37 results on '"Abdullahi, Khalid"'
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2. Comparison of serum prostate specific antigen (PSA), soluble E-cadherin (sE-cad), and inosine monophosphate dehydrogenase-2 (IMPDH-2) as aggressive prostate cancer predictors
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Ahmed Mohammed Umar, Ismaila Arzika Mungadi, Ngwobia Peter Agwu, Abdullah Abdulwahab-Ahmed, Abubakar Sadiq Muhammad, and Abdullahi Khalid
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Gleason score ,Inosine monophosphate dehydrogenase-2 ,Prostate cancer ,Prostate specific antigen ,Soluble E-cadherin ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Abstract Background This study aimed to compare serum prostate specific antigen (PSA), Soluble E-cadherin (sE-cad), and Inosine Monophosphate Dehydrogenase-2 in predicting prostate cancer aggressiveness by determining their correlations with Gleason score and International Society of Urological Pathology (ISUP) Grade Groups. Methods This was a hospital-based descriptive quantitative cross-sectional study whereby we enrolled 48 newly diagnosed prostate adenocarcinoma patients in the study. Their serum was analysed for PSA, sE-cad, and IMPDH-2. Pearson correlation coefficient was used to test the correlation between the serum sE-cad and Gleason score while Spearman rho correlation coefficient was used for PSA and IMPDH-2. The correlation coefficient (r) was graded as very weak (
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- 2024
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3. Focusing on the Trend in Africa. Comment on Black, P. Publishing Urologic Research from Low- and Middle-Income Countries. Soc. Int. Urol. J. 2024, 5, 225–226
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Saleh Abdelkerim Nedjim, Yannick Joël Djoua, Mahamat Ali Mahamat, Anteneh Tadesse Kifle, Ouima Justin Dieudonné Ziba, Kaleab Habtemichael Gebreselassie, Marcella D. C. Biyouma, Abdullahi Khalid, Rimtebaye Kimassoum, Choua Ouchemi, Dakir Mohamed, Debbagh Adil, Alain Khassim Ndoye, Mohamed Lezrek, and Rachid Aboutaieb
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n/a ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
In a recently published Editorial, Black [...]
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- 2024
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4. Observations and Reflections from Sub-Saharan Africa. Comment on Shahait, M. Urology Practice in Low- to Middle-Income Countries. Soc. Int. Urol. J. 2024, 5, 374–375
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Saleh A. Nedjim, Kaleab H. Gebreselassie, Mahamat A. Mahamat, Ouima J. D. Ziba, Anteneh T. Kifle, Abdullahi Khalid, Rimtebaye Kimassoum, Choua Ouchemi, and Alain Khassim Ndoye
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n/a ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Shahait’s article on “Urology Practice in Low- to Middle-Income Countries” [...]
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- 2024
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5. Status, Needs, and Perspectives on the Practice of Endourology in Africa: a Continental Survey of 21 Reference Centers
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Saleh Abdelkerim Nedjim, Ziba Ouima Justin Dieudonné, Hagguir Hissein, Kaleab Habtemichael Gebreselassie, Douglas Arthur, Mahamane Salissou, Mahamat Ali Mahamat, Abdullahi Khalid, Emmanuel Muhawenimana, Cléhaude Dibingue, Thoto Shabani Marebo, Gnimdou Botcho, Daniel Danai, Rimtebaye Kimassoum, Choua Ouchemi, Mamadou II Barry Barry, Odzebe Anani Wenceslas Sévérin, Kasonde Bowa, Berthé Honoré, John Lazarus, Coulibaly Noël, Alain Khassim Ndoye, and Aboutaieb Rachid
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africa ,survey ,modern urology ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Endourology occupies an important place in modern urological practice. Compared with conventional surgery, it offers improved safety and patients experience less severe postoperative effects. Its use requires a certain level of equipment and technical skills. In many developed countries, it has been established for years and its practice has become routine. In Africa, it is still not very practical or even non-existent in certain reference centers. This survey conducted among the heads of urology departments or training coordinators in African referral centers defines the current practice of endourology. According to the needs and perspectives identified, it is important, if not essential, to create services or reference centers specializing in endourology. The role of these centers will be to take care of patients and train urologists in technical skills. The creation of a sub-regional and international network could contribute to the development of this practice. Multi-stakeholder cooperation (inter-state, with non-governmental organizations, companies or corporations) is also necessary.
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- 2023
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6. Detection of Genetic Variations in Children with Tetralogy of Fallot Using Whole Exome Sequencing Technology Integrated Bioinformatics Analysis.
