints of variations at an approximate period of 21.1d (and its first harmonic), which we attribute to the rotation period of the star., Comment: accepted for publication as A&A Letter

Published
2017
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10. The CARMENES search for exoplanets around M dwarfs: High-resolution optical and near-infrared spectroscopy of 324 survey stars

Author

Reiners, A., Zechmeister, M., Caballero, J. A., Ribas, I., Morales, J. C., Jeffers, S. V., Schöfer, P., Tal-Or, L., Quirrenbach, A., Amado, P. J., Kaminski, A., Seifert, W., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Eiff, M. Ammler-von, Antona, R., Anglada-Escudé, G., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Barrado, D., Bauer, F. F., Becerril, S., Béjar, V. J. S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., del Burgo, C., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Dreizler, S., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Gómez, V., Galera, Hernández, J. I. González, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guenther, E. W., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hatzes, A. P., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Henning, Th., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Kürster, M., Lafarga, M., Lamert, A., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., Launhardt, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, López-Santiago, J., Luque, R., Madinabeitia, H. Magán, Mall, U., Mancini, L., Mandel, H., Marfil, E., Molina, J. A. Marín, Maroto, D., Fernández, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mathar, R. J., Mirabet, E., Montes, D., Moreno-Raya, M. E., Moya, A., Mundt, R., Nagel, E., Naranjo, V., Nortmann, L., Nowak, G., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pavlov, A., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reffert, S., Reinhart, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Rodríguez-López, C., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schmitt, J. H. M. M., Schiller, J., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Stürmer, J., Suárez, J. C., Tabernero, H. M., Tala, M., Trifonov, T., Tulloch, S. M., Ulbrich, R. G., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Earth and Planetary Astrophysics
Abstract

The CARMENES radial velocity (RV) survey is observing 324 M dwarfs to search for any orbiting planets. In this paper, we present the survey sample by publishing one CARMENES spectrum for each M dwarf. These spectra cover the wavelength range 520--1710nm at a resolution of at least $R > 80,000$, and we measure its RV, H$\alpha$ emission, and projected rotation velocity. We present an atlas of high-resolution M-dwarf spectra and compare the spectra to atmospheric models. To quantify the RV precision that can be achieved in low-mass stars over the CARMENES wavelength range, we analyze our empirical information on the RV precision from more than 6500 observations. We compare our high-resolution M-dwarf spectra to atmospheric models where we determine the spectroscopic RV information content, $Q$, and signal-to-noise ratio. We find that for all M-type dwarfs, the highest RV precision can be reached in the wavelength range 700--900nm. Observations at longer wavelengths are equally precise only at the very latest spectral types (M8 and M9). We demonstrate that in this spectroscopic range, the large amount of absorption features compensates for the intrinsic faintness of an M7 star. To reach an RV precision of 1ms$^{-1}$ in very low mass M dwarfs at longer wavelengths likely requires the use of a 10m class telescope. For spectral types M6 and earlier, the combination of a red visual and a near-infrared spectrograph is ideal to search for low-mass planets and to distinguish between planets and stellar variability. At a 4m class telescope, an instrument like CARMENES has the potential to push the RV precision well below the typical jitter level of 3-4ms$^{-1}$., Comment: accepted for publication in A&A, 13 pages plus 40 pages spectral atlas, first 10 atlas pages are reduced in quality to fit arXiv size limit; one CARMENES spectrum for each of the 324 stars is published in electronic format at http://carmenes.cab.inta-csic.es/

Published
2017
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11. The CARMENES search for exoplanets around M dwarfs. First visual-channel radial-velocity measurements and orbital parameter updates of seven M-dwarf planetary systems

