Search

Your search keyword '"Abella, N."' showing total 94 results
Start Over Author "Abella, N."
94 results on '"Abella, N."'

7. Murine Model for the Study of Influenza D Virus

Author

Oliva, J., primary, Mettier, J., additional, Sedano, L., additional, Delverdier, M., additional, Bourgès-Abella, N., additional, Hause, B., additional, Loupias, J., additional, Pardo, I., additional, Bleuart, C., additional, Bordignon, P. J., additional, Meunier, E., additional, Le Goffic, R., additional, Meyer, G., additional, and Ducatez, M. F., additional

Published
2020
Full Text
View/download PDF

8. Development of a dietary-PTU model of gradual thyroid disruption (hypothyroidism) in the mouse

Author

Claustre, Lucie, Viguié, Catherine, Layssol, C., Bury, A., Mialon, L., Bourgès-Abella, N., Kolf-Clauw, Martine, ProdInra, Migration, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA), Ecole Nationale Vétérinaire de Toulouse (ENVT), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Exposition, Perturbation Endocrino-métabolique et Reproduction (ToxAlim-EXPER), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3)

Subjects
[SDV.TOX] Life Sciences [q-bio]/Toxicology, [SDV.TOX]Life Sciences [q-bio]/Toxicology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019

15. Hematologic and biochemical biologic variation in laboratory cats

Author

cathy trumel, Monzali, C., Geffré, A., Concordet, D. V., Hourqueig, L., Braun, J. -P D., Bourgès-Abella, N. H., ProdInra, Migration, Université Fédérale Toulouse Midi-Pyrénées, AmatsiGroup, ToxAlim (ToxAlim), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Ecole d'Ingénieurs de Purpan (INPT - EI Purpan), and Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Recherche Agronomique (INRA)

Subjects
validation, parameters, [SDV] Life Sciences [q-bio], clinically healthy dogs, reference intervals, variability, [SDV]Life Sciences [q-bio], reference change values, leukocyte counts, consequences, analytes, sports
Abstract

International audience; The biologic variation associated with a clinical pathology result is important to consider before reference intervals (RI) are used. Most available RI are population-based RI, in which the analytical variability, interindividual variability, and intraindividual variability are confounded. In addition, when the intraindividual variability is considerably less than the interindividual variability, a population-based RI is insufficiently sensitive to detect changes in a subject over time. Here we determined the biologic variation and reference change value (RCV) of hematologic and biochemical variables in laboratory cats. Blood specimens from 14 (7 females and 7 males) overnight-fasted laboratory cats sampled 7 times (days 1, 2, 7,14, 31, 42, and 100) were analyzed regarding hematology and biochemistry variables. For each variable, analytical, intraindividual, and interindividual coefficients of variation were estimated prior to calculation of the index of individuality and the RCV. RBC variables (count, Hgb, Hct, MCV, MCH, MCHC, and RBC distribution width) and 5 biochemical analytes (cholesterol, creatinine, triglycerides, ALP, and calcium) exhibited marked individuality, therefore indicating that subject-based reference intervals or RCV would be preferable when monitoring these variables in laboratory cats. Population-based RI were shown to be adequate for glucose and sodium, and both types of population and individual RI were similarly efficient for albumin, total protein, urea, ALT, AST, creatine kinase, chloride, carbon dioxide, iron, magnesium, inorganic phosphate, and potassium and reticulocyte, WBC, neutrophil, lymphocyte, monocyte, eosinophil, and platelet counts. The RCV determined in the present study provide a valuable tool for monitoring hematologic and biochemical variables in healthy laboratory cats.

Published
2016

16. Use of Monoclonal Antibodies for Immunohistochemical Study of Bovine Lymph Nodes on Frozen Sections

Author

Delverdier, Maxence, Abella, N., Schelcher, F., Pradeau, P., Espinasse, J., Cabanie, P., Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], General Veterinary, Antigens, CD, T-Lymphocyte Subsets, [SDV]Life Sciences [q-bio], Animals, Antibodies, Monoclonal, Frozen Sections, Cattle, Female, Lymph Nodes, General Medicine, Immunohistochemistry
Abstract

Many monoclonal antibodies reactive with bovine leukocyte differentiation antigens are now available. Immunohistochemical staining on frozen sections using these monoclonal antibodies permits study of the functional morphology of bovine lymph nodes. Our study confirms usually accepted notions (B and T dependent-zones) and supplies complementary data about the repartition of CD4 cells (particularly intrafollicular positive cells), gamma delta T cells, MHC II expression and dendritic leukocytes.

Published
1993
Full Text
View/download PDF

17. Predictive toxicology: the paths of the future

Author

Detilleux, Ph, Vallier, L, Legallais, C, Leclerc, E, Prot J, M, Choucha, L, Baudoin, R, Dufresne, M, Gautier, A, Carpentier, B, Mansuy, D, Pery, Alexandre R.R., Brochot, C, Manivet, Ph, Rabilloud, Thierry, Spire, C, Coumoul, Xavier, Junot, Ch, Laprevote, O, Le Pape, A, Tourneur, E, Ben Mkaddem, S, Chassin, C, Aloulou, M, Goujon J, M, Hertif, A, Ouali, N, Vimont, S, Monteiro, R, Rondeau, E, Elbim, C, Werts, C, Vandewalle, A, Pedruzzi, E, Coant, N, Bens, M, Cluzeaud, F, Ogier-Denis, E, Pongnimitprasert, N, Babin-Chevaye, C, Fay, M, Bernard, M, Dupuy, C, Ei Benna, J, Gougerot-Pocidale M, A, Braut-Boucher, F, Pinton, Philippe, Lucioli, Joelma, Tsybulskyy, D, Joly, Baptiste, Laffitte, J, Bourges-Abella, N, Oswald, Isabelle P., Kolf-Clauw, Martine, Pierre, St, Bats A, S, Chevalier, Aline, Bui L, Ch, Ambolet-Camoit, A, Garlatti, M, Aggerbeck, M, Barouki, R, Al Khansa, I, Blanck, O, Guillouzo, A, Bars, R, Rouas, C, Bensoussan, H, Suhard, D, Tessier, C, Grandcolas, L, Pallardy, M, Gueguen, Y, Sparfel, L, Pinel-Marie M, L, Boize, M, Koscielny, S, Desmots, S, Fardel, O, Alvergnas, M, Rouleau, A, Lucchi, G, Mantion, G, Heyd, B, Richert, L, Ducoroy, P, Martin, H, Val, St, Martinon, L, Cachier, H, Yahyaoui, A, Marfaing, H, Baeza-Squiban, A, Martin-Chouly, Corinne, Bonvallet, M, Morzadec, C, Vernhet, L, Baverel, G, El Hage, M, Nazaret, R, Conjard-Duplany, A, Ferrier, B, Martin, G, Legendre, A, Lecomte, Anthony, Froment, P, Habert, R, Lemazurier, E, Robinel, F, Dupont, O, Sanfins, E, Dairou, J, Chaffotte A, F, Busi, F, Rodrigues Lima, F, Dupret J, M, Mayati, A, Le Ferrec, Eric, Levoin, N, Paris, H, Uriac, Ph, N'Diaye, M, Lagadic-Gossmann, D, Assemat, E, Boublil, L, Borot M, C, Marano, F, Martiny V, Y, Moroy, G, Badel, A, Miteva M, A, Hussain, S, Ferecatu, I, Borot, C, Andreau, K, Boland, S, Leroux, M, Zucchini-Pascal, Nathalie, Peyre, L, Rahmani, Roger, Buron, N, Porcedou, M, Fromenty, B, Borgne-Sanchez, A, Rogue, A, Claude, N, Le Guével, Rémy, Institut National de l'Environnement Industriel et des Risques (INERIS), Laboratoire pharmaceutique Biologie Servier, Biologie Servier, Pharmacologie, toxicologie et signalisation cellulaire (U747), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Faculté de Médecine Xavier Bichat, Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), Toxicité environnementale, cibles thérapeutiques, signalisation cellulaire (T3S - UMR_S 1124), Cytokines, chimiokines et immunopathologie, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biostatistique et d'épidémiologie (SBE), Direction de la recherche clinique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) (FDE), Université de Franche-Comté (UFC), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] (CLIPP), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Centre National de la Recherche Scientifique (CNRS), Cellules Souches et Radiations (SCSR (U967 / UMR-E_008)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris-Sud - Paris 11 (UP11), Laboratoire Bioprojet, Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes-Centre National de la Recherche Scientifique (CNRS), Unité de Biologie Fonctionnelle et Adaptative (BFA (UMR_8251 / U1133)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Mitologics SAS, Hôpital Robert Debré, Biomécanique et Bioingénierie (BMBI), Université de Technologie de Compiègne (UTC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de radiotoxicologie expérimentale (IRSN/DRPH/SRBE/LRTOX), Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Stabilité génétique, Cellules Souches et Radiations (SCSR (U_967)), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] (ICMUB), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Paris-Sud - Paris 11 (UP11)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Université Paris-Sud - Paris 11 (UP11)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Rennes-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES), Institut National de l'Environnement Industriel et des Risques ( INERIS ), Physiologie Cellulaire des Regulations Hormonales, Nutritionnelles et Pharmacologiques, Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de recherche biomédicale Bichat-Beaujon ( CRB3 ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Unité de recherche Pharmacologie-Toxicologie ( UPT ), Institut National de la Recherche Agronomique ( INRA ), Toxicologie, Pharmacologie et Signalisation Cellulaire ( U1124 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Centre National de la Recherche Scientifique ( CNRS ), Université Paris-Sud - Paris 11 ( UP11 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service de biostatistique et d'épidémiologie ( SBE ), Institut Gustave Roussy ( IGR ) -Institut Gustave Roussy ( IGR ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Fonctions et dysfonctions épithéliales - UFC (EA 4267) ( FDE ), Université de Franche-Comté ( UFC ), Plate-forme Protéomique CLIPP - Clinical and Innovation Proteomic Platform [Dijon] ( CLIPP ), Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) ( FEMTO-ST ), Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Université de Franche-Comté ( UFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Ecole Nationale Supérieure de Mécanique et des Microtechniques ( ENSMM ) -Université de Technologie de Belfort-Montbeliard ( UTBM ) -Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon] ( ICMUB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] ( LSCE ), Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Centre National de la Recherche Scientifique ( CNRS ), Cellules Souches et Radiations ( SCSR - U 967 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Institut des Sciences Chimiques de Rennes ( ISCR ), Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -Ecole Nationale Supérieure de Chimie de Rennes-Institut National des Sciences Appliquées ( INSA ) -Centre National de la Recherche Scientifique ( CNRS ), Biologie Fonctionnelle et Adaptative ( BFA ), and Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
[ SDV ] Life Sciences [q-bio], [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2010

