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25. The effect of arsenic trioxide on brain monoamine metabolism and locomotor activity of mice

Author

Murai Shigeo, Miyate Hiroki, Yi Fei Zhang, Nagahama Hiromichi, Itoh Tadanobu, Abe Eiichi, Saito Hiroko, and Saito Yuichi

Subjects
Male, medicine.medical_specialty, Central nervous system, Hippocampus, Administration, Oral, Striatum, Motor Activity, Toxicology, digestive system, Arsenicals, Arsenic, Mice, fluids and secretions, Arsenic Trioxide, Dopamine, Internal medicine, polycyclic compounds, medicine, Animals, Brain Chemistry, Arsenic toxicity, Chemistry, virus diseases, Brain, Oxides, General Medicine, digestive system diseases, Monoamine neurotransmitter, Endocrinology, medicine.anatomical_structure, Cerebral cortex, Hypothalamus, medicine.drug
Abstract

The arsenic trioxide (AsT) content, and monoamine levels in the cerebral cortex, hippocampus, hypothalamus and corpus striatum were determined in mice administered AsT (3 and 10 mg/kg) for 14 days. The vertical and horizontal motor activity was also examined. The AsT content in discrete brain areas differed but was clearly dose-dependent. Metabolites of norepinephrine and dopamine increased in the cerebral cortex, hippocampus and hypothalamus and decreased in the corpus striatum in AsT-treated mice. Metabolites of 5-hydroxytryptamine increased in all the discrete brain areas. The vertical and horizontal motor activity was increased by AsT at 3 mg/kg and decreased by AsT at 10 mg/kg. These results show that AsT modifies CNS metabolism and function at low doses. AsT penetrates the blood-brain barrier to cause these effects.

Published
1990

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