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2. A Generalized Zero-Shot Quantization of Deep Convolutional Neural Networks via Learned Weights Statistics

Author

Sharma, Prasen Kumar, Abraham, Arun, and Rajendiran, Vikram Nelvoy

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Machine Learning
Abstract

Quantizing the floating-point weights and activations of deep convolutional neural networks to fixed-point representation yields reduced memory footprints and inference time. Recently, efforts have been afoot towards zero-shot quantization that does not require original unlabelled training samples of a given task. These best-published works heavily rely on the learned batch normalization (BN) parameters to infer the range of the activations for quantization. In particular, these methods are built upon either empirical estimation framework or the data distillation approach, for computing the range of the activations. However, the performance of such schemes severely degrades when presented with a network that does not accommodate BN layers. In this line of thought, we propose a generalized zero-shot quantization (GZSQ) framework that neither requires original data nor relies on BN layer statistics. We have utilized the data distillation approach and leveraged only the pre-trained weights of the model to estimate enriched data for range calibration of the activations. To the best of our knowledge, this is the first work that utilizes the distribution of the pretrained weights to assist the process of zero-shot quantization. The proposed scheme has significantly outperformed the existing zero-shot works, e.g., an improvement of ~ 33% in classification accuracy for MobileNetV2 and several other models that are w & w/o BN layers, for a variety of tasks. We have also demonstrated the efficacy of the proposed work across multiple open-source quantization frameworks. Importantly, our work is the first attempt towards the post-training zero-shot quantization of futuristic unnormalized deep neural networks., Comment: Accepted by IEEE Transactions on Multimedia

Published
2021
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4. Stress Perfusion Cardiac Magnetic Resonance vs SPECT Imaging for Detection of Coronary Artery Disease

Author

Arai, Andrew E., Schulz-Menger, Jeanette, Shah, Dipan J., Han, Yuchi, Bandettini, W. Patricia, Abraham, Arun, Woodard, Pamela K., Selvanayagam, Joseph B., Hamilton-Craig, Christian, Tan, Ru-San, Carr, James, Teo, Lynette, Kramer, Christopher M., Wintersperger, Bernd J., Harisinghani, Mukesh G., Flamm, Scott D., Friedrich, Matthias G., Klem, Igor, Raman, Subha V., Haverstock, Daniel, Liu, Zheyu, Brueggenwerth, Guenther, Santiuste, Marta, Berman, Daniel S., and Pennell, Dudley J.

Published
2023
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6. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Author

Crivelli, Adriana N., Muñiz, Hector Solar, Chapman, Brooke R., Jones, Lynn, O'Callaghan, Margie, Osland, Emma, Hodgson, Ruth, Wallin, Siobhan, Lasenby, Kay, Van Gossum, Andre, Won Lee, Andre Dong, Doitchinova-Simeonova, Maryana, Krznaric, Zeljko, Rasmussen, Henrik Højgaard, Brandt, Chrisoffer, Jeppesen, Palle B., Chambrier, Cecile, Joly, Francisca, Boehm, Vanessa, Bataille, Julie, Billiauws, Lore, Poullenot, Florian, Schneider, Stéphane M., Seguy, David, Thibault, Ronan, Arends, Jann, Czako, Laszlo, Molnar, Tomas, Zsilak-Urban, Mihaly, Izbéki, Ferenc, Sahin, Peter, Udvarhelyi, Gábor, Schafer, Eszter, Theilla, Miriam, Sasdelli, Anna Simona, Brillanti, Giorgia, Nardi, Elena, Pironi, Loris, Aimasso, Umberto, Dario, Merlo F., Bertasi, Valentino, Masconale, Luisa, Guglielmi, Francesco W., Regano, Nunzia, Orlandoni, Paolo, Lidia, Santarpia, Alfonsi, Lucia, Spaggiari, Corrado, Taus, Marina, Busni, Debora, Kekstas, Gintautas, Serralde-Zúñiga, Aurora E., Gillanders, Lyn, Kunecki, Marek, Matras, Przemysław, Matysiak, Konrad, Szczepanek, Kinga, Zmarzly, Anna, Kozjek, Nada Rotovnik, Bueno, Marta, Cuerda, Cristina, Garde, Carmen, Virgili, Nuria M., Olveira, Gabriel, Jáuregui, M<ce:sup loc='post">a</ce:sup> Estrella Petrina, Sanz-Paris, Alejandro, Suárez-Llanos, José P., Murillo, Ana Zugasti, Ellegard, Lars, Serlie, Mireille, Jonker, Cora, Wanten, Geert, Cooper, Sheldon C., Daniels, Joanne, Di Caro, Simona, Keane, Niamh, Patel, Pinal, Forbes, Alastair, Nelson Hughes, Sarah-Jane, Jukes, Amelia, Lloyd, Rachel, Lal, Simon, Abraham, Arun, Garside, Gerda, Taylor, Michael, Wu, Jian, Smith, Trevor, Pither, Charlotte, Stroud, Michael, Wyer, Nicola, Parmar, Reena, Burch, Nicola, Zeraschi, Sarah, Compher, Charlene, Mundi, Manpreet, Jezerski, Denise, Steiger, Ezra, Sasdelli, Anna S., Mundi, Manpreet S., Rasmussen, Henrik H., Crivelli, Adriana, Santarpia, Lidia, Van Gossum, Andrè, Chapman, Brooke, Won Lee, Andre D., Díez, Marta Bueno, Jáuregui, Mª Estrella Petrina, and Youssef, Nader N.