18. Toxicologie predictive: les voies du futur

Author

Ph Detilleux, Vallier, L., Legallais, C., Leclerc, E., M Prot J, Choucha, L., Baudoin, R., Dufresne, M., Gautier, A., Carpentier, B., Mansuy, D., Pery, Alexandre R. R., Brochot, C., Ph Manivet, Thierry Rabilloud, Spire, C., Xavier Coumoul, Ch Junot, Laprevote, O., Le Pape, A., Ronan Le Guével, Tourneur, E., Ben Mkaddem, S., Chassin, C., Aloulou, M., M Goujon J, Hertif, A., Ouali, N., Vimont, S., Monteiro, R., Rondeau, E., Elbim, C., Werts, C., Vandewalle, A., Pedruzzi, E., Coant, N., Bens, M., Cluzeaud, F., Ogier-Denis, E., Pongnimitprasert, N., Babin-Chevaye, C., Fay, M., Bernard Fromenty, Dupuy, C., Ei Benna, J., A Gougerot-Pocidale M, Braut-Boucher, F., Ph Pinton, Lucioli, J., Tsybulskyy, D., Baptiste Joly, Laffitte, J., Bourges-Abella, N., P Oswald I, Kolf-Clauw, M., St Pierre, S Bats A, Aline Chevalier, Ch Bui L, Ambolet-Camoit, A., Garlatti, M., Aggerbeck, M., Barouki, R., Al Khansa, I., Blanck, O., Guillouzo, A., Bars, R., Rouas, C., Bensoussan, H., Suhard, D., Tessier, C., Grandcolas, L., Pallardy, M., Gueguen, Y., Sparfel, L., L Pinel-Marie M, Boize, M., Koscielny, S., Desmots, S., Fardel, O., Alvergnas, M., Rouleau, A., Lucchi, G., Mantion, G., Heyd, B., Richert, L., Ducoroy, P., Martin, H., St Val, Martinon, L., Cachier, H., Yahyaoui, A., Marfaing, H., Baeza-Squiban, A., Corinne Martin-Chouly, Bonvallet, M., Morzadec, C., Vernhet, L., Baverel, G., El Hage, M., Nazaret, R., Conjard-Duplany, A., Ferrier, B., Martin, G., Legendre, A., Lecomte, A., Froment, P., Habert, R., Lemazurier, E., Robinel, F., Dupont, O., Sanfins, E., Dairou, J., F Chaffotte A, Busi, F., Rodrigues Lima, F., M Dupret J, Mayati, A., Eric Le Ferrec, Levoin, N., Paris, H., Ph Uriac, Diaye, M. N., Lagadic-Gossmann, D., Assemat, E., Boublil, L., C Borot M, Marano, F., Y Martiny V, Moroy, G., Badel, A., A Miteva M, Hussain, S., Ferecatu, I., Borot, C., Andreau, K., Boland, S., Leroux, M., Zucchini-Pascal, N., Peyre, L., Rahmani, R., Buron, N., Porcedou, M., Fromenty, B., Borgne-Sanchez, A., Rogue, A., Claude, N., and Jonchère, Laurent

Subjects
[SDV] Life Sciences [q-bio], [SDV.TOX] Life Sciences [q-bio]/Toxicology
Published
2010

19. Effets de la consommatin d'aliments naturellement contaminés par du deoxynivalenol (DON) chez le porc en phase de croissance ou de finition

Author

Pinton, Philippe, Royer, Eric, Accensi, F, Marin, D, Guelfi, Jf, Bourges-Abella, N, Granier, R, Grosjean, F, Oswald, Isabelle P., Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), Inconnu, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2004

21. Cytométrie en flux et immunophénotypage des sous populations lymphocytaires bovines

Author

Abella, N., Schelcher, F., Delverdier, Maxence, Raymond, I., Espinasse, J., Cabanie, P., Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, CYTOMETRIE EN FLUX
Published
1994

23. Mise en évidence immunopéroxydasique du virus respiratoire syncytial bovin (B.R.S.V.) sur coupes en paraffine de tissu pulmonaire bovin

Author

Masson, C., Delverdier, Maxence, Schelcher, F., Abella, N., Valarcher, J.F., Espinasse, J., Cabanie, P., Unité associée de Physiopathologie respiratoire des ruminants, Institut National de la Recherche Agronomique (INRA), and ProdInra, Migration

Subjects
[SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health, [SDV.BA.MVSA] Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health
Published
1993

29. Study of canine cutaneous melanocytic tumours: evaluation of histological and immunohistochemical prognostic criteria in 65 cases.

Author

LACROUX, C., RAYMOND-LETRON, I., BOURGES-ABELLA, N., LUCAS, M. N., DEVIERS, A., SERRA, E., DEGORCE-RUBIALES, F., and DELVERDIER, M.

Abstract

The article presents a study on architectural and cytological criteria and immunohistochemical markers in 65 cases of canine cutaneous melanocytic tumors. Several minor and major histological criteria were proposed in the study, which includes neoplasm size, growth, symmetry, mitotic index, tumor shape and shape of the neoplastic cells. The study also recommends the use of Ki-67 antigen and CD44 adhesion abilities of the neoplastic melanocytic cells for the establishment of a more reliable prognosis.

Published
2012

31. Anaemia in dogs and cats.

Author

Trumel, C., Bourges-Abella, N., and Diquelou, A.

Abstract

Copyright of EMC-Veterinaire is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2004
Full Text
View/download PDF

32. Stable nanowire in macroscopic metallic contacts in air

Author

Abella´n, J., Arenas, A., Chico´n, R., and Reyes, F.

Abstract

Stability of nanowires formed between a sharp tip and a metallic sample in air at room temperature is demonstrated via simple experiments. Two kinds of experiments are carried out. In the first case the polarization voltage is kept constant and the system is subjected to small mechanical perturbations. In the second type of experiment the polarization voltage is changed, starting from a stable nanowire.

Published
1997
Full Text
View/download PDF

34. Effets zootechniques et immunitaires de la consommation d'aliment naturellement contaminé par du déoxynivalénol (DON) chez le porc en phase de croissance ou de finition

Author

Pinton, P., Royer, E., Francesc Accensi, Marin, D., Jf, Guelfi, Bourgès-Abella, N., Granier, R., Grosjean, F., Ip, Oswald, ProdInra, Migration, Unité de recherche Pharmacologie-Toxicologie (UPT), Institut National de la Recherche Agronomique (INRA), and Inconnu

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

39. A murine model for the study of influenza D virus.

Author

Oliva, J., Mettier, J., Sedano, L., Delverdier, M., Bourgès-Abella, N., Hause, B., Loupias, J., Pardo, I., Bleuart, C., Bordignon, P. J., Meunier, E., Goffic, R. Le, Meyer, G., and Ducatez, M. F.