Author

Trifonov, T., Kürster, M., Zechmeister, M., Tal-Or, L., Caballero, J. A., Quirrenbach, A., Amado, P. J., Ribas, I., Reiners, A., Reffert, S., Dreizler, S., Hatzes, A. P., Kaminski, A., Launhardt, R., Henning, Th., Montes, D., Béjar, V. J. S., Mundt, R., Pavlov, A., Schmitt, J. H. M. M., Seifert, W., Morales, J. C., Nowak, G., Jeffers, S. V., Rodríguez-López, C., del Burgo, C., Anglada-Escudé, G., López-Santiago, J., Mathar, R. J., Eiff, M. Ammler-von, Guenther, E. W., Barrado, D., Hernández, J. I. González, Mancini, L., Stürmer, J., Abril, M., Aceituno, J., Alonso-Floriano, F. J., Antona, R., Anwand-Heerwart, H., Arroyo-Torres, B., Azzaro, M., Baroch, D., Bauer, F. F., Becerril, S., Benítez, D., Berdiñas, Z. M., Bergond, G., Blümcke, M., Brinkmöller, M., Cano, J., Vázquez, M. C. Cárdenas, Casal, E., Cifuentes, C., Claret, A., Colomé, J., Cortés-Contreras, M., Czesla, S., Díez-Alonso, E., Feiz, C., Fernández, M., Ferro, I. M., Fuhrmeister, B., Galadí-Enríquez, D., Garcia-Piquer, A., Vargas, M. L. García, Gesa, L., Galera, V. Gómez, González-Peinado, R., Grözinger, U., Grohnert, S., Guàrdia, J., Guijarro, A., de Guindos, E., Gutiérrez-Soto, J., Hagen, H. -J., Hauschildt, P. H., Hedrosa, R. P., Helmling, J., Hermelo, I., Arabí, R. Hernández, Castaño, L. Hernández, Hernando, F. Hernández, Herrero, E., Huber, A., Huke, P., Johnson, E., de Juan, E., Kim, M., Klein, R., Klüter, J., Klutsch, A., Lafarga, M., Lampón, M., Lara, L. M., Laun, W., Lemke, U., Lenzen, R., del Fresno, M. López, López-González, J., López-Puertas, M., Salas, J. F. López, Luque, R., Madinabeitia, H. Magán, Mall, U., Mandel, H., Marfil, E., Molina, J. A. Marín, Fernández, D. Maroto, Martín, E. L., Martín-Ruiz, S., Marvin, C. J., Mirabet, E., Moya, A., Moreno-Raya, M. E., Nagel, E., Naranjo, V., Nortmann, L., Ofir, A., Oreiro, R., Pallé, E., Panduro, J., Pascual, J., Passegger, V. M., Pedraz, S., Pérez-Calpena, A., Medialdea, D. Pérez, Perger, M., Perryman, M. A. C., Pluto, M., Rabaza, O., Ramón, A., Rebolo, R., Redondo, P., Reinhardt, S., Rhode, P., Rix, H. -W., Rodler, F., Rodríguez, E., Trinidad, A. Rodríguez, Rohloff, R. -R., Rosich, A., Sadegi, S., Sánchez-Blanco, E., Carrasco, M. A. Sánchez, Sánchez-López, A., Sanz-Forcada, J., Sarkis, P., Sarmiento, L. F., Schäfer, S., Schiller, J., Schöfer, P., Schweitzer, A., Solano, E., Stahl, O., Strachan, J. B. P., Suárez, J. C., Tabernero, H. M., Tala, M., Tulloch, S. M., Veredas, G., Linares, J. I. Vico, Vilardell, F., Wagner, K., Winkler, J., Wolthoff, V., Xu, W., Yan, F., and Osorio, M. R. Zapatero

Subjects
Astrophysics - Earth and Planetary Astrophysics
Abstract

Context: The main goal of the CARMENES survey is to find Earth-mass planets around nearby M-dwarf stars. Seven M-dwarfs included in the CARMENES sample had been observed before with HIRES and HARPS and either were reported to have one short period planetary companion (GJ15A, GJ176, GJ436, GJ536 and GJ1148) or are multiple planetary systems (GJ581 and GJ876). Aims: We aim to report new precise optical radial velocity measurements for these planet hosts and test the overall capabilities of CARMENES. Methods: We combined our CARMENES precise Doppler measurements with those available from HIRES and HARPS and derived new orbital parameters for the systems. Bona-fide single planet systems are fitted with a Keplerian model. The multiple planet systems were analyzed using a self-consistent dynamical model and their best fit orbits were tested for long-term stability. Results: We confirm or provide supportive arguments for planets around all the investigated stars except for GJ15A, for which we find that the post-discovery HIRES data and our CARMENES data do not show a signal at 11.4 days. Although we cannot confirm the super-Earth planet GJ15Ab, we show evidence for a possible long-period ($P_{\rm c}$ = 7025$_{-629}^{+972}$ d) Saturn-mass ($m_{\rm c} \sin i$ = 51.8$_{-5.8}^{+5.5}M_\oplus$) planet around GJ15A. In addition, based on our CARMENES and HIRES data we discover a second planet around GJ1148, for which we estimate a period $P_{\rm c}$ = 532.6$_{-2.5}^{+4.1}$ d, eccentricity $e_{\rm c}$ = 0.34$_{-0.06}^{+0.05}$ and minimum mass $m_{\rm c} \sin i$ = 68.1$_{-2.2}^{+4.9}M_\oplus$. Conclusions: The CARMENES optical radial velocities have similar precision and overall scatter when compared to the Doppler measurements conducted with HARPS and HIRES. We conclude that CARMENES is an instrument that is up to the challenge of discovering rocky planets around low-mass stars., Comment: Accepted for publication in A&A, 24 pages, 16 figures, 14 tables

