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The identification of haplotypes influencing traits of agronomic interest, with well-defined effects across environments, is of key importance to develop varieties adapted to their context of use. It requires advanced crossing schemes, multi-environment characterization and relevant statistical tools. Here we present a sorghum multi-reference back-cross nested association mapping (BCNAM) population composed of 3901 lines produced by crossing 24 diverse parents to three elite parents from West and Central Africa (WCA-BCNAM). The population was characterized in environments contrasting for photoperiod, rainfall, temperature, and soil fertility. To analyse this multi-parental and multi-environment design, we developed a new methodology for QTL detection and parental effect estimation. In addition, envirotyping data were mobilized to determine the influence of specific environmental covariables on the genetic effects, which allowed spatial projections of the QTL effects. We mobilized this strategy to analyse the genetic architecture of flowering time and plant height, which represent key adaptation mechanisms in environments like West Africa. Our results allowed a better characterisation of well-known genomic regions influencing flowering time concerning their response to photoperiod with Ma6 and Ma1 being photoperiod sensitive and candidate gene Elf3 being insensitive. We also accessed a better understanding of plant height genetic determinism with the combined effects of phenology dependent (Ma6) and independent (qHT7.1 and Dw3) genomic regions. Therefore, we argue that the WCA-BCNAM constitutes a key genetic resource to feed breeding programs in relevant elite parental lines and develop climate-smart varieties.

L’étude porte sur la propagation du Lyssavirus chez les petits mammifères dans la Préfecture de Kindia (Basse Guinée) a été réalisée entre avril 2015 et mars 2016 dans les différents biotopes (Maisons habitées, Forêts-Buissons, Champs agricoles, Entrepôts et Berges) et qui a pour objectif: Contribuée à l’amélioration de l’état de santé de la population. Pendant cette période d’étude, 412 rongeurs repartis en 12 espèces ont été capturées à savoir le rat d’herbe-Arvicanthis rufinus, les rats-Cricetomys gambianus, les rats-Crocidurinae spp., les souris rayées-Lemniscomys striatus, Lophuromys ansorgei, Lophuromys sikapusi, le rat à mamelles multiples-Mastomys spp., souris de maison-Mus musculus, Pelomys fallax, le rat de forêt-Praomys rostratus, le rat noir-Rattus rattus et le Malacomys edyardsi spp. Les plus répandus sont les Mastomys, Rattus rattus, Mus musculus et Cricetomys gambianus. En saison sèche, le nombre de rongeurs capturés dans la préfecture de Kindia a atteint 292 (71%) contre 120 (29%) rongeurs en saison pluvieuse. Pour des fins de recherches virologiques, le cerveau de 221 rongeurs a été prélevé et analysé parmi eux, 18 (8%) ont été trouvé porteurs de l’ARN de Lyssavirus. English title: Spread of Lyssavirus among small mammals (Muridae and Soricidae) in Kindia prefecture, Republic of Guinea (Lower Guinea) The study focuses on the spread of Lyssavirus among small mammals in the Prefecture of Kindia (Lower Guinea) was carried out between April 2015 and March 2016 in the different biotopes (inhabited houses, Forests-Bushes, Agricultural fields, Warehouses and Banks) and which has for objective: Contributed to the improvement of the state of health of the population. During this period, 412 rodents were caught in 12 species including the grass rat-Arvicanthis rufinus, the Cricetomys gambianus-rats, the Crocidurinae spp rats, striped mice Lemniscomys striatus, Lophuromys ansorgei, Lophuromys sikapusi, the multiple-teat rat-Mastomys spp., house mouse-Mus musculus, Pelomys fallax, forest rat-Praomys rostratus, black rat-Rattus rattus, and Malacomys edwardsi spp. The most common are: Mastomys spp., Rattus rattus, Mus musculus and Cricetomys gambianus. In the dry season, the number of rodents caught in the prefecture of Kindia reached 292 (71%) against 120 (29%) rodents caught during the rainy season. For virological research purposes, the brain of 221 rodents was collected and analyzed among them 18 rodents (8%) were found to carry Lyssavirus RNA.

