46 results on '"Ablasser, Klemens"'
Search Results
2. Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy
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Zach, David K., Schwegel, Nora, Santner, Viktoria, Winkelbauer, Larissa, Hoeller, Viktoria, Kolesnik, Ewald, Gollmer, Johannes, Seggewiss, Hubert, Batzner, Angelika, Perl, Sabine, Wallner, Markus, Reiter, Ursula, Rainer, Peter P., Zirlik, Andreas, Ablasser, Klemens, and Verheyen, Nicolas
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- 2024
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3. Non-eligibility for pivotal HFpEF/HFmrEF outcome trials and mortality in a contemporary heart failure cohort
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Santner, Viktoria, Riepl, Hermann S., Posch, Florian, Wallner, Markus, Rainer, Peter P., Ablasser, Klemens, Kolesnik, Ewald, Hoeller, Viktoria, Zach, David, Schwegel, Nora, Kreuzer, Philipp, Lueger, Andreas, Petutschnigg, Johannes, Pieske, Burkert, Zirlik, Andreas, Edelmann, Frank, and Verheyen, Nicolas
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- 2023
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4. Phenotype clustering of hospitalized high-risk patients with COVID-19 — a machine learning approach within the multicentre, multinational PCHF-COVICAV registry
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Sokolski, Mateusz, primary, Trenson, Sander, additional, Reszka, Konrad, additional, Urban, Szymon, additional, Sokolska, Justyna M., additional, Biering-Sørensen, Tor, additional, Højbjerg Lassen, Mats C., additional, Skaarup, Kristoffer Grundtvig, additional, Basic, Carmen, additional, Mandalenakis, Zacharias, additional, Ablasser, Klemens, additional, Rainer, Peter P., additional, Wallner, Markus, additional, Rossi, Valentina A., additional, Lilliu, Marzia, additional, Loncar, Goran, additional, Cakmak, Huseyin A., additional, Ruschitzka, Frank, additional, and Flammer, Andreas J., additional
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- 2024
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5. Impact of SGLT2-Inhibitor Therapy on Survival in Patients with Transthyretin Amyloid Cardiomyopathy: Analysis of a Prospective Registry Study.
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Schwegel, Nora, Toferer, Christina, Zach, David K., Santner, Viktoria, Höller, Viktoria, Lugitsch, Jakob, Wallner, Markus, Gollmer, Johannes, Aziz, Faisal, von Lewinski, Dirk, Kolesnik, Ewald, Ablasser, Klemens, Zirlik, Andreas, Sourij, Harald, and Verheyen, Nicolas
- Subjects
HEART failure patients ,HYPERTROPHIC cardiomyopathy ,OVERALL survival ,RANDOMIZED controlled trials ,HEART failure - Abstract
Background: Patients with transthyretin amyloid cardiomyopathy (ATTR-CM) represent a high-risk heart failure population with continued unmet therapeutic needs. Sodium–glucose co-transporter 2 inhibitors (SGLT2i) improve cardiovascular outcomes in patients with heart failure across the whole spectrum of ejection fraction, and first evidence regarding their safety and effectiveness in patients with ATTR-CM is arising. This study investigates the association between SGLT2i therapy and clinical outcomes in these patients. Methods: This is an analysis of a prospective registry conducted at a referral centre for hypertrophic cardiomyopathies including 116 patients with confirmed ATTR-CM. Fifty-one patients (44%) were treated with SGLT2i while 65 patients (56%) remained SGLT2i-naïve. Results: During a median follow-up of 2.6 (1.7–3.7) years, 38 patients (33%) died, of whom 11 patients (9%) received SGLT2i treatment and 27 patients (23%) were treatment-naïve. SGLT2i therapy was significantly associated with lower mortality (HR 0.457, 95%CI 0.227–0.922, p = 0.029). This association persisted after adjusting for age and sex (HR 0.479, 95%CI 0.235–0.977, p = 0.043) and after additional adjustment for eGFR, NT-proBNP, LVEF, and concomitant therapy with tafamidis (HR 0.328, 95%CI 0.141–0.760, p = 0.009). However, when potential immortal time bias was considered, this association lost statistical significance (HR 1.075, 95%CI 0.524–2.206, p = 0.843). No significant associations between SGLT2i therapy and worsening heart-failure hospitalization or cardiovascular mortality were observed. Conclusions: In crude analysis, SGLT2i therapy associates with better survival in patients with ATTR-CM. However, after adjustment for immortal time, this association becomes statistically insignificant. Hence, to draw final conclusions on the effectiveness of SGLT2i therapy in these patients, a randomized controlled trial is warranted. [ABSTRACT FROM AUTHOR]
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- 2024
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6. The Prognostic Value of Right Ventricular Function in Patients with Chronic Heart Failure—A Prospective Study
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Schwegel, Nora, primary, Zach, David, additional, Peikert, Alexander, additional, Santner, Viktoria, additional, Höller, Viktoria, additional, Gollmer, Johannes, additional, Späth, Johannes, additional, Riepl, Hermann, additional, Rainer, Peter P., additional, Wallner, Markus, additional, Pilz, Stefan, additional, Zirlik, Andreas, additional, von Lewinski, Dirk, additional, Ablasser, Klemens, additional, Verheyen, Nicolas, additional, and Kolesnik, Ewald, additional
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- 2024
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7. Impact of the Timing of Mechanical Circulatory Support on the Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry
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Prunea, Dan M., primary, Bachl, Eva, additional, Herold, Lukas, additional, Kanoun Schnur, Sadeek S., additional, Pätzold, Sascha, additional, Altmanninger-Sock, Siegfried, additional, Sommer, Gudrun A., additional, Glantschnig, Theresa, additional, Kolesnik, Ewald, additional, Wallner, Markus, additional, Ablasser, Klemens, additional, Bugger, Heiko, additional, Buschmann, Eva, additional, Praschk, Andreas, additional, Fruhwald, Friedrich M., additional, Schmidt, Albrecht, additional, von Lewinski, Dirk, additional, and Toth, Gabor G., additional
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- 2024
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8. Impact of Mechanical Circulatory Support Timing on Outcomes in Myocardial Infarction-Related Cardiogenic Shock: Subanalysis of the PREPARE CS Registry
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Prunea, Dan Mihai, primary, Bachl, Eva, additional, Herold, Lukas, additional, Kanoun Schnur, Sadeek Sidney, additional, Pätzold, Sascha, additional, Altmanninger-Sock, Siegfried, additional, Sommer, Gudrun Angelika, additional, Glantschnig, Theresa, additional, Kolesnik, Ewald, additional, Wallner, Markus, additional, Ablasser, Klemens, additional, Bugger, Heiko, additional, Buschmann, Eva, additional, Praschk, Andreas, additional, Fruhwald, Friedrich M., additional, Schmidt, Albrecht, additional, Von Lewinski, Dirk, additional, and Toth-Gayor, Gabor, additional
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- 2024
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9. Low-grade systemic inflammation and left ventricular dysfunction in hypertensive compared to non-hypertensive hypertrophic cardiomyopathy
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Zach, David K., primary, Schwegel, Nora, additional, Santner, Viktoria, additional, Winkelbauer, Larissa, additional, Hoeller, Viktoria, additional, Kolesnik, Ewald, additional, Gollmer, Johannes, additional, Seggewiss, Hubert, additional, Batzner, Angelika, additional, Perl, Sabine, additional, Wallner, Markus, additional, Reiter, Ursula, additional, Rainer, Peter P., additional, Zirlik, Andreas, additional, Ablasser, Klemens, additional, and Verheyen, Nicolas, additional
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- 2023
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10. Diagnosis and treatment of cardiac amyloidosis: an interdisciplinary consensus statement
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Bonderman, Diana, Pölzl, Gerhard, Ablasser, Klemens, Agis, Hermine, Aschauer, Stefan, Auer-Grumbach, Michaela, Binder, Christina, Dörler, Jakob, Duca, Franz, Ebner, Christian, Hacker, Marcus, Kain, Renate, Kammerlander, Andreas, Koschutnik, Matthias, Kroiss, Alexander Stephan, Mayr, Agnes, Nitsche, Christian, Rainer, Peter P., Reiter-Malmqvist, Susanne, Schneider, Matthias, Schwarz, Roland, Verheyen, Nicolas, Weber, Thomas, Zaruba, Marc Michael, Badr Eslam, Roza, Hülsmann, Martin, and Mascherbauer, Julia
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- 2020
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11. Outcomes of ECLS-SHOCK Eligibility Criteria Applied to a Real-World Cohort
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von Lewinski, Dirk, primary, Herold, Lukas, additional, Bachl, Eva, additional, Bugger, Heiko, additional, Glantschnig, Theresa, additional, Kolesnik, Ewald, additional, Verheyen, Nicolas, additional, Benedikt, Martin, additional, Wallner, Markus, additional, von Lewinski, Friederike, additional, Schmidt, Albrecht, additional, Harb, Stefan, additional, Ablasser, Klemens, additional, Sacherer, Michael, additional, Scherr, Daniel, additional, Manninger-Wünscher, Martin, additional, Pätzold, Sascha, additional, Gollmer, Johannes, additional, Zirlik, Andreas, additional, and Toth, Gabor G., additional
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- 2023
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12. Myocardial GLP-1 Receptor Activation in the Presence of Glucose: Strong Partners
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Kolesnik, Ewald, Krainer, Thomas, Wallner, Markus, Djalinac, Natasa, Verheyen, Nicolas, Ablasser, Klemens, Eaton, Deborah M., Rainer, Peter P., Pelzmann, Brigitte, and von Lewinski, Dirk
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- 2019
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13. Transesophageal echocardiography‐guided versus fluoroscopy‐guided patent foramen ovale closure: A single center registry
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Achim, Alexandru, primary, Hochegger, Paul, additional, Kanoun Schnur, Sadeek S., additional, Moser, Lisa, additional, Stark, Cosima, additional, Pranevičius, Robertas, additional, Prunea, Dan, additional, Schmidt, Albrecht, additional, Ablasser, Klemens, additional, Verheyen, Nicolas, additional, Kolesnik, Ewald, additional, Maier, Robert, additional, Luha, Olev, additional, Ruzsa, Zoltan, additional, Zirlik, Andreas, additional, and Toth, Gabor G., additional
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- 2023
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14. Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium: GLP-1R mediated effects in human myocardium
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Wallner, Markus, Kolesnik, Ewald, Ablasser, Klemens, Khafaga, Mounir, Wakula, Paulina, Ljubojevic, Senka, Thon-Gutschi, Eva Maria, Sourij, Harald, Kapl, Martin, Edmunds, Nicholas J., Kuzmiski, J. Brent, Griffith, David A., Knez, Igor, Pieske, Burkert, and von Lewinski, Dirk
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- 2015
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15. Clinical utility of echocardiographic left-ventricular ejection fraction monitoring for cardiotoxicity risk assessment in patients with HER2+ early breast cancer undergoing trastuzumab-based therapy [Poster]
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Glantschnig, Theresa, Posch, Florian, Firla, Saskia, Moik, Florian, Ablasser, Klemens, Binder, Josepha S., Stoschitzky, Gergana, Wallner, Markus, Von Lewinski, Dirk, Stöger, Herbert, Zirlik, Andreas, Pichler, Martin, and Rainer, Peter P.
