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9 results on '"Abotsi, Justice"'

1. Infection with Mansonella perstans nematodes in Buruli ulcer patients, Ghana

Author

Phillips, Richard O., Frimpong, Michael, Sarfo, Fred S., Kretschmer, Birte, Beissner, Marcus, Debrah, Alexander, Ampem- Amoako, Yaw, Abass, Kabiru M., Thompson, William, Duah, Mabel Sarpong, Abotsi, Justice, Adjei, Ohene, Fleischer, Bernhard, Bretzel, Gisela, Wansbrough-Jones, Mark, and Jacobsen, Marc

Subjects
Nematoda -- Influence, Buruli ulcer -- Complications and side effects, Roundworm infections -- Risk factors, Children -- Health aspects, Health
Abstract

Buruli ulcer, caused by Mycobacterium ulcerans, is a neglected tropical disease common in rural parts of West Africa. Infection with M. ulcerans causes disfiguring skin ulcers, mainly in children. The [...]

Published
2014
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2. Short Report: Buruli Ulcer Control in a Highly Endemic District in Ghana: Role of Community-Based Surveillance Volunteers

Author

Abass, Kabiru Mohammed, van der Werf, Tjip S., Phillips, Richard O., Sarfo, Fred S., Abotsi, Justice, Mireku, Samuel Osei, Thompson, William N., Asiedu, Kingsley, Stienstra, Ymkje, Klis, Sandor-Adrian, and Microbes in Health and Disease (MHD)

Subjects
BENIN, FUNCTIONAL LIMITATIONS
Abstract

Buruli ulcer (BU) is an infectious skin disease that occurs mainly in West and Central Africa. It can lead to severe disability and stigma because of scarring and contractures. Effective treatment with antibiotics is available, but patients often report to the hospital too late to prevent surgery and the disabling consequences of the disease. In a highly endemic district in Ghana, intensified public health efforts, mainly revolving around training and motivating community-based surveillance volunteers (CBSVs), were implemented. As a result, 70% of cases were reported in the earliest-World Health Organization category I-stage of the disease, potentially minimizing the need for surgery. CBSVs referred more cases in total and more cases in the early stages of the disease than any other source. CBSVs are an important resource in the early detection of BU.

Published
2015

3. Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial

Author

Phillips, Richard O, Robert, Jérôme, Abass, Kabiru Mohamed, Thompson, William, Sarfo, Fred Stephen, Wilson, Tuah, Sarpong, Godfred, Gateau, Thierry, Chauty, Annick, Omollo, Raymond, Ochieng Otieno, Michael, Egondi, Thaddaeus W, Ampadu, Edwin O, Agossadou, Didier, Marion, Estelle, Ganlonon, Line, Wansbrough-Jones, Mark, Grosset, Jacques, Macdonald, John M, Treadwell, Terry, Saunderson, Paul, Paintsil, Albert, Lehman, Linda, Frimpong, Michael, Sarpong, Nanaa Francisca, Saizonou, Raoul, Tiendrebeogo, Alexandre, Ohene, Sally-Ann, Stienstra, Ymkje, Asiedu, Kingsley B, van der Werf, Tjip S, Osei Mireku, Samuel, Abotsi, Justice, Adu Poku, Joseph Ken, Asamoah-Frimpong, Richard, Osei-Wusu, Bright, Sarpong, Edward, Konadu, Beatrice, Opoku, Ernest, Forson, Mark, Ndogyele, Mathias, Ofori, Elizabeth, Aboagye, Felicity, Berko, Thomas, Amofa, George, Nsiah, Anastasia, Mensah-Bonsu, Joyce, Ofori Nyarko, Joseph, Amoako, Yaw Ampem, Koranteng Tannor, Elliot, Boakye-Appiah, Justice, Dzibordzi Loglo, Aloysius, Sarpong-Duah, Mabel, Agbavor, Bernadette, Ardent, Marie Françoise, Yamadjako, Arnaud, Adanmado Gersande, Naomi, Adeye, Ambroise, Kindjinou, Martial, Akpolan, Kiki, Maxime, Sodjinou, Espoir, Guegnard, Clémence, Klis, Sandor-Adrian, Velding, Kristien, Omansen, Till, Ofori-Adjei, David, Eyangoh, Sarah, Knell, Alan, and Faber, William

Abstract

Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulceransinfection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia. Standard antimicrobial treatment with oral rifampicin 10 mg/kg plus intramuscular streptomycin 15 mg/kg once daily for 8 weeks (RS8) is highly effective, but streptomycin injections are painful and potentially harmful. We aimed to compare the efficacy and tolerability of fully oral rifampicin 10 mg/kg plus clarithromycin 15 mg/kg extended release once daily for 8 weeks (RC8) with that of RS8 for treatment of early Buruli ulcer lesions.

Published
2020
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5. A Severe Case of Buruli Ulcer Disease with Pleural Effusions

Author

Sarfo, Fred S., primary, Thompson, William, additional, Phillips, Richard O., additional, Paintsil, Albert, additional, Abass, Mohammed K., additional, Frimpong, Michael, additional, Abotsi, Justice, additional, Asiedu, Kingsley, additional, and Wansbrough-Jones, Mark H., additional

Published
2014
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6. Infection withMansonella perstansNematodes in Buruli Ulcer Patients, Ghana

Author

Phillips, Richard O., primary, Frimpong, Michael, additional, Sarfo, Fred S., additional, Kretschmer, Birte, additional, Beissner, Marcus, additional, Debrah, Alexander, additional, Ampem-Amoako, Yaw, additional, Abass, Kabiru M., additional, Thompson, William, additional, Duah, Mabel Sarpong, additional, Abotsi, Justice, additional, Adjei, Ohene, additional, Fleischer, Bernhard, additional, Bretzel, Gisela, additional, Wansbrough-Jones, Mark, additional, and Jacobsen, Marc, additional

Published
2014
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8. Clinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulcerans Disease

Author

Phillips, Richard O., primary, Sarfo, Fred S., additional, Abass, Mohammed K., additional, Abotsi, Justice, additional, Wilson, Tuah, additional, Forson, Mark, additional, Amoako, Yaw A., additional, Thompson, William, additional, Asiedu, Kingsley, additional, and Wansbrough-Jones, Mark, additional

Published
2014
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9. Clinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulceransDisease

Author

Phillips, Richard O., Sarfo, Fred S., Abass, Mohammed K., Abotsi, Justice, Wilson, Tuah, Forson, Mark, Amoako, Yaw A., Thompson, William, Asiedu, Kingsley, and Wansbrough-Jones, Mark

Abstract

ABSTRACTBuruli ulcer, an ulcerating skin disease caused by Mycobacterium ulceransinfection, is common in tropical areas of western Africa. We determined the clinical and microbiological responses to administration of rifampin and streptomycin for 2 weeks followed by administration of rifampin and clarithromycin for 6 weeks in 43 patients with small laboratory-confirmed Buruli lesions and monitored for recurrence-free healing. Bacterial load in tissue samples before and after treatment for 6 and 12 weeks was monitored by semiquantitative culture. The success rate was 93%, and there was no recurrence after a 12-month follow-up. Eight percent had a positive culture 4 weeks after antibiotic treatment, but their lesions went on to heal. The findings indicate that rifampin and clarithromycin can replace rifampin and streptomycin for the continuation phase after rifampin and streptomycin administration for 2 weeks without any apparent loss of efficacy.

Published
2013
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