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Abdullahi, Khalid Mohamoud, Ali, Ahmed Faisal, Adan, Mohamed Mohamoud, and Shu, Qiang
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- 2024
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7. Schistosomiasis of the Prostate in Sokoto, Nigeria: a case series
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Abdullahi Khalid, Abdullah Abdulwahab-Ahmed, Ismaila Arzika Mungadi, Kabiru Abdullahi, Ngwobia Peter Agwu, and Abubakar Sadiq Muhammad
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Prostate ,Schistosomiasis ,Presentation ,Transurethral resection of prostate ,Nigeria ,Science - Abstract
Abstract Background Prostate schistosomiasis is a chronic inflammatory condition of the prostate. In an endemic environment, it may mimic the sinister condition of the prostate in its clinical presentation. Despite the high prevalence of urinary schistosomiasis documented in our environment, prostate involvement is rarely encountered in routine clinical practice. We report and share our experience in the management of two cases of prostate schistosomiasis that presented with abnormal digital rectal examination and elevated prostate-specific antigen suggestive of prostate cancer but proved otherwise by the histology report. Case presentation The first patient was a 50-year-old man who presented with a history of voiding and storage lower urinary tract symptoms (LUTS) and urinary retention relieved by urethral catheterization. There was no other significant history except for past childhood terminal hematuria. The remarkable findings on physical examination were in the digital rectal examination which revealed enlarged prostate, hard, nodular, obliterated median groove, and restricted mobility of overlying rectal mucosa. The total serum prostate-specific antigen (PSA) was 1.2 ng/ml. Transrectal ultrasound-guided prostate biopsy and histology confirmed prostate schistosomiasis on a background of nodular hyperplasia. The second patient was an 80-year-old man who presented with a history of voiding and storage lower urinary tract symptoms (LUTS) and urinary retention relieved by urethral catheterization. There was no other significant history and no past childhood terminal hematuria. There were no remarkable findings on physical examination except for the enlarged prostate with benign findings on digital rectal examination. The initial total serum prostate-specific antigen (PSA) was 31.0 ng/ml. The repeated PSA was 7.5 ng/ml after antimicrobial therapy. Transrectal ultrasound-guided prostate biopsy and histology confirmed prostate schistosomiasis on a background of nodular hyperplasia. He had two sessions of Bipolar Transurethral Resection of the Prostate following failed medical treatment. Conclusions Schistosomiasis of the prostate may mimic the clinical or biochemical presentation of prostate cancer. The attending physician requires high index of suspicion to arrive at this diagnosis, especially for the urologist practicing in an endemic area.
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- 2022
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8. Atypical presentation of vesicouterine fistula (Youssef’s syndrome) post-caesarean gossypiboma: a case report
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Abdullahi Khalid, Abdullahi Alhassan, James Oche Ejembi, and Abdullahi Abdulwahab-Ahmed
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atypical presentation ,caesarean section ,gossypiboma ,vesicouterine fistula ,Youssef's syndrome ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
Vesicouterine fistula as described by Youssef manifests with amenorrhea, and cyclic haematuria (menouria) without urinary incontinence commonly following caesarean section. Other aetiologies have been reported for this disease. The post-caesarean section gossypiboma, a dual aetiology causing this condition is rare and can make its presentation atypical, thus posing a diagnostic dilemma. The clinical evaluation alone in the atypical presentation of the vesicouterine fistula is insufficient except complemented by imaging investigations and endoscopic examination of the related organs. We report a case of vesicouterine fistula that was managed initially as chronic pelvic inflammatory disease despite urinary incontinence until further evaluation including a transvaginal ultrasound scan and urethrocystoscopy raised an index of suspicion of a vesical mass suggestive of gossypiboma. The mass was confirmed to be a foreign body, an abdominal gauze pack, or gossypiboma. Its removal and repair of the vesicouterine fistula were associated with a satisfactory outcome.
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- 2023
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9. Epidemiological analysis of human adenovirus in children diagnosed with acute respiratory tract infection.
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abdullahi, Khalid mohamoud, primary, Ali, Ahmed Faisal, additional, shu, Qiang, additional, Li, Wei, additional, Wang, Binghan, additional, and Guo, Yajun, additional
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- 2024
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10. Comparison of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer: a protocol for systematic review and meta-analysis
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Garba Haruna Yunusa, Aminu Umar Kaoje, Akintunde Taiwo Orunmuyi, Stuart S. More, Zabah Muhammad Jawa, and Abdullahi Khalid
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Prostate cancer ,Tc-99m PSMA SPECT/CT ,Ga-68 PSMA PET/CT ,Sensitivity ,Specificity ,Accuracy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Background A wide range of nuclear imaging probes have been developed to address different metabolic processes and cell receptors in prostate cancer patients using positron emission techniques to aid diagnosis, staging, and monitoring for recurrence after treatment. While 68Ga PSMA is a generator-derived PET radiopharmaceutical, SPECT/CT imaging using technetium-99m-labeled PSMA is now available as a suitable alternative. The aim of this study is to compare the pooled sensitivity, specificity, and accuracy of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer. Main body of the abstract A search strategy was developed using text words, MeSH, and entry terms. The following databases will be searched: PubMed, African Journals Online (AJOL), Embase, Google scholar, ResearchGate, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Web of Science. Eligibility criteria include (a) all studies that are published or retrievable in English language, (b) observational studies, and (c) histopathology analysis or clinical and imaging follow-up or comparison with reference standards. Exclusion criteria will be interventional studies, editorials, reviews, and commentaries. Quality of the studies will be assessed using QUADAS2 Quality scores and risk of bias for individual studies will be reported. Full text of the studies will be reviewed and snowballed for any relevant literature. Assessment of methodological, clinical, and statistical heterogeneity for all the included studies will be made. Publication bias will be assessed using funnel plots. Statistical analysis and forest plots will be performed using the Open Meta-analyst software. The systematic review and meta-analysis will be reported according to PRISMA 2015 Statement. Short conclusion This review will provide data on diagnostic accuracy of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT in patients with prostate cancer. Results from this study will help nuclear medicine service providers to make better decisions on the appropriate use of 99mTc-PSMA SPECT/CT and 68Ga-PSMA PET/CT especially with regard to the use of 99mTc-PSMA SPECT/CT which is relatively affordable and more readily available in developing countries when compared to 68-Ga PSMA PECT/CT.
