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Abstract Many irrigation schemes are performing poorly for a number of reasons, and this should be improved to increase the efficiency and productivity of the schemes. This study attempted to determine the performance of the Bilate and Furfuro irrigation schemes in Silti Zone, southern Ethiopia. For field data measurements, three farmers’ fields were selected at the head, middle, and tail end of each scheme. Average conveyance efficiencies were 53% and 56.1%, average field application efficiencies were 55.9% and 58.0%, average water storage efficiencies were 53% and 46.5%, irrigation uniformity was 91.03% and 92.9%, and overall irrigation efficiency was 28% and 32% for Bilate and Furfuro schemes respectively. This implied that the two schemes were performing inefficiently and inadequately, but water was distributed uniformly. The reason might be most canal sections had unreasonable losses of water in two schemes. Additionally, relative water supply was 0.68 and 0.79, relative irrigation supply was 0.61 and 0.77, output per unit irrigated area was 4140.4 and 1781.5 ($/ha), output per unit command area was 4510.3 and 1968.5 ($/ha), output per unit irrigation supply was 0.94 and 0.28 ($/m3), output per unit water consumed was 0.99 and 0.39 ($/m3), sustainability of irrigation area was 1.05 and 1.02, and irritation ratio was 1.11 and 1.09 for Bilate and Furfuro schemes respectively. This revealed that the applied water was not satisfied the crop water demand, but their irrigated lands were expanded for two irrigation schemes. Furfuro scheme was better than Bilate in terms of relative water supply and relative irrigation supply, but their results obtained were below acceptable values. However, Bilate scheme had significantly better land and water productivity than Furfuro scheme. This may be use high value crops, better agricultural inputs, and removal of grass cover and sedimentation from canal systems. Hence, Bilate irrigation scheme was better performing than Furfuro scheme. Therefore, adopt the best practices learned from Bilate irrigation scheme for the Furfuro scheme.

The resting membrane potential enables neurons to rapidly initiate and conduct electrical signals. K2p channels are key in maintaining this membrane potential and electrical excitability. They direct the resting membrane potential toward the K+ equilibrium potential. Doxapram is a known blocker for a subset of K2p channels that are pH sensitive. We assessed the effects of 0.1 and 5 mM doxapram on the neural activity within the propodite-dactylopodite (PD) proprioceptive sensory organ in the walking legs of blue crabs (Callinectes sapidus). Results indicate that 0.1 mM doxapram enhances excitation, while the higher concentration 5 mM may over-excite the neurons and promote a sustained absolute refractory period until the compound is removed. The effect of 5 mM doxapram mimics the effect of 40 mM K+ exposure. Verapamil, another known K2p channel blocker as well as an L-type Ca2+ channel blocker, reduces neural activity at both 0.1 and 5 mM. Verapamil may block stretch activated channels in sensory endings, in addition to reducing the amplitude of the compound action potential with whole nerve preparations. These findings are notable as they demonstrate that doxapram has acute effects on neurons of crustaceans, suggesting a targeted K2p channel. The actions of verapamil are complex due to the potential of affecting multiple ion channels in this preparation. Crustacean neurons can aid in understanding the mechanisms of action of various pharmacological agents as more information is gained.

In this formative experiment, the authors focused on developing professional development for upper elementary school teachers and investigating how it was integrated into teachers' instruction to improve their ability to make writing a more digital, participatory process. Theoretical perspectives pertaining to technology use in education specify that this instruction should emphasize students creating rather than consuming information from media sources and that this creation process should be social. However, recent research of preadolescents has shown that although these students are using technology more in schools, they are often using technology to consume rather than create information. Further, literacy teachers, in particular, have identified barriers to integrating technology effectively into their curriculum. Thus, there is a critical need for professional development that helps teachers more effectively integrate technology into their classrooms. The objective of this study was to develop a professional development model that helps teachers engage students in writing as both a digital process and a social process. The essential elements studied in this model include the following: (a) sustained professional development, including the gradual release of teacher inquiry; (b) writing as a social practice; and (c) the use of digital tools to engage students in writing. Using both qualitative and quantitative methods, the authors studied the implementation of this professional development model in a summer institute and in teacher classrooms.

