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Your search keyword '"Abramson, M. J."' showing total 281 results
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281 results on '"Abramson, M. J."'

1. An observational analysis on the influence of parental allergic rhinitis, asthma and smoking on exhaled nitric oxide in offspring

Author

Zaigham, Suneela, Bertelsen, R J, Dharmage, S C, Schlünssen, V, Jögi, N O, Gomez, L Palacios, Holm, M, Oudin, A, Abramson, M J, Sigsgaard, T, Jõgi, R, Svanes, C, Olin, A C, Forsberg, B, Janson, Christer, Nerpin, E, Johannessen, A, Malinovschi, Andrei, Zaigham, Suneela, Bertelsen, R J, Dharmage, S C, Schlünssen, V, Jögi, N O, Gomez, L Palacios, Holm, M, Oudin, A, Abramson, M J, Sigsgaard, T, Jõgi, R, Svanes, C, Olin, A C, Forsberg, B, Janson, Christer, Nerpin, E, Johannessen, A, and Malinovschi, Andrei

Abstract

BACKGROUND: Parental allergic diseases and smoking influence respiratory disease in the offspring but it is not known whether they influence fractional exhaled nitric oxide (FeNO) in the offspring. We investigated whether parental allergic diseases, parental smoking and FeNO levels in parents were associated with FeNO levels in their offspring. METHODS: We studied 609 offspring aged 16-47 years from the Respiratory Health in Northern Europe, Spain and Australia generation (RHINESSA) study with parental information from the Respiratory Health in Northern Europe (RHINE) III study and the European Community Respiratory Health Survey (ECRHS) III. Linear regression models were used to assess the association between offspring FeNO and parental FeNO, allergic rhinitis, asthma and smoking, while adjusting for potential confounding factors. RESULTS: Parental allergic rhinitis was significantly associated with higher FeNO in the offspring, both on the paternal and maternal side (percent change: 20.3 % [95%CI 5.0-37.7], p = 0.008, and 13.8 % [0.4-28.9], p = 0.043, respectively). Parental allergic rhinitis with asthma in any parent was also significantly associated with higher offspring FeNO (16.2 % [0.9-33.9], p = 0.037). However, parental asthma alone and smoking were not associated with offspring FeNO. Parental FeNO was not associated with offspring FeNO after full adjustments for offspring and parental factors. CONCLUSIONS: Parental allergic rhinitis but not parental asthma was associated with higher levels of FeNO in offspring. These findings suggest that parental allergic rhinitis status should be considered when interpreting FeNO levels in offspring beyond childhood.

Published
2024
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2. Residential greenspace and lung function decline over 20 years in a prospective cohort: the ECRHS study

Author

Markevych, I., Zhao, T., Fuertes, E., Marcon, A., Dadvand, P., Vienneau, D., Garcia Aymerich, J., Nowak, D., de Hoogh, K., Jarvis, D., Abramson, M. J., Accordini, S., Amaral, A. F., Bentouhami, H., Jacobsen Bertelsen, R., Boudier, A., Bono, R., Bowatte, G., Casas, L., Dharmage, S. C., Forsberg, B., Gislason, T., Gnesi, M., Holm, M., Jacquemin, B., Janson, C., Jogi, R., Johannessen, A., Keidel, D., Leynaert, B., Maldonado Perez, J. A., Marchetti, P., Migliore, E., Martínez-Moratalla, J., Orru, H., Pin, I., Potts, J., Probst-Hensch, N., Ranzi, A., Sánchez-Ramos, J. L., Siroux, V., Soussan, D., Sunyer, J., Urrutia Landa, I., Villani, S., and Heinrich, J.

Subjects
Green space, FEV1, Arbetsmedicin och miljömedicin, Spirometry, Respiratory Medicine and Allergy, Occupational Health and Environmental Health, ECRHS, FVC, Nature, Lungmedicin och allergi
Abstract

BACKGROUND: The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is affected. OBJECTIVE: We explored the association between residential greenspace and change in lung function over 20 years in 5559 adults from 22 centers in 11 countries participating in the population-based, international European Community Respiratory Health Survey. METHODS: Forced expiratory volume in 1 s (FEV(1)) and forced vital capacity (FVC) were measured by spirometry when participants were approximately 35 (1990-1994), 44 (1999-2003), and 55 (2010-2014) years old. Greenness was assessed as the mean Normalized Difference Vegetation Index (NDVI) in 500 m, 300 m, and 100 m circular buffers around the residential addresses at the time of lung function measurement. Green spaces were defined as the presence of agricultural, natural, or urban green spaces in a circular 300 m buffer. Associations of these greenspace parameters with the rate of lung function change were assessed using adjusted linear mixed effects regression models with random intercepts for subjects nested within centers. Sensitivity analyses considered air pollution exposures. RESULTS: A 0.2-increase (average interquartile range) in NDVI in the 500 m buffer was consistently associated with a faster decline in FVC (-1.25 mL/year [95% confidence interval: -2.18 to -0.33]). These associations were especially pronounced in females and those living in areas with low PM(10) levels. We found no consistent associations with FEV(1) and the FEV(1)/FVC ratio. Residing near forests or urban green spaces was associated with a faster decline in FEV(1), while agricultural land and forests were related to a greater decline in FVC. CONCLUSIONS: More residential greenspace was not associated with better lung function in middle-aged European adults. Instead, we observed slight but consistent declines in lung function parameters. The potentially detrimental association requires verification in future studies.

Published
2023
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