Published
2021
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10. Outcomes for central venous catheter repair in patients receiving long‐term home parenteral support: A descriptive cohort study.

Author

Bond, Ashley, Hall, Kirsty, Taylor, Michael, Duxbury, Andrea, Cawley, Cathy, Abraham, Arun, Teubner, Antje, and Lal, Simon

Subjects
PERIPHERALLY inserted central catheters, CENTRAL venous catheters, CATHETER-related infections, COHORT analysis
Abstract

Background: Central venous catheter (CVC) complications are frequently reported in patients receiving home parenteral support (HPS). Compromised CVC integrity or breakage is one such issue. Repairing such breakages can potentially avoid costly and risky catheter replacements. Methods: We completed a retrospective descriptive cohort study using a prospectively maintained data set, in a national UK intestinal failure reference center. Repair success, CVC longevity, and catheter‐related bloodstream infection (CRBSI) rates after repair were the primary outcome measures. Results: A total of 763 patients received HPS. There were 137 CVC repairs: 115 (84%) tunneled CVCs and 22 peripherally inserted central catheters (PICCs) attempted in 72 patients. Of the 137 attempts at CVC repair, 120 (88%) were deemed to be successful, allowing a median duration of subsequent CVC use of 336 days following repair (range 3–1696 days), which equates to 99,602 catheter days of HPS infusion. Three patients had a CRBSI within 90 days of repair, and patients required admission to the hospital for refeeding on 14 occasions following repair, such that hospitalization was avoided in 103/120 (86%) occasions following successful CVC repair. There was no increase in the recorded rate of CRBSIs in patients undergoing CVC repair compared with the CRBSI rates of all HPS‐dependent patients under our care during the study period (0.03 vs 0.344/1000 catheter days, respectively). Conclusion: This is the largest single‐center experience to demonstrate that CVCs, including PICCs, used for the administration of HPS can be safely repaired, prolonging CVC longevity without leading to an increased risk of CRBSI. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Home Parenteral Nutrition in Patients with Advanced Cancer: Quality Outcomes from a Centralized Model of Care Delivery

Author

Kopczynska, Maja, primary, Teubner, Antje, additional, Abraham, Arun, additional, Taylor, Michael, additional, Bond, Ashley, additional, Clamp, Andrew, additional, Wight, Rebecca, additional, Salih, Zena, additional, Hasan, Jurjees, additional, Mitchell, Claire, additional, Jayson, Gordon C., additional, and Lal, Simon, additional

Published
2022
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24. Hepatic fat as a novel marker for high-risk coronary atherosclerosis in familial hypercholesterolaemia: a CT-based study

Author

Huangfu, Gavin, primary, Jaltotage, Biyanka, additional, Pang, Jing, additional, Lan, Nick, additional, Abraham, Arun, additional, Otto, Jacobus, additional, Ihdayhid, Abdul, additional, Rankin, Jamie, additional, Chow, Benjamin, additional, Watts, Gerald, additional, Dwivedi, Girish, additional, and Ayonrinde, Oyekoya, additional

Published
2022
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28. A Case Study on Risk of Musculoskeletal Disorder Due to Poor Ergonomics in First Time Lactating Mother with Recurrent Myofascial Trigger

Author

George, Susan Annie, Abraham, Arun Thomas, and Kumar, Ajay

Subjects
Musculoskeletal Disorder, Breast Feeding Mother, Ergonomics, Myofascial Trigger, Post-Partum Depression
Abstract

