42 results on '"Abell, Lynn"'
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2. Immune-modulating enzyme indoleamine 2,3-dioxygenase is effectively inhibited by targeting its apo-form
3. Discovery of 12(BMS-986172) as a Highly Potent MGAT2 Inhibitor that Achieved Targeted Efficacious Exposures at a Low Human Dose for the Treatment of Metabolic Disorders
4. Screening Hit to Clinical Candidate: Discovery of BMS-963272, a Potent, Selective MGAT2 Inhibitor for the Treatment of Metabolic Disorders
5. Effect of Metal Ions and Adenylylation State on the Energetics of the E. Coli Glutamine Synthetase Reaction
6. Anion Gap, Anion Gap Corrected for Albumin, and Base Deficit Fail to Accurately Diagnose Clinically Significant Hyperlactatemia in Critically Ill Patients
7. Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase
8. Development and validation of a platelet calcium flux assay using a fluorescent imaging plate reader
9. Understanding Intra-Abdominal Hypertension: From the Bench to the Bedside
10. Cloning and functional expression of the small subunit of acetolactate synthase from Nicotiana plumbaginifolia
11. Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase
12. Identification of Reversible Small Molecule Inhibitors of Endothelial Lipase (EL) That Demonstrate HDL-C Increase In Vivo
13. Identifying critically ill patients at high risk for developing acute renal failure: A pilot study
14. Effect of metal-ligand mutations on phosphoryl transfer reactions catalyzed by Escherichia coli glutamine synthetase
15. Corrigendum to “Identification of substituted benzothiazole sulfones as potent and selective inhibitors of endothelial lipase” [Bioorg. Med. Chem. Lett. 29 (2019) 1918–1921]
16. Identification of RIPK3 Type II Inhibitors Using High-Throughput Mechanistic Studies in Hit Triage
17. Biochemical Approaches to Herbicide Discovery
18. Discovery and synthesis of tetrahydropyrimidinedione-4-carboxamides as endothelial lipase inhibitors
19. Sulfonylated Benzothiazoles as Inhibitors of Endothelial Lipase
20. Potent Triazolopyridine Myeloperoxidase Inhibitors
21. PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
22. Triazolopyrimidines identified as reversible myeloperoxidase inhibitors
23. Development of a RapidFire mass spectrometry assay and a fluorescence assay for the discovery of kynurenine aminotransferase II inhibitors to treat central nervous system disorders
24. Mechanism of Inhibition for BMS-791325, a Novel Non-nucleoside Inhibitor of Hepatitis C Virus NS5B Polymerase
25. Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea, a Potent, Selective, and Bioavailable P2Y1 Antagonist
26. Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor
27. Discovery of 2-(Phenoxypyridine)-3-phenylureas as Small Molecule P2Y1 Antagonists
28. Dissecting the Activation of Thienopyridines by Cytochromes P450 Using a Pharmacodynamic Assay In Vitro
29. Understanding Intra-Abdominal Hypertension
30. Use of the Kinetic Equilibrium between Aminoacyl-tRNA Formation and Hydrolysis in Inhibition Assays of Aminoacyl-tRNA Synthetase
31. Conformationally Constrained ortho-Anilino Diaryl Ureas: Discovery of 1-(2-(1′-Neopentylspiro[indoline-3,4′-piperidine]-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea,a Potent, Selective, and Bioavailable P2Y1Antagonist.
32. Biochemical Approaches to Herbicide Discovery: Advances in Enzyme Target Identification and Inhibitor Design
33. Active site inhibitors of acetolactate synthase
34. DISARMING THE ITALIAN TORPEDO: THE 2006 ITALIAN ARBITRATION LAW REFORMS AS A SMALL STEP TOWARD RESOLVING THE WEST TANKERS DILEMMA.
35. Discovery of 2-(Phenoxypyridine)-3-phenylureasas Small Molecule P2Y1Antagonists.
36. Oxygenase side reactions of acetolactate synthase and other carbanion-forming enzymes
37. Investigation of the mechanism of phosphinothricin inactivation of Escherichia coli glutamine synthetase using rapid quench kinetic techniques
38. Effect of metal ions and adenylylation state on the internal thermodynamics of phosphoryl transfer in the Escherichia coli glutamine synthetase reaction
39. Isotope effect studies of the pyruvate-dependent histidine decarboxylase from Lactobacillus 30a
40. Isotope effect studies of the pyridoxal 5'-phosphate dependent histidine decarboxylase from Morganella morganii
41. Nitrogen isotope effects on glutamate decarboxylase from Escherichia coli
42. Imaginative appropriation : confronting otherness through the female body in the works of Cesare Pavese and Italo Calvino
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