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- 2023
16. Diagnostic Accuracy of Bone Scintigraphy for the Histopathological Diagnosis of Cardiac Transthyretin Amyloidosis—A Retrospective Austrian Multicenter Study
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Verheyen, Nicolas, primary, Ungericht, Maria, additional, Paar, Lisa, additional, Danninger, Kathrin, additional, Schneiderbauer-Porod, Stefanie, additional, Duca, Franz, additional, Cherouny, Bernhard, additional, Hoeller, Viktoria, additional, Ablasser, Klemens, additional, Zach, David, additional, Kolesnik, Ewald, additional, Kiblboeck, Daniel, additional, Frick, Matthias, additional, Bonderman, Diana, additional, Dierneder, Josef, additional, Ebner, Christian, additional, Weber, Thomas, additional, and Pölzl, Gerhard, additional
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- 2022
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17. Not to Rush—Laboratory Parameters and Procedural Complications in Patients Undergoing Left Atrial Appendage Closure
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Zweiker, David, primary, Fiedler, Lukas, additional, Toth, Gabor G., additional, Strouhal, Andreas, additional, Delle-Karth, Georg, additional, Stix, Guenter, additional, Gabriel, Harald, additional, Binder, Ronald K., additional, Rammer, Martin, additional, Pfeffer, Michael, additional, Vock, Paul, additional, Lileg, Brigitte, additional, Steinwender, Clemens, additional, Sihorsch, Kurt, additional, Hintringer, Florian, additional, Mueller, Silvana, additional, Barbieri, Fabian, additional, Martinek, Martin, additional, Tkalec, Wolfgang, additional, Verheyen, Nicolas, additional, Ablasser, Klemens, additional, Zirlik, Andreas, additional, and Scherr, Daniel, additional
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- 2022
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18. Riociguat in pulmonary hypertension and heart failure with preserved ejection fraction: the haemoDYNAMIC trial
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Dachs, Theresa Marie, primary, Duca, Franz, additional, Rettl, René, additional, Binder-Rodriguez, Christina, additional, Dalos, Daniel, additional, Ligios, Luciana Camuz, additional, Kammerlander, Andreas, additional, Grünig, Ekkehard, additional, Pretsch, Ingrid, additional, Steringer-Mascherbauer, Regina, additional, Ablasser, Klemens, additional, Wargenau, Manfred, additional, Mascherbauer, Julia, additional, Lang, Irene M, additional, Hengstenberg, Christian, additional, Badr-Eslam, Roza, additional, Kastner, Johannes, additional, and Bonderman, Diana, additional
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- 2022
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19. A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
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Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Lang, Nora, Pereira, Maria J., Lee, Yuhan, Friehs, Ingeborg, Vasilyev, Nikoay V., Feins, Eric N., Ablasser, Klemens, O'Cearbhail, Eoin D., Xu, Chenjie, Fabozzo, Assunta, Padera, Robert, Wasserman, Steven, Freudenthal, Franz, Ferreira, Lino S., Langer, Robert S, Karp, Jeffrey M., del Nido, Pedro J., Massachusetts Institute of Technology. Department of Biological Engineering, Massachusetts Institute of Technology. Department of Chemical Engineering, Koch Institute for Integrative Cancer Research at MIT, Lang, Nora, Pereira, Maria J., Lee, Yuhan, Friehs, Ingeborg, Vasilyev, Nikoay V., Feins, Eric N., Ablasser, Klemens, O'Cearbhail, Eoin D., Xu, Chenjie, Fabozzo, Assunta, Padera, Robert, Wasserman, Steven, Freudenthal, Franz, Ferreira, Lino S., Langer, Robert S, Karp, Jeffrey M., and del Nido, Pedro J.
- Abstract
Currently, there are no clinically approved surgical glues that are nontoxic, bind strongly to tissue, and work well withinwet and highly dynamic environments within the body. This is especially relevant tominimally invasive surgery that is increasingly performed to reduce postoperative complications, recovery times, and patient discomfort. We describe the engineering of a bioinspired elastic and biocompatible hydrophobic light-activated adhesive (HLAA) that achieves a strong level of adhesion to wet tissue and is not compromised by preexposure to blood. The HLAA provided an on-demand hemostatic seal, within seconds of light application, when applied to high-pressure large blood vessels and cardiac wall defects in pigs. HLAA-coated patches attached to the interventricular septum in a beating porcine heart and resisted supraphysiologic pressures by remaining attached for 24 hours, which is relevant to intracardiac interventions in humans. The HLAA could be used for many cardiovascular and surgical applications, with immediate application in repair of vascular defects and surgical hemostasis.
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- 2022
20. Implantation of the HeartMate III Left Ventricular Assist Device in a Giant Left Ventricular Aneurysm: Is Left Ventricular Reconstruction Mandatory?
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Spiliopoulos, Sotirios, Wasler, Andrae, Fruehwald, Friedrich, Ablasser, Klemens, Stoschitzky, Gergana, and Dapunt, Otto
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- 2017
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21. Cohort profile: ‘Biomarkers of Personalised Medicine’ (BioPersMed): a single-centre prospective observational cohort study in Graz/Austria to evaluate novel biomarkers in cardiovascular and metabolic diseases
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Haudum, Christoph Walter, primary, Kolesnik, Ewald, additional, Colantonio, Caterina, additional, Mursic, Ines, additional, Url-Michitsch, Marion, additional, Tomaschitz, Andreas, additional, Glantschnig, Theresa, additional, Hutz, Barbara, additional, Lind, Alice, additional, Schweighofer, Natascha, additional, Reiter, Clemens, additional, Ablasser, Klemens, additional, Wallner, Markus, additional, Tripolt, Norbert Joachim, additional, Pieske-Kraigher, Elisabeth, additional, Madl, Tobias, additional, Springer, Alexander, additional, Seidel, Gerald, additional, Wedrich, Andreas, additional, Zirlik, Andreas, additional, Krahn, Thomas, additional, Stauber, Rudolf, additional, Pieske, Burkert, additional, Pieber, Thomas R, additional, Verheyen, Nicolas, additional, Obermayer-Pietsch, Barbara, additional, and Schmidt, Albrecht, additional
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- 2022
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22. Myocardial Deformation Analysis in MYBPC3 and MYH7 Related Sarcomeric Hypertrophic Cardiomyopathy—The Graz Hypertrophic Cardiomyopathy Registry
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Höller, Viktoria, primary, Seebacher, Heidelis, additional, Zach, David, additional, Schwegel, Nora, additional, Ablasser, Klemens, additional, Kolesnik, Ewald, additional, Gollmer, Johannes, additional, Waltl, Gert, additional, Rainer, Peter P., additional, Verheyen, Sarah, additional, Zirlik, Andreas, additional, and Verheyen, Nicolas, additional
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- 2021
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23. Heart failure in COVID‐19: the multicentre, multinational PCHF‐COVICAV registry
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Sokolski, Mateusz, primary, Trenson, Sander, additional, Sokolska, Justyna M., additional, D'Amario, Domenico, additional, Meyer, Philippe, additional, Poku, Nana K., additional, Biering‐Sørensen, Tor, additional, Højbjerg Lassen, Mats C., additional, Skaarup, Kristoffer G., additional, Barge‐Caballero, Eduardo, additional, Pouleur, Anne‐Catherine, additional, Stolfo, Davide, additional, Sinagra, Gianfranco, additional, Ablasser, Klemens, additional, Muster, Viktoria, additional, Rainer, Peter P., additional, Wallner, Markus, additional, Chiodini, Alessandra, additional, Heiniger, Pascal S., additional, Mikulicic, Fran, additional, Schwaiger, Judith, additional, Winnik, Stephan, additional, Cakmak, Huseyin A., additional, Gaudenzi, Margherita, additional, Mapelli, Massimo, additional, Mattavelli, Irene, additional, Paul, Matthias, additional, Cabac‐Pogorevici, Irina, additional, Bouleti, Claire, additional, Lilliu, Marzia, additional, Minoia, Chiara, additional, Dauw, Jeroen, additional, Costa, Jérôme, additional, Celik, Ahmet, additional, Mewton, Nathan, additional, Montenegro, Carlos E.L., additional, Matsue, Yuya, additional, Loncar, Goran, additional, Marchel, Michal, additional, Bechlioulis, Aris, additional, Michalis, Lampros, additional, Dörr, Marcus, additional, Prihadi, Edgard, additional, Schoenrath, Felix, additional, Messroghli, Daniel R., additional, Mullens, Wilfried, additional, Lund, Lars H., additional, Rosano, Giuseppe M.C., additional, Ponikowski, Piotr, additional, Ruschitzka, Frank, additional, and Flammer, Andreas J., additional
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- 2021
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24. Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry.