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- 2021
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11. Intestinal proinflammatory macrophages induce a phenotypic switch in interstitial cells of Cajal
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Chen, Xuyong, Meng, Xinyao, Zhang, Hongyi, Feng, Chenzhao, Wang, Bin, Li, Ning, Abdullahi, Khalid Mohamoud, Wu, Xiaojuan, Yang, Jixin, Li, Zhi, Jiao, Chunlei, Wei, Jia, Xiong, Xiaofeng, Fu, Kang, Yu, Lei, Besner, Gail E., and Feng, Jiexiong
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Pediatric research ,Macrophages -- Physiological aspects -- Health aspects ,Hirschsprung's disease -- Complications and side effects ,Smooth muscle -- Physiological aspects ,Muscle cells -- Physiological aspects -- Health aspects -- Genetic aspects ,Enterocolitis -- Development and progression ,Health care industry - Abstract
Interstitial cells of Cajal (ICCs) are pacemaker cells in the intestine, and their function can be compromised by loss of C-KIT expression. Macrophage activation has been identified in intestine affected by Hirschsprung disease-associated enterocolitis (HAEC). In this study, we examined proinflammatory macrophage activation and explored the mechanisms by which it downregulates C-KIT expression in ICCs in colon affected by HAEC. We found that macrophage activation and TNF-[alpha] production were dramatically increased in the proximal dilated colon of HAEC patients and 3-week-old [Ednrb.sup.-/-] mice. Moreover, ICCs lost their [C-KIT.sup.+] phenotype in the dilated colon, resulting in damaged pacemaker function and intestinal dysmotility. However, macrophage depletion or TNF-[alpha] neutralization led to recovery of ICC phenotype and restored their pacemaker function. In isolated ICCs, TNF-[alpha]-mediated phosphorylation of p65 induced overexpression of microRNA-221 (miR-221), resulting in suppression of C-KIT expression and pacemaker currents. We also identified a TNF-[alpha]/NF-[kappa]B/miR-221 pathway that downregulated C-KIT expression in ICCs in the colon affected by HAEC. These findings suggest the important roles of proinflammatory macrophage activation in a phenotypic switch of ICCs, representing a promising therapeutic target for HAEC., Introduction Hirschsprung disease (HSCR) is a birth defect characterized by the absence of ganglion cells in the distal bowel (1). HSCR-associated enterocolitis (HAEC), the most common and serious complication of [...]
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- 2020
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12. West Africa Sub-Regional Training and Skills Transfer: My Experience at the Urology Unit of the Korle-Bu Teaching Hospital, Accra, Ghana
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Abdullahi Khalid
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urology ,surgery ,west africa ,training ,Diseases of the genitourinary system. Urology ,RC870-923 - Abstract
None.
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- 2021
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13. Assessment of the Factors Influencing Delays on Construction Projects in Mogadishu Somalia
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Farah, Abdiweli Ali, primary, Osman, Yasir Hassan, additional, Mohamud, Faizo Ahmed, additional, Abdullahi, Khalid Abdiwahab, additional, and Hassan, Ali Muse, additional
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- 2023
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14. Selenium supplementation and clinical outcomes: an umbrella review protocol
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Mosanya, Adaobi Uchenna, primary, Umeh, Ifeoma, additional, Abdullahi, Khalid Abba, additional, Ukoha-Kalu, Onyinye Blessing, additional, Adibe, Maxwell Ogochukwu, additional, and Sanmartin, Carmen, additional
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- 2023
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15. Clinicopathological Correlates of Patients with Prostate Cancer in a Tertiary Hospital in Northwestern Nigeria
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Oyibo, Emmanuel U., Umar, Mohammed A., Abdullahi, Khalid, Muhammad, Sadiq A., and Agwu, Peter N.
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Background: Worldwide, prostate cancer is a common cause of significant morbidity and mortality in ageing men. Digital rectal examination(DRE) and serum total prostate specific antigen(tPSA) are widely used tools for prostate cancer(CaP) screening and diagnosis before transrectal ultrasound (TRUS)- guided prostate biopsy. Objectives: This study aimed at finding the clinical, biochemical, radiological and pathological correlates in patients with an enlarged prostate and elevated serum tPSA. Methodology: This is a 12-month cross-sectional study of 80 male patients aged 50 years and above with lower urinary tract symptoms(LUTS), abnormal digital rectal examination and/or elevated PSAgreater than 4ng/mL. Aged-matched males were also included as a negative biopsy group with serum levels of tPSA determined using ELISA methods among both groups. Clinical, procedural (TRUS guided biopsy) assessment, transrectal ultrasound-guided biopsies of the prostate for histological characterisation of all patients and Gleason score categorization for prostate in cancer group were done. The relationship between serum tPSA and Gleason score of prostate cancer patients was determined using Spearman's correlation. Results: The mean serum total PSAin patients with prostate cancer and the negative biopsy group was 82.93 ± 35.02 and 28.85±30.92 ng/ml respectively. The majority of the patients in the prostate cancer group (90.0%) had suspicious findings on DRE compared to the negative biopsy group (46.2%). There is a positive correlation between serum tPSA and Gleason score in patients with prostate cancer. Serum tPSA levels were significantly lower in the negative biopsy group. The Gleason score pattern of distribution among patients with Prostate cancer showed that the majority had a score greater than 8 and ISUP Grade V. Conclusion: Findings of elevated total serum PSA and abnormal digital rectal examinations in patients with an enlarged prostate in our practice are predictive of high Gleason score prostate cancer on TRUS-guided biopsy of the prostate. 
