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2. Sleep Habits and Disturbances Among Tunisian Adults: A Cross-Sectional Online Survey

Author

Msaad S, Ketata N, Kammoun N, Gargouri R, Khemakhem R, Abid S, Bader S, Efidha S, Abid N, El Ghoul J, Sahnoun I, Altalaa H, Jdidi J, Jlidi M, Keskes Boudaouara N, Gargouri I, Bahloul N, and Kammoun S

Subjects
sleep-wake habits - sleep quality - insomnia - excessive daytime sleepiness -prevalence - risk factors., Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
Abstract

Sameh Msaad,1 Nouha Ketata,2 Nesrine Kammoun,3 Rahma Gargouri,1 Rim Khemakhem,1 Sourour Abid,1 Saeb Bader,1 Sabrine Efidha,4 Narjes Abid,5 Jamel El Ghoul,6 Imen Sahnoun,4 Hazem Altalaa,1 Jihen Jdidi,2 Mohamed Jlidi,7 Nadia Keskes Boudaouara,8 Imen Gargouri,9 Najla Bahloul,1 Samy Kammoun1 1Department of Respiratory and Sleep Medicine, Hedi Chaker University Hospital of Sfax, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia; 2Department of Preventive Medicine, Hedi Chaker University Hospital of Sfax, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia; 3Tunisian Occupational Health and Safety Institute, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia; 4Department of Pneumology, Abderrahman Mami University Hospital of Ariana, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia; 5Department of Pneumology, Mohamed Taher Maamouri University Hospital of Nabeul, Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia; 6Department of Pneumology, Habib Bourguiba University Hospital of Medenine, Faculty of Medicine of Sfax, University of Sfax, Sfax, Tunisia; 7Orthopedics and Traumatology Department, Mohamed Taher Maâmouri University Hospital of Nabeul, Faculty of Medicine of Tunis, University of Tunis EL Manar, Tunis, Tunisia; 8Department of Pneumology, Taher Sfar University Hospital of Mahdia, Faculty of Medicine of Monastir, University of Monastir, Monastir, Tunisia; 9Department of Pneumology, Farhat Hached University Hospital of Sousse, Faculty of Medicine of Sousse, University of Sousse, Sousse, TunisiaCorrespondence: Sameh Msaad, Tel +216 94 977 355, Email pneumo1972@gmail.comBackground: Sleep quality and disturbances have gained heightened scholarly attention due to their well-established association with both mental and physical health. This study aims to assess sleep-wake habits and disturbances in Tunisian adults.Methodology: This cross-sectional study employed an online questionnaire to assess 3074 adults ≥ 18 years. Primary outcomes, including sleep quality, daytime vigilance, mood, and subjective well-being, were measured using validated questionnaires [the Pittsburgh Sleep Quality Index (PSQI), the Insomnia Severity Index (ISI), the Epworth Sleepiness Scale (ESS), the Patient Health Questionnaire (PHQ)-9, and the World Health Organisation-Five Well-Being Index (WHO-5)].Results: Less than two-thirds (n= 1941; 63.1%) of participants were females and the mean age was 36.25± 13.56. The prevalence of poor sleep quality was 53.8% when defined as a PSQI > 5. The prevalence of insomnia, short sleep duration, long sleep duration, EDS, severe depression, and poor well-being were 14.5%, 34.7%, 12.3%, 32.4%, 7.4%, and 40.2%, respectively. Some factors were associated with an increased likelihood of poor sleep quality, including female gender, chronic hypnotics use, internet use close to bedtime, daily time spent on the internet > 3 hours, smoking, university- level education, nocturnal work, severe depression, impaired well-being status, insomnia, and EDS.Conclusion: The high prevalence of sleep-wake disturbances among Tunisian adults emphasizes the need for an appropriate screening strategy for high-risk groups. Individuals with unhealthy habits and routines were significantly more likely to experience these kinds of disturbances. Consequently, there is a pressing need for educational programs on sleep to foster healthier sleep patterns.Keywords: sleep, wake habits, sleep quality, insomnia, excessive daytime sleepiness, prevalence, risk factors

Published
2024

7. Clinical Efficacy among Patients with Chronic Rhinosinusitis with Nasal Polyps and Clinical Features of Obstructive Lung Disease: Post Hoc Analysis of the Phase III SINUS-24 and SINUS-52 Studies

Author

Maspero JF, Bachert C, Martinez FJ, Hanania NA, Ortiz B, Patel N, Mannent LP, Praestgaard A, Pandit-Abid N, Siddiqui S, and Hardin M

Subjects
obstructive lung disease, chronic obstructive pulmonary disease, dupilumab, type 2 inflammation, interleukin-4, interleukin-13, Immunologic diseases. Allergy, RC581-607
Abstract

Jorge F Maspero,1 Claus Bachert,2,3 Fernando J Martinez,4 Nicola A Hanania,5 Benjamin Ortiz,6 Naimish Patel,7 Leda P Mannent,8 Amy Praestgaard,7 Nami Pandit-Abid,9 Shahid Siddiqui,6 Megan Hardin7 1Allergy and Respiratory Research Unit, Fundación CIDEA, Buenos Aires, Argentina; 2Upper Airway Research Laboratory, Department of Otorhinolaryngology, Ghent University Hospital, Ghent, Belgium; 3Division of ENT Diseases, CLINTEC, Karolinska Institutet, Stockholm, Sweden; 4Division of Pulmonary and Critical Care, Weill Cornell Medical College, New York, NY, USA; 5Section of Pulmonary and Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA; 6Immunology and Allergy Medical Affairs, Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA; 7Immunology and Inflammation, Sanofi, Cambridge, MA, USA; 8Global Clinical Development, Sanofi, Chilly-Mazarin, France; 9Immunology and Inflammation, Sanofi, Bridgewater, NJ, USACorrespondence: Jorge F Maspero, Allergy and Respiratory Research Unit, Fundación CIDEA, Paraguay 2035, Buenos Aires, C1121ABE, Argentina, Tel +54 91141837294, Email jorge.maspero@fundacioncidea.org.arPurpose: To provide a descriptive summary of clinical efficacy and health-related quality of life (HRQoL) measures in patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and clinical features of obstructive lung disease in the Phase III dupilumab studies SINUS-24 and SINUS-52 (NCT02912468, NCT02898454).Patients and Methods: Patients met a “broad” definition of having clinical features of obstructive lung disease with any of 3 criteria: (i) pre-bronchodilator forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) < 0.70 and smoking history; (ii) patient-reported medical history of chronic obstructive pulmonary disease (COPD); or (iii) asthma with > 10 pack-years’ smoking history. A “narrow” definition including criteria (i) or (ii) was also analyzed. CRSwNP and HRQoL measures were evaluated in all patients and lung function (FEV1; FEV1/FVC ratio) was captured and analyzed only in those patients who had a self-reported history of asthma.Results: Across both studies, 131 patients met the “broad” definition, of whom 90 also had asthma, and 115 patients met the “narrow” definition, of whom 74 had asthma. CRSwNP outcomes and HRQoL were improved with dupilumab vs placebo in both the broad and narrow subgroups. Among the 90 patients who met the broad definition and had asthma, dupilumab improved pre-bronchodilator FEV1 and FEV1/FVC ratio at Week 16 (least squares mean differences vs placebo: 0.38 L [95% confidence interval: 0.17, 0.59; p = 0.0004] and 4.8% [1.7%, 7.9%; p = 0.0024], respectively) sustained through Week 24. Similar results were seen in the “narrow” subgroup with asthma.Conclusion: In a population of patients with CRSwNP and clinical features of obstructive lung disease, dupilumab improved CRSwNP and HRQoL outcomes, and, among those with a history of asthma, also improved lung function. These results support further analyses of dupilumab in patients with evidence of type 2 inflammation and obstructive lung disease such as COPD.Keywords: obstructive lung disease, chronic obstructive pulmonary disease, dupilumab, type 2 inflammation, interleukin-4, interleukin-13