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UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Sokolski, Mateusz, Trenson, Sander, Sokolska, Justyna M, D'Amario, Domenico, Meyer, Philippe, Poku, Nana K, Biering-Sørensen, Tor, Højbjerg Lassen, Mats C, Skaarup, Kristoffer G, Barge-Caballero, Eduardo, Pouleur, Anne-Catherine, Stolfo, Davide, Sinagra, Gianfranco, Ablasser, Klemens, Muster, Viktoria, Rainer, Peter P, Wallner, Markus, Chiodini, Alessandra, Heiniger, Pascal S, Mikulicic, Fran, Schwaiger, Judith, Winnik, Stephan, Cakmak, Huseyin A, Gaudenzi, Margherita, Mapelli, Massimo, Mattavelli, Irene, Paul, Matthias, Cabac-Pogorevici, Irina, Bouleti, Claire, Lilliu, Marzia, Minoia, Chiara, Dauw, Jeroen, Costa, Jérôme, Celik, Ahmet, Mewton, Nathan, Montenegro, Carlos E L, Matsue, Yuya, Loncar, Goran, Marchel, Michal, Bechlioulis, Aris, Michalis, Lampros, Dörr, Marcus, Prihadi, Edgard, Schoenrath, Felix, Messroghli, Daniel R, Mullens, Wilfried, Lund, Lars H, Rosano, Giuseppe M C, Ponikowski, Piotr, Ruschitzka, Frank, Flammer, Andreas J, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Département cardiovasculaire, Sokolski, Mateusz, Trenson, Sander, Sokolska, Justyna M, D'Amario, Domenico, Meyer, Philippe, Poku, Nana K, Biering-Sørensen, Tor, Højbjerg Lassen, Mats C, Skaarup, Kristoffer G, Barge-Caballero, Eduardo, Pouleur, Anne-Catherine, Stolfo, Davide, Sinagra, Gianfranco, Ablasser, Klemens, Muster, Viktoria, Rainer, Peter P, Wallner, Markus, Chiodini, Alessandra, Heiniger, Pascal S, Mikulicic, Fran, Schwaiger, Judith, Winnik, Stephan, Cakmak, Huseyin A, Gaudenzi, Margherita, Mapelli, Massimo, Mattavelli, Irene, Paul, Matthias, Cabac-Pogorevici, Irina, Bouleti, Claire, Lilliu, Marzia, Minoia, Chiara, Dauw, Jeroen, Costa, Jérôme, Celik, Ahmet, Mewton, Nathan, Montenegro, Carlos E L, Matsue, Yuya, Loncar, Goran, Marchel, Michal, Bechlioulis, Aris, Michalis, Lampros, Dörr, Marcus, Prihadi, Edgard, Schoenrath, Felix, Messroghli, Daniel R, Mullens, Wilfried, Lund, Lars H, Rosano, Giuseppe M C, Ponikowski, Piotr, Ruschitzka, Frank, and Flammer, Andreas J
- Abstract
We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P < 0.001). After adjusting, HF remained associated with in-hospital mortality (OR 1.45 [95% confidence interval: 1.01-2.06], P = 0.041). Importantly, 186 of 1282 [15%] patients had an acute HF event during hospitalization (76 [40%] with de novo HF), which was associated with higher in-hospital mortality (89 [48%] vs. 220 [23%]) than in patients without HF event (OR 3.10 [2.24-4.29], P < 0.001). Hospitalized COVID-19 patients with HF are at increased risk for in-hospital death. In-hospital worsening of HF or acute HF de novo are common and associated with a further increase in in-hospital mortality.
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- 2021
25. Advanced isolated light chain amyloid cardiomyopathy with negative immunofixation and normal free light chain ratio
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Zach, David, primary, Ablasser, Klemens, additional, Kolesnik, Ewald, additional, Hoeller, Viktoria, additional, Fruhwald, Friedrich, additional, Prüller, Florian, additional, Reiter, Clemens, additional, Beham‐Schmid, Christine, additional, Lipp, Rainer, additional, Rainer, Peter P., additional, Zirlik, Andreas, additional, Wölfler, Albert, additional, and Verheyen, Nicolas, additional
- Published
- 2021
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26. Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials
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Teerlink, John R., Diaz, Rafael, Felker, G. Michael, McMurray, John J.V., Metra, Marco, Solomon, Scott D., Adams, Kirkwood F., Anand, Inder, Arias‐Mendoza, Alexandra, Biering‐Sørensen, Tor, Böhm, Michael, Bonderman, Diana, Cleland, John G.F., Corbalan, Ramon, Crespo‐Leiro, Maria G., Dahlström, Ulf, Echeverria Correa, Luis E., Fang, James C., Filippatos, Gerasimos, Fonseca, Cândida, Goncalvesova, Eva, Goudev, Assen R., Howlett, Jonathan G., Lanfear, David E., Lund, Mayanna, Macdonald, Peter, Mareev, Vyacheslav, Momomura, Shin‐ichi, O'Meara, Eileen, Parkhomenko, Alexander, Ponikowski, Piotr, Ramires, Felix J. A., Serpytis, Pranas, Sliwa, Karen, Spinar, Jindrich, Suter, Thomas M., Tomcsanyi, Janos, Vandekerckhove, Hans, Vinereanu, Dragos, Voors, Adriaan A., Yilmaz, Mehmet B., Zannad, Faiez, Sharpsten, Lucie, Legg, Jason C., Abbasi, Siddique A., Varin, Claire, Malik, Fady I., Kurtz, Christopher E., Besada, Diego Alejandro, Majul, Claudio Rodolfo, Bruno, Marco Raul Litvak, Sassone, Sonia, Avaca, Horacio Alberto, Rasmussen, Mariela, Aiub, Jorge Roberto, Hominal, Miguel Angel, Perna, Eduardo, Duran, Ruben Omar Garcia, Schiavi, Lilia, Marquez, Lilia Luz Lobo, Vilamajo, Oscar Alberto Gomez, Mackinnon, Ignacio, Fuente, Ricardo Alfonso Leon, Montana, Oscar Romano, Novaretto, Leonardo, Guerrero, Rodolfo Andres Ahuad, Brasca, Daniela Garcia, Prado, Aldo, Garrido, Marcelo Alejandro, Luquez, Hugo, Martinez, Diego Felipe, Nicolosi, Liliana, Parody, Maria Leonor, Zaidman, Cesar, Berra, Fernando Colombo, Ibañez, Julio, Zapata, Gerardo, Caccavo, Alberto, Colque, Roberto, Diez, Mirta, Poy, Carlos, Salomone, Oscar Alejandro, Vogel, Daniel, Bordonava, Anselmo Paulino, Fernandez, Alberto, French, John, Atherton, John, Hamilton, Andrew, Begg, Alistair, Abhayaratna, Walter, Judkins, Christopher, De Pasquale, Carmine, McKenzie, Scott, Amerena, John, Szto, Gregory, Kearney, Leighton, Zimmet, Hendrik, Sverdlov, Aaron, Beltrame, John, Korczyk, Dariusz, Sindone, Andrew, Moertl, Deddo, Huber, Kurt, Huelsmann, Martin, Ablasser, Klemens, Ebner, Christian, Siostrzonek, Peter, Drexel, Heinz, Poelzl, Gerhard, Dujardin, Karl, Dupont, Matthias, Buysschaert, Ian, Lancellotti, Patrizio, Droogne, Walter, Chouchane, Iman, Silveira, Fabio, Rassi, Salvador, Reis, Gilmar, Filho, Pedro Pimentel, Simoes, Marcus Vinicius, Braga, Joao Carlos, Giorgeto, Flavio Eduardo, Ferraz, Almir, Jaeger, Cristiano Pederneiras, Saraiva, Jose Francisco, Tognon, Alexandre, Cardoso, Juliano, Greco, Oswaldo, Paiva, Maria Sanali, Paolino, Bruno, Filho, Otavio Coelho, Maia, Lilia Nigro, Silva, Rodrigo, Canesin, Manoel, Rossi, Paulo Roberto Ferreira, Fortes, Jose Augusto Ribas, Cerci, Rodrigo Julio, Manenti, Euler Roberto Fernandes, Leaes, Paulo Ernesto, Silva Neto, Luis Beck, Souza, Weimar Kunz Barroso, Bacal, Fernando, Chaves, Renato, Ramires, Felix, Vidotti, Maria Helena, Barros e Silva, Pedro Gabriel Melo, Piegas, Leopoldo Soares, Todorov, Georgi, Tzekova, Maria, Goudev, Assen, Mincheva, Valentina, Vasilev, Ivaylo, Tisheva‐ Gospodinova, Snezhanka, Petrov, Ivo, Postadzhiyan, Arman, Velikov, Chavdar, Dimov, Bojidar, Constance, Christian, Phaneuf, Denis‐Carl, Mielniczuk, Lisa, Pandey, A Shekhar, Senaratne, Manohara, Zieroth, Shelley, Savard, Daniel, Stewart, Robert, Huynh, Thao, Giannetti, Nadia, Moe, Gordon, Bourgeois, Ronald, Ezekowitz, Justin, Hartleib, Michael, Sussex, Bruce, Babapulle, Mohan, Chehayeb, Raja, Gaudet, Daniel, McKelvie, Robert, Nguyen, Viviane, Roth, Sherryn, Gupta, Milan, Pesant, Yves, Rupka, Dennis, Bhargava, Rakesh, Costa‐Vitali, Atilio, Proulx, Guy, Vega, Mario, Potthoff, Sergio, Cid, Maria Cristina Schnettler, Sepulveda, Alex Mauricio Villablanca, Zanetti, Fernando Tomas Lanas, Gajardo, Victor Areli Saavedra, Kindel, Carlos Conejeros, Jofre, Christian Paolo Pincetti, Segarra, Jorge Leonardo Cobos, Venegas, Manuel Eduardo Rodriguez, Hidalgo, Mario Yanez, Jalaf, Margarita Gertrudis Vejar, Li, Weimin, Zhang, Jinguo, Fu, Xin, Zhang, Xuelian, Li, Dongye, Wang, Zhifang, Qu, Yanling, Zheng, Zhe, Tang, Huifang, Yang, Ping, Zhang, Yuhui, Zheng, Yang, Mi, Yafei, Huang, He, Bu, Peili, Chen, Guoqin, Chen, Jiyan, Han, Yajun, Li, Zhangquan, Ma, Shumei, Yang, Xuming, Yuan, Zuyi, Dong, Yugang, Li, Zhaoping, Mahemuti, Ailiman, Niu, Wentang, Yang, Zhenyu, Zhang, Yuqing, Sun, Yuemin, Wu, Weiheng, Liu, Feng, Yan, Jing, Li, Yinjun, Wang, Yi, Zhang, Shouyan, Zhou, Changyong, Cui, Hanbin, Li, Jianjun, Li, Tianfa, Han, Qinghua, Wei, Yu, Correa, Luis