Subjects
*SENDAI virus, *PATHOLOGY, *GUINEA pigs, *FERRET, *VIRAL replication, *TYPE I interferons, *BOS, *MICE
Abstract

A novel genus within the Orthomyxoviridae family was identified in the USA and named Influenza D virus (IDV). Bovine have been proposed to be the primary host and three main viral lineages (D/OK-like, D/660-like and D/Japan-like) have been described. Experimental infections were so far performed in swine, ferret, calf and guinea pig, in order to study IDV pathogenesis. We developed a murine experimental model to ease the study of IDV pathogenesis and immune response. DBA/2 mice were inoculated with 105 TCID50 of D/bovine/France/5920/2014 (D/OK-like). No clinical signs and weight loss were observed. Viral replication was observed mainly in the upper respiratory tract (nasal turbinates) but also in lower respiratory tract of infected mice, with a peak at 4 days post-infection. Moreover, the virus was also detected in the intestines. All infected mice seroconverted by 14 days post infection. Transcriptomic analyses demonstrated that IDV induced an activation of pro inflammatory genes such as IFN-γ and CCL2. Inoculation of NFκB-luciferase and Ifnar1-/- mice demonstrated that IDV induced mild inflammation and that type I interferons response was not necessary in IDV clearance. Adaptation of IDV by serial passages in mice was not sufficient to induce disease or increased pathogenesis. Taken together, present data and comparisons with the calf model show that our mouse model allows for the study of IDV replication and fitness (before selected viruses may be inoculated on calves) and also of the immune response. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