Published
2017
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12. Pancreas transplantation: review.

Author

Espinoza-Loyola, Pamela S., Fernández-López, Luis J., Mogrovejo-Vázquez, Paul S., González-Moreno, Fernando Mondragón-Rodríguez. José A., Real, Daniel A. Torres-Del, Páez-Zayas, Víctor M., García-Sánchez, Carla A. Escorza-Molina. Abril M., Sánchez-Cedillo, Isidoro A., Vásquez-Gómez, Omar, Chapa-Azuela, Oscar, and Visag-Castillo, Víctor J.

Subjects
PANCREAS transplantation, GLUCOSE in the body, DIABETES complications, INSULIN therapy, SURGICAL complications, IMMUNOSUPPRESSION
Abstract

Copyright of Cirugía y Cirujanos is the property of Publicidad Permanyer SLU and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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14. Comprehensive transient-state study for CARMENES-NIR high thermal stability

Author

Becerril, S., Sánchez, M. A., Cárdenas, M. C., Rabaza, O., Ramón, A., Abril, M., Costillo, L. P., Morales, R., Rodríguez, A., Amado, P. J., and team, the international CARMENES

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

CARMENES has been proposed as a next-generation instrument for the 3.5m Calar Alto Telescope. Its objective is finding habitable exoplanets around M dwarfs through radial velocity measurements (m/s level) in the near-infrared. Consequently, the NIR spectrograph is highly constraint regarding thermal/mechanical requirements. As a first approach, the thermal stability has been limited to \pm 0.01K (within year period) over a working temperature of 243K. This can be achieved by means of several temperature-controlled rooms. The options considered to minimise the complexity of the thermal design are here presented, as well as the transient-state thermal analyses realised to make the best choice.

Published
2010
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15. CARMENES: Calar Alto high-Resolution search for M dwarfs with Exo-earths with a Near-infrared Echelle Spectrograph

Author

Quirrenbach, A., Amado, P. J., Mandel, H., Caballero, J. A., Ribas, I., Reiners, A., Mundt, R., Abril, M., Afonso, C., Bean, J. L., Bejar, V. J. S., Becerril, S., Boehm, A., Cardenas, C., Claret, A., Colome, J., Costillo, L. P., Dreizler, S., Fernandez, M., Francisco, X., Garrido, R., Hernandez, J. I. Gonzalez, Guenther, E. W., Gutierrez-Soto, J., Joergens, V., Hatzes, A. P., Henning, T., Herrero, E., Kurster, M., Laun, W., Lenzen, R., Mall, U., Martin, E. L., Martin-Ruiz, S., Montes, D., Morales, J. C., Munoz, R. Morales, Moya, A., Naranjo, V., Rabaza, O., Ramon, A., Rebolo, R., Reffert, S., Rodler, F., Rodriguez, E., Trinidad, A. Rodriguez, Rohloff, R. -R., Carrasco, M. A. Sanchez, Schmidt, C., Seifert, W., Setiawan, J., Stahl, O., Suarez, J. C., Wiedemann, G., del Burgo, C., Galadi, D., Sanchez-Blanco, E., and Xu, W.