Published
2023

15. Impact of Early Transient Increase in Eosinophil Count on the Long-term Efficacy of Dupilumab in Patients With Moderate-to-Severe Asthma: Liberty Asthma Traverse

Author

Lugogo, N.L., primary, Pavord, I.D., additional, Castro, M., additional, Papi, A., additional, Bourdin, A., additional, Wechsler, M.E., additional, Cote, A., additional, Xia, C., additional, Soliman, M., additional, Pandit-Abid, N., additional, Jacob-Nara, J.A., additional, and Sacks, H.J., additional

Published
2024
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16. Social media group support for antidepressant deprescribing: a mixed-methods survey of patient experiences

Author

Coe, A, Abid, N, Kaylor-Hughes, C, Coe, A, Abid, N, and Kaylor-Hughes, C

Abstract

Background Antidepressant use has continually increased in recent decades and although they are an effective treatment for moderate-to-severe depression, when there is no longer a clinical benefit, deprescribing should occur. Currently, routine deprescribing is not part of clinical practice and research shows that there has been an increase in antidepressant users seeking informal support online. This small scoping exercise used a mixed-methods online survey to investigate the motives antidepressant users have for joining social media deprescribing support groups, and what elements of the groups are most valuable to them. Methods Thirty members of two antidepressant deprescribing Facebook groups completed an online survey with quantitative and open-text response questions to determine participant characteristics and motivation for group membership. Quantitative data were analysed using descriptive statistics, and open-text responses were analysed thematically through NVivo. Results Two overarching themes were evident: first, clinician expertise , where participants repeatedly reported a perceived lack of skills around deprescribing by their clinician, not being included in shared decision-making about their treatment, and symptoms of withdrawal during deprescribing going unaddressed. Motivated by the lack of clinical support, peer support developed as the second theme. Here, people sought help online where they received education, knowledge sharing and lived experience guidance for tapering. The Facebook groups also provided validation and peer support, which motivated people to continue engaging with the group. Conclusions Antidepressant users who wish to cease their medication are increasingly subscribing to specialised online support groups due to the lack of information and support from clinicians. This study highlights the ongoing need for such support groups. Improved clinician understanding about the complexities of antidepressant deprescribing is needed to e

Published
2024

19. Efficacité à long terme du dupilumab chez des patients souffrant d’asthme de type 2 en fonction de l’âge au moment de l’apparition : LIBERTY ASTHMA TRAVERSE

Author

Busse, W., primary, Soumagne, T., additional, Kraft, M., additional, Domingo, C., additional, de Mir, I., additional, Maselli, D., additional, Soler, X., additional, Xia, C., additional, Pandit-Abid, N., additional, Jacob-Nara, J., additional, Sacks, H., additional, Rowe, P., additional, and Deniz, Y., additional

Published
2024
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20. Efficacité du dupilumab chez des patients avec et sans réduction minimale importante de la fraction de monoxyde d’azote dans l’air expiré après 2 semaines

Author

Pavord, I., primary, Guilleminault, L., additional, Wechsler, M., additional, Busse, W., additional, Domingo, C., additional, Xia, C., additional, Gall, R., additional, Pandit-Abid, N., additional, Jacob-Nara, J., additional, Radwan, A., additional, Rowe, P., additional, and Deniz, Y., additional

Published
2024
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24. In-vitro Investigation of Antibiotics Efficacy Against Uropathogenic Escherichia coli Biofilms and Antibiotic Induced Biofilm Formation at Sub-Minimum Inhibitory Concentration of Ciprofloxacin

Author

Rafaque Z, Abid N, Liaqat N, Afridi P, Siddique S, Masood S, Kanwal S, and Dasti JI

Subjects
biofilms, mic, mbec, sub-mic, ciprofloxacin, uropathogenic escherichia coli, Infectious and parasitic diseases, RC109-216
Abstract

Zara Rafaque,1,2 Nasira Abid2 ,* Nida Liaqat,2 Pashmina Afridi,2,3 Saima Siddique,2 Safia Masood,2 Sehrish Kanwal,2 Javid Iqbal Dasti2 1Department of Microbiology, Faculty of Life Sciences, University of Central Punjab, Lahore, Pakistan; 2Department of Microbiology, Faculty of Biological Sciences, Quaid-I-Azam University, Islamabad 45320, Pakistan; 3Department of Allied Health Sciences, Iqra National University, Peshawar, Pakistan*These authors contributed equally to this workCorrespondence: Javid Iqbal Dasti Email iqbal78@hushmail.comBackground: Community-acquired urinary tract infections are associated with significant morbidity, and uropathogenic Escherichia coli (UPEC) alone causes 90% of urinary tract infections. This bacterium retains a diverse armament of virulence factors including fimbria, hemolysins, and siderophores production. In a post invasion scenario, formation of intracellular communities mimic biofilm-like characteristics and are linked to recurrent urinary tract infections. We investigated the effects of different frontline antibiotics on the formation, inhibition, and eradication of biofilms of virulent UPEC strains.Materials and Methods: A total of 155 UPEC strains were scrutinized for various virulence factors including gelatinase, cell surface hydrophobicity, hemagglutination, and serum bactericidal activity. Biofilm formation was confirmed by three different methods: Congo red agar, test tube, and tissue culture plate method. Biofilm inhibition and eradication assays were performed according to the standard protocols. Topographical analysis of biofilms was done by scanning electronic microscopy (SEM).Results: Out of 155 strains, 113 (73%) were strong biofilm formesr, while 37 (24%) produced biofilms at moderate level. Significant differences were observed between MICs of planktonic cells (MIC-p) and MICs of UPEC biofilms (MIC-b). Among tested frontline antibiotics, levofloxacin successfully inhibited biofilms at a concentration of 32 μg/mL, while trimethoprim eradicated biofilms at higher concentrations (512– 1024 μg/mL). Ciprofloxacin treatment at sub-MIC level significantly enhanced biofilm formation (P< 0.05).Conclusion: The majority of UPEC strains are strong biofilm formers and show higher tolerance towards frontline antibiotics in biofilm form. We observed significant inhibitory effects of levofloxacin (32 μg/mL) on UPEC biofilms, while treatment with sub-minimal concentrations of ciprofloxacin significantly enhanced biofilm formation. Out of all tested antibiotics, trimethoprim (512– 1024 μg/mL) eradicated UPEC biofilms.Keywords: biofilms, MIC, MBEC, sub-MIC, ciprofloxacin, uropathogenic Escherichia coli

Published
2020

25. Green-Oriented Crowdfunding Campaign: An Explorative Study

Author

Za, S, Winter, R, Lazazzara, A, Abid, N, Ceci, F, di Pietro, F, Masciarelli, F, Abid N., Ceci F., di Pietro F., Masciarelli F., Za, S, Winter, R, Lazazzara, A, Abid, N, Ceci, F, di Pietro, F, Masciarelli, F, Abid N., Ceci F., di Pietro F., and Masciarelli F.