40. Search for CP Violation in Ds+ → KS0 π+, D+ → KS0 K+, and D+ →φπ+ Decays

Author

Aaij, R., Abellán Beteta, C., Adeva, B., Adinolfi, M., Aidala, C. A., Ajaltouni, Z., Akar, S., Albicocco, P., Albrecht, J., Alessio, F., Alexander, M., Alfonso Albero, A., Alkhazov, G., Alvarez Cartelle, P., Alves, A. A., Amato, S., Amhis, Y., An, L., Anderlini, L., Andreassi, G., Andreotti, M., Andrews, J. E., Archilli, F., d’Argent, P., Arnau Romeu, J., Artamonov, A., Artuso, M., Arzymatov, K., Aslanides, E., Atzeni, M., Audurier, B., Bachmann, S., Back, J. J., Baker, S., Balagura, V., Baldini, W., Baranov, A., Barlow, R. J., Barrand, G. C., Barsuk, S., Barter, W., Bartolini, M., Baryshnikov, F., Batozskaya, V., Batsukh, B., Battig, A., Battista, V., Bay, A., Bedeschi, F., Bediaga, I., Beiter, A., Bel, L. J., Belin, S., Beliy, N., Bellee, V., Belloli, N., Belous, K., Belyaev, I., Ben-Haim, E., Bencivenni, G., Benson, S., Beranek, S., Berezhnoy, A., Bernet, R., Berninghoff, D., Bertholet, E., Bertolin, A., Betancourt, C., Betti, F., Bettler, M. O., van Beuzekom, M., Bezshyiko, Ia., Bhasin, S., Bhom, J., Bieker, M. S., Bifani, S., Billoir, P., Birnkraut, A., Bizzeti, A., Bjørn, M., Blago, M. P., Blake, T., Blanc, F., Blusk, S., Bobulska, D., Bocci, V., Boente Garcia, O., Boettcher, T., Bondar, A., Bondar, N., Borghi, S., Borisyak, M., Borsato, M., Boubdir, M., Bowcock, T. J. V., Bozzi, C., Braun, S., Brodski, M., Brodzicka, J., Brossa Gonzalo, A., Brundu, D., Buchanan, E., Buonaura, A., Burr, C., Bursche, A., Buytaert, J., Byczynski, W., Cadeddu, S., Cai, H., Calabrese, R., Calladine, R., Calvi, M., Calvo Gomez, M., Camboni, A., Campana, P., Campora Perez, D. H., Capriotti, L., Carbone, A., Carboni, G., Cardinale, R., Cardini, A., Carniti, P., Carvalho Akiba, K., Casse, G., Cattaneo, M., Cavallero, G., Cenci, R., Chamont, D., Chapman, M. G., Charles, M., Charpentier, Ph., Chatzikonstantinidis, G., Chefdeville, M., Chekalina, V., Chen, C., Chen, S., Chitic, S.-G., Chobanova, V., Chrzaszcz, M., Chubykin, A., Ciambrone, P., Cid Vidal, X., Ciezarek, G., Cindolo, F., Clarke, P. E. L., Clemencic, M., Cliff, H. V., Closier, J., Coco, V., Coelho, J. A. B., Cogan, J., Cogneras, E., Cojocariu, L., Collins, P., Colombo, T., Comerma-Montells, A., Contu, A., Coombs, G., Coquereau, S., Corti, G., Costa Sobral, C. M., Couturier, B., Cowan, G. A., Craik, D. C., Crocombe, A., Cruz Torres, M., Currie, R., D’Ambrosio, C., Da Silva, C. L., Dall’Occo, E., Dalseno, J., Danilina, A., Davis, A., De Aguiar Francisco, O., De Bruyn, K., De Capua, S., De Cian, M., De Miranda, J. M., De Paula, L., De Serio, M., De Simone, P., Dean, C. T., Dean, W., Decamp, D., Del Buono, L., Delaney, B., Dembinski, H.-P., Demmer, M., Dendek, A., Derkach, D., Deschamps, O., Desse, F., Dettori, F., Dey, B., Di Canto, A., Di Nezza, P., Didenko, S., Dijkstra, H., Dordei, F., Dorigo, M., Dosil Suárez, A., Douglas, L., Dovbnya, A., Dreimanis, K., Dufour, L., Dujany, G., Durante, P., Durham, J. M., Dutta, D., Dzhelyadin, R., Dziewiecki, M., Dziurda, A., Dzyuba, A., Easo, S., Egede, U., Egorychev, V., Eidelman, S., Eisenhardt, S., Eitschberger, U., Ekelhof, R., Eklund, L., Ely, S., Ene, A., Escher, S., Esen, S., Evans, T., Falabella, A., Farley, N., Farry, S., Fazzini, D., Fernandez Declara, P., Fernandez Prieto, A., Ferrari, F., Ferreira Lopes, L., Ferreira Rodrigues, F., Ferreres Sole, S., Ferro-Luzzi, M., Filippov, S., Fini, R. A., Fiorini, M., Firlej, M., Fitzpatrick, C., Fiutowski, T., Fleuret, F., Fontana, M., Fontanelli, F., Forty, R., Franco Lima, V., Frank, M., Frei, C., Fu, J., Funk, W., Färber, C., Féo, M., Gabriel, E., Gallas Torreira, A., Galli, D., Gallorini, S., Gambetta, S., Gan, Y., Gandelman, M., Gandini, P., Gao, Y., Garcia Martin, L. M., Garcia Plana, B., García Pardiñas, J., Garra Tico, J., Garrido, L., Gascon, D., Gaspar, C., Gazzoni, G., Gerick, D., Gersabeck, E., Gersabeck, M., Gershon, T., Gerstel, D., Ghez, Ph., Gibson, V., Girard, O. G., Gironella Gironell, P., Giubega, L., Gizdov, K., Gligorov, V. V., Golubkov, D., Golutvin, A., Gomes, A., Gorelov, I. V., Gotti, C., Govorkova, E., Grabowski, J. P., Graciani Diaz, R., Granado Cardoso, L. A., Graugés, E., Graverini, E., Graziani, G., Grecu, A., Greim, R., Griffith, P., Grillo, L., Gruber, L., Gruberg Cazon, B. R., Gu, C., Guo, X., Gushchin, E., Guth, A., Guz, Yu., Gys, T., Göbel, C., Hadavizadeh, T., Hadjivasiliou, C., Haefeli, G., Haen, C., Haines, S. C., Hamilton, B., Han, X., Hancock, T. H., Hansmann-Menzemer, S., Harnew, N., Harrison, T., Hasse, C., Hatch, M., He, J., Hecker, M., Heinicke, K., Heister, A., Hennessy, K., Henry, L., van Herwijnen, E., Heuel, J., Heß, M., Hicheur, A., Hidalgo Charman, R., Hill, D., Hilton, M., Hopchev, P. H., Hu, J., Hu, W., Huang, W., Huard, Z. C., Hulsbergen, W., Humair, T., Hushchyn, M., Hutchcroft, D., Hynds, D., Ibis, P., Idzik, M., Ilten, P., Inglessi, A., Inyakin, A., Ivshin, K., Jacobsson, R., Jakobsen, S., Jalocha, J., Jans, E., Jashal, B. K., Jawahery, A., Jiang, F., John, M., Johnson, D., Jones, C. R., Joram, C., Jost, B., Jurik, N., Kandybei, S., Karacson, M., Kariuki, J. M., Karodia, S., Kazeev, N., Kecke, M., Keizer, F., Kelsey, M., Kenzie, M., Ketel, T., Khanji, B., Kharisova, A., Khurewathanakul, C., Kim, K. E., Kirn, T., Kirsebom, V. S., Klaver, S., Klimaszewski, K., Koliiev, S., Kolpin, M., Kopecna, R., Koppenburg, P., Kostiuk, I., Kotriakhova, S., Kozeiha, M., Kravchuk, L., Kreps, M., Kress, F., Kretzschmar, S., Krokovny, P., Krupa, W., Krzemien, W., Kucewicz, W., Kucharczyk, M., Kudryavtsev, V., Kunde, G. J., Kuonen, A. K., Kvaratskheliya, T., Lacarrere, D., Lafferty, G., Lai, A., Lancierini, D., Lanfranchi, G., Langenbruch, C., Latham, T., Lazzeroni, C., Le Gac, R., Leflat, A., Lefèvre, R., Lemaitre, F., Leroy, O., Lesiak, T., Leverington, B., Li, H., Li, P.-R., Li, Y., Li, Z., Liang, X., Likhomanenko, T., Lindner, R., Ling, P., Lionetto, F., Lisovskyi, V., Liu, G., Liu, X., Loh, D., Loi, A., Longstaff, I., Lopes, J. H., Loustau, G., Lovell, G. H., Lucchesi, D., Lucio Martinez, M., Luo, Y., Lupato, A., Luppi, E., Lupton, O., Lusiani, A., Lyu, X., Ma, R., Maccolini, S., Machefert, F., Maciuc, F., Macko, V., Mackowiak, P., Maddrell-Mander, S., Maev, O., Maguire, K., Maisuzenko, D., Majewski, M. W., Malde, S., Malecki, B., Malinin, A., Maltsev, T., Malygina, H., Manca, G., Mancinelli, G., Marangotto, D., Maratas, J., Marchand, J. F., Marconi, U., Marin Benito, C., Marinangeli, M., Marino, P., Marks, J., Marshall, P. J., Martellotti, G., Martinelli, M., Martinez Santos, D., Martinez Vidal, F., Massafferri, A., Materok, M., Matev, R., Mathad, A., Mathe, Z., Matiunin, V., Matteuzzi, C., Mattioli, K. R., Mauri, A., Maurice, E., Maurin, B., McCann, M., McNab, A., McNulty, R., Mead, J. V., Meadows, B., Meaux, C., Meinert, N., Melnychuk, D., Merk, M., Merli, A., Michielin, E., Milanes, D. A., Millard, E., Minard, M.-N., Minzoni, L., Mitzel, D. S., Mogini, A., Moise, R. D., Mombächer, T., Monroy, I. A., Monteil, S., Morandin, M., Morello, G., Morello, M. J., Moron, J., Morris, A. B., Mountain, R., Muheim, F., Mukherjee, M., Mulder, M., Murphy, C. H., Murray, D., Mödden, A., Müller, D., Müller, J., Müller, K., Müller, V., Naik, P., Nakada, T., Nandakumar, R., Nandi, A., Nanut, T., Nasteva, I., Needham, M., Neri, N., Neubert, S., Neufeld, N., Newcombe, R., Nguyen, T. D., Nguyen-Mau, C., Nieswand, S., Niet, R., Nikitin, N., Nolte, N. S., O’Hanlon, D. P., Oblakowska-Mucha, A., Obraztsov, V., Ogilvy, S., Oldeman, R., Onderwater, C. J. G., Osborn, J. D., Ossowska, A., Otalora Goicochea, J. M., Ovsiannikova, T., Owen, P., Oyanguren, A., Pais, P. R., Pajero, T., Palano, A., Palutan, M., Panshin, G., Papanestis, A., Pappagallo, M., Pappalardo, L. L., Parker, W., Parkes, C., Passaleva, G., Pastore, A., Patel, M., Patrignani, C., Pearce, A., Pellegrino, A., Penso, G., Pepe Altarelli, M., Perazzini, S., Pereima, D., Perret, P., Pescatore, L., Petridis, K., Petrolini, A., Petrov, A., Petrucci, S., Petruzzo, M., Pietrzyk, B., Pietrzyk, G., Pikies, M., Pili, M., Pinci, D., Pinzino, J., Pisani, F., Piucci, A., Placinta, V., Playfer, S., Plews, J., Plo Casasus, M., Polci, F., Poli Lener, M., Poliakova, M., Poluektov, A., Polukhina, N., Polyakov, I., Polycarpo, E., Pomery, G. J., Ponce, S., Popov, A., Popov, D., Poslavskii, S., Price, E., Prouve, C., Pugatch, V., Puig Navarro, A., Pullen, H., Punzi, G., Qian, W., Qin, J., Quagliani, R., Quintana, B., Raab, N. V., Rachwal, B., Rademacker, J. H., Rama, M., Ramos Pernas, M., Rangel, M. S., Ratnikov, F., Raven, G., Ravonel Salzgeber, M., Reboud, M., Redi, F., Reichert, S., dos Reis, A. C., Reiss, F., Remon Alepuz, C., Ren, Z., Renaudin, V., Ricciardi, S., Richards, S., Rinnert, K., Robbe, P., Robert, A., Rodrigues, A. B., Rodrigues, E., Rodriguez Lopez, J. A., Roehrken, M., Roiser, S., Rollings, A., Romanovskiy, V., Romero Vidal, A., Roth, J. D., Rotondo, M., Rudolph, M. S., Ruf, T., Ruiz Vidal, J., Saborido Silva, J. J., Sagidova, N., Saitta, B., Salustino Guimaraes, V., Sanchez Gras, C., Sanchez Mayordomo, C., Sanmartin Sedes, B., Santacesaria, R., Santamarina Rios, C., Santimaria, M., Santovetti, E., Sarpis, G., Sarti, A., Satriano, C., Satta, A., Saur, M., Savrina, D., Schael, S., Schellenberg, M., Schiller, M., Schindler, H., Schmelling, M., Schmelzer, T., Schmidt, B., Schneider, O., Schopper, A., Schreiner, H. F., Schubiger, M., Schulte, S., Schune, M. H., Schwemmer, R., Sciascia, B., Sciubba, A., Semennikov, A., Sepulveda, E. S., Sergi, A., Serra, N., Serrano, J., Sestini, L., Seuthe, A., Seyfert, P., Shapkin, M., Shears, T., Shekhtman, L., Shevchenko, V., Shmanin, E., Siddi, B. G., Silva Coutinho, R., Silva de Oliveira, L., Simi, G., Simone, S., Skiba, I., Skidmore, N., Skwarnicki, T., Slater, M. W., Smeaton, J. G., Smith, E., Smith, I. T., Smith, M., Soares, M., Soares Lavra, l., Sokoloff, M. D., Soler, F. J. P., Souza De Paula, B., Spaan, B., Spadaro Norella, E., Spradlin, P., Stagni, F., Stahl, M., Stahl, S., Stefko, P., Stefkova, S., Steinkamp, O., Stemmle, S., Stenyakin, O., Stepanova, M., Stevens, H., Stocchi, A., Stone, S., Stracka, S., Stramaglia, M. E., Straticiuc, M., Straumann, U., Strokov, S., Sun, J., Sun, L., Sun, Y., Swientek, K., Szabelski, A., Szumlak, T., Szymanski, M., T’Jampens, S., Tang, Z., Tekampe, T., Tellarini, G., Teubert, F., Thomas, E., van Tilburg, J., Tilley, M. J., Tisserand, V., Tobin, M., Tolk, S., Tomassetti, L., Tonelli, D., Tou, D. Y., Tourinho Jadallah Aoude, R., Tournefier, E., Traill, M., Tran, M. T., Trisovic, A., Tsaregorodtsev, A., Tuci, G., Tully, A., Tuning, N., Ukleja, A., Usachov, A., Ustyuzhanin, A., Uwer, U., Vagner, A., Vagnoni, V., Valassi, A., Valat, S., Valenti, G., Van Hecke, H., Van Hulse, C. B., Vazquez Gomez, R., Vazquez Regueiro, P., Vecchi, S., van Veghel, M., Velthuis, J. J., Veltri, M., Venkateswaran, A., Vernet, M., Veronesi, M., Vesterinen, M., Viana Barbosa, J. V., Vieira, D., Vieites Diaz, M., Viemann, H., Vilasis-Cardona, X., Vitkovskiy, A., Vitti, M., Volkov, V., Vollhardt, A., Vom Bruch, D., Voneki, B., Vorobyev, A., Vorobyev, V., Voropaev, N., de Vries, J. A., Vázquez