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In-silico Computer-Aided Drug Design (CADD) significantly relies on cybernetic screening of Plant Based Natural Products (PBNPs) as a prime source of bioactive compounds/ drug leads due to their unique chemical structural scaffolds and distinct functional characteristic features amenable to drug design and development. In the Post-COVID-Era a large number of publications have focused on PBNPs. Moreover, PBNPs still remain as an ideal source of novel therapeutic agents of GRAS standard. However, a well-structured, in-depth ADME/Tox profile with deeper dimensions of PBNPs has been lacking for many of natural pharma lead molecules that hamper successful exploitation of PBNPs. In the present study, ADMET-informatics of Octadecanoic Acid (Stearic Acid - SA) from ethyl acetate fraction of Moringa oleifera leaves has been envisaged to predict ADMET and pharmacokinetics (DMPK) outcomes. This work contributes to the deeper understanding of SA as major source of drug lead from Moringa oleifera with immense therapeutic potential. The data generated herein could be useful for the development of SA as plant based natural product lead (PBNPL) for drug development programs. Keywords: Moringa oleifera; Bioactive Substances; Octadecanoic Acid; Stearic Acid; ADME/Tox; Natural Product Based Drug Lead; PBNPs

The popularly known Kazharchi Kai (Tamil), Caesalpinia bonduc L. (Fam: Caesalpiniaceae) is a traditional medicinal plant widely distributed in India which finds use as a therapeutic in indigenous systems of medicine such as Ayurveda, Siddha, Unani and Homoeopathy is a herbal remedy for  treating of various ailments. The plant has been reported for its anticancer, hepatoprotective, antioxidant, antimalarial, antimicrobial, antipyretic, antifertility, anti-inflammatory and antimalarial properties. In particular C. bonduc seeds contain cassane diterpenoids viz., caesalpinins and caesalmins, cassane diterpenoids, and norcassane diterpenoids. This plant contains bioactive secondary metabolites (BASM) with unique structures and diverse mechanisms of action that can be well exploited to finetune novel therapeutic herbal formulations. In the present study an attempt has been made to screen for bioactive metabolites in the seed extracts of C. bonduc followed by GCMS analysis. GCMS analysis indicated the presence of 2,2,3,5-tetramethylheptane, (Z)-hept-2-enal, 2,2,3,5-tetramethylheptane, 3,3- dimethyloctane, 5-ethyl-2,2,3-trimethylheptane, 2,6,10-trimethyldodecane, 3- methylnonane, 3,8-dimethylundecane, 6-Ethyl-3,8-dimethylundecane, 2,3,4- trimethyldecane, 3-Methyldecane, (2E,4E)-deca-2,4-dienal, (1R,4E,9S)-4,11,11- trimethyl-8-methylidenebicyclo[7.2]undec-4-ene, Hexadecanoic acid, methyl (9Z,12Z)-octadeca-9,12-dienoate, (9Z)-octadeca-9,17-dienal, 2- (ethylhexoxycarbonyl) benzoic acid. Of all, compounds such as Hexadecanoic acid, methyl (9Z,12Z)-octadeca-9,12-dienoate, and (9Z)-octadeca-9,17-dienal with unusual bioactivity score could serve as promising lead candidate for the design of novel anticancer drug, In-silico predictions of molecular and biological activity of these bioactive compounds phytocompounds could pave way for its effective utilization   in pharma industry scale as a potential candidate towards biomedical applications. However, before such an

Moringa oleifera has been reported to be the store-house of wide range of bioactive compounds. Most commonly used plant part has been the leaves which are reported to be rich in Vitamins, Carotenoids, Polyphenols, Phenolic Acids, Flavonoids Alkaloids, Glucosinolates, Isocyanides, Tannins and Saponins. Moringa leaves are used as Keerai while, green pods are commonly used as vegetable in the traditional preparation of Sambar in South-India. MO is gaining popularity because of its nutrient-rich root, leaves, flowers and fruits, having immense traditional medicinal uses and proved pharmacological properties. Not much of work has been carried out on analysis of bioactive compounds present in the pods. In the present study an attempt has been made to screen and analyze the range of bioactive compounds present in Moringa oleifera seed removed ripened natural dried pods. Phytochemical screening and GCMS analysis revealed the presence of 12 compounds namely - 7-Octadecyne, 2-methyl- (C19H36); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); 6,9,12,15-Docosatetraenoic acid, me (C23H38O2); Cyclohexanol, 5-methyl-2-(1-methylethyl)- (C10H20O); 3,7,11,15-Tetramethyl-2-hexadecen-1-ol (C20H40O); Palmitic acid vinyl ester (C18H34O2); .gamma.-Tocopherol (C28H48O2); Vitamin E (C29H50O2); Cholesta-7,9(11)-dien-3-ol, 4,4-dim (C29H48O); gamma.-Sitosterol (C29H50O); Stigmasta-5,24(28)-dien-3-ol, (3.beta.,24Z)- (C29H48O). Further, in-silico ADMET analysis is expected to provide in-death physiochemical and biomolecular details of these molecules in order to exploit them for production of novel drugs for the pharma market with wide array of bio medical applications. Keywords: Bioactive Compounds; GCMS; Phytochemical Screening; MOPME; Plant Based Natural Products

In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic. Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care

Physalis minima (PM) belongs to the family Solanaceae. PM has been traditionally used to cure and prevent several disorders as documented in Vedic Texts. Nevertheless, scientific values of traditional claims haven't been explored yet. In the previous study, GCMS analysis of P. minima ethanolic leaf extracts (PMELE) indicated the presence of Cyclobutanol (C4H8O); D-Alanine (C3H7O2N); 2-Heptanol, 6-Amino-2-Methyl (C8H19ON); 1-Pentanol, 4-Amino (C5H13NO); Benzeneethanamine, 3-Fluoro-Beta.,5-Dihydroxy-N-Methyl (C9H12FNO2) and L-Alanine, N-(N-Acetylglycyl)-, Butyl Ester (C11H20N2O4). However, biological activities of these bioactive compounds are not known which hampers the exploitation of these compounds by pharma-industries on a commercial scale. This study on ADMET, Pharmacokinetics, Drug-likeness and Medicinal Chemistry of Bioactive Compounds in PMELE aims to provide baseline information on PBNPs as a potential source of natural lead molecules for next generation drug design, development and therapeutics. Keywords: PM-PBNPs; ADMET; PMELE; Pharmacokinetics; Drug-likeness; Drug Development; Bioactive Compounds