Abstract

The worldwide growing concern for environmental protection compels businesses to incorporate green orientation in their strategies. Crowdfunding has opened new possibilities to attract investors by encompassing green concerns in their agenda. This study investigates the relationship between green orientation and UK crowdfunding campaign success. We have used both qualitative and quantitative approaches to build the green orientation index, for which we have chosen 210 green campaigns out of 720 crowdfunding campaigns. Then we performed a cluster analysis to identify three clusters (social enthusiast, green fan, and tech-oriented) of green-oriented crowdfunding campaign. We performed a predictive validity analysis to identify which cluster is more effective in ensuring the crowdfunding’s performance. The results show that tech-oriented obtain the highest value and share a positive relationship with the amount raised and crowdfunding’s success. Social enthusiast effectively attracts more crowd through the social platform and thereby successfully raises funds. Green orientation, however, does not affect crowdfunding success or overfunding, which shows that there is a huge difference between the clusters, suggesting that the green orientation itself is not considered so important for the crowdfunding campaigns. It also highlights a crucial point the in the crowdfunding’s objectives, the realization of the environmental concern, society, and the long-term sustainability concern is not promising.

Published
2023

27. PCR200 Characteristics at Baseline of Patients with Asthma and Prior Systemic Corticosteroid Use Initiating Dupilumab Enrolled in the Real-World Study Rapid

Author

Lugogo, N.L., primary, Heffler, E., additional, Plaza, V., additional, Hilberg, O., additional, Xia, C., additional, Nash, S., additional, Pandit-Abid, N., additional, Jacob-Nara, J.A., additional, Sacks, H., additional, Rowe, P.J., additional, Deniz, Y., additional, Hardin, M., additional, Ledanois, O., additional, and Soler, X., additional

Published
2023
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32. A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors.

Author

Murari, Andrea, Rossi, Riccardo, Craciunescu, Teddy, Vega, Jesús, Mailloux, J., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., and Alegre, D.

Abstract

The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET. [ABSTRACT FROM AUTHOR]

Published
2024
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34. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author