Sierra, C., Waldi, R., Walsh, J., Wang, J., Wang, M., Wang, Y., Wang, Z., Ward, D. R., Wark, H. M., Watson, N. K., Websdale, D., Weiden, A., Weisser, C., Whitehead, M., Wilkinson, G., Wilkinson, M., Williams, I., Williams, M. R. J., Williams, M., Williams, T., Wilson, F. F., Winn, M., Wislicki, W., Witek, M., Wormser, G., Wotton, S. A., Wyllie, K., Xiao, D., Xie, Y., Xing, H., Xu, A., Xu, M., Xu, Q., Xu, Z., Yang, Z., Yao, Y., Yeomans, L. E., Yin, H., Yu, J., Yuan, X., Yushchenko, O., Zarebski, K. A., Zavertyaev, M., Zeng, M., Zhang, D., Zhang, L., Zhang, W. C., Zhang, Y., Zhelezov, A., Zheng, Y., Zhu, X., Zhukov, V., Zonneveld, J. B., Zucchelli, S., Aaij, R, AbellA¡n Beteta, C, Adeva, B, Adinolfi, M, Aidala, C, Ajaltouni, Z, Akar, S, Albicocco, P, Albrecht, J, Alessio, F, Alexander, M, Alfonso Albero, A, Alkhazov, G, Alvarez Cartelle, P, Alves, A, Amato, S, Amhis, Y, An, L, Anderlini, L, Andreassi, G, Andreotti, M, Andrews, J, Archilli, F, Da€™argent, P, Arnau Romeu, J, Artamonov, A, Artuso, M, Arzymatov, K, Aslanides, E, Atzeni, M, Audurier, B, Bachmann, S, Back, J, Baker, S, Balagura, V, Baldini, W, Baranov, A, Barlow, R, Barrand, G, Barsuk, S, Barter, W, Bartolini, M, Baryshnikov, F, Batozskaya, V, Batsukh, B, Battig, A, Battista, V, Bay, A, Bedeschi, F, Bediaga, I, Beiter, A, Bel, L, Belin, S, Beliy, N, Bellee, V, Belloli, N, Belous, K, Belyaev, I, Ben-Haim, E, Bencivenni, G, Benson, S, Beranek, S, Berezhnoy, A, Bernet, R, Berninghoff, D, Bertholet, E, Bertolin, A, Betancourt, C, Betti, F, Bettler, M, van Beuzekom, M, Bezshyiko, I, Bhasin, S, Bhom, J, Bieker, M, Bifani, S, Billoir, P, Birnkraut, A, Bizzeti, A, Bjarn, M, Blago, M, Blake, T, Blanc, F, Blusk, S, Bobulska, D, Bocci, V, Boente Garcia, O, Boettcher, T, Bondar, A, Bondar, N, Borghi, S, Borisyak, M, Borsato, M, Boubdir, M, Bowcock, T, Bozzi, C, Braun, S, Brodski, M, Brodzicka, J, Brossa Gonzalo, A, Brundu, D, Buchanan, E, Buonaura, A, Burr, C, Bursche, A, Buytaert, J, Byczynski, W, Cadeddu, S, Cai, H, Calabrese, R, Calladine, R, Calvi, M, Calvo Gomez, M, Camboni, A, Campana, P, Campora Perez, D, Capriotti, L, Carbone, A, Carboni, G, Cardinale, R, Cardini, A, Carniti, P, Carvalho Akiba, K, Casse, G, Cattaneo, M, Cavallero, G, Cenci, R, Chamont, D, Chapman, M, Charles, M, Charpentier, P, Chatzikonstantinidis, G, Chefdeville, M, Chekalina, V, Chen, C, Chen, S, Chitic, S, Chobanova, V, Chrzaszcz, M, Chubykin, A, Ciambrone, P, Cid Vidal, X, Ciezarek, G, Cindolo, F, Clarke, P, Clemencic, M, Cliff, H, Closier, J, Coco, V, Coelho, J, Cogan, J, Cogneras, E, Cojocariu, L, Collins, P, Colombo, T, Comerma-Montells, A, Contu, A, Coombs, G, Coquereau, S, Corti, G, Costa Sobral, C, Couturier, B, Cowan, G, Craik, D, Crocombe, A, Cruz Torres, M, Currie, R, Da€™ambrosio, C, Da Silva, C, Dalla€™occo, E, Dalseno, J, Danilina, A, Davis, A, De Aguiar Francisco, O, De Bruyn, K, De Capua, S, De Cian, M, De Miranda, J, De Paula, L, De Serio, M, De Simone, P, Dean, C, Dean, W, Decamp, D, Del Buono, L, Delaney, B, Dembinski, H, Demmer, M, Dendek, A, Derkach, D, Deschamps, O, Desse, F, Dettori, F, Dey, B, Di Canto, A, Di Nezza, P, Didenko, S, Dijkstra, H, Dordei, F, Dorigo, M, Dosil SuA¡rez, A, Douglas, L, Dovbnya, A, Dreimanis, K, Dufour, L, Dujany, G, Durante, P, Durham, J, Dutta, D, Dzhelyadin, R, Dziewiecki, M, Dziurda, A, Dzyuba, A, Easo, S, Egede, U, Egorychev, V, Eidelman, S, Eisenhardt, S, Eitschberger, U, Ekelhof, R, Eklund, L, Ely, S, Ene, A, Escher, S, Esen, S, Evans, T, Falabella, A, Farley, N, Farry, S, Fazzini, D, Fernandez Declara, P, Fernandez Prieto, A, Ferrari, F, Ferreira Lopes, L, Ferreira Rodrigues, F, Ferreres Sole, S, Ferro-Luzzi, M, Filippov, S, Fini, R, Fiorini, M, Firlej, M, Fitzpatrick, C, Fiutowski, T, Fleuret, F, Fontana, M, Fontanelli, F, Forty, R, Franco Lima, V, Frank, M, Frei, C, Fu, J, Funk, W, Fa¤rber, C, Facopyrighto, M, Gabriel, E, Gallas Torreira, A, Galli, D, Gallorini, S, Gambetta, S, Gan, Y, Gandelman, M, Gandini, P, Gao, Y, Garcia Martin, L, Garcia Plana, B, GarcA­a PardiA+/-as, J, Garra Tico, J, Garrido, L, Gascon, D, Gaspar, C, Gazzoni, G, Gerick, D, Gersabeck, E, Gersabeck, M, Gershon, T, Gerstel, D, Ghez, P, Gibson, V, Girard, O, Gironella Gironell, P, Giubega, L, Gizdov, K, Gligorov, V, Golubkov, D, Golutvin, A, Gomes, A, Gorelov, I, Gotti, C, Govorkova, E, Grabowski, J, Graciani Diaz, R, Granado Cardoso, L, Graugacopyrights, E, Graverini, E, Graziani, G, Grecu, A, Greim, R, Griffith, P, Grillo, L, Gruber, L, Gruberg Cazon, B, Gu, C, Guo, X, Gushchin, E, Guth, A, Guz, Y, Gys, T, Gabel, C, Hadavizadeh, T, Hadjivasiliou, C, Haefeli, G, Haen, C, Haines, S, Hamilton, B, Han, X, Hancock, T, Hansmann-Menzemer, S, Harnew, N, Harrison, T, Hasse, C, Hatch, M, He, J, Hecker, M, Heinicke, K, Heister, A, Hennessy, K, Henry, L, van Herwijnen, E, Heuel, J, Heay, M, Hicheur, A, Hidalgo Charman, R, Hill, D, Hilton, M, Hopchev, P, Hu, J, Hu, W, Huang, W, Huard, Z, Hulsbergen, W, Humair, T, Hushchyn, M, Hutchcroft, D, Hynds, D, Ibis, P, Idzik, M, Ilten, P, Inglessi, A, Inyakin, A, Ivshin, K, Jacobsson, R, Jakobsen, S, Jalocha, J, Jans, E, Jashal, B, Jawahery, A, Jiang, F, John, M, Johnson, D, Jones, C, Joram, C, Jost, B, Jurik, N, Kandybei, S, Karacson, M, Kariuki, J, Karodia, S, Kazeev, N, Kecke, M, Keizer, F, Kelsey, M, Kenzie, M, Ketel, T, Khanji, B, Kharisova, A, Khurewathanakul, C, Kim, K, Kirn, T, Kirsebom, V, Klaver, S, Klimaszewski, K, Koliiev, S, Kolpin, M, Kopecna, R, Koppenburg, P, Kostiuk, I, Kotriakhova, S, Kozeiha, M, Kravchuk, L, Kreps, M, Kress, F, Kretzschmar, S, Krokovny, P, Krupa, W, Krzemien, W, Kucewicz, W, Kucharczyk, M, Kudryavtsev, V, Kunde, G, Kuonen, A, Kvaratskheliya, T, Lacarrere, D, Lafferty, G, Lai, A, Lancierini, D, Lanfranchi, G, Langenbruch, C, Latham, T, Lazzeroni, C, Le Gac, R, Leflat, A, Lefavre, R, Lemaitre, F, Leroy, O, Lesiak, T, Leverington, B, Li, H, Li, P, Li, Y, Li, Z, Liang, X, Likhomanenko, T, Lindner, R, Ling, P, Lionetto, F, Lisovskyi, V, Liu, G, Liu, X, Loh, D, Loi, A, Longstaff, I, Lopes, J, Loustau, G, Lovell, G, Lucchesi, D, Lucio Martinez, M, Luo, Y, Lupato, A, Luppi, E, Lupton, O, Lusiani, A, Lyu, X, Ma, R, Maccolini, S, Machefert, F, Maciuc, F, Macko, V, Mackowiak, P, Maddrell-Mander, S, Maev, O, Maguire, K, Maisuzenko, D, Majewski, M, Malde, S, Malecki, B, Malinin, A, Maltsev, T, Malygina, H, Manca, G, Mancinelli, G, Marangotto, D, Maratas, J, Marchand, J, Marconi, U, Marin Benito, C, Marinangeli, M, Marino, P, Marks, J, Marshall, P, Martellotti, G, Martinelli, M, Martinez Santos, D, Martinez Vidal, F, Massafferri, A, Materok, M, Matev, R, Mathad, A, Mathe, Z, Matiunin, V, Matteuzzi, C, Mattioli, K, Mauri, A, Maurice, E, Maurin, B, Mccann, M, Mcnab, A, Mcnulty, R, Mead, J, Meadows, B, Meaux, C, Meinert, N, Melnychuk, D, Merk, M, Merli, A, Michielin, E, Milanes, D, Millard, E, Minard, M, Minzoni, L, Mitzel, D, Mogini, A, Moise, R, Momba¤cher, T, Monroy, I, Monteil, S, Morandin, M, Morello, G, Morello, M, Moron, J, Morris, A, Mountain, R, Muheim, F, Mukherjee, M, Mulder, M, Murphy, C, Murray, D, Madden, A, Ma¼ller, D, Ma¼ller, J, Ma¼ller, K, Ma¼ller, V, Naik, P, Nakada, T, Nandakumar, R, Nandi, A, Nanut, T, Nasteva, I, Needham, M, Neri, N, Neubert, S, Neufeld, N, Newcombe, R, Nguyen, T, Nguyen-Mau, C, Nieswand, S, Niet, R, Nikitin, N, Nolte, N, Oa€™hanlon, D, Oblakowska-Mucha, A, Obraztsov, V, Ogilvy, S, Oldeman, R, Onderwater, C, Osborn, J, Ossowska, A, Otalora Goicochea, J, Ovsiannikova, T, Owen, P, Oyanguren, A, Pais, P, Pajero, T, Palano, A, Palutan, M, Panshin, G, Papanestis, A, Pappagallo, M, Pappalardo, L, Parker, W, Parkes, C, Passaleva, G, Pastore, A, Patel, M, Patrignani, C, Pearce, A, Pellegrino, A, Penso, G, Pepe Altarelli, M, Perazzini, S, Pereima, D, Perret, P, Pescatore, L, Petridis, K, Petrolini, A, Petrov, A, Petrucci, S, Petruzzo, M, Pietrzyk, B, Pietrzyk, G, Pikies, M, Pili, M, Pinci, D, Pinzino, J, Pisani, F, Piucci, A, Placinta, V, Playfer, S, Plews, J, Plo Casasus, M, Polci, F, Poli Lener, M, Poliakova, M, Poluektov, A, Polukhina, N, Polyakov, I, Polycarpo, E, Pomery, G, Ponce, S, Popov, A, Popov, D, Poslavskii, S, Price, E, Prouve, C, Pugatch, V, Puig Navarro, A, Pullen, H, Punzi, G, Qian, W, Qin, J, Quagliani, R, Quintana, B, Raab, N, Rachwal, B, Rademacker, J, Rama, M, Ramos Pernas, M, Rangel, M, Ratnikov, F, Raven, G, Ravonel Salzgeber, M, Reboud, M, Redi, F, Reichert, S, Dos Reis, A, Reiss, F, Remon Alepuz, C, Ren, Z, Renaudin, V, Ricciardi, S, Richards, S, Rinnert, K, Robbe, P, Robert, A, Rodrigues, A, Rodrigues, E, Rodriguez Lopez, J, Roehrken, M, Roiser, S, Rollings, A, Romanovskiy, V, Romero Vidal, A, Roth, J, Rotondo, M, Rudolph, M, Ruf, T, Ruiz Vidal, J, Saborido Silva, J, Sagidova, N, Saitta, B, Salustino Guimaraes, V, Sanchez Gras, C, Sanchez Mayordomo, C, Sanmartin Sedes, B, Santacesaria, R, Santamarina Rios, C, Santimaria, M, Santovetti, E, Sarpis, G, Sarti, A, Satriano, C, Satta, A, Saur, M, Savrina, D, Schael, S, Schellenberg, M, Schiller, M, Schindler, H, Schmelling, M, Schmelzer, T, Schmidt, B, Schneider, O, Schopper, A, Schreiner, H, Schubiger, M, Schulte, S, Schune, M, Schwemmer, R, Sciascia, B, Sciubba, A, Semennikov, A, Sepulveda, E, Sergi, A, Serra, N, Serrano, J, Sestini, L, Seuthe, A, Seyfert, P, Shapkin, M, Shears, T, Shekhtman, L, Shevchenko, V, Shmanin, E, Siddi, B, Silva Coutinho, R, Silva de Oliveira, L, Simi, G, Simone, S, Skiba, I, Skidmore, N, Skwarnicki, T, Slater, M, Smeaton, J, Smith, E, Smith, I, Smith, M, Soares, M, Soares Lavra, L, Sokoloff, M, Soler, F, Souza De Paula, B, Spaan, B, Spadaro Norella, E, Spradlin, P, Stagni, F, Stahl, M, Stahl, S, Stefko, P, Stefkova, S, Steinkamp, O, Stemmle, S, Stenyakin, O, Stepanova, M, Stevens, H, Stocchi, A, Stone, S, Stracka, S, Stramaglia, M, Straticiuc, M, Straumann, U, Strokov, S, Sun, J, Sun, L, Sun, Y, Swientek, K, Szabelski, A, Szumlak, T, Szymanski, M, Ta€™jampens, S, Tang, Z, Tekampe, T, Tellarini, G, Teubert, F, Thomas, E, van Tilburg, J, Tilley, M, Tisserand, V, Tobin, M, Tolk, S, Tomassetti, L, Tonelli, D, Tou, D, Tourinho Jadallah Aoude, R, Tournefier, E, Traill, M, Tran, M, Trisovic, A, Tsaregorodtsev, A, Tuci, G, Tully, A, Tuning, N, Ukleja, A, Usachov, A, Ustyuzhanin, A, Uwer, U, Vagner, A, Vagnoni, V, Valassi, A, Valat, S, Valenti, G, Van Hecke, H, Van Hulse, C, Vazquez Gomez, R, Vazquez Regueiro, P, Vecchi, S, van Veghel, M, Velthuis, J, Veltri, M, Venkateswaran, A, Vernet, M, Veronesi, M, Vesterinen, M, Viana Barbosa, J, Vieira, D, Vieites Diaz, M, Viemann, H, Vilasis-Cardona, X, Vitkovskiy, A, Vitti, M, Volkov, V, Vollhardt, A, Vom Bruch, D, Voneki, B, Vorobyev, A, Vorobyev, V, Voropaev, N, de Vries, J, VA¡zquez Sierra, C, Waldi, R, Walsh, J, Wang, J, Wang, M, Wang, Y, Wang, Z, Ward, D, Wark, H, Watson, N, Websdale, D, Weiden, A, Weisser, C, Whitehead, M, Wilkinson, G, Wilkinson, M, Williams, I, Williams, M, Williams, T, Wilson, F, Winn, M, Wislicki, W, Witek, M, Wormser, G, Wotton, S, Wyllie, K, Xiao, D, Xie, Y, Xing, H, Xu, A, Xu, M, Xu, Q, Xu, Z, Yang, Z, Yao, Y, Yeomans, L, Yin, H, Yu, J, Yuan, X, Yushchenko, O, Zarebski, K, Zavertyaev, M, Zeng, M, Zhang, D, Zhang, L, Zhang, W, Zhang, Y, Zhelezov, A, Zheng, Y, Zhu, X, Zhukov, V, Zonneveld, J, and Zucchelli, S