Introduction: Acute generalized peritonitis is a life-threatening emergency. It is most often secondary to a perforation of the digestive organ and or to the spread of an intra-abdominal septic area. Methodology: We carried out a descriptive retrospective study lasting from January 1, 2018 to December 31, 2018 on the contribution of imaging in the management of acute generalized peritonitis general surgery department of the hospital Chinese-Guinean. Were included in our study, all records of patients with acute generalized peritonitis will be confirmed by imaging. We carried out an exhaustive recruitment of all complete files. Our variables were analyzed using the Epi-info 7.2 software. Result:Out of 578 hospitalized patients, peritonitis represented 8.8% of cases. We noted a male predominance with 60.8% and a Sex-ratio: M / F = 1.6 whose mean age was 41.9 ± 13.5 years; extremes ranging from 17 and 67 years with a modal class ≥ 30 years or 88.3%. Housewives were the most collected with 25.5% Abdominal pain was the main reason for consultation, i.e., 90.2%, the physical sign was dominated by a convex and sensitive Douglas-fir, i.e., 27.5%. The clinical diagnosis was supported by abdomen without preparation and abdominal ultrasound; performed in 84.3% and 15.7% of patients, respectively. We noted a morbidity rate of 15.7% dominated by septic shock (15.7%). Conclusion: Our study made it possible to determine the contribution of imaging in the management. In addition, in our study, the abdomen without preparation and the abdomino-pelvic ultrasound were revealed as a key link in the management of acute generalized peritonitis.

Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer (PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists.

Soil fertility is inherently low in sub Saharan Africa. The objective of this study was therefore to determine millet yield for two varieties in each zone using organic and inorganic fertiliser in two agro-ecological zones in Mali. A two-year experiment was conducted at Agricultural Research Station of Sotuba and Cinzana in 2013 and 2014. A combination of two pearl millet varieties and four fertilizer treatments were used. The fertilizers treatments used were: T1 Control (no application); T2 MANURE of 23:10:17 (5000 kg/ha); T3 NPK of 15: 15: 15 (50 kg/ha) and T4 combination of NPK + MANURE. The experiments were conducted in a randomised complete block design (RCBD) with four replications in a plot size of 10 m x 4.2 m. The varieties evaluated at Sotuba station were Sanioni, an improved local variety and Cho, a local variety while at Cinzana station Sosat, an improved variety form IER /ICRISAT and IBV8001, and an improved variety from ICRISAT were used. At Sotuba high grain with NPK+MANURE (1948 kg ha -1 ) followed by NPK (1281 kg ha -1 ), MANURE (1130 kg ha -1 )and the Control (813 kg ha -1 ). In 2014, the grain yield NPK+MANURE) was 1602 kg ha -1 , followed by NPK (1502 kg ha -1 ), MANURE (1466 kg ha -1 ) and the control (1440 kg ha -1 ). The grain yield gap for the Control treatment in 2013 (813 kg ha - 1) and in 2014 (1440 kg ha 1 ) was high compared to the NPK+MANURE, MANURE and NPK treatment grain yield gap for the same years. In Cinzana In 2013, higher grain yield with the treatments of NPK+MANURE, (1440 kgha -1 )> NPK (1429 kg ha -1 )> MANURE (1416 kg ha -1 )>Control (1276 kg ha -1 ) were observed . In 2014, the highest grain yield with NPK+MANURE (1915 kg ha -1 ) followed by NPK (1561 kg ha -1 ), MANURE (1523 kg ha -1 1 ) and Control (1121 kg ha -1 ). The grain yield gap for the combined NPK+MANURE treatment in 2103 (1440 kg ha - 1) and in 2014 (1915 kg ha 1 ) was high compared to the others for the fertilizer grain yield gap for both years.