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- 2023
16. An enigma: case series of vesical calculi from prolonged and neglected indwelling catheter
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Abdullahi Khalid, Abdullah Abdulwahab-Ahmed, Abubakar Sadiq Muhammad, Gamdu Jesini, Ngwobia Peter Agwu, and Isma'ila Arzika Mungadi
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Surgery - Abstract
Vesical calculus is a common condition with familiar aetiology in our environment as it is obtained in other parts of the world. Notwithstanding, uncommon aetiology of this pathology still exists though rarely encountered especially where out-of-pocket payment is the norm for accessing health care services. This is a report of three patients with varying indications for indwelling vesical catheter insertion via urethral or suprapubic route and who developed vesical calculus from prolonged and neglected indwelling vesical catheter. These cases are indeed an enigma in contemporary surgical patient care. We share our experience in the care of these patients and to underscore the extra role expected of health care providers in adequate patient education, close attention to guidance and counseling during patients’ visits to health facilities.
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- 2023
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17. Understanding Information Ethics Practice through the PAPA Framework
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Baharuddin, Kasmarini, primary, Mustafa, A’dillah, additional, Abdullah, Siti Nurul Maryam, additional, and Abdullahi, Khalid Ayuba, additional
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- 2022
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18. Medical expulsive therapy symptomatic aggravation in blind right orthotopic ureterocoele and contralateral impacted left ureteral meatus stones: A Case Report
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Abdullahi Khalid, Abubakar Sadiq Muhammad, Haruna Usman Kamba, and Abubakar Isyaku
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medicine.medical_specialty ,Meatus ,Impaction ,business.industry ,medicine ,business ,Surgery - Abstract
A ureterocoele with stone may present with recurrent flank pain and urinary tract infection. Medical expulsive therapy (MET) may be associated with symptomatic aggravation when there is ureteric obstruction or stone impaction. The definitive treatment is by deroofing and retrieval of the stone endoscopically or by open intravesical approach. We report a case of symptomatic aggravation of right orthotopic blind ureterocoele stone and contralateral impacted left ureteral meatus stone following MET using tamsulosin who was treated by open deroofing and retrieval of stones. Case presentation: This is a 17-year-old lady who presented with recurrent suprapubic colicky abdominal pain that was aggravated by Medical Expulsive Therapy (MET) using tamsulosin but improves with opioid analgesics. Abdominopelvic ultrasound done before MET revealed bladder stone but the repeat ultrasound after the MET revealed bilateral ureterocoele with stones. A computerized tomographic scan urogram (CTU) revealed a right ureterocoele stone and bladder stone. She had bladder exploration with the finding of blind right orthotopic ureterocoele containing stone measuring 2.5cm x 3cm and an impacted peeping left ureteric meatus stone of 1.2x1 cm. She had deroofing of the right ureterocoele and retrieval of the stones bilaterally. The stitches and stents were removed and discharged on 9 and 10 postoperative days respectively. The postoperative period was uneventful. Conclusion: Medical expulsive therapy may be associated with symptomatic aggravation in blind orthotopic ureterocoele and sizeable impacted ureteral meatus stone. Findings of the Imaging studies may be conflicting and inaccurate. Deroofing of the ureterocoele and stone retrieval is associated with a good outcome.
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- 2021
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19. Clinicopathological Correlates of Patients with Prostate Cancer in a Tertiary Hospital in Northwestern Nigeria
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Oyibo U. Emmanuel, Umar A. Mohammed, Abdullahi Khalid, Muhammad A. Sadiq, and Agwu N. Peter
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Digital rectal examination ,Clinicopathological ,Prostate cancer Serum total prostate specific antigen (tPSA) ,Gleason score ,Transrectal guided ultrasound biopsy - Abstract
Background: Worldwide, prostate cancer is a common cause of significant morbidity and mortality in aging men. Digital rectal examination(DRE) and serum total prostate-specific antigen(tPSA) are widely used tools for prostate cancer(CaP) screening and diagnosis before transrectal ultrasound (TRUS)-guided prostate biopsy. Objectives: This study aimed at finding the clinical, biochemical, radiological, and pathological correlates in patients with an enlarged prostate and elevated serum tPSA. Materials and Methods: This is a 12-month cross-sectional study of 80 male patients aged 50 years and above with lower urinary tract symptoms(LUTS), abnormal digital rectal examination, and/or elevated PSA greater than 4ng/mL. Aged-matched males were also included as a negative biopsy group with serum levels of tPSA determined using ELISA methods among both groups. Clinical, procedural (TRUS guided biopsy) assessment, transrectal ultrasound-guided biopsies of the prostate for histological characterisation of all patients and Gleason score categorization for prostate in cancer group were done. The relationship between serum tPSA and Gleason score of prostate cancer patients was determined using Spearman's correlation. Results: The mean serum total PSA in patients with prostate cancer and the negative biopsy group was 82.93 ± 35.02 and 28.85±30.92 ng/ml respectively. The majority of the patients in the prostate cancer group (90.0%) had suspicious findings on DRE compared to the negative biopsy group (46.2%). There is a positive correlation between serum tPSA and Gleason score in patients with prostate cancer. Serum tPSA levels were significantly lower in the negative biopsy group. The Gleason score pattern of distribution among patients with Prostate cancer showed that the majority had a score greater than 8 and ISUP Grade V. Conclusion: Findings of elevated total serum PSA and abnormal digital rectal examinations in patients with an enlarged prostate in our practice are predictive of high Gleason score prostate cancer on TRUS-guided biopsy of the prostate.