The current study examined psychological and family health predictors of change over time in household income, using data from longitudinal studies of African American (N = 889, 93.5% female) and Mexican origin (N = 674, 100% female) families. Participants self-reported their household income, as well as their emotional, personality, and cognitive resources. Participant behavioral and physical resources were coded from observed family interactions. Although income did not predict change in any personal resources, all five classes of personal resources (i.e., emotional, personality, cognitive, behavioral, physical) predicted change in income across a 10-year span (Study 1) and a 6-year span (Study 2). Income is potentially caused by these personal resources, or both income and these personal resources share a common cause. The dominant approach of assuming income causes personal and family health needs stronger support. (PsycINFO Database Record

Habtamu Abuye,1 Woldemichael Abraham,2 Selass Kebede,1 Ramanjireddy Tatiparthi,3,4 Sultan Suleman4,5 1Department of Pharmacy, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia; 2Department of Pharmacy, College of Medicine and Health Sciences, Wolayita Sodo University, Wolayita Sodo, Ethiopia; 3Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Jimma University, Jimma, Ethiopia; 4Jimma University Laboratory of Drug Quality (JuLaDQ), College of Health Sciences, Jimma University, Jimma, Ethiopia; 5School of Pharmacy, College of Health Sciences, Jimma University, Jimma, EthiopiaCorrespondence: Habtamu AbuyeDepartment of Pharmacy, College of Medicine and Health Sciences, Wachemo University, Hossana, EthiopiaTel +251 913571974Email harohabe@gmail.comBackground: Malaria is a complex disease and main community health problem in Africa and the top leading cause of outpatient visits, admissions, and deaths in Ethiopia. Its effective management is possible through early diagnosis and immediate treatment employing antimalarials. The quality of these drugs has to be good enough to attain their intended purpose. However, there are treatment failures resulted from the consumption of falsified and substandard antimalarials. Therefore, the current study was undertaken to evaluate the quality of two commonly used antimalarial drugs [chloroquine phosphate and quinine sulfate tablets] and to determine whether the quality of these drugs was affected by the origin, brand and sample collection sites in South-West Ethiopia.Methods: Random sampling based on Ethiopian malaria eco-epidemiological strata map, with different levels of medicines outlets, was applied to select sampling sites.Results: Sixty samples were bought from 43 drug retails (pharmacy, drug store, and drug vendor) in twelve different geographical locations of South-West Ethiopia between June and July 2016. Visual inspection was done for all samples before the lab experiment. A 28.3%, 31.7%, and 6.8% of samples failed to comply with the Pharmacopoeial quality standards for visual inspection, hardness and weight variation tests, respectively. Statistical analysis revealed that origin and geography from which samples were collected significantly affects the active pharmaceutical content of both drugs at P < 0.05 level. Significant variation was observed for chloroquine samples within batches of the same manufacturing and between origins.Conclusion: This study indicated that all the chloroquine and quinine tablets met the quality specification concerning friability, dissolution and assay. Out-of-specification results for weight variation, hardness and visual inspection tests for the chloroquine tablets are signs of substandard/spurious/falsely labeled/falsified/counterfeit actions that may compromise the quality of these drugs. Besides, within the acceptance limit, the origin of drugs and collection sites have found to determine the quality which raises good manufacturing practice and storage (drug supply chain system) issues to be evaluated.Keywords: chloroquine, quinine, identification, assay, dissolution, uniformity of weight, hardness, friability, visual inspection

COVID-19 remains a serious disruption to human health, social, and economic existence. Reinfection with the virus intensifies fears and raises more questions among countries, with few documented reports. This study investigated cases of COVID-19 reinfection using patients' laboratory test results between March 2020 and July 2021 in Liberia. Data obtained from Liberia's Ministry of Health COVID-19 surveillance was analyzed in Excel 365 and ArcGIS Pro 2.8.2. Results showed that with a median interval of 200 days (Range: 99-415), 13 out of 5,459 cases were identified and characterized as reinfection in three counties during the country's third wave of the outbreak. Eighty-six percent of the COVID-19 reinfection cases occurred in Montserrado County within high clusters, which accounted for over 80% of the randomly distributed cases in Liberia. More cases of reinfection occurred among international travelers within populations with high community transmissions. This study suggests the need for continued public education and surveillance to encourage longer-term COVID-19 preventive practices even after recovery.