Mazzi, S., Garcia, J., Zarzoso, D., Kazakov, Y., Ongena, J., Dreval, M., Nocente, M., Stancar, Z., Szepesi, G., Eriksson, J., Sahlberg, A., Benkadda, S., Abid, N., Abraham, K., Abreu, P., Adabonyan, O., Adrich, P., Afanasev, V., Afzal, M., Ahlgren, T., Aho-Mantila, L., Aiba, N., Airila, M., Akhtar, M., Albanese, R., Alderson-Martin, M., Alegre, D., Aleiferis, S., Aleksa, A., Alekseev, A., Alessi, E., Aleynikov, P., Algualcil, J., Ali, M., Allinson, M., Alper, B., Alves, E., Ambrosino, G., Ambrosino, R., Amosov, V., Andersson Sunden, E., Andrew, P., Angelini, B., Angioni, C., Antoniou, I., Appel, L., Appelbee, C., Aria, S., Ariola, M., Artaserse, G., Arter, W., Artigues, V., Asakura, N., Ash, A., Ashikawa, N., Aslanyan, V., Astrain, M., Asztalos, O., Auld, D., Auriemma, F., Austin, Y., Avotina, L., Aymerich, E., Baciero, A., Bairaktaris, F., Balbin, J., Balbinot, L., Balboa, I., Balden, M., Balshaw, C., Balshaw, N., Bandaru, V., Banks, J., Baranov, Y., Barcellona, C., Barnard, A., Barnard, M., Barnsley, R., Barth, A., Baruzzo, M., Barwell, S., Bassan, M., Batista, A., Batistoni, P., Baumane, L., Bauvir, B., Baylor, L., Beaumont, P., Beckett, D., Begolli, A., Beidler, M., Bekris, N., Beldishevski, M., Belli, E., Belli, F., Belonohy, E., Ben Yaala, M., Benayas, J., Bentley, J., Bergsaker, H., Bernardo, J., Bernert, M., Berry, M., Bertalot, L., Betar, H., Beurskens, M., Bickerton, S., Bieg, B., Bielecki, J., Bierwage, A., Biewer, T., Bilato, R., Bílkova, P., Birkenmeier, G., Bishop, H., Bizarro, J., Blackburn, J., Blanchard, P., Blatchford, P., Bobkov, V., Boboc, A., Bohm, P., Bohm, T., Bolshakova, I., Bolzonella, T., Bonanomi, N., Bonfiglio, D., Bonnin, X., Bonofiglo, P., Boocock, S., Booth, A., Booth, J., Borba, D., Borodin, D., Borodkina, I., Boulbe, C., Bourdelle, C., Bowden, M., Boyd, K., Bozicevic Mihalic, I., Bradnam, S., Braic, V., Brandt, L., Bravanec, R., Breizman, B., Brett, A., Brezinsek, S., Brix, M., Bromley, K., Brown, B., Brunetti, D., Buckingham, R., Buckley, M., Budny, R., Buermans, J., Bufferand, H., Buratti, P., Burgess, A., Buscarino, A., Busse, A., Butcher, D., Cal, E., Calabro, G., Calacci, L., Calado, R., Camenen, Y., Canal, G., Cannas, B., Cappelli, M., Carcangiu, S., Card, P., Cardinali, A., Carman, P., Carnevale, D., Carr, M., Carralero, D., Carraro, L., Carvalho, I., Carvalho, P., Casiraghi, I., Casson, F., Castaldo, C., Catalan, J., Catarino, N., Causa, F., Cavedon, M., Cecconello, M., Challis, C., Chamberlain, B., Chang, C., Chankin, A., Chapman, B., Chernyshova, M., Chiariello, A., Chmielewski, P., Chomiczewska, A., Chone, L., Ciraolo, G., Ciric, D., Citrin, J., Ciupinski, t., Clark, M., Clarkson, R., Clements, C., Cleverly, M., Coad, J., Coates, P., Cobalt, A., Coccorese, V., Coelho, R., Coenen, J., Coffey, I., Colangeli, A., Colas, L., Collins, C., Collins, J., Collins, S., Conka, D., Conroy, S., Conway, B., Conway, N., Coombs, D., Cooper, P., Cooper, S., Corradino, C., Corrigan, G., Coster, D., Cox, P., Craciunescu, T., Cramp, S., Crapper, C., Craven, D., Craven, R., Crialesi Esposito, M., Croci, G., Croft, D., Croitoru, A., Crombe, K., Cronin, T., Cruz, N., Crystal, C., Cseh, G., Cufar, A., Cullen, A., Curuia, M., Czarski, T., Dabirikhah, H., Dal Molin, A., Dale, E., Dalgliesh, P., Dalley, S., Dankowski, J., David, P., Davies, A., Davies, S., Davis, G., Dawson, K., Dawson, S., Day, I., De Bock, M., De Temmerman, G., De Tommasi, G., Deakin, K., Deane, J., Dejarnac, R., Del Sarto, D., Delabie, E., Del-Castillo-Negrete, D., Dempsey, A., Dendy, R., Devynck, P., Di Siena, A., Di Troia, C., Dickson, T., Dinca, P., Dittmar, T., Dobrashian, J., Doerner, R., Donne, A., Dorling, S., Dormido-Canto, S., Douai, D., Dowson, S., Doyle, R., Drewelow, P., Drews, P., Drummond, G., Duckworth, P., Dudding, H., Dumont, R., Dumortier, P., Dunai, D., Dunatov, T., Dunne, M., Duran, I., Durodie, F., Dux, R., Dvornova, A., Eastham, R., Edwards, J., Eich, T., Eichorn, A., Eidietis, N., Eksaeva, A., Haroun, H., Ellwood, G., Elsmore, C., Embreus, O., Emery, S., Ericsson, G., Eriksson, B., Eriksson, F., Eriksson, L., Ertmer, S., Esquembri, S., Esquisabel, A., Estrada, T., Evans, G., Evans, S., Fable, E., Fagan, D., Faitsch, M., Falessi, M., Fanni, A., Farahani, A., Farquhar, I., Fasoli, A., Faugeras, B., Fazinie, S., Felici, F., Felton, R., Fernandes, A., Fernandes, H., Ferrand, J., Ferreira, D., Ferreira, J., Ferro, G., Fessey, J., Ficker, O., Field, A., Figueiredo, A., Figueiredo, J., Fil, A., Fil, N., Finburg, P., Fiorucci, D., Fischer, U., Fishpool, G., Fittill, L., Fitzgerald, M., Flammini, D., Flanagan, J., Flinders, K., Foley, S., Fonnesu, N., Fontana, M., Fontdecaba, J., Forbes, S., Formisano, A., Fornal, T., Fortuna, L., Fortuna-Zalesna, E., Fortune, M., Fowler, C., Fransson, E., Frassinetti, L., Freisinger, M., Fresa, R., Fridstrom, R., Frigione, D., Fülop, T., Furseman, M., Fusco, V., Futatani, S., Gadariya, D., Gal, K., Galassi, D., Gafezka, K., Galeani, S., Gallart, D., Galvao, R., Gao, Y., Garcia-Munoz, M., Gardener, M., Garzotti, L., Gaspar, J., Gatto, R., Gaudio, P., Gear, D., Gebhart, T., Gee, S., Gelfusa, M., George, R., Gerasimov, S., Gervasini, G., Gethins, M., Ghani, Z., Gherendi, M., Ghezzi, F., Giacalone, J., Giacomelli, L., Giacometti, G., Gibson, C., Gibson, K., Gil, L., Gillgren, A., Gin, D., Giovannozzi, E., Giroud, C., Glen, R., Gloggler, S., Goff, J., Gohil, P., Goloborodko, V., Gomes, R., Goncalves, B., Goniche, M., Goodyear, A., Gore, S., Gorini, G., Görler, T., Gotts, N., Goulding, R., Gow, E., Graham, B., Graves, J., Greuner, H., Grierson, B., Griffiths, J., Griph, S., Grist, D., Gromelski, W., Groth, M., Grove, R., Gruca, M., Guard, D., Gupta, N., Gurl, C., Gusarov, A., Hackett, L., Hacquin, S., Hager, R., Hagg, L., Hakola, A., Halitovs, M., Hall, S., Hallworth-Cook, S., Ham, C., Hamaguchi, D., Hamed, M., Hamlyn-Harris, C., Hammond, K., Harford, E., Harrison, J., Harting, D., Hatano, Y., Hatch, D., Haupt, T., Hawes, J., Hawkes, N., Hawkins, J., Hayashi, T., Hazael, S., Hazel, S., Heesterman, P., Heidbrink, B., Helou, W., Hemming, O., Henderson, S., Henriques, R., Hepple, D., Herfindal, J., Hermon, G., Hill, J., Hillesheim, J., Hizanidis, K., Hjalmarsson, A., Ho, A., Hobirk, J., Hoenen, O., Hogben, C., Hollingsworth, A., Hollis, S., Hollmann, E., Hoelzl, M., Homan, B., Hook, M., Hopley, D., Horacek, J., Horsley, D., Horsten, N., Horton, A., Horton, L., Horvath, L., Hotchin, S., Howell, R., Hu, Z., Huber, A., Huber, V., Huddleston, T., Huijsmans, G., Huynh, P., Hynes, A., Iliasova, M., lmrie, D., lmrísek, M., lngleby, J., Innocente, P., Insulander Björk, K., Isernia, N., lvanova-Stanik, I., lvings, E., Jablonski, S., Jachmich, S., Jackson, T., Jacquet, P., Järleblad, H., Jaulmes, F., Jenaro Rodriguez, J., Jepu, I., Joffrin, E., Johnson, R., Johnson, T., Johnston, J., Jones, C., Jones, G., Jones, L., Jones, N., Jones, T., Joyce, A., Juarez, R., Juvonen, M., Kalnina, P., Kaltiaisenaho, T., Kaniewski, J., Kantor, A., Kappatou, 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moléculaires (PIIM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche sur la Fusion par confinement Magnétique (IRFM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Swiss Plasma Center (SPC), Ecole Polytechnique Fédérale de Lausanne (EPFL), Laboratory for Plasma Physics (LPP), Ecole Royale Militaire / Koninklijke Militaire School (ERM KMS), Kharkiv Institute of Physics and Technology (Ukraine), V.N. Karazin Kharkiv National University (KhNU), Dipartimento di Fisica (Milano), Università degli Studi di Milano = University of Milan (UNIMI), Consiglio Nazionale delle Ricerche [Milano] (CNR), Jozef Stefan Institute [Ljubljana] (IJS), Culham Centre for Fusion Energy (CCFE), Department of Physics and Astronomy [Uppsala], Uppsala University, This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014–2018 and 2019–2020 under Grant agreement No 633053., Mazzi, S, Garcia, J, Zarzoso, D, Kazakov, Y, Ongena, J, Dreval, M, Nocente, M, Stancar, Z, Szepesi, G, Eriksson, J, Sahlberg, A, Benkadda, S, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, 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K., Zoulias, I., Zwingmann, W., Zychor, I., JET Contributors, Science and Technology of Nuclear Fusion, EIRES Eng. for Sustainable Energy Systems, Magneto-Hydro-Dynamic Stability of Fusion Plasmas, Applied Physics and Science Education, Kazakov, Yo, VTT Technical Research Centre of Finland, Culham Science Centre, Princeton Plasma Physics Laboratory, Department of Applied Physics, European Commission, Forschungszentrum Jülich, Universidade Lisboa, Fusion and Plasma Physics, University of Milan - Bicocca, Aalto University, General Atomics, ITER, University of Toyama, CEA, Oak Ridge National Laboratory, Technical University of Madrid, Swiss Federal Institute of Technology Lausanne, Dutch Institute for Fundamental Energy Research, Royal Military Academy, Seoul National University, Chalmers University of Technology, Max Planck Institute for Plasma Physics, KTH Royal Institute of Technology, and Aalto-yliopisto