Purpose: A case study was done to analyze the risk of musculoskeletal disorder due to poor ergonomics and to evaluate the post-partum depression in first-time lactating mothers with recurrent Myofascial triggers. Design/Methodology/Approach: The researchers used a descriptive research methodology to assess and analyze all the activities which could help to meet the objectives of the study. The positions of lactating mothers are explained accurately and factually based on observation, personal interviews, and analyzed postpartum depression using Edinburg Postnatal Depression Scale (EPDS). Thus, this design may help to open a few facts about the breastfeeding positions of first-time moms, which is still having a scarcity of literature. Data collected from the study are noted, explained, and analyzed for comparison and further studies. The respondents of the study were the patients/mother who came to health care services due to physical and mental issues after eight weeks of delivery. Finding/Result: This case study has shown that new moms who are breastfeeding their babies are more prone to the risks of musculoskeletal disorders due to their poor ergonomics. It is also clear that post-partum depression is common in new mothers. From secondary data, there is an association between poor ergonomics and recurrent Myofascial triggers. So, it is important to give proper guidance in good ergonomics for newly lactating mothers during an antenatal and post-natal period to avoid the risk of musculoskeletal disorders. Originality/Value: An ergonomic dimension of this study. Paper Type: Case Study Research

Published
2022
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33. Long‐term survival following fungal catheter‐related bloodstream infection for patients with intestinal failure receiving home parenteral support.

Author

Bond, Ashley, Kopczynska, Maja, Conley, Thomas, Teubner, Antje, Taylor, Michael, Abraham, Arun, Pironi, Loris, and Lal, Simon

Subjects
PARENTERAL therapy, FUNGEMIA, BLOOD diseases, INTESTINAL diseases, TREATMENT effectiveness
Abstract

Background: A fungal‐related catheter‐related bloodstream infection (CRBSI) is less frequent than those induced by bacteria. In the past, a single episode of fungal CRBSI has been used as a marker of home parenteral nutrition (HPN) failure and thus a possible indication for intestinal transplantation. Methods: Survival outcomes were assessed from a prospectively maintained database of patients initiated on HPN for underlying chronic intestinal failure between 1993 and 2018, with a censoring date of December 31, 2020. Cox regression was performed to assess predictors of mortality with univariable and multivariable analysis. Results: A total of 1008 patients were included in the study, with a total of 1 364 595 catheter days. There were 513 CRBSI events recorded in 262 patients, equating to a CRBSI rate of 0.38/1000 catheter days. A total of 38/262 (14.5%) patients had at least one episode of fungal CRBSI, whereas 216/262 (82.4%) had at least one bacterial but no fungal CRBSI. The median time between HPN initiation and the first CRBSI episode was 20.6 months (95% confidence interval, 16.5–24.1). Episodes of fungal or bacterial CRBSI and the number of CRBSI episodes were not associated with increased mortality. Overall, 15 CRBSI‐related deaths were observed in the observation period (0.01 CRBSI deaths/1000 catheter days), two of these were fungal in origin. Conclusion: The occurrence of a fungal CRBSI does not increase the risk of death compared with patients who have bacterial CRBSI or those without a CRBSI event. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Characteristics of adult patients with chronic intestinal failure due to short bowel syndrome: An international multicenter survey