Subjects
CP Violation, Branching fraction, Hadron-Hadron scattering (experiments), QCD, D+, Ds+
Abstract

A search for charge-parity (\ud C\ud P\ud ) violation in Cabibbo-suppressed \ud D\ud +\ud s\ud →\ud K\ud 0\ud S\ud π\ud +\ud , \ud D\ud +\ud →\ud K\ud 0\ud S\ud K\ud +\ud , and \ud D\ud +\ud →\ud ϕ\ud π\ud +\ud decays is reported using proton-proton collision data, corresponding to an integrated luminosity of \ud 3.8\ud \ud \ud fb\ud −\ud 1\ud , collected at a center-of-mass energy of 13 TeV with the LHCb detector. High-yield samples of kinematically and topologically similar Cabibbo-favored \ud D\ud +\ud (\ud s\ud )\ud decays are analyzed to subtract nuisance asymmetries due to production and detection effects, including those induced by \ud C\ud P\ud violation in the neutral kaon system. The results are\ud A\ud C\ud P\ud (\ud D\ud +\ud s\ud →\ud K\ud 0\ud S\ud π\ud +\ud )\ud =\ud (\ud 1.3\ud ±\ud 1.9\ud ±\ud 0.5\ud )\ud ×\ud 10\ud −\ud 3\ud ,\ud A\ud C\ud P\ud (\ud D\ud +\ud →\ud K\ud 0\ud S\ud K\ud +\ud )\ud =\ud (\ud −\ud 0.09\ud ±\ud 0.65\ud ±\ud 0.48\ud )\ud ×\ud 10\ud −\ud 3\ud ,\ud A\ud C\ud P\ud (\ud D\ud +\ud →\ud ϕ\ud π\ud +\ud )\ud =\ud (\ud 0.05\ud ±\ud 0.42\ud ±\ud 0.29\ud )\ud ×\ud 10\ud −\ud 3\ud ,\ud where the first uncertainties are statistical and the second systematic. They are the most precise measurements of these quantities to date, and are consistent with \ud C\ud P\ud symmetry. A combination with previous LHCb measurements, based on data collected at 7 and 8 TeV, is also reported.