Eduardo Echeverria, Mendoza, Jose Luis Accini, Jattin, Fernando Manzur, Osorio, Wilder Castaño, Luengas, Carlos Alberto, Arroyo, Julian Alonso Coronel, Corredor, Miguel Alfredo Moncada, Giraldo, Clara Ines Saldarriaga, Lopez, Rodrigo Botero, Salazar, Dora Ines Molina, Triana, Miguel Urina, Lopez, Luis Horacio Atehortua, Rojas, Pastor Olaya, Pelaez, Sebastian Velez, Pareja, Monica Lopez, Bonfanti, Alberto Cadena, Polasek, Rostislav, Monhart, Zdenek, Sochor, Karel, Motovska, Zuzana, Belohlavek, Jan, Busak, Ladislav, Krupicka, Jiri, Tyl, Petr, Jerabek, Ondrej, Podpera, Ivo, Skrobakova, Janka, Peterka, Karel, Spacek, Rudolf, Cech, Vladimir, Kellnerova, Ivana, Nechvatal, Libor, Pozdisek, Zbynek, Houra, Marek, Kryza, Radim, Machova, Vilma, Cepelak, Michal, Stepek, David, Zeman, Kamil, Klimsa, Zdenek, Koleckar, Pavel, Schee, Alexandr, Spinarova, Lenka, Coufal, Zdenek, Jeppesen, Jorgen, Vraa, Soren, Wiggers, Henrik, Nyvad, Ole, Nielsen, Tonny, Kaiser‐Nielsen, Peter, Videbaek, Lars, Galinier, Michel, Lefebvre, Jean‐Marie, Tartiere, Jean‐Michel, De Geeter, Guillaume, Roubille, Francois, Ricci, Jean Etienne, Salvat, Muriel, Gueffet, Jean‐Pierre, Decoulx, Eric, Berdague, Philippe, Jondeau, Guillaume, Ovize, Michel, Groote, Pascal De, Donal, Erwan, Isnard, Richard, Sabatier, Rémi, Trochu, Jean Noel, Damy, Thibaud, Georges, Jean‐Louis, Rosamel, Yann, Picard, François, Aboyans, Victor, Laperche, Thierry, Mitrovic, Veselin, Taggeselle, Jens, Störk, Stefan, Ebelt, Henning, Genth‐Zotz, Sabine, Rassaf, Tienush, Duengen, Hans‐Dirk, Mittag, Marcus, Menck, Niels, Zeymer, Uwe, Haehling, Stephan, Boehm, Michael, Frankenstein, Lutz, Killat, Holger, Bourhaial, Hakima, Beug, Daniel, Horacek, Thomas, Pfister, Roman, Sandri, Marcus, Westenfeld, Ralf, Kadel, Christoph, Karvounis, Haralambos, Patsilinakos, Sotirios, Mantas, Ioannis, Karavidas, Apostolos, Giamouzis, Grigorios, Tsioufis, Konstantinos, Naka, Katerina, Tziakas, Dimitrios, Parissis, John, Styliadis, Ioannis, Barbetseas, Ioannis, Manolis, Athanasios, Kochiadakis, George, Herczeg, Bela, Nagy, Laszlo, Nyolczas, Noemi, Toth, Kalman, Merkely, Bela, Laszlo, Zoltan, Mark, Laszlo, Szakal, Imre, Papp, Andras, Bezzegh, Katalin, Lakatos, Ferenc, Hajko, Erik, Papp, Aniko, Forster, Tamas, Lupkovics, Geza, Mohacsi, Attila, Salamon, Csaba, Aradi, Daniel, Andreka, Peter, Szasz, Gyula, Zilahi, Zsolt, Kazinczy, Rita, Margonato, Alberto, Agostoni, Piergiuseppe, Fucili, Alessandro, Piovaccari, Giancarlo, Senni, Michele, Carluccio, Erberto, Bilato, Claudio, Frigerio, Maria, Indolfi, Ciro, Sinagra, Gianfranco, Brunetti, Natale Daniele, Perna, Gianpiero, Pini, Daniela, Volterrani, Maurizio, Leonardi, Sergio, Mortara, Andrea, Friz, Hernan Emilio Francisco Polo, Rossini, Roberta, Tocchetti, Carlo Gabriele, Vincenzi, Antonella, Cavallini, Claudio, Floresta, Agata Marina, Zaca, Valerio, Giudici, Vittorio, Villani, Giovanni Quinto, Higashino, Yorihiko, Oishi, Shogo, Wada, Atsuyuki, Fukuzawa, Shigeru, Onoue, Kenji, Koike, Akihiro, Koizumi, Tomomi, Masuda, Seigo, Mitsuo, Kazuhisa, Takahashi, Natsuki, Takenaka, Takashi, Tanabe, Jun, Watanabe, Naoki, Yoshida, Takeshi, Amano, Tetsuya, Ishikawa, Masahiro, Kida, Keisuke, Kubota, Toru, Nakamura, Kentaro, Sakamoto, Tomohiro, Shimomura, Mitsuhiro, Yuge, Masaru, Doi, Masayuki, Domae, Hiroshi, Ebato, Mio, Fujii, Kenshi, Fujiwara, Wakaya, Gohara, Seiichiro, Hata, Yoshiki, Kanda, Junji, Kitaoka, Hiroaki, Matsumoto, Takashi, Michishita, Ichiro, Miura, Shinichiro, Miyazaki, Tetsuro, Nakamura, Akihiro, Ogawa, Tomohiro, Okumura, Takahiro, Okumura, Yasuo, Sakai, Tetsuo, Sato, Yukihito, Shimizu, Wataru, Sugino, Hiroshi, Suzuki, Masahiro, Takagi, Atsutoshi, Takaishi, Hiroshi, Tanaka, Takahiro, Terasaki, Toshiro, Tsujimoto, Mitsuru, Ueda, Yasunori, Ujino, Keiji, Usui, Makoto, Yamamoto, Mitsutaka, Yoshikawa, Masaki, Ando, Kenji, Asakura, Masanori, Asano, Hiroshi, Fujii, Shigeru, Hara, Hisao, Inomata, Takayuki, Isshiki, Takaaki, Kadokami, Toshiaki, Kai, Hisashi, Kasai, Toshio, Kawamitsu, Katsunori, Kawasaki, Tomohiro, Koga, Tokushi, Komiyama, Nobuyuki, Maejima, Yasuhiro, Manita, Mamoru, Miyamoto, Nobuhide, Node, Koichi, Numaguchi, Kotaro, Sakata, Yasushi, Serikawa, Takeshi, Takama, Noriaki, Tatebe, Shunsuke, Ueno, Hideki, Hidaka, Takayuki, Hiroi, Shitoshi, Iseki, Harukazu, Ito, Hiroshi, Kajinami, Kouji, Kawakami, Hideo, Momiyama, Yukihiko, Mori, Masuki, Morita, Yukiko, Okishige, Kaoru, Sakagami, Satoru, Takeishi, Yasuchika, Terasawa, Akihiro, Utsu, Noriaki, Badariene, Jolita, Celutkiene, Jelena, Slapikas, Rimvydas, Jarasuniene, Dalia, Castillo, Armando Garcia, De los Rios Ibarra, Manuel Odin, Lopez, Gabriel Arturo Ramos, Llamas, Edmundo Alfredo Bayram, Esperon, Guillermo Antonio Llamas, Vazquez, Eduardo Salcido, Gonzalez, Ricardo Garcia, Leon, Jose Luis Arenas, Gonzalez, Salvador Leon, Mendoza, Maria Alexandra Arias, Rodriguez, Alicia Contreras, Machado, Gustavo Francisco Mendez, Salazar, Melchor Alpizar, Ruiz, Alberto Esteban Bazzoni, Flores, Ana Maria De Leon, Carrasco, Jose Alfredo Pagola, Araiza, Raul Reyes, Römer, Tjeerd, Remmen, Johannes, Van Eck, Jacob, Elvan, Arif, Smilde, Tom, Voors, Adriaan, Wal, Ruud, Schaap, Jeroen, Sluis, Aize, Linssen, Gerardus, Magro, Michael, Willems, Frank, Hal, John, Zwaan, Coenraad, Beelen, Driek, Boswijk, Dirk, Hermans, Walter, Van Kesteren, Henricus, Scott, Russell, Hart, Hamish, Lund, Marianne, Szczasny, Marcin, Blicharski, Tomasz, Kafara, Mariusz, Stankiewicz, Anna, Skonieczny, Grzegorz, Zabowka, Maciej, Kania, Grzegorz, Kopaczewski, Jerzy, Pawlowicz, Lidia, Spyra, Janusz, Wlodarczyk, Aleksander, Sciborski, Ryszard, Balsam, Pawel, Drozdz, Jaroslaw, Sobkowicz, Bozena, Konieczynska, Malgorzata, Lelonek, Malgorzata, Bednarkiewicz, Zbigniew, Trebacz, Jaroslaw, Jankowski, Piotr, Sidor, Mateusz, Berkowski, Piotr, Chmielak, Zbigniew, Lenartowska, Lucyna, Nessler, Jadwiga, Straburzynska‐Migaj, Ewa, Kalarus, Zbigniew, Kowalski, Robert, Kalecinska‐Krystkiewicz, Ewa, Gola, Zbigniew, Pijanowski, Zbigniew, Wozakowska‐Kaplon, Beata, Cymerman, Krzysztof, Rynkiewicz, Andrzej, Miekus, Pawel, Monteiro, Pedro, Sarmento, Pedro Morais, Almeida, Filipa, Duarte, Tatiana, Fonseca, Candida, Oliveira, Luis, Santos, Luis, Brito, Dulce, Stanciulescu, Gabriela, Spiridon, Marilena Renata, Militaru, Constantin, Podoleanu, Cristian Gheorghe, Zdrenghea, Dumitru, Popescu, Mircea Ioachim, Macarie, Cezar‐Eugen, Giuca, Alina, Mitu, Florin, Voicu, Olga‐Cristina, Dorobantu, Maria, Lighezan, Daniel, Stamate, Sorin, Bykov, Alexander, Kobalava, Zhanna, Zrazhevskiy, Konstantin, Semenova, Irina, Vishnevsky, Alexander, Shutemova, Elena, Tereschenko, Sergey, Shvarts, Yury, Barbarash, Olga, Lukyanov, Yury, Voevoda, Mikhail, Dovgolis, Svetlana, Dronov, Dmitry, Goloshchekin, Boris, Sitnikova, Maria, Ezhov, Marat, Tarasov, Nikolay, Kotelnikov, Mikhail, Kostenko, Viktor, Solovev, Oleg, Goncharov, Ivan, Myasnikov, Roman, Rafalskiy, Vladimir, Ryabov, Vyacheslav, Kosmacheva, Elena, Motylev, Igor, Nosov, Vladimir, Osipova, Irina, Salukhov, Vladimir, Belenkiy, Dmitriy, Bolshakova, Olga, Pimenov, Leonid, Shilkina, Nataliya, Kulibaba, Elena, Repin, Alexey, Timofeev, Alexander, Mitrokhin, Vladislav, Sherenkov, Alexander, Arbolishvili, Georgy, Antalik, Lubomir, Dzupina, Andrej, Fulop, Peter, Majercak, Ivan, Gonsorcik, Jozef, Vinanska, Daniela, Lenner, Egon, Lukacova, Jana, Margoczy, Roman, Smik, Rudolf, Stevlik, Jan, Uhliar, Rudolf, Burgess, Lesley, Badat, Aysha, Klug, Eric, Van Zyl, Louis, Abelson, Mark, Moodley, Rajendran, Tsabedze, Nqoba, Fourie, Nyda, Bonet, Luis Almenar, Prado, Jose Maria Arizon, Oliveira Soares, Manue Martinez‐Selles D, Villota, Julio Eduardo Nuñez, Leiro, Maria