Subjects
[PHYS]Physics [physics], Settore FIS/01, Settore ING-IND/18 - Fisica dei Reattori Nucleari, General Physics and Astronomy, simulation, magnetically confined plasma, nuclear fusion, tokamaks, turbulence suppression, Plasma, [PHYS.PHYS.PHYS-PLASM-PH]Physics [physics]/Physics [physics]/Plasma Physics [physics.plasm-ph], confinement, transport, Alpha particles, Fusion reactors, Turbulence, physics
Abstract

openaire: EC/H2020/633053/EU//EUROfusion Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Funding Information: We thank M. Baruzzo and F. Nave for the preparation and execution of JET experiments discussed in this paper; E. de la Luna for support in detailing the experimental diagnostics of JET; A. Ho for assistance in processing the experimental data; T. Görler for providing essential advice to ensure the correct numerical setup for the GENE modelling reported in this paper; Y. Camenen, X. Garbet and A. Bierwage for fruitful discussions about the gyrokinetic analyses; G. Giruzzi for valuable suggestions on the article strategy. The simulations were performed on the IRENE Joliot-Curie HPC system, in the framework of the PRACE projects IONFAST and AFIETC, led by J. Garcia, and on the CINECA Marconi HPC within the project GENE4EP, led by D. Zarzoso. This work has been carried out within the framework of the EUROfusion Consortium and has received funding from the Euratom research and training programme 2014-2018 and 2019-2020 under grant agreement no. 633053. The views and opinions express herein do not necessarily reflect those of the European Commission. Part of the work by Ye. O. Kazakov and J.Ongena was also carried out in the framework of projects done for the ITER Scientist Fellow Network (ISFN). Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Limited. Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.

Published
2022
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35. Disruption prediction with artificial intelligence techniques in tokamak plasmas