Published
2019

41. Validation of the Sysmex XN-V hematology analyzer for feline specimens.

Author

Guerlin M, Granat F, Grebert M, Braun JP, Geffré A, Bourgès-Abella N, and Trumel C

Subjects
Animals, Cats blood, Reproducibility of Results, Blood Cell Count veterinary, Blood Cell Count instrumentation, Hematology instrumentation, Hematologic Tests veterinary, Hematologic Tests instrumentation
Abstract

Background: The Sysmex XN-V is derived from the new Sysmex XN series of human hematology analyzers. The main changes from the previously validated XT-2000iV analyzer include an optic-fluorescent analysis for platelets and a nucleated red blood cell (NRBC) count., Objective: We aimed to validate the Sysmex XN-V for feline blood following the American College for Veterinary Clinical Pathology and International Council for Standardization in Hematology recommendations., Methods: Feline EDTA blood specimens were analyzed on the Sysmex XN-V to evaluate repeatability, linearity, comparison with the XT-2000iV analyzer and manual methods, stability, and to verify the previously established Sysmex XT-2000iV RIs., Results: Repeatability was excellent for most variables. Visually determined linearity was excellent or good for most variables except eosinophils and platelet variables. The correlation between the XN-V and XT-2000iV analyzers was good (≥0.82) for all variables except reticulocyte indices. Correlations between the Sysmex XN-V and manual differential counts were good to excellent for most variables, acceptable for neutrophils, and fair for monocytes and NRBC. The previously established Sysmex XT-2000iV RIs can be used to interpret results from the Sysmex XN-V analyzer for most variables except red cell distribution width and reticulocyte variables. The RI for platelet variables could not be evaluated because of platelet clumps. Changes in the Sysmex XN-V measurements after storage at 4 and 24°C were similar to those described for the Sysmex XT-2000iV analyzer., Conclusions: The performance of the Sysmex XN-V analyzer was good and compared favorably with the Sysmex XT-2000iV analyzer., (© 2024 The Author(s). Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.)

Published
2024
Full Text
View/download PDF

43. C/EBPα Confers Dependence to Fatty Acid Anabolic Pathways and Vulnerability to Lipid Oxidative Stress-Induced Ferroptosis in FLT3-Mutant Leukemia.

Author

Sabatier M, Birsen R, Lauture L, Mouche S, Angelino P, Dehairs J, Goupille L, Boussaid I, Heiblig M, Boet E, Sahal A, Saland E, Santos JC, Armengol M, Fernández-Serrano M, Farge T, Cognet G, Simonetta F, Pignon C, Graffeuil A, Mazzotti C, Avet-Loiseau H, Delos O, Bertrand-Michel J, Chedru A, Dembitz V, Gallipoli P, Anstee NS, Loo S, Wei AH, Carroll M, Goubard A, Castellano R, Collette Y, Vergez F, Mansat-De Mas V, Bertoli S, Tavitian S, Picard M, Récher C, Bourges-Abella N, Granat F, Kosmider O, Sujobert P, Colsch B, Joffre C, Stuani L, Swinnen JV, Guillou H, Roué G, Hakim N, Dejean AS, Tsantoulis P, Larrue C, Bouscary D, Tamburini J, and Sarry JE

Subjects
Humans, CCAAT-Enhancer-Binding Protein-alpha genetics, CCAAT-Enhancer-Binding Protein-alpha metabolism, fms-Like Tyrosine Kinase 3 genetics, fms-Like Tyrosine Kinase 3 metabolism, Fatty Acids, Mutation, Oxidative Stress, Protein Kinase Inhibitors therapeutic use, Cell Line, Tumor, Ferroptosis, Leukemia, Myeloid, Acute drug therapy, Leukemia, Myeloid, Acute genetics, Leukemia, Myeloid, Acute metabolism
Abstract

Although transcription factor CCAAT-enhancer binding protein α (C/EBPα) is critical for normal and leukemic differentiation, its role in cell and metabolic homeostasis is largely unknown in cancer. Here, multiomics analyses uncovered a coordinated activation of C/EBPα and Fms-like tyrosine kinase 3 (FLT3) that increased lipid anabolism in vivo and in patients with FLT3-mutant acute myeloid leukemia (AML). Mechanistically, C/EBPα regulated the fatty acid synthase (FASN)-stearoyl-CoA desaturase (SCD) axis to promote fatty acid (FA) biosynthesis and desaturation. We further demonstrated that FLT3 or C/EBPα inactivation decreased monounsaturated FA incorporation to membrane phospholipids through SCD downregulation. Consequently, SCD inhibition enhanced susceptibility to lipid redox stress that was exploited by combining FLT3 and glutathione peroxidase 4 inhibition to trigger lipid oxidative stress, enhancing ferroptotic death of FLT3-mutant AML cells. Altogether, our study reveals a C/EBPα function in lipid homeostasis and adaptation to redox stress, and a previously unreported vulnerability of FLT3-mutant AML to ferroptosis with promising therapeutic application., Significance: FLT3 mutations are found in 30% of AML cases and are actionable by tyrosine kinase inhibitors. Here, we discovered that C/EBPα regulates FA biosynthesis and protection from lipid redox stress downstream mutant-FLT3 signaling, which confers a vulnerability to ferroptosis upon FLT3 inhibition with therapeutic potential in AML. This article is highlighted in the In This Issue feature, p. 1501., (©2023 American Association for Cancer Research.)

Published
2023
Full Text
View/download PDF

44. Additional Value of Second Harmonic Generation Microscopy in the Diagnosis of Feline Collagen Type III Glomerulopathy.

Author

Guillaume E, Zacharopoulou M, Reynolds B, Aresu L, Lobjois L, Bleuart C, Bourgès-Abella N, Delverdier M, Lucas MN, Lavoué R, and Gaide N

Subjects
Animals, Cats, Collagen Type III, Female, Kidney, Kidney Glomerulus, Cat Diseases diagnosis, Kidney Diseases veterinary, Second Harmonic Generation Microscopy veterinary
Abstract

A 1.5-year-old neutered female Domestic Shorthair cat was euthanized after the diagnosis of end-stage protein-losing nephropathy associated with the onset of nephrotic syndrome. At necropsy, both kidneys were diffusely pale and swollen with a granular cortex. Histologically, glomeruli had diffuse global mesangial and capillary wall expansion by homogeneous pale eosinophilic material. This material was Congo red negative, blue with Masson's trichrome stain, weakly positive with periodic acid-Schiff stain, bright red with Picrosirius red and birefringent under polarized light. Transmission electron microscopy and second harmonic generation (SHG) microscopy revealed mesangial and subendothelial collagen fibril deposition. Type III collagen deposition was confirmed by immunohistochemistry. This study provides an original and complete description of feline collagen type III glomerulopathy and emphasizes the possibility of directly diagnosing glomerular collagen deposition on unstained slides through SHG microscopy., Competing Interests: Conflict of Interest Statement The authors declared no potential conflicts of interest with respect to the research, authorship or publication of this article., (Copyright © 2021 Elsevier Ltd. All rights reserved.)

Published
2021
Full Text
View/download PDF

45. Validation of the Sysmex XN-V hematology analyzer for canine specimens.

Author

Grebert M, Granat F, Braun JP, Leroy Q, Bourgès-Abella N, and Trumel C

Subjects
Animals, Dogs, Erythrocyte Count veterinary, Leukocyte Count veterinary, Reproducibility of Results, Dog Diseases diagnosis, Hematologic Tests veterinary, Hematology
Abstract

Background: The Sysmex XN-V is derived from the new Sysmex XN series of human hematology analyzers. The main changes from the previously validated XT-2000iV analyzer include an optic-fluorescent analysis for platelets and nucleated RBC count., Objective: We aimed to validate the Sysmex XN-V for canine blood according to American College for Veterinary Clinical Pathology and International Council for Standardization in Hematology recommendations., Materials and Methods: Canine EDTA blood specimens and quality control material were analyzed on the Sysmex XN-V to evaluate imprecision, bias, linearity, a comparison with the XT-2000iV analyzer, interference effects, carry-over, and stability. We also verified previously established Sysmex XT-2000iV reference intervals (RIs)., Results: Imprecision and bias were low (<5%) for most variables. Observed total error was lower than allowable total error for most measured variables except lymphocytes and monocytes. Visually determined linearity was excellent for all variables, except for lymphocytes. The correlation between the XN-V and XT-2000iV analyzers was high (>0.93) for all variables except MCHC and reticulocyte indices. Correlations between the Sysmex XN-V and manual differential counts were good for neutrophils and eosinophils, acceptable for lymphocytes, and fair for monocytes. Hemolysis, lipemia, and to a lesser extent icterus, had significant effects on measured hemoglobin concentration and associated variables. Carry-over was not visually observed for any variable. Changes in the Sysmex XN-V measurements after storage at 4℃ and 24℃ were similar to those described for the Sysmex XT-2000iV analyzer. The previously established Sysmex XT-2000iV RIs can be used to interpret results from the Sysmex XN-V analyzer for most variables except red blood cell distribution width and mean platelet volume., Conclusions: The performance of the Sysmex XN-V analyzer was excellent and compared favorably with the Sysmex XT-2000iV analyzer., (© 2021 The Authors. Veterinary Clinical Pathology published by Wiley Periodicals LLC on behalf of American Society for Veterinary Clinical Pathology.)