Generosa Crespo, Juanatey, Jose Ramon Gonzalez, Figal, Domingo Andres Pascual, Palomas, Juan Luis Bonilla, Perez, Sonia Mirabet, Jimenez, Juan Francisco Delgado, Padron, Antonio Lara, Diaz, Victor Alfonso Jimenez, Cubero, Javier Segovia, Paya, Vicente Eduardo Climent, Mayoral, Alejandro Recio, Fuente Galan, Luis, Doblas, Juan Jose Gomez, Freire, Ramon Bover, Peiro, Maria Teresa Blasco, Molina, Beatriz Diaz, Martinez, Laura Jordan, Vilchez, Francisco Gonzalez, Boman, Kurt, Karlstrom, Patric, Berglund, Stefan, Szabo, Barna, Peterson, Magnus, Wodlin, Peter, Lindholm, Carl‐Johan, Moccetti, Tiziano, Mueller, Christian, Suter, Thomas, Hullin, Roger, Meyer, Philippe, Noll, Georg, Yigit, Zerrin, Turgut, Okan Onur, Bekar, Lutfu, Sahin, Tayfun, Koldas, Zehra Lale, Celik, Ahmet, Cavusoglu, Yuksel, Demir, Mesut, Onrat, Ersel, Duzenli, Mehmet, Cosansu, Kahraman, Muderrisoglu, Ibrahim Haldun, Tuncer, Mustafa, Badak, Ozer, Nalbantgil, Sanem, Kirma, Cevat, Okuyan, Ertugrul, Guray, Umit, Prokhorov, Oleksandr, Karpenko, Oleksandr, Vakaliuk, Igor, Yagensky, Andriy, Kracz, Igor, Stanislavchuk, Mykola, Kulynych, Oleksii, Rishko, Mykola, Stets, Roman, Tseluyko, Vira, Mishchenko, Larysa, Rudenko, Leonid, Rudyk, Iurii, Alieksieieva, Liudmyla, Korzh, Oleksii, Mostovoy, Yuriy, Parkhomenko, Oleksandr, Rasputina, Lesya, Voronkov, Leonid, Lymar, Yurii, Vasilyeva, Larysa, Keeling, Philip, Barr, Craig, Wong, Kenneth, Price, Dallas, Skaria, Binoy, Clark, Andrew, Chandrasekaran, Badrinathan, Trevelyan, Jasper, Gordon, Brian, Donnelly, Patrick, Glover, Jason, Ryding, Alisdair, Weir, Robin, Lang, Chim, Roy, Debashis, Adhya, Shaumik, Clifford, Piers, Ludman, Andrew, Kalra, Paul, Lynch, Mary, Mahmood, Shahid, Al Mohammad, Abdallah, Asubiaro, Joshua, Elmahi, Einas, Muthumala, Amal, Taylor, Justin, Gupta, Dinesh, Nadar, Venkatesh, Henderson, David, Zolty, Ronald, Sauer, Andrew, Adams, Kirkwood, Chandra, Lokesh, Jaffrani, Naseem, Grewal, Gurinder, Mancini, Donna, McLean, Dalton, Vasallo, Javier, Gottlieb, Stephen, Joseph, Susan, Barua, Rajat, Gorodeski, Eiran, Mouhaffel, Asad, Chung, Eugene, Desai, Pratik, Portnay, Edward, Rama, Bhola, Shandling, Adrian, Stahl, Llyod, Heilman, Karl, Jacob, Binu, Londono, Juan, Almousalli, Omar, Ashcom, Thomas, Bauerlein, Eugene Joseph, Koo, Charles, McGrew, Frank, Rajagopalan, Navin, Robinson, Shawn, Schultz, David, Starling, Randall, Ambardekar, Amrut, Bhagwat, Ravi, Boehmer, John, Bouza, Manuel, Farris, Neil, Feitell, Scott, Ganji, Jagadeesh, Geltman, Edward, Javier, Julian, Morrow, John Andrew, Pianko, Leonard, Smart, Frank, Adler, Alexander, Brinkley, Douglas, Cardona, Jose, Coletti, Andrew, Harris, John, Hunter, Vernon, Krantz, Mori, Lang, Christopher, Lovell, Charles, Murray, David, Pillutla, Priya, Shah, Amit, Bogaev, Roberta, Dauber, Ira, Franchi, Francesco, Fremont, Richard, Hart, Terence, Hattler, Brack, Janik, Matthew, Khalife, Wissam, Malhotra, Sanjay, Mamdani, Shafiq, Nelson, William, Orgera, Marisa, Ortiz, Aurelio, Rahko, Peter, Rennyson, Stephen, Shin, Jooyoung, Tsao, Lana, Uretsky, Barry, Wahid, Faisal, Wilkett, Matt, Amanullah, Aman, Baker, Mathue, Berk, Martin, Boccalandro, Fernando, Cruz, Kimberly, Doyle, Timothy, Gianfagna, Robert, Jones, Alonzo, King, Anthony, Lepor, Norman, Martinez‐Castrillon, Melvin, Pham, Michael, Radin, Michael, Radojevic, Joseph, Ramanathan, Kodangudi, Schmalfuss, Carsten, Schnitzler, Robert, Shah, Keyur, Takata, Theodore, Bertolet, Barry, Bostick, Brian, Civitello, Andrew, Collins, John, Dib, Nabil, Fang, James, Gilmore, Richard, Gray, Wayne, Grazette, Luanda, Haddad, Tariq, Hearne, Steven, Janmohamed, Munir, Katz, Richard, Kazemi, Navid, Llerena, Sara, Lohr, Nicole, Marzouka, George, Mignone, John, Ooi, Henry, Paszczuk, Anna, Pickett, Christopher, Sampognaro, Gregory, Sawyer, Douglas, Shayani, Steven, Treasure, Charles, Vaz, Garth, Vijay, Nampalli, Williams, Celeste, Yeoman, Gary, Zhang, Lily, Aaronson, Keith, Abo‐Auda, Wael, Alharethi, Rami, Anderson, William, Ariani, Mehrdad, Banerji, Sourin, Baweja, Paramdeep, Carson, Peter, Eberly, Arthur, Elliott, James, Fernando, Ronald, Fisher, Daniel, Forman, Steven, Gabriel, George, Gogia, Harinder, Hametz, Craig, Houston, Brian, Ibrahim, Hassan, Jadbabaie, Farid, Kassiotis, Christos, Krishnamoorthy, Arun, Kwan, Michael, Lupovitch, Steven, Macias, Leonardo, Malik, Adnan, Martinez, Luis, Miyamoto, Michael, Mody, Freny, Patel, Devesh, Peart, Brenda, Pisani, Barbara, Ramos, Mark, Rivero, Mariel, Shah, Anil, Sharma, Mukesh, Sichrovsky, Tina, Simon, Marc, Singh, Deovrat, Tallet, Julio, Vaccari, Christopher, Villoch, Mario, Wheeler, Matthew, Yousuf, Kabir, Abadier, Rafik, Abdullah, Shuaib, Arora, Raveen, Aslam, Shamaila, Buynak, Robert, Chang, David, Contreras, Johanna, Halpern, Stephen, Handel, Franklin, Heitner, John, Herzog, William, Jackson, Bruce, Kao, John, Kondo, Nicholas, Koren, Michael, LeWinter, Martin, Martindale, Jeffrey, Martinez‐Arraras, Joaquin, Olsen, Stephanie, Piatek, Marek, Ranadive, Nandkishore, Randall, William, Rao, Sunder, Rawitscher, David, Rider, James, Sokos, George, Strader, J Russell, Sulemanjee, Nasir, Tahirkheli, Naeem, Trichon, Benjamin, Vanhecke, Thomas, Whellan, David, Abuannadi, Mohammad, Aggarwala, Gaurav, Ahmad, Saad, Artis, Andre, Cheirif, Jorge, Cotarlan, Vladimir, Cox, Jeremy, Eaton, Charles, Florea, Viorel, Frank, Theodore, Friedman, Keith, Ganeshram, Vedampattu, Gass, Alan, Gemignani, Anthony, Hasni, Syed, Hedgepeth, Chester, Itchhaporia, Dipti, Kaluski, Edo, Karim, Amin, Kono, Alan, Lader, Ellis, Lakshminarayanan, Batlagundu, Lewis, Neil, Malhotra, Vinay, Mayer, Nolan, Mohapatra, Robert, Nair, Nandini, O'Brien, Terrence, Pauwaa, Sunil, Rowan, Christopher, Saxena, Sanjeev, Seto, Arnold, Shah, Nishant, Singh, Pradeep, Skopicki, Hal, Stoddard, Marcus, and Sweitzer, Nancy
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R1 - Abstract
Aims:\ud The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials.\ud \ud Methods and Results:\ud Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure
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- 2020
27. Hereditary ATTR Amyloidosis in Austria: Prevalence and Epidemiological Hot Spots
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Auer-Grumbach, Michaela, Rettl, Rene, Ablasser, Klemens, Agis, Hermine, Beetz, Christian, Duca, Franz, Gattermeier, Martin, Glaser, Franz, Hacker, Markus, Kain, Renate, Kaufmann, Birgit, Kovacs, Gabor G., Lampl, Christian, Ljevakovic, Neira, Nagele, Jutta, Pölzl, Gerhard, Quasthoff, Stefan, Raimann, Bernadette, Rauschka, Helmut, Reiter, Christian, Skrahina, Volha, Schuhfried, Othmar, Sunder-Plassmann, Raute, Verheyen, Nicolas D., Wanschitz, Julia, Weber, Thomas, Windhager, Reinhard, Wurm, Raphael, Zimprich, Friedrich, Löscher, Wolfgang N., and Bonderman, Diana
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amyloidosis ,Austria ,prevalence ,lcsh:R ,nutritional and metabolic diseases ,lcsh:Medicine ,macromolecular substances ,polyneuropathy ,TTR ,cardiomyopathy ,Article ,transthyretin - Abstract