Author

Vega, J, Murari, A, Dormido-Canto, S, Ratta, G, Gelfusa, M, Mailloux, J, Abid, N, Abraham, K, Abreu, P, Adabonyan, O, Adrich, P, Afanasev, V, Afzal, M, Ahlgren, T, Aho-Mantila, L, Aiba, N, Airila, M, Akhtar, M, Albanese, R, Alderson-Martin, M, Alegre, D, Aleiferis, S, Aleksa, A, Alekseev, A, Alessi, E, Aleynikov, P, Algualcil, J, Ali, M, Allinson, M, Alper, B, Alves, E, Ambrosino, G, Ambrosino, R, Amosov, V, Sunden, E, Andrew, P, Angelini, B, Angioni, C, Antoniou, I, Appel, L, Appelbee, C, Aria, S, Ariola, M, Artaserse, G, Arter, W, Artigues, V, Asakura, N, Ash, A, Ashikawa, N, Aslanyan, V, Astrain, M, Asztalos, O, Auld, D, Auriemma, F, Austin, Y, Avotina, L, Aymerich, E, Baciero, A, Bairaktaris, F, Balbin, J, Balbinot, L, Balboa, I, Balden, M, Balshaw, C, Balshaw, N, Bandaru, V, Banks, J, Baranov, Y, Barcellona, C, Barnard, A, Barnard, M, Barnsley, R, Barth, A, Baruzzo, M, Barwell, S, Bassan, M, Batista, A, Batistoni, P, Baumane, L, Bauvir, B, Baylor, L, Beaumont, P, Beckett, D, 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A., Huynh P., Hynes A., Iliasova M., lmrie D., lmrisek M., lngleby J., Innocente P., Bjork K. I., Isernia N., lvanova-Stanik I., lvings E., Jablonski S., Jachmich S., Jackson T., Jacquet P., Jarleblad H., Jaulmes F., Rodriguez J. J., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Jones C., Jones G., Jones L., Jones N., Jones T., Joyce A., Juarez R., Juvonen M., Kalnina P., Kaltiaisenaho T., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Kashchuk Y., Kaufman M., Kaveney G., Kazakov Y. E. O., Kazantzidis V., Keeling D. L., Kelly R., Kempenaars M., Kennedy C., Kennedy D., Kent J., Khan K., Khilkevich E., Kiefer C., Kilpelainen J., Kim C., Kim H. -T., Kim S. H., King D. B., King R., Kinna D., Kiptily V. G., Kirjasuo A., Kirov K. K., Kirschner A., kiviniemi T., Kizane G., Klas M., Klepper C., Klix A., Kneale G., Knight M., Knight P., Knights R., Knipe S., Knolker M., Knott S., Kocan M., Kochl F., Kodeli I., Kolesnichenko Y., Kominis Y., Kong M., Korovin V., Kos B., Kos D., Koslowski H. R., Kotschenreuther M., Koubiti M., Kowalska-Strzeciwilk E., Koziol K., Krasilnikov A., Krasilnikov V., Kresina M., Krieger K., Krishnan N., Krivska A., Kruezi U., Ksiezek I., Kukushkin A. B., Kumpulainen H., Kurki-Suonio T., Kurotaki H., Kwak S., Kwon O. J., Laguardia L., Lagzdina E., Lahtinen A., Laing A., Lam N., Lambertz H. T., Lane B., Lane C., Neto E. L., Laszyriska E., Lawson K. D., Lazaros A., Lazzaro E., Learoyd G., Lee C., Lee S. E., Leerink S., Leeson T., Lefebvre X., Leggate H. J., Lehmann J., Lehnen M., Leichtle D., Leipold F., Lengar I., Lennholm M., Gutierrez E. L., Lepiavko B., Leppanen J., Lerche E., Lescinskis A., Lewis J., Leysen W., Li L., Li Y., Likonen J., Linsmeier C., Lipschultz B., Litaudon X., Litherland-Smith E., Liu F., Loarer T., Loarte A., Lobel R., Lomanowski B., Lomas P. J., Lopez J. M., Lorenzini R., Loreti S., Losada U., Loschiavo V. P., Loughlin M., Louka Z., Lovell J., Lowe T., Lowry C., Lubbad S., Luce T., Lucock R., Lukin A., Luna C., de la Luna E., Lungaroni M., Lungu C. P., Lunt T., Lutsenko V., Lyons B., Lyssoivan A., Machielsen M., Macusova E., Maenpaa R., Maggi C. F., Maggiora R., Magness M., Mahesan S., Maier H., Maingi R., Malinowski K., Manas P., Mantica P., Mantsinen M. J., Manyer J., Manzanares A., Maquet P., Marceca G., Marcenko N., Marchetto C., Marchuk O., Mariani A., Mariano G., Marin M., Marinelli M., Markovic T., Marocco D., Marot L., Marsden S., Marsh J., Marshall R., Martellucci L., Martin A., Martin A. J., Martone R., Maruyama S., Maslov M., Masuzaki S., Matejcik S., Mattei M., Matthews G. F., Matveev D., Matveeva E., Mauriya A., Maviglia F., Mayer M., Mayoral M. -L., Mazzi S., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McClenaghan J., McCullen P., McDonald D. C., McGuckin D., McHugh D., Mclntyre G., McKean R., McKehon J., McMillan B., McNamee L., McShee A., Meakins A., Medley S., Meekes C. J., Meghani K., Meigs A. G., Meisl G., Meitner S., Menmuir S., Mergia K., Merriman S., Mertens P., Meshchaninov S., Messiaen A., Michling R., Middleton P., Middleton-Gear D., Mietelski J., Milanesio D., Milani E., Militello F., Asp A. M., Milnes J., Milocco A., Miloshevsky G., Minghao C., Minucci S., Miron I., Miyamoto M., Mlynar J., Moiseenko V., Monaghan P., Monakhov I., Moody T., Moon S., Mooney R., Moradi S., Morales J., Morales R. B., Mordijck S., Moreira L., Morgan L., Moro F., Morris J., Morrison K. -M., Moser L., Moulton D., Mrowetz T., Mundy T., Muraglia M., Muraro A., Muthusonai N., N'Konga B., Na Y. -S., Nabais F., Naden M., Naish J., Naish R., Napoli F., Nardon E., Naulin V., Nave M. F. F., Nedzelskiy I., Nemtsev G., Nesenevich V., Nestoras I., Neu R., Neverov V. S., Ng S., Nicassio M., Nielsen A. H., Nina D., Nishijima D., Noble C., Nobs C. R., Nocente M., Nodwell D., Nordlund K., Nordman H., Normanton R., Noterdaeme J. M., Nowak S., Nunn E., Nystrom H., Oberparleiter M., Obryk B., O'Callaghan J., Odupitan T., Oliver H. J. C., Olney R., O'Mullane M., Ongena J., Organ E., Orsitto F., Orszagh J., Osborne T., Otin R., Otsuka T., Owen A., Oya Y., Oyaizu M., Paccagnella R., Pace N., Packer L. W., Paige S., Pajuste E., Palade D., Pamela S. J. P., Panadero N., Panontin E., Papadopoulos A., Papp G., Papp P., Parail V. V., Pardanaud C., Parisi J., Diaz F. P., Parsloe A., Parsons M., Parsons N., Passeri M., Patel A., Pau A., Pautasso G., Pavlichenko R., Pavone A., Pawelec E., Soldan C. P., Peacock A., Pearce M., Peluso