Subjects
Astrophysics - Solar and Stellar Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

CARMENES, Calar Alto high-Resolution search for M dwarfs with Exo-earths with a Near-infrared Echelle Spectrograph, is a study for a next-generation instrument for the 3.5m Calar Alto Telescope to be designed, built, integrated, and operated by a consortium of nine German and Spanish institutions. Our main objective is finding habitable exoplanets around M dwarfs, which will be achieved by radial velocity measurements on the m/s level in the near-infrared, where low-mass stars emit the bulk of their radiation., Comment: Astronomical Society of the Pacific Conference Series, "Pathways towards habitable planets", eds. V. Coude du Foresto, D. M. Gelino & I. Ribas, 14-18 Sep 2009, Barcelona, Spain (in press) Note: Because of space restriction, the printed conference paper will appear with only an abbreviated author list

Published
2009

16. Structure and composition of microbial communities in the water column from Southern Gulf of Mexico and detection of putative hydrocarbon‐degrading microorganisms.

Author

Valencia‐Agami, Sonia S., Cerqueda‐García, Daniel, Gamboa‐Muñoz, Abril M., Aguirre‐Macedo, M. Leopoldina, and García‐Maldonado, José Q.

Subjects
BACTERIOPLANKTON, MICROBIAL communities, MICROORGANISMS, PETROLEUM, ONE-way analysis of variance, PROCHLOROCOCCUS, SOIL microbial ecology, BACTERIAL diversity
Abstract

This study assessed the bacterioplankton community and its relationship with environmental variables, including total petroleum hydrocarbon (TPH) concentration, in the Yucatan shelf area of the Southern Gulf of Mexico. Beta diversity analyses based on 16S rRNA sequences indicated variations in the bacterioplankton community structure among sampling sites. PERMANOVA indicated that these variations could be mainly related to changes in depth (5 to 180 m), dissolved oxygen concentration (2.06 to 5.93 mg L−1), and chlorophyll‐a concentration (0.184 to 7.65 mg m3). Moreover, SIMPER and one‐way ANOVA analyses showed that the shifts in the relative abundances of Synechococcus and Prochlorococcus were related to changes in microbial community composition and chlorophyll‐a values. Despite the low TPH content measured in the studied sites (0.01 to 0.86 μL L−1), putative hydrocarbon‐degrading bacteria such as Alteromonas, Acinetobacter, Balneola, Erythrobacter, Oleibacter, Roseibacillus, and the MWH‐UniP1 aquatic group were detected. The relatively high copy number of the alkB gene detected in the water column by qPCR and the enrichment of hydrocarbon‐degrading bacteria obtained during lab crude oil tests exhibited the potential of bacterioplankton communities from the Yucatan shelf to respond to potential hydrocarbon impacts in this important area of the Gulf Mexico. [ABSTRACT FROM AUTHOR]

Published
2024
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20. The CARMENES search for exoplanets around M dwarfs