Published
2021
Full Text
View/download PDF

46. Detection of circulating microfilariae in canine EDTA blood using lens-free technology: preliminary results.

Author

Lavabre T, Polizopoulou ZS, Isèbe D, Cioni O, Rebuffel V, Blandin P, Bourgès-Abella N, and Trumel C

Subjects
Animals, Dirofilariasis blood, Dog Diseases blood, Dogs, Female, Male, Microfilariae isolation & purification, Dirofilaria immitis isolation & purification, Dirofilariasis diagnosis, Dog Diseases diagnosis, Edetic Acid blood, Veterinary Medicine instrumentation
Abstract

Dirofilaria immitis causes life-threatening heart disease in dogs, thus screening of dog populations is important. Lens-free technology (LFT) is a low-cost imaging technique based on light diffraction that allows computerized recognition of small objects in holographic images. We evaluated an algorithm capable of recognizing microfilariae in canine whole blood using the LFT. We examined 3 groups of 10 EDTA blood specimens, from dogs with microfilaremia (group A), healthy dogs (B), and dogs with hematologic modifications other than microfilaremia (C). The LFT analyzer photographed repeated series of 5 images of all samples. The algorithm declared a sample positive if a microfilaria was detected on ≥1, ≥2, or ≥3 of the 5 images of a series. Microfilariae were detected visually in the images in 9 of 10 cases in group A; no microfilariae were seen in the images from groups B and C. Of the 30 cases, there were 14, 4, and only 3 false-positives with the 1 of 5, 2 of 5, and 3 of 5 image cutoffs, respectively. There were no false-negatives, regardless of cutoff. LFT seems useful for detecting microfilaria and could have application in clinical pathology.

Published
2021
Full Text
View/download PDF

47. Abnormal Sysmex XT-2000iV DIFF scattergram in a cat with a prominent mastocytemia.

Author

Lavabre T, Betting A, Bourgès-Abella N, Layssol-Lamour C, and Trumel C

Subjects
Animals, Cat Diseases diagnosis, Cat Diseases pathology, Cats, Male, Mastocytosis, Systemic blood, Mastocytosis, Systemic diagnosis, Mastocytosis, Systemic pathology, Blood Cell Count veterinary, Cat Diseases blood, Mast Cells, Mastocytosis, Systemic veterinary
Abstract

A 2-year-old neutered male domestic shorthair cat was presented to the emergency service of the National Veterinary School of Toulouse (France) for acute vomiting and diarrhea with lethargy, inappetence, and adypsia for the past 48 hours. Complete blood counts were performed with the ProCyte DX at the emergency department and with the Sysmex XT-2000iV at the laboratory 2 weeks later. The scattergrams from the two analyzers revealed similar unusual and abnormal dot plots. The Sysmex XT-2000iV DIFF scattergram also showed no clear separation between different leukocyte populations. The eosinophil cluster was in an abnormal location compared with that of the "typical" location in a normal cat. A blood smear evaluation revealed the presence of numerous mast cells. Thus, we hypothesized that the Sysmex XT-2000iV had detected the mast cell population, and this led to errors in the differential counts. To explore this hypothesis, we manually gated on the DIFF scattergram and performed a manual differential on the blood smear. With this new gating strategy, the Sysmex XT-2000iV and manual differentials were similar. Thus, in the case of systemic mastocytosis, mast cells can be located between the lymphocyte, monocyte, and eosinophil clusters on scattergrams., (© 2019 American Society for Veterinary Clinical Pathology.)

Published
2019
Full Text
View/download PDF

48. The effects of storage at 4°C and 20°C on the hemograms of C57BL/6 mice and Wistar rats using the IDEXX ProCyte Dx and blood smear evaluations.

Author

Layssol-Lamour C, Lavabre T, Braun JP, Trumel C, and Bourgès-Abella N

Subjects
Animals, Blood Preservation, Erythrocyte Indices, Mice, Mice, Inbred C57BL, Rats, Rats, Wistar, Temperature, Blood Cell Count instrumentation, Blood Cell Count methods
Abstract

Background: Delayed blood analysis might be unavoidable in laboratory practice, but little is known about rodent blood stability, especially cell morphology and scattergram results., Objectives: This study aimed to evaluate the stability of rodent blood cell counts and morphologies at different temperatures using the ProCyte Dx analyzer and performing manual observations., Methods: Ten Wistar rats and 10 C57bl/6 mice were sampled on EDTA tubes and aliquoted for storage (4°C, 20°C). Hematologic analyses were performed immediately and at T6h, T24h, T48h (rats and mice), and T72h (rats only) after storage., Results: In rats, at any temperature, red blood cell counts, hemoglobin concentrations (HGB), mean corpuscular hemoglobin (MCH) levels, and reticulocyte, white blood cell (WBC), eosinophil, and impedance platelet counts remained stable over time. The main changes were observed at 20°C for hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and WBC differential counts. Optical platelet counts (PLT-O) and platelet variables underwent changes at both temperatures from T24h. In mice, red blood cell counts by impedance (RBC-I), MCH, and WBC, lymphocyte, eosinophil, and platelet counts, and plateletcrit (PCT) were stable over time and at all temperatures. As in rats, the most significant changes were observed at 20°C and concerned the optical RBC (RBC-O) counts, HCTs, MCVs, MCHCs, and reticulocyte, neutrophil, and monocyte counts. For both species, blood cell morphologies were altered from T24h at all temperatures, and platelet clumps were more numerous at 4°C., Conclusions: When rodent blood analyses need to be delayed, storage at 4°C is preferred and should not exceed 24 hours. PLT counts should be interpreted cautiously in refrigerated specimens with mandatory blood smear evaluations when abnormal scattergrams are observed., (© 2019 American Society for Veterinary Clinical Pathology.)

Published
2019
Full Text
View/download PDF

49. What is your diagnosis? Abnormal platelets dot plot from a dog.

Author

Piane L, Zémori C, Ribleau P, Guerlin M, Bourgès-Abella N, and Trumel C

Subjects
Animals, Diagnosis, Differential, Dog Diseases blood, Dog Diseases parasitology, Dogs, Male, Trypanosomiasis diagnosis, Dog Diseases diagnosis, Platelet Count veterinary, Trypanosomiasis veterinary
Published
2019
Full Text
View/download PDF

50. Urinalysis and determination of the urine protein-to-creatinine ratio reference interval in healthy cows.

Author

Herman N, Bourgès-Abella N, Braun JP, Ancel C, Schelcher F, and Trumel C

Subjects
Animals, Dairying, Female, Lactation urine, Reference Values, Urinalysis methods, Urine cytology, Cattle urine, Creatinine urine, Proteinuria veterinary, Urinalysis veterinary
Abstract

Background: There are no reference intervals for urinalysis in cattle., Hypothesis/objectives: Characterize the urine of healthy cows, establish urine protein-to-creatinine ratio (UPC) reference intervals, and test possible differences among dairy and beef cattle, age groups, or stage of lactation., Animals: Seventy-seven dairy and 74 beef 2.5 to 17 year-old cows of different breeds housed mainly in free stall., Methods: In this prospective study, urine specimens were collected by catheterization. Complete urinalysis was performed within 1 hour including specific gravity, dipstick evaluation, visual urine pH evaluation with 0.3 pH unit graded strips, and microscopic evaluation of the sediment. Urinary protein and creatinine concentrations and protein electrophoresis were determined on frozen aliquots., Results: Overall reference intervals were 1.020 to 1.045 for USG, 7.0 to 8.7 for pH, and 0.04 to 0.25 for UPC; because of differences in creatinine concentration, UPC was lower in beef (0.04-0.14) than in dairy (0.05-0.25) cows and in the latter in dry than lactating cows. With dipstick evaluation, most analytes were absent except for blood, ketone, and protein in 24.7, 16.0, and 64.7% of cases, respectively. Microscopic evaluation revealed less than 3 red blood cells, leukocytes, and epithelial cells in 84, 99.3, and 100% cows, respectively. No band was observed at electrophoresis, except in 1 case at MW ~66 000., Conclusions and Clinical Importance: Creatininuria is higher in beef than dairy cows and proteinuria is likely more efficiently characterized by protein concentration than by UPC., (© 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.)

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results