Author

Pironi, Loris, primary, Steiger, Ezra, additional, Joly, Francisca, additional, Jeppesen, Palle B., additional, Wanten, Geert, additional, Sasdelli, Anna S., additional, Chambrier, Cecile, additional, Aimasso, Umberto, additional, Mundi, Manpreet S., additional, Szczepanek, Kinga, additional, Jukes, Amelia, additional, Theilla, Miriam, additional, Kunecki, Marek, additional, Daniels, Joanne, additional, Serlie, Mireille, additional, Poullenot, Florian, additional, Cooper, Sheldon C., additional, Rasmussen, Henrik H., additional, Compher, Charlene, additional, Seguy, David, additional, Crivelli, Adriana, additional, Santarpia, Lidia, additional, Guglielmi, Francesco W., additional, Kozjek, Nada Rotovnik, additional, Schneider, Stéphane M., additional, Ellegard, Lars, additional, Thibault, Ronan, additional, Matras, Przemysław, additional, Matysiak, Konrad, additional, Van Gossum, Andrè, additional, Forbes, Alastair, additional, Wyer, Nicola, additional, Taus, Marina, additional, Virgili, Nuria M., additional, O'Callaghan, Margie, additional, Chapman, Brooke, additional, Osland, Emma, additional, Cuerda, Cristina, additional, Udvarhelyi, Gábor, additional, Jones, Lynn, additional, Won Lee, Andre D., additional, Masconale, Luisa, additional, Orlandoni, Paolo, additional, Spaggiari, Corrado, additional, Díez, Marta Bueno, additional, Doitchinova-Simeonova, Maryana, additional, Serralde-Zúñiga, Aurora E., additional, Olveira, Gabriel, additional, Krznaric, Zeljko, additional, Czako, Laszlo, additional, Kekstas, Gintautas, additional, Sanz-Paris, Alejandro, additional, Jáuregui, Mª Estrella Petrina, additional, Murillo, Ana Zugasti, additional, Schafer, Eszter, additional, Arends, Jann, additional, Suárez-Llanos, José P., additional, Youssef, Nader N., additional, Brillanti, Giorgia, additional, Nardi, Elena, additional, Lal, Simon, additional, Crivelli, Adriana N., additional, Muñiz, Hector Solar, additional, Chapman, Brooke R., additional, Hodgson, Ruth, additional, Wallin, Siobhan, additional, Lasenby, Kay, additional, Van Gossum, Andre, additional, Won Lee, Andre Dong, additional, Rasmussen, Henrik Højgaard, additional, Brandt, Chrisoffer, additional, Boehm, Vanessa, additional, Bataille, Julie, additional, Billiauws, Lore, additional, Molnar, Tomas, additional, Zsilak-Urban, Mihaly, additional, Izbéki, Ferenc, additional, Sahin, Peter, additional, Sasdelli, Anna Simona, additional, Pironi, Loris, additional, Dario, Merlo F., additional, Bertasi, Valentino, additional, Regano, Nunzia, additional, Lidia, Santarpia, additional, Alfonsi, Lucia, additional, Busni, Debora, additional, Gillanders, Lyn, additional, Zmarzly, Anna, additional, Bueno, Marta, additional, Garde, Carmen, additional, Jáuregui, Ma Estrella Petrina, additional, Jonker, Cora, additional, Di Caro, Simona, additional, Keane, Niamh, additional, Patel, Pinal, additional, Nelson Hughes, Sarah-Jane, additional, Lloyd, Rachel, additional, Abraham, Arun, additional, Garside, Gerda, additional, Taylor, Michael, additional, Wu, Jian, additional, Smith, Trevor, additional, Pither, Charlotte, additional, Stroud, Michael, additional, Parmar, Reena, additional, Burch, Nicola, additional, Zeraschi, Sarah, additional, Mundi, Manpreet, additional, and Jezerski, Denise, additional

Published
2021
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45. Gadobutrol-Enhanced Cardiac Magnetic Resonance Imaging for Detection of Coronary Artery Disease

Author

Arai, Andrew E., primary, Schulz-Menger, Jeanette, additional, Berman, Daniel, additional, Mahrholdt, Heiko, additional, Han, Yuchi, additional, Bandettini, W. Patricia, additional, Gutberlet, Matthias, additional, Abraham, Arun, additional, Woodard, Pamela K., additional, Selvanayagam, Joseph B., additional, McCann, Gerry P., additional, Hamilton-Craig, Christian, additional, Schoepf, U. Joseph, additional, San Tan, Ru, additional, Kramer, Christopher M., additional, Friedrich, Matthias G., additional, Haverstock, Daniel, additional, Liu, Zheyu, additional, Brueggenwerth, Guenther, additional, Bacher-Stier, Claudia, additional, Santiuste, Marta, additional, Pennell, Dudley J., additional, Pennell, Dudley, additional, Kramer, Ulrich, additional, von der Recke, Giso, additional, Nassenstein, Kai, additional, Tillmanns, Christoph, additional, Taupitz, Matthias, additional, Pache, Gregor, additional, Mohrs, Oliver, additional, Lotz, Joachim, additional, Ko, Sung-Min, additional, Choo, Ki Seok, additional, Sung, Yon Mi, additional, Kang, Joon-Won, additional, Muzzarelli, Stefano, additional, Valeti, Uma, additional, McCann, Gerry, additional, Binukrishnam, Sukumaran, additional, Croisille, Pierre, additional, Jacquier, Alexis, additional, Cowan, Brett, additional, Arai, Andrew, additional, Shah, Dipan, additional, Woodard, Pamela, additional, Avery, Ryan, additional, Schoepf, Joseph, additional, Carr, James, additional, Kramer, Christopher, additional, Flamm, Scott, additional, Harsinghani, Mukesh, additional, Lerakis, Stamitios, additional, Kim, Raymond, additional, Raman, Subha, additional, Marcotte, Francois, additional, Islam, Ali, additional, Friedrich, Matthias, additional, Selvanayagam, Joseph, additional, Chong, Woon Kit, additional, and San Lynette Teo, Li, additional

Published
2020
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47. Catheter‐related infection rates in patients receiving customized home parenteral nutrition compared with multichamber bags.