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- 2022
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20. Comparison of Serum Microseminoprotein-Beta (MSMB) with Total Prostate Specific Antigen (TPSA) in the Diagnosis of Prostate Cancer in African Men
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Oyibo, Emmanuel U., Abdullahi, Khalid, Abubakar S. Muhammad, Ngwobia P. Agwu, Abdullahi Abdulwahab-Ahmed, and Ismaila A. Mungadi
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The burden of prostate cancer is high globally and especially among men of African descent. Serum prostate specific antigen(PSA) has long been used for diagnosis,however,its low specificity and indiscriminate use has led to unnecessary biopsies,over-diagnosis and over treatment of apparently indolent tumours.This weakness of PSA as a biomarker for cancer prostate has necessitated the search and identification of an alternative to it. To compare the sensitivity, specificity, positive predictive value, and negative predictive value of serum Microseminoprotein-beta(MSMB) with serum total prostate specific antigen (tPSA) in the diagnosis of prostate cancer in African men. This is a 12-month prospective study of patients aged 50 years and above with lower urinary tract symptoms (LUTS), PSA greater than 4ng/ml and/or abnormal digital rectal examination, leading to the suspicion of prostate cancer. Patients with a histological diagnosis of prostate cancer formed the study group while those with negative biopsy/benign prostatic hyperplasia on histology served as the control group.All had detailed history and focused examination with serum levels of Microseminoproteinbeta(MSMB) and total PSA (tPSA) determined using Enzyme-linked immunosorbent assay methods. Data were analyzed using SPSS version 20.0 for windows. The mean age of patients with prostate cancer and those with benign prostatic hyperplasia (BPH)/negative biopsy was 67.40 ± 9.08 and 65.43 ± 9.68 years, with an age range of 50-91 and 50-89 years, respectively. Compared to MSMB, tPSA had a higher sensitivity (82.5 vs 57.5%), specificity (77.5 vs 30.0%), PPV (78.6 vs 45.1), NPV (81.6 vs 41.4%) and diagnostic accuracy (80.6 vs 43.8%). Serum total PSA had a higher validity than serum MSMB in diagnosing prostate cancer. Hence, tPSA remains a relevant serum tumour biomarker in diagnosing prostate cancer in our urological practice.
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- 2022
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21. Spectrum of Bladder Cancer Patients Morbidity and Mortality in a Tertiary Hospital of Northwestern Nigeria: A 7-Year Review
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Abubakar Sadiq Muhammad and Abdullahi Khalid
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medicine.medical_specialty ,Blood transfusion ,Bladder cancer ,business.industry ,Urinary system ,medicine.medical_treatment ,Retrospective cohort study ,Anorexia ,urologic and male genital diseases ,medicine.disease ,female genital diseases and pregnancy complications ,Weight loss ,Lower urinary tract symptoms ,Radiological weapon ,Internal medicine ,Medicine ,medicine.symptom ,business - Abstract
Background: Bladder cancer is a common cause of morbidity and mortality in our institution due to the late presentation. Morbidity is defined as a development of complications that may lead to mortality. Uraemia is a common presentation that constitutes a management challenge in our patients. We study the spectrum of morbidity and mortality in bladder cancer patients in our institution. Materials and Methods: This is a retrospective study of patients with clinical, radiological, cytological and or histological features of bladder cancer that had a morbidity and or mortality managed at Usmanu Danfodiyo University Teaching Hospital Sokoto from January 2011 to December, 2017. Data were retrieved from patients’ case notes via a proforma and analyzed using SPSS 20.0 version for windows. The results were presented in number percent, tables and chart. Results: There were morbidity and or mortality in 234 bladder cancer patients within the study period with a mean age of 48.4 ± 14.1 years and a range of 3 - 106 years. There were 219 males (91.5%) and 20 females (8.5%) with a male to female ratio of 11:1. There were haematuria and lower urinary tract symptoms (LUTS) in 230 patients (98.3%). There were necroturia ± weight loss and anorexia in 126 patients (53.8%). There was urinary tract infection (UTI) in 75 patients (32.1%), anaemia in 131 patients (56.0%) and uraemia in 161 patients (68.8%). Mortality was recorded in 84 patients (35.9%) which was due to uraemia in 52 patients (22.2%), urosepsis in 22 patients (9.4%) and anaemia in 8 patients (3.4%), intestinal obstruction and blood transfusion reaction in 1 patient each (0.4%). Conclusion: Anaemia, urosepsis and uraemia are the most common causes of morbidity and or mortality in bladder tumour patients in Sokoto. This poses great diagnostic and therapeutic dilemma to the urologist, patients and their relatives.