Pasar Sanggeng, pasar Wosi, pelabuhan, PLTD (Pembangkit Listrik Tenaga Disel), perhotelan dan pemukiman penduduk yang terletak di pesisir Teluk Doreri Kota Manokwari, menjadi salah satu pusat aktivitas yang melayani kebutuhan masyarakat. Akibat adanya aktivitas yang tinggi tersebut menyebabkan pembungan sampah-sampah organik dan anorganik tidak terawasi atau terkontrol dengan baik. Kondisi ini berlangsung secara terus menerus setiap hari sehingga dapat menyebabkan terjadi degradasi kualitas perairan. Tujuan Penelitian yaitu untuk mengetahui status kualitas perairan di Teluk Doreri Kabupaten Manokwari. Penelitian dilakukan dari bulan Agustus tahun 2016 bertempat di Laboratorium Kelautan, Ilmu Kelautan Unipa dan Laboratorium Prolink IPB Bogor. Lokasi pengambilan sampel air di sekitar perairan Sawaibu, Wosi, Andai, Sowi dan Perairan Maruni. Data parameter yang diambil melalui pengukuran langsung dan tidak langsung. Pengukuran secara langsung meliputi parameter salinitas, pH, suhu dan oksigen terlarut. Sedangkan pengukuran tidak langsung dengan cara mengambil sampel air. Pengambilan sampel air digunakan untuk penentuan parameter kekeruhan, nitrat, fosfat dan logam berat. Sampel air tersebut langsung dimasukan dalam botol polyetelin dan dikirim ke Prolink IPB Bogor untuk dianalisis. Pengukuran mengacu pada Standard Methods for the Examination of Water and Wastewater (APHA, 1998). Hasil penelitian dari lima lokasi di perairan Teluk Doreri berkisar antara 0,17 – 6,16 NTU untuk kekeruhan, 4,64 – 5,04 untuk pH, 5,1 -6 mg/L untuk oksigen terlarut, 30 – 33 ‰ untuk salinitas, 29, 8 – 30,6 oC untuk suhu air, 0,1 -0,8 mg/L untuk nitrat dan fosfat berkisar 0,08 – 0,16 mg/L. Hasil logam berat cadmium (Cd) menunjukan potensi toksik yang tinggi bagi biota perairan di Teluk Doreri. Parameter logam berat cadmium, nitrat dan fosfat sangat mengkuatirkan serta dapat menyebabkan gangguan terhadap lingkungan khususnya bagi biota perairan. Parameter – parameter tersebut telah melampaui baku mutu yang ditetapkan kementerian lingkungan hidup no 51 tahun 2004. WATER QUALITY IN THE DORERI BAY DISTRICT MANOKWARI. Traditional markets (Pasar Sanggeng and Wosi), port, PLTD (Power Plant), hotels and residential areas are located in the cost of Doreri bay in Manokwari district. Activities in those areas create organic and inorganic wastes that have been used the Doreri bay as a water dump. The waste has been dumped since long time ago and continue up to nowadays. That cause water quality degradation of Doreri bay. The research objective was to determine the status of water quality in Doreri Bay, Manokwari Regency. The water quality study has been carried out in August 2016 in Marine laboratory of UNIPA and Prolink laboratory in IPB. Water samples collected from Sawaibu, Wosi, Andai, Sowi and Maruni beach. Data were divided base on the data collection which is directly and indirectly collected. Water salinity, pH, temperature and dissolved oxygen are direct data collection. Turbidity, nitrate, phosphate and heavy metals are indirect data collection that has been analyzed in Prolink IPB. The water has been analyses by using Standard Method for Examination of Water and Wastewater (APHA, 1998). The results show that turbidity of five areas range from 0.17 to 6.16 NTU, pH range from 4.64 to 5.04, dissolved oxygen between 5.1 -6 mg/L, water salinity range from 30-33%, water temperature between 29, 8 - 30.6 oC, 0.1 -0.8 mg/L for nitrate and phosphate between 0.08 - 0.16 mg/L. Heavy metal (cadmium) showed high potential toxic risk on the biota of Doreri bay. Cadmium, nitrate, and phosphate are a heavy metal that categorized as concerned pollutant to the Dorery bay. Those heavy metal have been exceeded the water quality standard base on Ministry of environment number 51-2004.

Background. Elevated lactate levels in critically ill patients are most often thought to be indicative of relative tissue hypoxia or type A lactic acidosis. Shock, severe anemia, and thromboembolic events can all cause elevated lactate due to tissue hypoperfusion, as well as the mitochondrial dysfunction thought to occur in sepsis and other critically ill states. Malignancy can also lead to elevation in lactate, a phenomenon described as type B lactic acidosis, which is much less commonly encountered in the critically ill. Case Presentation. We present the case of a 73-year-old Caucasian woman with type 2 diabetes and hypertension who presented with abdominal pain, nausea, vomiting, nonbloody diarrhea, and weight loss over five weeks and was found to have unexplained refractory lactic acidosis despite fluids and antibiotics. She was later diagnosed with small cell carcinoma of the lung. Conclusions. In this case report, we describe a critically ill patient whose elevated lactate was incorrectly attributed to her acute illness, when in truth it was an indicator of an underlying, as yet undiagnosed, malignancy. We believe this case is instructive to the critical care clinician as a reminder of the importance of considering malignancy on the differential diagnosis of a patient presenting with elevated lactate out of proportion to their critical illness.