Author

Crooks, Benjamin, Harrison, Simon, Millward, Graham, Hall, Kirsty, Taylor, Michael, Farrer, Kirstine, Abraham, Arun, Teubner, Antje, and Lal, Simon

Subjects
CATHETER-related infections, PARENTERAL feeding, HOSPITAL patients, CATHETERS, INTESTINAL disease treatment, PARENTERAL feeding equipment, CHRONIC disease treatment, HOSPITALS, CONFIDENCE intervals, HOME care services, NUTRITION, DISEASE incidence, TREATMENT duration, RISK assessment, COMPARATIVE studies, DESCRIPTIVE statistics, ODDS ratio, BLOODBORNE infections, CENTRAL venous catheters, DISEASE risk factors
Abstract

Background: The risk of bloodstream infections may be increased in hospitalized patients receiving ready‐made parenteral nutrition (PN) multichamber bags (MCBs) compared with customized PN; however, as highlighted in recent international guidelines, there are no comparable data relating to home PN (HPN). Methods: Data from a prospectively maintained database were analyzed to compare incidence rates of catheter‐related bloodstream infections (CRBSIs) between patients receiving customized HPN compared with MCB HPN at a national UK referral center between May 2018 and August 2020. Results: Sixty patients with chronic intestinal failure were commenced on MCBs and 45 received customized HPN for a total of 5914 and 7641 catheter days, respectively. No difference in CRBSI incidence was found (0.51/1000 catheter days for MCBs, 0.39/1000 catheter days for customized HPN; incidence rate ratio, 1.29; 95% CI, 0.26–6.37). Eighteen patients were switched from customized HPN to MCB HPN. The study period covered 7401 catheter days receiving customized HPN and 4834 days on MCBs. No significant change was noted in the CRBSI rates following this switch (0.27/1000 catheter days receiving customized HPN vs 0.21/1000 catheter days on MCBs; incidence rate ratio, 1.31; 95% CI, 0.12–14.3). Conclusion: The use of MCBs for HPN patients is not associated with an increased risk of CRBSI. This study will inform international guidelines and provide reassurance for the continued, safe use of MCB HPN. [ABSTRACT FROM AUTHOR]

Published
2022
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48. Factors affecting antidepressant use by patients requiring home parenteral nutrition.

Author

Cloutier, Anabelle, Deutsch, Liat, Miller, Bethany, Leahy, Gavin, Ablett, Joanne, Healey, Andrew, Twist, Katherine, Teubner, Antje, Abraham, Arun, Taylor, Michael, Pironi, Loris, and Lal, Simon

Subjects
PARENTERAL feeding, PSYCHOLOGICAL distress, ANTIDEPRESSANTS, ACQUISITION of data, INTESTINAL disease treatment, HOME care services, NUTRITION, CHRONIC diseases, COMPARATIVE studies, DISEASE prevalence, DESCRIPTIVE statistics, LONGITUDINAL method
Abstract

Background: Home parenteral nutrition (HPN) is a life‐saving therapy for patients with chronic intestinal failure but can be associated with a degree of psychological distress. The factors associated with the need for antidepressants (ADs) in this cohort have not yet been described. Methods: The study involved prospective data collection from patients attending an HPN clinic at a national intestinal failure referral center. Patients requiring HPN as a result of active malignancy were excluded. Patients were divided in 2 groups according to AD usage; demographic, anthropometric, socioeconomic characteristics, and intravenous supplementation (IVS) regimens were compared between groups. Results: A total of 184 patients were recruited between July 2018 and April 2019, with an overall prevalence of AD use of 41.7% (70/168 patients). Daily mean IVS volume was significantly higher among patients taking AD ("AD" group; 2125.48 ± 991.8 ml/day, "no‐AD" group; 1828.54 ± 847.0 ml/day, P =.039), with the proportion of patients needing high‐volume IVS (≥3000 ml/day) being 3 times higher in the AD group (20.0%(14/70 patients) vs 6.1% (6/98 patients), P =.006). The average energy IVS infusion per day was similar between the groups. Conclusion: This is the first study to demonstrate that AD use correlates with higher IVS volume rather than energy requirements in HPN patients, suggesting that high IVS volume requirements may be better associated with the patient's disease burden. Early and tailored mental health intervention may be beneficial in those with high IVS volume requirements. [ABSTRACT FROM AUTHOR]

Published
2022
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