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- 2021
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22. Clinical Presentation of Prostatic Disease Patients in a Hospital Setting
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Abdullahi, Khalid, primary, I. Arzika, Mungadi, additional, N. Peter, Agwu, additional, Abdullah, Abdulwahab-Ahmed, additional, A. Sadiq, Muhammad, additional, Abdullahi, Kabiru, additional, and Habibullah, Adamu, additional
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- 2022
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23. Expectations of participants attending urological workshops and scientific conferences
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Abdullahi Khalid, Abdullahi Abdulwahab-Ahmed, Ngwobia Peter Agwu, Abubakar Sadiq Muhammad, Uzodimma Ejike Onwuasoanya, and Ismaila Arzika Mungadi
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- 2020
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24. Histological pattern of bladder cancer at a tertiary hospital in North Western Nigeria: an update
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Uzodimma E. Onwuasoanya, Ismaila A. Mungadi, Ngwobia Peter Agwu, Abdullahi Abdulwahab-Ahmed, Kabiru Abdullahi, Abubakar Sadiq Muhammad, and Abdullahi Khalid
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Background: An update on the histopathological patterns of bladder cancer in our environment is pertinent to determine the current prevalent histological type and if there is worsening schistosomal infestation as these can guide the management of bladder cancer.Methods: This is a prospective study of patients managed for bladder cancer at the urology unit, department of surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria between 02 February 2018 and 01 February 2019. Histology of biopsy specimens were done at the histopathology department of Usmanu Danfodiyo University Teaching Hospital, Sokoto. Data was collected using a structured proforma and analyzed using statistical package for the social sciences (SPSS) version 20.0.Results: A total of 65 patients were recruited into the study with mean age of 51.9 years and standard deviation of ±14.7. The male to female ratio was 6:1 and the commonest occupation of the patients was farming (41.5%). A total of 46 patients (70.8%) had squamous cell carcinoma following histology, followed by transitional cell carcinoma seen in 9.2% of patients and adenocarcinoma seen in 3.1% of patients. Schistosoma ova was seen in 13.8% of the patients while 3.1% of the patients had cystitis cystica.Conclusions: The commonest histological type of bladder cancer in our environment is squamous cell carcinoma. In this current study, the percentage of patients with squamous cell carcinoma is higher than the previously reported percentages while the percentage of patients with transitional cell carcinoma is lower than the previously reported percentages thus revealing worsening schistosomal infestation in our environment.
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- 2022
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25. Impact of Socioeconomic Status on Prostate Cancer Outcomes Globally: A Protocol for Systematic Review and Meta-analysis
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Bertilla Uzoma Ezeonwu, Kokogho Afoke, Chinemerem Eunice Onwuchekwa, Ifeoma Bridget Udigwe, Emmanuel Okechukwu Nna, Kyegwim Nianglong Kenneth, Rosamund Akuse, Dorathy Chinwe Obu, Ifeoma Okoye, Richard Chinaza Ikeagwulonu, Uzoma Vivian Asiegbu, Adejumoke Idowu Ayede, Maria Ahuoiza Garba, and Abdullahi Khalid
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Protocol (science) ,Oncology ,medicine.medical_specialty ,Prostate cancer ,Text mining ,business.industry ,Internal medicine ,Meta-analysis ,medicine ,business ,medicine.disease ,Socioeconomic status - Abstract
BackgroundOne in every four men will be affected by prostate cancer. Choice of treatment depends on factors including grade and stage of the disease, age of the patient, availability of treatment options and socioeconomic status. We aimed to develop a protocol to assess the impact of socioeconomic status on prostate cancer outcomes globally.Methods A search strategy is developed using MeSH, text words, and entry terms. Nine databases will be searched, including PubMed, African Journals Online (AJOL), Google Scholar, Scopus, Cochrane Library, CINAHL, Web of Science, Embase and ResearchGate.Only observational studies, retrievable in the English language will be included. The primary outcome of this study is the socioeconomic status of prostate cancer patients. Secondary outcomes include mortality due to prostate cancer, health related quality of life, prostate cancer recurrence, need for secondary treatment, time to return to work, treatment choice regret and hospice enrollment. Identified studies will be screened and selected based on inclusion criteria. Data items will be managed in Zotero software, Microsoft Excel and CMA software. Both quality scores and the risk of bias for individual studies will be reported. Studies will be assessed for methodological, clinical, and statistical heterogeneity. Funnel Plots will be used for assessing publication bias. DiscussionThis protocol will enable a transparent, reliable and accurate method for assessing the impact of socioeconomic status on the global prostate cancer outcomes. It will allow discussions on outcomes such as mortality due to prostate cancer and how income disparity and availability of treatment options can influence prostate cancer outcomes. The final report of this study will be published in a peer-reviewed journal and the findings will be made available to health authorities.Systematic review RegistrationThis protocol has been registered in PROSPERO, with registration number CRD42020213700
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- 2020
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26. Management of Adult Renal Tumours: Review of Nine (9) Years Experience