E., Penot C., Pepperell K., Pereira R., Pereira T., Cippo E. P., Pereslavtsev P., Perez von Thun C., Pericoli V., Perry D., Peterka M., Petersson P., Petravich G., Petrella N., Peyman M., Pillon M., Pinches S., Pintsuk G., Pires de Sa W., Pires dos Reis A., Piron C., Piron L., Pironti A., Pitts R., van de Plassche K. L., Platt N., Plyusnin V., Podesta M., Pokol G., Poli F. M., Pompilian O. G., Popovichev S., Poradzinski M., Porfiri M. T., Porkolab M., Porosnicu C., Porton M., Poulipoulis G., Predebon I., Prestopino G., Price C., Price D., Price M., Primetzhofer D., Prior P., Provatas G., Pucella G., Puglia P., Purahoo K., Pusztai I., Putignano O., Putterich T., Quercia A., Rachlew E., Radulescu G., Radulovic V., Rainford M., Raj P., Ralph G., Ramogida G., Rasmussen D., Rasmussen J. J., Ratynskaia S., Rebai M., Refy D., Reichle R., Reinke M., Reiser D., Reux C., Reynolds S., Richiusa M. L., Richyal S., Rigamonti D., Rimini F. G., Risner J., Riva M., Rivero-Rodriguez J., Roach C. M., Robins R., Robinson S., Robson D., Rodionov R., Rodrigues P., Ramos M. R., Rodriguez-Fernandez P., Romanelli F., Romanelli M., Romanelli S., Romazanov J., Rossi R., Rowe S., Rowlands D., Rubel M., Rubinacci G., Rubino G., Ruchko L., Ruiz M., Ruiz J. R., Ruset C., Rzadkiewicz J., Saarelma S., Safi E., Sahlberg A., Salewski M., Salmi A., Salmon R., Salzedas F., Sanders I., Sandiford D., Santos B., Santucci A., Sarkimaki K., Sarwar R., Sarychev I., Sauter O., Sauwan P., Scapin N., Schluck F., Schmid K., Schmuck S., Schneider M., Schneider P. A., Schworer D., Scott G., Scott M., Scraggs D., Scully S., Segato M., Seo J., Sergienko G., Sertoli M., Sharapov S. E., Shaw A., Sheikh H., Sheikh U., Shepherd A., Shevelev A., Shigin P., Shinohara K., Shiraiwa S., Shiraki D., Short M., Sias G., Silburn S. A., Silva A., Silva C., Silva J., Silvagni D., Simfukwe D., Simpson J., Sinclair D., Sipila S. K., Sips A. C. C., Siren P., Sirinelli A., Sjostrand H., Skinner N., Slater J., Smith N., Smith P., Snell J., Snoep G., Snoj L., Snyder P., Soare S., Solano E. R., Solokha V., Somers A., Sommariva C., Soni K., Sorokovoy E., Sos M., Sousa J., Sozzi C., Spagnolo S., Spelzini T., Spineanu F., Spong D., Sprada D., Sridhar S., Srinivasan C., Stables G., Staebler G., Stamatelatos I., Stancar Z., Staniec P., Stankunas G., Stead M., Stefanikova E., Stephen A., Stephens J., Stevenson P., Stojanov M., Strand P., Strauss H. R., Strikwerda S., Strom P., Stuart C. I., Studholme W., Subramani M., Suchkov E., Sumida S., Sun H. J., Susts T. E., Svensson J., Svoboda J., Sweeney R., Sytnykov D., Szabolics T., Szepesi G., Tabia B., Tadic T., Tal B., Tala T., Tallargio A., Tamain P., Tan H., Tanaka K., Tang W., Tardocchi M., Taylor D., Teimane A. S., Telesca G., Teplova N., Teplukhina A., Terentyev D., Terra A., Terranova D., Terranova N., Testa D., Tholerus E., Thomas J., Thoren E., Thorman A., Tierens W., Tinguely R. A., Tipton A., Todd H., Tokitani M., Tolias P., Tomes M., Tookey A., Torikai Y., von Toussaint U., Tsavalas P., Tskhakaya D., Turner I., Turner M., Turner M. M., Turnyanskiy M., Tvalashvili G., Tyrrell S., Tyshchenko M., Uccello A., Udintsev V., Urbanczyk G., Vadgama A., Valcarcel D., Valisa M., Olivares P. V., Vallhagen O., Valovic M., Eester D. V., Varje J., Vartanian S., Vasilopoulou T., Vayakis G., Vecsei M., Ventre S., Verdoolaege G., Verona C., Rinati G. V., Veshchev E., Vianello N., Viezzer E., Vignitchouk L., Vila R., Villari R., Villone F., Vincenzi P., Vinyar I., Viola B., Virtanen A. J., Vitins A., Vizvary Z., Vlad G., Vlad M., Vondracek P., de Vries P., Wakeling B., Walkden N. R., Walker M., Walker R., Walsh M., Wang E., Wang N., Warder S., Warren R., Waterhouse J., Watts C., Wauters T., Weckmann A., Maxwell H. W., Weiland M., Weisen H., Weiszflog M., Welch P., Wendler N., West A., Wheatley M., Wheeler S., Whitehead A., Whittaker D., Widdowson A., Wiesen S., Wilkinson J., Williams J. C., Willoughby D., Wilson I., Wilson J., Wilson T., Wischmeier M., Wise P., Withenshaw G., Withycombe A., Witts D., Wojcik-Gargula A., Wolfrum E., Wood R., Woodley C., Woodley R., Woods B., Wright J., Wright J. C., Xu T., Yadikin D., Yajima M., Yakovenko Y., Yang Y., Yanling W., Yanovskiy V., Young I., Young R., Zabolockis R. J., Zacks J., Zagorski R., Zaitsev F. S., Zakharov L., Zarins A., Fernandez D. Z., Zastrow K. -D., Zayachuk Y., Zerbini M., Zhang W., Zhou Y., Zlobinski M., Zocco A., Zohar A., Zoita V., Zoletnik S., Zotta V. 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J., Vitins A., Vizvary Z., Vlad G., Vlad M., Vondracek P., de Vries P., Wakeling B., Walkden N. R., Walker M., Walker R., Walsh M., Wang E., Wang N., Warder S., Warren R., Waterhouse J., Watts C., Wauters T., Weckmann A., Maxwell H. W., Weiland M., Weisen H., Weiszflog M., Welch P., Wendler N., West A., Wheatley M., Wheeler S., Whitehead A., Whittaker D., Widdowson A., Wiesen S., Wilkinson J., Williams J. C., Willoughby D., Wilson I., Wilson J., Wilson T., Wischmeier M., Wise P., Withenshaw G., Withycombe A., Witts D., Wojcik-Gargula A., Wolfrum E., Wood R., Woodley C., Woodley R., Woods B., Wright J., Wright J. C., Xu T., Yadikin D., Yajima M., Yakovenko Y., Yang Y., Yanling W., Yanovskiy V., Young I., Young R., Zabolockis R. J., Zacks J., Zagorski R., Zaitsev F. S., Zakharov L., Zarins A., Fernandez D. Z., Zastrow K. -D., Zayachuk Y., Zerbini M., Zhang W., Zhou Y., Zlobinski M., Zocco A., Zohar A., Zoita V., Zoletnik S., Zotta V. K., Zoulias I., Zwingmann W., and Zychor I.