Background: Hereditary transthyretin amyloidosis (hATTR) is an autosomal dominantly inherited disorder caused by an accumulation of amyloid fibrils in tissues due to mutations in the transthyretin (TTR) gene. The prevalence of hATTR is still unclear and likely underestimated in many countries. In order to apply new therapies in a targeted manner, early diagnosis and knowledge of phenotype-genotype correlations are mandatory. This study aimed to assess the prevalence and phenotypic spectrum of hATTR in Austria. Methods: Within the period of 2014&ndash, 2019, patients with ATTR-associated cardiomyopathy and/or unexplained progressive polyneuropathies were screened for mutations in the TTR gene. Results: We identified 43 cases from 22 families carrying 10 different TTR missense mutations and confirmed two mutational hot spots at c.323A>, G (p.His108Arg) and c.337G>, C (p.Val113Leu). Two further patients with late onset ATTR carried TTR variants of unknown significance. The majority of patients initially presented with heart failure symptoms that were subsequently accompanied by progressive polyneuropathy in most cases. A total of 55% had a history of carpal tunnel syndrome before the onset of other organ manifestations. Conclusions: Our study underlined the relevance of hATTR in the pathogenesis of amyloid-driven cardiomyopathy and axonal polyneuropathy and indicated considerable genetic heterogeneity of this disease in the Austrian population. The estimated prevalence of hATTR in Austria based on this study is 1:200,000 but a potentially higher number of unknown cases must be taken into account. With respect to new therapeutic approaches, we strongly propose genetic testing of the TTR gene in an extended cohort of patients with unexplained heart failure and progressive polyneuropathy.
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- 2020
28. Up-regulation of soluble vascular endothelial growth factor receptor-1 prevents angiogenesis in hypertrophied myocardium
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Kaza, Elisabeth, Ablasser, Klemens, Poutias, Dimitrios, Griffiths, Eric R., Saad, Fawzy A., Hofstaetter, Jochen G., del Nido, Pedro J., and Friehs, Ingeborg
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- 2011
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29. Indications and Outcome in Patients Undergoing Left Atrial Appendage Closure—The Austrian LAAC Registry
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Zweiker, David, primary, Sieghartsleitner, Raphael, additional, Fiedler, Lukas, additional, Toth, Gabor G., additional, Luha, Olev, additional, Stix, Guenter, additional, Gabriel, Harald, additional, Vock, Paul, additional, Lileg, Brigitte, additional, Strouhal, Andreas, additional, Delle-Karth, Geort, additional, Pfeffer, Michael, additional, Aichinger, Josef, additional, Tkalec, Wolfgang, additional, Steinwender, Clemens, additional, Sihorsch, Kurt, additional, Binder, Ronald K., additional, Rammer, Martin, additional, Barbieri, Fabian, additional, Mueller, Silvana, additional, Verheyen, Nicolas, additional, Ablasser, Klemens, additional, Zirlik, Andreas, additional, and Scherr, Daniel, additional
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- 2020
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30. Linksventrikuläre Non-Compaction-Kardiomyopathie
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Verheyen, Nicolas, additional, Juch, Herbert, additional, and Ablasser, Klemens, additional
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- 2020
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31. Impact of EMpagliflozin on cardiac function and biomarkers of heart failure in patients with acute MYocardial infarction—The EMMY trial
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Tripolt, Norbert J, primary, Kolesnik, Ewald, additional, Pferschy, Peter N, additional, Verheyen, Nicolas, additional, Ablasser, Klemens, additional, Sailer, Sandra, additional, Alber, Hannes, additional, Berger, Rudolf, additional, Kaulfersch, Carl, additional, Leitner, Katharina, additional, Lichtenauer, Michael, additional, Mader, Arthur, additional, Moertl, Deddo, additional, Oulhaj, Abderrahim, additional, Reiter, Christian, additional, Rieder, Thomas, additional, Saely, Christoph H., additional, Siller-Matula, Jolanta, additional, Weidinger, Franz, additional, Zechner, Peter M, additional, von Lewinski, Dirk, additional, and Sourij, Harald, additional
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- 2020
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32. Unfolding Cardiac Amyloidosis –From Pathophysiology to Cure
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Ablasser, Klemens, primary, Verheyen, Nicolas, additional, Glantschnig, Theresa, additional, Agnetti, Giulio, additional, and Rainer, Peter P., additional
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- 2019
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33. Cangrelor Induces More Potent Platelet Inhibition without Increasing Bleeding in Resuscitated Patients
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Prüller, Florian, primary, Bis, Lukasz, additional, Milke, Oliver, additional, Fruhwald, Friedrich, additional, Pätzold, Sascha, additional, Altmanninger-Sock, Siegfried, additional, Siller-Matula, Jolanta, additional, von Lewinski, Friederike, additional, Ablasser, Klemens, additional, Sacherer, Michael, additional, and von Lewinski, Dirk, additional
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- 2018
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34. Myocardial GLP-1 Receptor Activation in the Presence of Glucose: Strong Partners
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Kolesnik, Ewald, primary, Krainer, Thomas, additional, Wallner, Markus, additional, Djalinac, Natasa, additional, Verheyen, Nicolas, additional, Ablasser, Klemens, additional, Eaton, Deborah M., additional, Rainer, Peter P., additional, Pelzmann, Brigitte, additional, and von Lewinski, Dirk, additional
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- 2018
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35. Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
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Verheyen, Nicolas, primary, Fahrleitner-Pammer, Astrid, additional, Belyavskiy, Evgeny, additional, Gruebler, Martin R., additional, Dimai, Hans Peter, additional, Amrein, Karin, additional, Ablasser, Klemens, additional, Martensen, Johann, additional, Catena, Cristiana, additional, Pieske-Kraigher, Elisabeth, additional, Colantonio, Caterina, additional, Voelkl, Jakob, additional, Lang, Florian, additional, Alesutan, Ioana, additional, Meinitzer, Andreas, additional, März, Winfried, additional, Brussee, Helmut, additional, Pieske, Burkert, additional, Pilz, Stefan, additional, and Tomaschitz, Andreas, additional
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- 2017
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36. Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial
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Verheyen, Nicolas, primary, Meinitzer, Andreas, additional, Grübler, Martin Robert, additional, Ablasser, Klemens, additional, Kolesnik, Ewald, additional, Fahrleitner-Pammer, Astrid, additional, Belyavskiy, Evgeny, additional, Trummer, Christian, additional, Schwetz, Verena, additional, Pieske-Kraigher, Elisabeth, additional, Voelkl, Jakob, additional, Alesutan, Ioana, additional, Catena, Cristiana, additional, Sechi, Leonardo Alberto, additional, Brussee, Helmut, additional, Lewinski, Dirk von, additional, März, Winfried, additional, Pieske, Burkert, additional, Pilz, Stefan, additional, and Tomaschitz, Andreas, additional
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- 2017
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37. Cardiologists of Tomorrow, Austria
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Ablasser, Klemens, primary and Wallner, Markus, additional
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- 2016
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38. Early markers of outcome in initially successful out-of-hospital resuscitation
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Ablasser, Klemens, primary, Altmanninger-Sock, Siegfried, additional, Pätzold, Sascha, additional, Von Lewinski, Dirk, additional, and Fruhwald, Friedrich, additional
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- 2015
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39. Low-grade inflammation and tryptophankynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial.