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Saddik Malam Sahabi, Abubakar Sadiq Muhammad, Ismaila Arzika Mungadi, Ngwobia Peter Agwu, Abdullahi Abdulwahab-Ahmed, Abdullahi Khalid, and Uzodimma Ejike Onwuasoanya
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Sorafenib ,medicine.medical_specialty ,Angiomyolipoma ,Pleural effusion ,business.industry ,medicine.medical_treatment ,General surgery ,medicine.disease ,Nephrectomy ,Targeted therapy ,Late presentation ,medicine.anatomical_structure ,Quality of life ,Prostate ,medicine ,business ,medicine.drug - Abstract
Background: Renal tumours appear to be relatively uncommon in our routine urological practice compared to other urological malignancies of bladder and prostate origins. Their presentations are often late despite increasing availability and affordability of routine imaging modalities for early detection. This therefore poses management challenge in our environment. This study aims to review our 9-year experience with the management of renal tumours at the Urology Unit of a tertiary health facility in North-western Nigeria Methodology: A retrospective review of 20 patients managed for renal tumour at our facility from September 2009 to August 2017. Data of all adult patients managed for renal tumours was retrieved and analyzed using SPSS 20.0 version for windows. The results were presented in percentages and mean ± SD as well as charts. Results: Twenty (20) patients were managed for renal tumours during the review period. The mean age of patients was 39.94 ± 12.19 years with median of 35 years and male to female ratio of 1:2. Nineteen (19) patient (95%) and 1(5%) had malignant and benign renal tumours respectively. Clinical presentations were flank mass seen in 18 patients (90%), flank pain 16 (80%), haematuria 10(50%), cough 2(10%), and pleural effusion 2(10%). Only clinical stages III and IV tumour were seen. 70% were clear cell variety while 5% was angiomyolipoma. Sixteen (80%) of patients had radical nephrectomy and two (10%) with inoperable tumour benefited from targeted molecular therapy preoperatively using Sorafenib. Conclusion: Late presentation of patients with renal tumours to our facility despite the availability of imaging facilities such as ultrasound scanning is still the norm. This makes surgery which offers best chance of survival and quality of life difficult and challenging. Targeted therapy using sorafenib, if available and affordable in our environment will be useful in management of patients with inoperable tumours.
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- 2020
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27. Perceptions towards research data sharing: A qualitative study of Nigerian academics
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Abdullahi, Khalid Ayuba, primary and Noorhidawati, A., additional
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- 2020
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28. Spectrum of urological cases in a West African Tertiary Hospital
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Abdullahi Khalid and Ismaila Arzika Mungadi
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Male ,prostate adenocarcinoma ,Urethral stricture ,calculs urinaires ,bladder tumor ,mesh:des calculs urinaires des voies supérieures ,Outpatient clinic ,Child ,Aged, 80 and over ,General Medicine ,Middle Aged ,benign prostatic enlargement ,Child, Preschool ,Workforce ,Original Article ,Urologic disease ,Adult ,Urologic Diseases ,urologie africaine ,medicine.medical_specialty ,urinary calculi ,Adolescent ,mesh:Une hypertrophie bénigne de la prostate ,mesh:une tumeur de la vessie ,Nigeria ,Context (language use) ,Young Adult ,adénocarcinome de la prostate ,medicine ,Humans ,Sex Distribution ,Hospitals, Teaching ,Aged ,Retrospective Studies ,Urethral Stricture ,business.industry ,General surgery ,Infant ,Prostatic Neoplasms ,Retrospective cohort study ,Emergency department ,tumeur de la vessie ,Hypertrophie bénigne de la prostate ,medicine.disease ,African urology ,Cross-Sectional Studies ,Etiology ,rétrécissement urétral ,mesh:une sténose urétrale et un adénocarcinome de la prostate sont courants dans notre environnement ,business - Abstract
Context: Urological diseases vary from one geographical location to another worldwide. The knowledge of their distribution in each location could determine local workforce and facility needs and as well guide the areas of subspecialization. Aims: The aim of this study is to document the annual frequency and distribution of urological diseases at the Usmanu Danfodiyo University Teaching Hospital, Sokoto. Settings and Design: A cross-sectional retrospective study from January 2016 to December 2016 of all new patients seen at the urology outpatient clinic, emergency department as well as inpatient referrals from other departments of Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. Materials and Methods: The relevant records were extracted from the patient's case notes and entered into a semistructured questionnaire. Statistical Analysis Used: Data were analyzed using the SPSS software version 20. Results: A total of 607 new patients were seen over the study period. There were 576 (94.9%) males and 31 (5.1%) females, with a male-to-female ratio of 18.6:1. The median age was 45 years, with age range of 1–106 years. Urological emergencies were seen in 35.0% patients. Ninety-one percent of cases were acquired, whereas 8.2% were of congenital etiology. Overall, the most commonly diagnosed urologic diseases among new patients in order of decreasing frequency were benign prostatic enlargement (BPE) (18.6%), bladder tumor (11.8%), upper tract urinary calculi (10.3%), urethral stricture (8.9%), and prostate adenocarcinoma (7.4%). Conclusions: BPE, bladder tumor, upper tract urinary calculi, urethral stricture, and prostate adenocarcinoma are common in our environment. Knowledge of these diseases distribution may guide service expansion and workforce needs, inspire subspecialization as well as direct research and government policy in this community. Nongovernmental organizations wanting to have impact will be suitably directed.