Agriculture in Mali is vulnerable to climate change. Rainfall remains uncertain for the future, while the increase in temperature is almost a certainty. The objective of this present study was to assess the performance of DSSAT model in simulating the yield of two millet varieties in two agro-ecological zones of Mali under different scenarios of climate change.The performance of two millet varieties in two agro-ecological zones of Mali was assessed using Decision Support System for Agro-Technology Transfer (DSSAT) model under different climate scenarios. Two year experiments were therefore conducted at The Agricultural Research Station of Sotuba located in Sudanian zone and Cinzana in Sahelian zone according to a randomised complete block design with 4 replications. The treatments included Control, Manure 23:10:17 (5000 kg/ha) NPK 15: 15: 15 (50 kg/ha) and NPK+Manure. DSSAT model was used to simulate crop grain yields under two different weather conditions (historical and future). Millet grain yields were higher under the simulations with historical weather data than the simulations with climate change scenarios. Simulation of climate change effects on millet grain yield showed that all scenarios underestimated crop yield compared to the baseline for all treatments and all varieties (CHO, Sanioni, Sosat and IBV8001) All of the varieties showed lowest grain yields under the four treatments for ACCESS1-0 (Hot-Wet) among the scenarios. Based on these findings, it is suggested that, policy should be developed to enhance farmers’ adaptation strategies in the Sudanian and Sahelian zones of Mali Keywords : Agriculture, Rainfall, Temperature, Treatments, Model, Simulation, Grain Yield.

Mucinous cystadenocarcinoma in men is very rare; we reported 1 case of mucinous cystadenocarcinoma in the pancreatic disease institute of Wuhan union hospital in China. The aim of the study was to focus our attention on the gender of this patient. The mucinous cystadenocarcinoma is a pathology frequently seen among women. The clinical presentation of this patient is a characteristic which deserves to be described.

Witchweed (Striga spp.) infestations are the greatest obstacle to sorghum [Sorghum bicolor (L.) Moench] grain production in many areas in Africa. The objective of this study was to evaluate the efficacy of herbicide seed treatments for controlling Striga infestation of sorghum. Seeds of an acetolactate synthase (ALS) herbicide–tolerant sorghum hybrid were treated with two ALS-inhibiting herbicides. Treatments included three rates of imazapyr (IMI), three rates of metsulfuron-methyl (MET), and an untreated control group. In greenhouse trials, observations at 32, 46, and 60 d after planting showed that seeds treated with the highest herbicide rates had the fewest Striga attachments and the greatest delay in attachment. All plants in the untreated group died at or before sorghum flowering; however, herbicide seed treatments, particularly metsulfuron, reduced Striga emergence and significantly increased sorghum grain yield and dry matter production. Field studies comparing seed treatments produced similar results with delayed Striga emergence and fewer emerged Striga plants in herbicide-treated plots. These studies indicate that herbicide seed treatments may provide a highly effective tool for managing Striga in sorghum

The aim of this study is to reveal the etiologic link that exists between pancreatic cancer and chronic pancreatitis through our unicentric experience. The clinical and cyto-pathological results of 300 patients were studied prospectively from January to December 2014 in the pancreatic center of Wuhan union hospital in china. Of the 300 pancreatic lesions patients, 196 were male and 104 female with a sex ratio of 1.8:1 (p=0.001). The factors assessed for the determination of etiologic link were the age, gender, the diameter of the lesion, the antecedents of disease (such as ulcer,cholecystectomy, smoking ,alcohol abuse ),the pancreatic lesion site, the diabetic link, the clinical presentations, the level of transaminases (GGT, ALP), peripheral blood analysis and cytopathological results of both PC and CP groups . According to the clinical data along with the respective results of the examinations, causal factors that link CP and PC are illustrated and it opens the pathway for further detailed studies as an investment for the future.