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Verheyen, Nicolas, Meinitzer, Andreas, Grübler, Martin Robert, Ablasser, Klemens, Kolesnik, Ewald, Fahrleitner-Pammer, Astrid, Belyavskiy, Evgeny, Trummer, Christian, Schwetz, Verena, Pieske-Kraigher, Elisabeth, Voelkl, Jakob, Alesutan, Ioana, Catena, Cristiana, Sechi, Leonardo Alberto, Brussee, Helmut, von Lewinski, Dirk, März, Winfried, Pieske, Burkert, Pilz, Stefan, and Tomaschitz, Andreas
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HYPERPARATHYROIDISM ,ENDOCRINE diseases ,PARATHYROID gland diseases ,ANTI-inflammatory agents ,SPONDYLODISCITIS ,TRYPTOPHAN - Abstract
Background: Primary hyperparathyroidism (pHPT) is associated with low-grade inflammation, left ventricular hypertrophy and increased cardiovascular mortality, but the association between inflammatory markers and parameters of adverse cardiac remodeling is unknown. We investigated the relationship between C-reactive protein (CRP), the essential amino acid tryptophan and its proinflammatory derivatives kynurenine and quinolinic acid (QUIN) with echocardiographic parameters. Methods: Cross-sectional baseline data from the "Eplerenone in Primary Hyperparathyroidism" trial were analyzed. Patients with any acute illness were excluded. We assessed associations between CRP, serum levels of tryptophan, kynurenine and QUIN and left ventricular mass index (LVMI), left atrial volume index (LAVI) and E/e'. Results: Among 136 subjects with pHPT (79% females), 100 (73%) had arterial hypertension and the prevalence of left ventricular hypertrophy was 52%. Multivariate linear regression analyses with LVMI, LAVI and E/e' as respective dependent variables, and C-reactive protein and tryptophan, kynurenine and QUIN as respective independent variables were performed. Analyses were adjusted for age, sex, blood pressure, parathyroid hormone, calcium and other cardiovascular risk factors. LVMI was independently associated with CRP (adjusted ß-coefficient = 0.193, p = 0.030) and QUIN (ß = 0.270, p = 0.007), but not kynurenine. LAVI was related with CRP (ß = 0.315, p < 0.001), kynurenine (ß = 0.256, p = 0.005) and QUIN (ß = 0.213, p = 0.044). E/e' was related with kynurenine (ß = 0.221, p = 0.022) and QUIN (ß = 0.292, p = 0.006). Tryptophan was not associated with any of the remodeling parameters. [Correction added after online publication (22 April 2017: The sentence "Among 136 subjects with pHPT (79% females), 100 (73%) had left ventricular hypertrophy."was corrected to "Among 136 subjects with pHPT (79% females), 100 (73%) had arterial hypertension and the prevalence of left ventricular hypertrophy was 52%."]. Conclusions: Cardiac remodeling is common in pHPT and is associated with low-grade inflammation and activation of the tryptophan-kynurenine pathway. The potential role of kynurenine and QUIN as cardiovascular risk factors may be further investigated in future studies. [ABSTRACT FROM AUTHOR]
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- 2017
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40. Aldosterone to Active Renin Ratio Is Associated With Nocturnal Blood Pressure in Obese and Treated Hypertensive Patients: The Styrian Hypertension Study
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Grübler, Martin R., primary, Kienreich, Katharina, additional, Gaksch, Martin, additional, Verheyen, Nicolas, additional, Fahrleitner‐Pammer, Astrid, additional, Schmid, Johannes, additional, Grogorenz, Jana, additional, Ablasser, Klemens, additional, Pieske, Burkert, additional, Tomaschitz, Andreas, additional, and Pilz, Stefan, additional
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- 2014
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41. A Blood-Resistant Surgical Glue for Minimally Invasive Repair of Vessels and Heart Defects
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Lang, Nora, primary, Pereira, Maria J., additional, Lee, Yuhan, additional, Friehs, Ingeborg, additional, Vasilyev, Nikolay V., additional, Feins, Eric N., additional, Ablasser, Klemens, additional, O’Cearbhaill, Eoin D., additional, Xu, Chenjie, additional, Fabozzo, Assunta, additional, Padera, Robert, additional, Wasserman, Steve, additional, Freudenthal, Franz, additional, Ferreira, Lino S., additional, Langer, Robert, additional, Karp, Jeffrey M., additional, and del Nido, Pedro J., additional
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- 2014
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42. Abstract 19644: A Biocompatible Light-Activated Adhesive for Intra- and Extracardiac Applications in Acquired and Congenital Heart Disease
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Lang, Nora, primary, Nunes Pereira, Maria, additional, Friehs, Ingeborg, additional, Vasilyev, Nikolay, additional, Ablasser, Klemens, additional, O'Cearbhaill, Eoin, additional, Xu, Chenjie, additional, Yamauchi, Haruo, additional, Hammer, Peter, additional, Wasserman, Steve, additional, Karp, Jeffrey M, additional, and del Nido, Pedro, additional
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- 2012
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43. Endogenous Angiogenesis Inhibitors Prevent Adaptive Capillary Growth in Left Ventricular Pressure Overload Hypertrophy
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Nikolova, Andriana, primary, Ablasser, Klemens, additional, Wyler von Ballmoos, Moritz C., additional, Poutias, Dimitrios, additional, Kaza, Elisabeth, additional, McGowan, Francis X., additional, Moses, Marsha A., additional, del Nido, Pedro J., additional, and Friehs, Ingeborg, additional
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- 2012
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44. Low-grade inflammation and tryptophan-kynurenine pathway activation are associated with adverse cardiac remodeling in primary hyperparathyroidism: the EPATH trial
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Verheyen, Nicolas, Meinitzer, Andreas, Grübler, Martin Robert, Ablasser, Klemens, Kolesnik, Ewald, Fahrleitner-Pammer, Astrid, Belyavskiy, Evgeny, Trummer, Christian, Schwetz, Verena, Pieske-Kraigher, Elisabeth, Voelkl, Jakob, Alesutan, Ioana, Catena, Cristiana, Sechi, Leonardo Alberto, Brussee, Helmut, Lewinski, Dirk von, März, Winfried, Pieske, Burkert, Pilz, Stefan, Tomaschitz, Andreas, Verheyen, Nicolas, Meinitzer, Andreas, Grübler, Martin Robert, Ablasser, Klemens, Kolesnik, Ewald, Fahrleitner-Pammer, Astrid, Belyavskiy, Evgeny, Trummer, Christian, Schwetz, Verena, Pieske-Kraigher, Elisabeth, Voelkl, Jakob, Alesutan, Ioana, Catena, Cristiana, Sechi, Leonardo Alberto, Brussee, Helmut, Lewinski, Dirk von, März, Winfried, Pieske, Burkert, Pilz, Stefan, and Tomaschitz, Andreas
- Abstract
Background: Primary hyperparathyroidism (pHPT) is associated with low-grade inflammation, left ventricular hypertrophy and increased cardiovascular mortality, but the association between inflammatory markers and parameters of adverse cardiac remodeling is unknown. We investigated the relationship between C-reactive protein (CRP), the essential amino acid tryptophan and its pro-inflammatory derivatives kynurenine and quinolinic acid (QUIN) with echocardiographic parameters. Methods: Cross-sectional baseline data from the "Eplerenone in Primary Hyperparathyroidism” trial were analyzed. Patients with any acute illness were excluded. We assessed associations between CRP, serum levels of tryptophan, kynurenine and QUIN and left ventricular mass index (LVMI), left atrial volume index (LAVI) and E/e′. Results: Among 136 subjects with pHPT (79% females), 100 (73%) had arterial hypertension and the prevalence of left ventricular hypertrophy was 52%. Multivariate linear regression analyses with LVMI, LAVI and E/e′ as respective dependent variables, and C-reactive protein and tryptophan, kynurenine and QUIN as respective independent variables were performed. Analyses were adjusted for age, sex, blood pressure, parathyroid hormone, calcium and other cardiovascular risk factors. LVMI was independently associated with CRP (adjusted β-coefficient=0.193, p=0.030) and QUIN (β=0.270, p=0.007), but not kynurenine. LAVI was related with CRP (β=0.315, p<0.001), kynurenine (β=0.256, p=0.005) and QUIN (β=0.213, p=0.044). E/e′ was related with kynurenine (β=0.221, p=0.022) and QUIN (β=0.292, p=0.006). Tryptophan was not associated with any of the remodeling parameters. [Correction added after online publication (22 April 2017: The sentence "Among 136 subjects with pHPT (79% females), 100 (73%) had left ventricular hypertrophy.” was corrected to "Among 136 subjects with pHPT (79% females), 100 (73%) had arterial hypertension and the prevalence of left ventricular hypertrophy was 52%
45. Heart failure in COVID-19: the multicentre, multinational PCHF-COVICAV registry
