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12 results on '"Abplanalp, Wesley Tyler"'

1. DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

Author

Shumliakivska, Mariana, Luxán, Guillermo, Hemmerling, Inga, Scheller, Marina, Li, Xue, Müller-Tidow, Carsten, Schuhmacher, Bianca, Sun, Zhengwu, Dendorfer, Andreas, Debes, Alisa, Glaser, Simone-Franziska, Muhly-Reinholz, Marion, Kirschbaum, Klara, Hoffmann, Jedrzej, Nagel, Eike, Puntmann, Valentina O., Cremer, Sebastian, Leuschner, Florian, Abplanalp, Wesley Tyler, John, David, Zeiher, Andreas M., and Dimmeler, Stefanie

Published
2024
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2. A human cell atlas of the pressure-induced hypertrophic heart

Author

Nicin, Luka, Schroeter, Sam Michael, Glaser, Simone Franziska, Schulze-Brüning, Ralf, Pham, Minh-Duc, Hille, Susanne S., Yekelchyk, Michail, Kattih, Badder, Abplanalp, Wesley Tyler, Tombor, Lukas, Müller, Oliver J., Braun, Thomas, Meder, Benjamin, Reich, Christoph, Arsalan, Mani, Holubec, Tomas, Walther, Thomas, Emrich, Fabian, Krishnan, Jaya, Zeiher, Andreas M., John, David, and Dimmeler, Stefanie

Published
2022
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4. DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

Author

Shumliakivska, Mariana, primary, Luxán, Guillermo, additional, Hemmerling, Inga, additional, Abplanalp, Wesley Tyler, additional, Li, Xue, additional, Scheller, Marina, additional, Müller-Tidow, Carsten, additional, Leuschner, Florian, additional, Schuhmacher, Bianca, additional, Debes, Alisa, additional, Glaser, Simone-Franziska, additional, Reinholz, Marion Muhly, additional, Kirschbaum, Klara, additional, Hoffmann, Jedrzej, additional, Nagel, Eike, additional, Puntmann, Valentina O., additional, John, David, additional, Cremer, Sebastian, additional, Zeiher, Andreas M., additional, and Dimmeler, Stefanie, additional

Published
2023
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8. Efficiency and Target Derepression of Anti-miR-92a: Results of a First in Human Study

Author

Abplanalp, Wesley Tyler, primary, Fischer, Ariane, additional, John, David, additional, Zeiher, Andreas M., additional, Gosgnach, Willy, additional, Darville, Helene, additional, Montgomery, Rusty, additional, Pestano, Linda, additional, Allée, Guillaume, additional, Paty, Isabelle, additional, Fougerousse, Francoise, additional, and Dimmeler, Stefanie, additional

Published
2020
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10. Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

Author

Hoffmann, Jedrzej, primary, Luxán, Guillermo, additional, Abplanalp, Wesley Tyler, additional, Glaser, Simone-Franziska, additional, Rasper, Tina, additional, Fischer, Ariane, additional, Muhly-Reinholz, Marion, additional, John, David, additional, Assmus, Birgit, additional, Zeiher, Andreas Michael, additional, and Dimmeler, Stefanie, additional

Published
2020
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11. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts

Author

Nicin, Luka, primary, Abplanalp, Wesley Tyler, additional, Mellentin, Hannah, additional, Kattih, Badder, additional, Tombor, Lukas, additional, John, David, additional, Schmitto, Jan D, additional, Heineke, Jörg, additional, Emrich, Fabian, additional, Arsalan, Mani, additional, Holubec, Tomas, additional, Walther, Thomas, additional, Zeiher, Andreas M, additional, and Dimmeler, Stefanie, additional

Published
2020
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12. Cardiovascular and hematopoietic responses to volatile benzene exposure.

Author

Abplanalp, Wesley Tyler

Subjects
benzene, air pollution, insulin resistance, oxidative stress, stem cells, inflammation, Cellular and Molecular Physiology
Abstract

The rapid and recent increase in the global epidemic of diabetes and cardiovascular disease suggests a strong component of the environment is contributing. Benzene is a ubiquitous volatile pollutant generated by cigarette smoke, automobile exhaust, wildfires and industrial activities. Consequently, it is found in almost all urban and rural air samples. Benzene is known to cause hematotoxicity and its metabolism generates oxidative stress. Although, benzene has been studied for many years, few investigations have probed what influence benzene exposure may have on other physiological processes. Here we hypothesize that benzene metabolism by hepatic-CYP450 2E1 generates oxidative stress and inflammation, which then promote insulin resistance and endothelial dysfunction. To test this hypothesis, we measured hematological progenitor differentiation and circulating blood cell types as well as indices of oxidative stress, vascular damage, insulin resistance and stem cell function to assess relative sensitivity of hematological and vascular biomarkers. Our findings show that benzene-exposed mice exhibit oxidative stress, inflammation, vascular damage, insulin resistance, thrombosis with diminished vascular repair capacity at levels similar to hematological changes typically found in acute studies assaying for the lowest observed adverse effect level. These data suggest that individuals exposed to this ubiquitous air pollutant are likely to experience inflammation and vascular complications.

Published
2016

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