Author

Ribas, I., primary, Reiners, A., additional, Zechmeister, M., additional, Caballero, J. A., additional, Morales, J. C., additional, Sabotta, S., additional, Baroch, D., additional, Amado, P. J., additional, Quirrenbach, A., additional, Abril, M., additional, Aceituno, J., additional, Anglada-Escudé, G., additional, Azzaro, M., additional, Barrado, D., additional, Béjar, V. J. S., additional, Benítez de Haro, D., additional, Bergond, G., additional, Bluhm, P., additional, Calvo Ortega, R., additional, Cardona Guillén, C., additional, Chaturvedi, P., additional, Cifuentes, C., additional, Colomé, J., additional, Cont, D., additional, Cortés-Contreras, M., additional, Czesla, S., additional, Díez-Alonso, E., additional, Dreizler, S., additional, Duque-Arribas, C., additional, Espinoza, N., additional, Fernández, M., additional, Fuhrmeister, B., additional, Galadí-Enríquez, D., additional, García-López, A., additional, González-Álvarez, E., additional, González Hernández, J. I., additional, Guenther, E. W., additional, de Guindos, E., additional, Hatzes, A. P., additional, Henning, Th., additional, Herrero, E., additional, Hintz, D., additional, Huelmo, Á. L., additional, Jeffers, S. V., additional, Johnson, E. N., additional, de Juan, E., additional, Kaminski, A., additional, Kemmer, J., additional, Khaimova, J., additional, Khalafinejad, S., additional, Kossakowski, D., additional, Kürster, M., additional, Labarga, F., additional, Lafarga, M., additional, Lalitha, S., additional, Lampón, M., additional, Lillo-Box, J., additional, Lodieu, N., additional, López González, M. J., additional, López-Puertas, M., additional, Luque, R., additional, Magán, H., additional, Mancini, L., additional, Marfil, E., additional, Martín, E. L., additional, Martín-Ruiz, S., additional, Molaverdikhani, K., additional, Montes, D., additional, Nagel, E., additional, Nortmann, L., additional, Nowak, G., additional, Pallé, E., additional, Passegger, V. M., additional, Pavlov, A., additional, Pedraz, S., additional, Perdelwitz, V., additional, Perger, M., additional, Ramón-Ballesta, A., additional, Reffert, S., additional, Revilla, D., additional, Rodríguez, E., additional, Rodríguez-López, C., additional, Sadegi, S., additional, Sánchez Carrasco, M. Á., additional, Sánchez-López, A., additional, Sanz-Forcada, J., additional, Schäfer, S., additional, Schlecker, M., additional, Schmitt, J. H. M. M., additional, Schöfer, P., additional, Schweitzer, A., additional, Seifert, W., additional, Shan, Y., additional, Skrzypinski, S. L., additional, Solano, E., additional, Stahl, O., additional, Stangret, M., additional, Stock, S., additional, Stürmer, J., additional, Tabernero, H. M., additional, Tal-Or, L., additional, Trifonov, T., additional, Vanaverbeke, S., additional, Yan, F., additional, and Zapatero Osorio, M. R., additional

Published
2023
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21. The CARMENES search for exoplanets around M dwarfs

Author

Ribas, I, Reiners, A, Zechmeister, M, Caballero, Ja, Morales, Jc, Sabotta, S, Baroch, D, Amado, Pj, Quirrenbach, A, Abril, M, Aceituno, J, Anglada-Escudé, G, Azzaro, M, Barrado, D, Béjar, Vjs, Benítez de Haro, D, Bergond, G, Bluhm, P, Calvo Ortega, R, Cardona Guillén, C, Chaturvedi, P, Cifuentes, C, Colomé, J, Cont, D, Cortés-Contreras, M, Czesla, S, Díez-Alonso, E, Dreizler, S, Duque-Arribas, C, Espinoza, N, Fernández, M, Fuhrmeister, B, Galadí-Enríquez, D, García-López, A, González-Álvarez, E, González Hernández, Ji, Guenther, Ew, de Guindos, E, Hatzes, Ap, Henning, T, Herrero, E, Hintz, D, Huelmo, Al, Jeffers, Sv, Johnson, En, de Juan, E, Kaminski, A, Kemmer, J, Khaimova, J, Khalafinejad, S, Kossakowski, D, Kürster, M, Labarga, F, Lafarga, M, Lalitha, S, Lampón, M, Lillo-Box, J, Lodieu, N, López González, Mj, López-Puertas, M, Luque, R, Magán, H, Mancini, L, Marfil, E, Martín, El, Martín-Ruiz, S, Molaverdikhani, K, Montes, D, Nagel, E, Nortmann, L, Nowak, G, Pallé, E, Passegger, Vm, Pavlov, A, Pedraz, S, Perdelwitz, V, Perger, M, Ramón-Ballesta, A, Reffert, S, Revilla, D, Rodríguez, E, Rodríguez-López, C, Sadegi, S, Sánchez Carrasco, Ma, Sánchez-López, A, Sanz-Forcada, J, Schäfer, S, Schlecker, M, Schmitt, Jhmm, Schöfer, P, Schweitzer, A, Seifert, W, Shan, Y, Skrzypinski, Sl, Solano, E, Stahl, O, Stangret, M, Stock, S, Stürmer, J, Tabernero, Hm, Tal-Or, L, Trifonov, T, Vanaverbeke, S, Yan, F, and Zapatero Osorio, Mr

Subjects
Astrophysics - Solar and Stellar Astrophysics, solar neighborhood, Settore FIS/05, stars: late-type, techniques: spectroscopic, astronomical databases: miscellaneous, planetary systems, Astrophysics - Earth and Planetary Astrophysics, Astrophysics - Instrumentation and Methods for Astrophysics
Published
2023

24. Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

Author

Xu, Wei, Weissmiller, Abril M., White, II, Joseph A., Fang, Fang, Wang, Xinyi, Wu, Yiwen, Pearn, Matthew L., Zhao, Xiaobei, Sawa, Mariko, Chen, Shengdi, Gunawardena, Shermali, Ding, Jianqing, Mobley, William C., and Wu, Chengbiao

Subjects
Nerve growth factor -- Analysis -- Health aspects, Amyloid beta-protein -- Health aspects -- Research, Alzheimer's disease -- Diagnosis -- Research, Health care industry
Abstract

The endosome/lysosome pathway is disrupted early in the course of both Alzheimer's disease (AD) and Down syndrome (DS); however, it is not clear how dysfunction in this pathway influences the development of these diseases. Herein, we explored the cellular and molecular mechanisms by which endosomal dysfunction contributes to the pathogenesis of AD and DS. We determined that full-length amyloid precursor protein (APP) and its β-C-terminal fragment (β-CTF) act though increased activation of Rab5 to cause enlargement of early endosomes and to disrupt retrograde axonal trafficking of nerve growth factor (NGF) signals. The functional impacts of APP and its various products were investigated in PC12 cells, cultured rat basal forebrain cholinergic neurons (BFCNs), and BFCNs from a mouse model of DS. We found that the full-length wild-type APP ([APP.sup.WT]) and β-CTF both induced endosomal enlargement and disrupted NGF signaling and axonal trafficking. β-CTF alone induced atrophy of BFCNs that was rescued by the dominant-negative Rab5 mutant, [Rab5.sup.S34N]. Moreover, expression of a dominant-negative Rab5 construct markedly reduced APP-induced axonal blockage in Drosophila. Therefore, increased APP and/or β-CTF impact the endocytic pathway to disrupt NGF trafficking and signaling, resulting in trophic deficits in BFCNs. Our data strongly support the emerging concept that dysregulation of Rab5 activity contributes importantly to early pathogenesis of AD and DS., Introduction Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing memory loss and cognitive decline unless disease-modifying treatments are applied (1-6). The classical neuropathological hallmarks, Aβ-amyloid-containing plaques and tau-containing neurofibrillary [...]

Published
2016
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25. A Scheduling Order-Based Method to Solve Timetabling Problems

Author

Ingolotti, L., Barber, F., Tormos, P., Lova, A., Salido, M. A., Abril, M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Marín, Roque, editor, Onaindía, Eva, editor, Bugarín, Alberto, editor, and Santos, José, editor

Published
2006
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26. New Heuristics to Solve the 'CSOP' Railway Timetabling Problem

Author

Ingolotti, L., Lova, A., Barber, F., Tormos, P., Salido, M. A., Abril, M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Ali, Moonis, editor, and Dapoigny, Richard, editor

Published
2006
Full Text
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29. An Efficient Method to Schedule New Trains on a Heavily Loaded Railway Network

Author

Ingolotti, Laura, Barber, Federico, Tormos, Pilar, Lova, Antonio, Salido, M. A., Abril, M., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Dough, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Carbonell, Jaime G., editor, Siekmann, Jörg, editor, Lemaître, Christian, editor, Reyes, Carlos A., editor, and González, Jesús A., editor

Published
2004
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42. La vulneración de derechos sociales en el caso de las Villas Panamericanas

Author

Ledesma-Zermeño, Abril M. and Marroquín-Farrera, José R.

Subjects
Derecho Constitucional, Medio Ambiente, Derechos Sociales, Impacto Ambiental
Abstract

El caso de las Villas Panamericanas en el municipio de Zapopan, Jalisco, ha sido blanco de diversos señalamientos por parte de organizaciones civiles dedicadas a la protección del medio ambiente y sociedad civil en general y, por ende, mediático. Desde el inicio de la concepción del proyecto, existieron controversias en cuanto a su emplazamiento, primero propuesto en el centro de la ciudad de Guadalajara como oportunidad de reactivación económica y redensificación habitacional para, tras un abrupto giro sin fundamentación clara, ser emplazado en la zona de amortiguamiento de uno de los principales pulmones del Área Metropolitana de Guadalajara (AMG en adelante), ubicado en el municipio de Zapopan: el Bosque de la Primavera. Su presencia pudo comprometer la preservación de una importante red de acuíferos dado el impacto ambiental de la edificación derivado de la oscuridad en las gestiones del proyecto, principalmente en materia de tratamiento de residuos de agua de la que, según las noticias publicadas por diversos medios, ha sido protagonista la Villa. El análisis de las posibles vulneraciones a Derechos sociales especialmente en detrimento del Derecho a un medio ambiente sano entre otros, derivadas de la existencia de este proyecto vistos desde la perspectiva del Derecho Constitucional y los Derechos Humanos, fue el eje toral de este trabajo. ITESO, .A.C.