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Nathan Mewton, Tor Biering-Sørensen, Marcus Dörr, Andreas J. Flammer, Michał Marchel, Wilfried Mullens, Domenico D'Amario, Yuya Matsue, Huseyin A. Cakmak, Gianfranco Sinagra, Davide Stolfo, Kristoffer Grundtvig Skaarup, Claire Bouleti, Marzia Lilliu, Felix Schoenrath, Edgard Prihadi, Irene Mattavelli, Justyna M. Sokolska, Carlos Eduardo Lucena Montenegro, Daniel Messroghli, Anne-Catherine Pouleur, Frank Ruschitzka, Matthias Paul, Nana K. Poku, Lampros K. Michalis, Mateusz Sokolski, Jérôme Costa, Alessandra Chiodini, Viktoria Muster, Jeroen Dauw, Goran Loncar, Peter P. Rainer, Philippe Meyer, Eduardo Barge-Caballero, Massimo Mapelli, Aris Bechlioulis, Fran Mikulicic, Ahmet Çelik, Piotr Ponikowski, Klemens Ablasser, Chiara Minoia, Judith Schwaiger, Sander Trenson, Markus Wallner, Lars Lund, Giuseppe M.C. Rosano, P S Heiniger, Mats Christian Højbjerg Lassen, Margherita Gaudenzi, Irina Cabac-Pogorevici, Stephan Winnik, University of Wrocław [Poland] (UWr), University hospital of Zurich [Zurich], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Geneva University Hospital (HUG), Herlev and Gentofte Hospital, University of Copenhagen = Københavns Universitet (UCPH), Complejo Hospitalario Universitario A Coruña [A Coruña, Spain] (CHUAC), Instituto de Investigación Biomédica de A Coruña [La Corogne, Espagne] (INIBIC), A Coruña University Hospital [La Corogne, Espagne], Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares [Spain] (CIBERCV), Cliniques universitaires St Luc [Bruxelles], Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Università degli studi di Trieste = University of Trieste, Medical University of Graz, Temple University [Philadelphia], Pennsylvania Commonwealth System of Higher Education (PCSHE), Center for Biomarker Research in Medicine [Graz, Austria] (CBmed GmbH), Mustafakemalpasa State Hospital [Bursa, Turkey] (MSH), Centro Cardiologico Monzino [Milano], Dpt di Scienze Cliniche e di Comunità [Milano] (DISCCO), Università degli Studi di Milano = University of Milan (UNIMI)-Università degli Studi di Milano = University of Milan (UNIMI)-Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Università degli Studi di Milano = University of Milan (UNIMI), Johns Hopkins University Applied Physics Laboratory [Laurel, MD] (APL), Luzerner Kantonsspital [Lucerne, Switzerland] (LUKS), University Nicolae Testemitanu [Kishinev, Moldova] (UNT), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hospital 'Magalini' Villafranca - ULSS 9 Scaligera [Verona, Italy], Public Health Company Valle Olona [Busto Arsizio, Italy] (PHCVO), Ziekenhuis Oost-Limburg (ZOL), Hasselt University (UHasselt), Centre Hospitalier Universitaire de Reims (CHU Reims), Mersin University, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Hôpital Louis Pradel [CHU - HCL], Hospices Civils de Lyon (HCL), Centre d'Investigation Clinique [Bron] (CIC1407), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupement Hospitalier Est [Bron], Universidade Federal de Pernambuco [Recife] (UFPE), Juntendo University Hospital [Tokyo], Institute for Cardiovascular Diseases Dedinje [Belgrade, Serbia] (IC2D), University of Belgrade [Belgrade], Medical University of Warsaw - Poland, University Hospital of Ioannina, University of Medicine Greifswald, German Center for Cardiovascular Research (DZHK), Berlin Institute of Health (BIH), ZNA Heart Centre [Antwerp, Belgium], German Heart Institute Berlin [Berlin, Germany] (GHIB), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Deutsches Herzzentrum Berlin, Karolinska Institute, Karolinska University Hospital [Stockholm], IRCCS San Raffaele [Rome, Italy], Wrocław Medical University, CarMeN, laboratoire, UCL - SSS/IREC/CARD - Pôle de recherche cardiovasculaire, UCL - (SLuc) Service de cardiologie, Mapelli, Massimo/0000-0001-9985-7407, celik, Ahmet/0000-0002-9417-7610, Sokolski, Mateusz/0000-0001-9925-3566, Sokolska, Justyna/0000-0002-4759-5879, Lassen, Mats/0000-0002-2255-582X, Skaarup, Kristoffer/0000-0002-2690-7511, Sokolski, Mateusz, Trenson, Sander, Sokolska, Justyna M., D'Amario, Domenico, Meyer, Philippe, Poku, Nana K., Biering-Sorensen, Tor, Lassen, Mats C. Hojbjerg, Skaarup, Kristoffer G., Barge-Caballero, Eduardo, Pouleur, Anne-Catherine, Stolfo, Davide, Sinagra, Gianfranco, Ablasser, Klemens, Muster, Viktoria, Rainer, Peter P., Wallner, Markus, Chiodini, Alessandra, Heiniger, Pascal S., Mikulicic, Fran, Schwaiger, Judith, Winnik, Stephan, Cakmak, Huseyin A., Gaudenzi, Margherita, Mapelli, Massimo, Mattavelli, Irene, Paul, Matthias, Cabac-Pogorevici, Irina, Bouleti, Claire, Lilliu, Marzia, Minoia, Chiara, DAUW, Jeroen, Costa, Jerome, Celik, Ahmet, Mewton, Nathan, Montenegro, Carlos E. L., Matsue, Yuya, Loncar, Goran, Marchel, Michal, Bechlioulis, Aris, Michalis, Lampros, Dorr, Marcus, Prihadi, Edgard, Schoenrath, Felix, Messroghli, Daniel R., MULLENS, Wilfried, Lund, Lars H., Rosano, Giuseppe M. C., Ponikowski, Piotr, Ruschitzka, Frank, and Flammer, Andreas J.
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Male ,Cardiac & Cardiovascular Systems ,[SDV]Life Sciences [q-bio] ,Disease ,030204 cardiovascular system & hematology ,0302 clinical medicine ,Interquartile range ,Original Research Articles ,Clinical endpoint ,Original Research Article ,Hospital Mortality ,Registries ,030212 general & internal medicine ,Incidence (epidemiology) ,Cardiovascular disease ,3. Good health ,[SDV] Life Sciences [q-bio] ,Female ,Cardiology and Cardiovascular Medicine ,Life Sciences & Biomedicine ,medicine.medical_specialty ,SARS‐CoV2 ,Heart failure ,CORONAVIRUS DISEASE 2019 ,SARS-CoV2 ,03 medical and health sciences ,COVID‐19 ,Diabetes mellitus ,Internal medicine ,medicine ,Diseases of the circulatory (Cardiovascular) system ,Humans ,Aged ,Retrospective Studies ,Heart Failure ,Science & Technology ,SARS-CoV-2 ,business.industry ,COVID-19 ,Odds ratio ,medicine.disease ,Confidence interval ,Risk factors ,RC666-701 ,Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE ,Cardiovascular System & Cardiology ,INHIBITORS ,business - Abstract
AIMS: We assessed the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients with heart failure (HF) compared with patients with other cardiovascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia). We further wanted to determine the incidence of HF events and its consequences in these patient populations. METHODS AND RESULTS: International retrospective Postgraduate Course in Heart Failure registry for patients hospitalized with COVID-19 and CArdioVascular disease and/or risk factors (arterial hypertension, diabetes, or dyslipidaemia) was performed in 28 centres from 15 countries (PCHF-COVICAV). The primary endpoint was in-hospital mortality. Of 1974 patients hospitalized with COVID-19, 1282 had cardiovascular disease and/or risk factors (median age: 72 [interquartile range: 62-81] years, 58% male), with HF being present in 256 [20%] patients. Overall in-hospital mortality was 25% (n = 323/1282 deaths). In-hospital mortality was higher in patients with a history of HF (36%, n = 92) compared with non-HF patients (23%, n = 231, odds ratio [OR] 1.93 [95% confidence interval: 1.44-2.59], P
- Published
- 2021
46. Prevalence and prognostic impact of bone disease in chronic heart failure with reduced ejection fraction.
- Author
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Verheyen N, Schmid J, Kolesnik E, Schwegel N, Späth J, Kattnig L, Riepl H, Zach D, Santner V, Höller V, Pilz S, Tomaschitz A, Fuchsjäger M, Fahrleitner-Pammer A, Dimai HP, Obermayer-Pietsch B, Fruhwald F, Scherr D, Zirlik A, von Lewinski D, and Ablasser K
- Subjects
- Humans, Female, Male, Prospective Studies, Prevalence, Aged, Prognosis, Middle Aged, Osteoporosis epidemiology, Osteoporosis physiopathology, Bone Density physiology, Ventricular Function, Left physiology, Follow-Up Studies, Absorptiometry, Photon, Risk Factors, Chronic Disease, Heart Failure physiopathology, Heart Failure epidemiology, Heart Failure complications, Stroke Volume physiology
- Abstract
Aims: Chronic heart failure is associated with a bone-catabolic state and increases the risk of osteoporosis and fractures. Prospective studies investigating the clinical relevance of bone disease in heart failure are lacking. We aimed to assess the prevalence and prognostic impact of osteoporosis and vertebral fractures (VFs) in chronic heart failure with reduced ejection fraction (HFrEF)., Methods and Results: Symptomatic outpatients with chronic heart failure and a previous diagnosis of overtly reduced left ventricular ejection fraction < 40% on stable, optimal HFrEF therapy and left ventricular ejection fraction < 50% at enrolment were included into a prospective single-centre study. Osteoporosis was determined with dual-energy X-ray absorptiometry and defined as a T-score ≤ 2.5 at any site. VFs were assessed using X-ray of both thoracic and lumbar spine applying the semiquantitative Genant score. We enrolled 205 patients (22% women), with a median age of 66 (IQR 58-74) years. Median left ventricular ejection fraction was 37 (IQR 30-43) % and median N-terminal pro B-type natriuretic peptide was 964 (IQR 363-2173) pg/mL. Osteoporosis, as defined by bone mineral density, and at least one VF were prevalent in 31 (15%) and 29 patients (14%). Osteoporosis or VF were present in 55 patients (27%) and 5 patients (2%) had both osteoporosis and a VF. During a median follow-up of 4.7 (IQR 4.0-5.3) years, 18 patients (9%) died due to cardiovascular (CV) cause, and 46 patients (22%) had a worsening heart failure (WHF) hospitalization. In multivariate Cox regression analyses, presence of VF independently predicted CV death (HR 2.82, 95% CI 1.04-7.65, P = 0.042), WHF hospitalizations (HR 2.39, 95% CI 1.18-4.82, P = 0.015), and a composite endpoint of CV death and WHF hospitalizations (HR 2.44, 95% CI 1.23-4.82, P = 0.011). Osteoporosis was not significantly associated with CV events., Conclusions: In a prospective study, bone disease affected every fourth patient with HFrEF, and patients with VF at baseline had a two-fold risk of subsequent CV death or WHF hospitalization. Prevalent bone disease, particularly VF, should be considered as a clinically relevant comorbidity in HFrEF., (© 2024 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
- Published
- 2024
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- View/download PDF
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