Abstract

In nuclear fusion reactors, plasmas are heated to very high temperatures of more than 100 million kelvin and, in so-called tokamaks, they are confined by magnetic fields in the shape of a torus. Light nuclei, such as deuterium and tritium, undergo a fusion reaction that releases energy, making fusion a promising option for a sustainable and clean energy source. Tokamak plasmas, however, are prone to disruptions as a result of a sudden collapse of the system terminating the fusion reactions. As disruptions lead to an abrupt loss of confinement, they can cause irreversible damage to present-day fusion devices and are expected to have a more devastating effect in future devices. Disruptions expected in the next-generation tokamak, ITER, for example, could cause electromagnetic forces larger than the weight of an Airbus A380. Furthermore, the thermal loads in such an event could exceed the melting threshold of the most resistant state-of-the-art materials by more than an order of magnitude. To prevent disruptions or at least mitigate their detrimental effects, empirical models obtained with artificial intelligence methods, of which an overview is given here, are commonly employed to predict their occurrence—and ideally give enough time to introduce counteracting measures.

Published
2022

36. Enhanced performance in fusion plasmas through turbulence suppression by megaelectronvolt ions

Author

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M., Turnyanskiy M., Tvalashvili G., Tyrrell S., Tyshchenko M., Uccello A., Udintsev V., Urbanczyk G., Vadgama A., Valcarcel D., Valisa M., Vallejos Olivares P., Vallhagen O., Valovic M., Van Eester D., Varje J., Vartanian S., Vasilopoulou T., Vayakis G., Vecsei M., Vega J., Ventre S., Verdoolaege G., Verona C., Rinati G. V., Veshchev E., Vianello N., Viezzer E., Vignitchouk L., Vila R., Villari R., Villone F., Vincenzi P., Viola B., Virtanen A. J., Vitins A., Vizvary Z., Vlad G., Vlad M., Vondracek P., de Vries P., Wakeling B., Walkden N. R., Walker M., Walker R., Walsh M., Wang E., Wang N., Warder S., Warren R., Waterhouse J., Watts C., Wauters T., Weckmann A., Wedderburn Maxwell H., Weiland M., Weisen H., Weiszflog M., Welch P., Wendler N., West A., Wheatley M., Wheeler S., Whitehead A., Whittaker D., Widdowson A., Wiesen S., Wilkinson J., Williams J. 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A., Huynh P., Hynes A., Imrie D., Imrisek M., Ingleby J., Innocente P., Insulander Bjork K., Isernia N., Ivanova-Stanik I., Ivings E., Jablonski S., Jachmich S., Jackson T., Jacquet P., Jarleblad H., Jaulmes F., Rodriguez J. J., Jepu I., Joffrin E., Johnson R., Johnson T., Johnston J., Jones C., Jones G., Jones L., Jones N., Jones T., Joyce A., Juarez R., Juvonen M., Kalnina P., Kaltiaisenaho T., Kaniewski J., Kantor A., Kappatou A., Karhunen J., Karkinsky D., Kaufman M., Kaveney G., Kazantzidis V., Keeling D. L., Kelly R., Kempenaars M., Kennedy C., Kennedy D., Kent J., Khan K., Kiefer C., Kilpelainen J., Kim C., Kim H. -T., Kim S. H., King D. B., King R., Kinna D., Kiptily V. G., Kirjasuo A., Kirov K. K., Kirschner A., Kiviniemi T., Kizane G., Klas M., Klepper C., Klix A., Kneale G., Knight M., Knight P., Knights R., Knipe S., Knolker M., Knott S., Kocan M., Kochl F., Kodeli I., Kolesnichenko Y., Kominis Y., Kong M., Korovin V., Kos B., Kos D., Koslowski H. R., Kotschenreuther M., Koubiti M., Kowalska-Strzeciwilk E., Koziol K., Krasilnikov V., Kresina M., Krieger K., Krishnan N., Krivska A., Kruezi U., Ksiazek I., Kukushkin A. B., Kumpulainen H., Kurki-Suonio T., Kurotaki H., Kwak S., Kwon O. J., Laguardia L., Lagzdina E., Lahtinen A., Laing A., Lam N., Lambertz H. T., Lane B., Lane C., Lascas Neto E., Laszynska E., Lawson K. D., Lazaros A., Lazzaro E., Learoyd G., Lee C., Lee S. E., Leerink S., Leeson T., Lefebvre X., Leggate H. J., Lehmann J., Lehnen M., Leichtle D., Leipold F., Lengar I., Lennholm M., Leon Gutierrez E., Lepiavko B., Leppanen J., Lerche E., Lescinskis A., Lewis J., Leysen W., Li L., Li Y., Likonen J., Linsmeier C., Lipschultz B., Litaudon X., Litherland-Smith E., Liu F., Loarer T., Loarte A., Lobel R., Lomanowski B., Lomas P. J., Lopez J. M., Lorenzini R., Loreti S., Losada U., Loschiavo V. P., Loughlin M., Louka Z., Lovell J., Lowe T., Lowry C., Lubbad S., Luce T., Lucock R., Luna C., de la Luna E., Lungaroni M., Lungu C. P., Lunt T., Lutsenko V., Lyons B., Lyssoivan A., Machielsen M., Macusova E., Maenpaa R., Maggi C. F., Maggiora R., Magness M., Mahesan S., Maier H., Mailloux J., Maingi R., Malinowski K., Manas P., Mantica P., Mantsinen M. J., Manyer J., Manzanares A., Maquet P., Marceca G., Marchetto C., Marchuk O., Mariani A., Mariano G., Marin M., Marinelli M., Markovic T., Marocco D., Marot L., Marsden S., Marsh J., Marshall R., Martellucci L., Martin A., Martin A. J., Martone R., Maruyama S., Maslov M., Masuzaki S., Matejcik S., Mattei M., Matthews G. F., Matveev D., Matveeva E., Mauriya A., Maviglia F., Mayer M., Mayoral M. -L., Mazzotta C., McAdams R., McCarthy P. J., McClements K. G., McClenaghan J., McCullen P., McDonald D. C., McGuckin D., McHugh D., McIntyre G., McKean R., McKehon J., McMillan B., McNamee L., McShee A., Meakins A., Medley S., Meekes C. J., Meghani K., Meigs A. G., Meisl G., Meitner S., Menmuir S., Mergia K., Merriman S., Mertens P., Messiaen A., Michling R., Middleton P., Middleton-Gear D., Mietelski J., Milanesio D., Milani E., Militello F., Militello Asp A., Milnes J., Milocco A., Miloshevsky G., Minghao C., Minucci S., Miron I., Miyamoto M., Mlynar J., Moiseenko V., Monaghan P., Monakhov I., Moody T., Moon S., Mooney R., Moradi S., Morales J., Morales R. B., Mordijck S., Moreira L., Morgan L., Moro F., Morris J., Morrison K. -M., Moser L., Moulton D., Mrowetz T., Mundy T., Muraglia M., Murari A., Muraro A., Muthusonai N., N'Konga B., Na Y. -S., Nabais F., Naden M., Naish J., Naish R., Napoli F., Nardon E., Naulin V., Nave M. F. F., Nedzelskiy I., Nestoras I., Neu R., Ng S., Nicassio M., Nielsen A. H., Nina D., Nishijima D., Noble C., Nobs C. R., Nodwell D., Nordlund K., Nordman H., Normanton R., Noterdaeme J. -M., Nowak S., Nunn E., Nystrom H., Oberparleiter M., Obryk B., O'Callaghan J., Odupitan T., Oliver H. J. 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Abstract

Alpha particles with energies on the order of megaelectronvolts will be the main source of plasma heating in future magnetic confinement fusion reactors. Instead of heating fuel ions, most of the energy of alpha particles is transferred to electrons in the plasma. Furthermore, alpha particles can also excite Alfvénic instabilities, which were previously considered to be detrimental to the performance of the fusion device. Here we report improved thermal ion confinement in the presence of megaelectronvolts ions and strong fast ion-driven Alfvénic instabilities in recent experiments on the Joint European Torus. Detailed transport analysis of these experiments reveals turbulence suppression through a complex multi-scale mechanism that generates large-scale zonal flows. This holds promise for more economical operation of fusion reactors with dominant alpha particle heating and ultimately cheaper fusion electricity.

Published
2022

38. Dupilumab Reduced Severe Exacerbation Rates and Improved Pre-bronchodilator Fev1 in Patients With Moderate-to-Severe Asthma Regardless of Exacerbation History of 蠅1, 蠅2, or 蠅3 Prior Exacerbations: Liberty Asthma Traverse

Author

Maspero, J.F., primary, Corren, J., additional, Katelaris, C., additional, Castro, M., additional, Humbert, M.J.C., additional, Halpin, D.M.G., additional, Altincatal, A., additional, Pandit-Abid, N., additional, Soler, X., additional, Radwan, A., additional, Jacob-Nara, J.A., additional, Deniz, Y.M., additional, and Rowe, P.J., additional

Published
2023
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39. Dupilumab Induces Clinical Remission in Patients With Uncontrolled, Moderate-to-Severe, Type 2 Inflammatory Asthma

Author

Pavord, I.D., primary, Israel, E., additional, Szefler, S.J., additional, Brusselle, G., additional, Rabe, K.F., additional, Chen, Z., additional, Altincatal, A., additional, Radwan, A., additional, Pandit-Abid, N., additional, Amin, N., additional, Jacob-Nara, J.A., additional, Rowe, P.J., additional, Deniz, Y.M., additional, Khan, A., additional, Lederer, D.J., additional, Zhang, Y., additional, and Busse, W., additional

Published
2023
Full Text
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45. An Updated Combined Biomass index of abundance for North Atlantic Swordfish Stock 1963-2012

Author

Ortiz-de-Urbina-Gutiérrez, J.M. (José María), Mejuto-García, J. (Jaime), Andrushchenko, I. (Irene), Walter, J., Neves-dos-Santos, M., and Abid, N.

Subjects
Pesquerías, Centro Oceanográfico de A Coruña
Abstract

Surplus Production Models of North Atlantic swordfish have been used in addition to age structured virtual population analyses by ICCAT's SCRS to evaluate the status of the resource and to provide a basis for management advice. Production models require a standardized index of relative abundance in terms of biomass. The standardized biomass index of abundance developed for the 2006, 2008 and 2012 ICCAT SCRS meetings for North Atlantic swordfish was revised and updated with data through 2015. Generalized Linear Modeling (GLM) procedures were used to standardize swordfish catch (biomass) and effort (number of hooks) data from the major longline fleets operating in the North Atlantic; United States, EU-Spain, Canada, Japan, Morocco and EU-Portugal. As in past analyses, main effects included: year, area, quarter, a nation-operation variable accounting for gear and operational differences thought to influence swordfish catchability, and a target variable to account for trips where fishing operations varied according to the main target species. Interactions among main factors were also evaluated. 0

Published
2023

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