Published
2021

48. Hydrogen Embrittlement at Cleavage Planes and Grain Boundaries in Bcc Iron-Revisiting the First-Principles Cohesive Zone Model

Author

Azócar Guzmán, Abril (M. Sc.), Jeon, Jeongwook, Hartmaier, Alexander (Prof. Dr. rer. nat.), and Janisch, Rebecca (PD Dr. habil.)

Subjects
lcsh:QH201-278.5, lcsh:T, grain boundary segregation, lcsh:Technology, Article, hydrogen embrittlement, lcsh:TA1-2040, hydrogen enhanced decohesion, lcsh:Descriptive and experimental mechanics, lcsh:Electrical engineering. Electronics. Nuclear engineering, ddc:620, lcsh:Engineering (General). Civil engineering (General), lcsh:Microscopy, lcsh:TK1-9971, density functional theory, lcsh:QC120-168.85
Abstract

Hydrogen embrittlement, which severely affects structural materials such as steel, comprises several mechanisms at the atomic level. One of them is hydrogen enhanced decohesion (HEDE), the phenomenon of H accumulation between cleavage planes, where it reduces the interplanar cohesion. Grain boundaries are expected to play a significant role for HEDE, since they act as trapping sites for hydrogen. To elucidate this mechanism, we present the results of first-principles studies of the H effect on the cohesive strength of &alpha, Fe single crystal (001) and (111) cleavage planes, as well as on the &Sigma, 5(310)[001] and &Sigma, 3(112)[11&macr, 0] symmetrical tilt grain boundaries. The calculated results show that, within the studied range of concentrations, the single crystal cleavage planes are much more sensitive to a change in H concentration than the grain boundaries. Since there are two main types of procedures to perform ab initio tensile tests, different in whether or not to allow the relaxation of atomic positions, which can affect the quantitative and qualitative results, these methods are revisited to determine their effect on the predicted cohesive strength of segregated interfaces.

Published
2020

49. Target product profile for a test for the early assessment of treatment efficacy in chagas disease patients: An expert consensus

Author

Generalitat de Catalunya, Instituto de Salud Carlos III, National Institutes of Health (US), National Institute of Allergy and Infectious Diseases (US), Ministerio de Economía y Competitividad (España), Ministero della Salute, Alonso-Padillaid, J., Abril, M., de Noya, B.A., Almeida, Igor C., Angheben, A., Jorge, T.A., Chatelain, E., Esteva, Monica, Gascón, Joaquim, Grijalva, M.J., Guhl, F., Hasslochermoreno, A.M., López López, Manuel Carlos, Luquetti, A., Noya, O., Pinazo, M.J., Ramsey, J.M., Ribeiro, I., Ruiz, A.M., Schijman, A.G., Sosa-Estani, S., Thomas, María del Carmen, M., Torrico, F., Zreinid, M., Picado, A., Generalitat de Catalunya, Instituto de Salud Carlos III, National Institutes of Health (US), National Institute of Allergy and Infectious Diseases (US), Ministerio de Economía y Competitividad (España), Ministero della Salute, Alonso-Padillaid, J., Abril, M., de Noya, B.A., Almeida, Igor C., Angheben, A., Jorge, T.A., Chatelain, E., Esteva, Monica, Gascón, Joaquim, Grijalva, M.J., Guhl, F., Hasslochermoreno, A.M., López López, Manuel Carlos, Luquetti, A., Noya, O., Pinazo, M.J., Ramsey, J.M., Ribeiro, I., Ruiz, A.M., Schijman, A.G., Sosa-Estani, S., Thomas, María del Carmen, M., Torrico, F., Zreinid, M., and Picado, A.

Abstract

descripción no proporcionada por scopus

Published
2020

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