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- 2021
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29. Pattern of presentation and management of benign upper urinary tract obstruction in Sokoto Northwest Nigeria
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Abdullahi Khalid, Ngwobia Peter Agwu, Abubakar Sadiq Muhammad, Ismaila Arzika Mungadi, Abdullahi Abdulwahab-Ahmed, and A Abdullahi
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medicine.medical_specialty ,business.industry ,Urinary system ,General Engineering ,Reflux ,Renal function ,urologic and male genital diseases ,medicine.disease ,Malignancy ,Ureteric obstruction ,female genital diseases and pregnancy complications ,Surgery ,Ureteric obstruction, urolithiasis, pelvi-ureteric junction obstruction ,Medicine ,Presentation (obstetrics) ,business ,Urinary tract obstruction ,Upper urinary tract - Abstract
Background: Upper urinary tract obstruction is a common cause of severe symptoms, recurrent urinary tract infection and deterioration or complete loss of renal function when intervention is not timely.Objective: To document the pattern of presentation and the management options for the benign upper urinary tract obstruction in our practice.Materials and Methods: The study retrospectively reviewed patients managed for benign upper urinary tract obstruction in our facility from February 2011 to February 2016. A total of 52 patients were treated during the study period. All the patients with benign upper urinary tract obstruction were included in the study. While Patients with lower urinary tract obstruction without secondary vesico-ureteric reflux (VUR), upper urinary tract obstruction from malignancy and those with incomplete records were excluded.Data was collected via a proforma and analysis was done using SPSS 20.0 versionResults: The mean age of patients in the study was 32.9±12.8 years and Male: female ratio was 3.3:1. The mode of presentations were flank pain in 47 patients (90.2%), haematuria in 36 patients (69.2%), childhood haematuria in 23 patients (44.2%) and urinary tract infection (UTI) in19 patients (36.5 %). The causes of upper tract obstruction were urolithiasis in 32 patients (61.6%), ureteric obstruction in 15 patients (28.8 %) and pelvi-ureteric junction obstruction in 5 patients (9.6 %). The definitive treatments were open in 27 patients (51.9 %), endoscopic in 14 patients (26.9%), and non-operative in 11 patients (21.2%).Conclusion: Urolithiasis, ureteric obstruction and pelvi-ureteric junction obstruction are the commonest cause of benign upper tract obstruction in our environment. Treatment can be open, endoscopic or medical.Keywords: Ureteric obstruction, urolithiasis, pelvi-ureteric junction obstruction
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- 2017
30. The pattern of urine cytology in a tertiary health care facility Northwest Nigeria
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Kabiru Abdullahi, Abdullahi Abdulwahab-Ahmed, Abubakar Sadiq Muhammad, Ngwobia Peter Agwu, Mohammed A. Umar, and Abdullahi Khalid
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Family medicine ,Health care ,Medicine ,business ,Urine cytology - Abstract
Background: Urine cytology is an important investigation in the management of urothelial cancer. It is particularly an important test in the management of urinary tract cancers because of its non-invasive nature. Objective of study to review our practice of urine cytology as a diagnostic tool in the management of urinary tract pathology.Methods: A seventeen years retrospective study from 1st January, 2001 to 31st December, 2017 where records of patients who had urine cytology in Usmanu Danfodio University Teaching Hospital (UDUTH), Sokoto, Nigeria were reviewed and data was extracted and analyzed using the SPSS 20.Results: Of the 766 specimens, representing 10.1% of all cytology done in UDUTH (7,554) during the period under review, the highest number of urine cytology was done in 2013 (12%). The age range of the patients was between 2 to 90 years with modal age of 60 years. Majority of the patients were between the ages of 51 to 60 years (24.7%) and male to female ratio was 6.3:1. The commonest indication for urine cytology was bladder tumour (66.8%). However, the commonest cytological diagnosis was negative (44.6%) while 19.3% showed Non Specific Chronic Inflammation and only 77 specimens were malignant representing 10.1% of the specimen.Conclusions: Despite its variable sensitivity, urine cytology remains a useful tool in evaluating suspected bladder malignancies and can serve as an adjunct to cystoscopy in these cases.
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- 2019
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31. Metastatic Cervical and Supraclavicular Lymphadenopathy from Prostate Mimicking Lymphoma: A Case Series
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Muhammad, Abubakar Sadiq, primary, Agwu, Ngwobia Peter, additional, Abdulwahab-Ahmed, Abdullahi, additional, Abdullahi, Khalid, additional, Abdullahi, Kabiru, additional, Umar, Ahmed Mohammed, additional, and Mungadi, Ismaila Arzika, additional
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- 2019
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32. Management of obstructive nephropathy in a tertiary hospital in North West Nigeria: A five-year review
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Muhammad, A. Sadiq, primary, Abdulwahab-Ahmed, Abdullahi, additional, Agwu, Peter N., additional, Abdullahi, Khalid, additional, and Mungadi, Ismaila A., additional
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- 2018
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33. Ex utero intrapartum treatment for giant congenital omphalocele
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Chen, Xu-Yong, primary, Yang, Ji-Xin, additional, Zhang, Hong-Yi, additional, Xiong, Xiao-Feng, additional, Abdullahi, Khalid Mohamoud, additional, Wu, Xiao-Juan, additional, and Feng, Jie-Xiong, additional
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- 2018
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34. An alternative to DJ-stenting for ureteroneocystostomy: Experience at a tertiary health facility
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Abdullahi Khalid and Ngwobia Peter Agwu
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medicine.medical_specialty ,Multidisciplinary ,business.industry ,Ureteric catheter ,medicine.medical_treatment ,Stent ,Retrospective cohort study ,Surgery ,surgical procedures, operative ,Health facility ,Female patient ,medicine ,Case note ,In patient ,Complication ,business - Abstract
Background: Stenting of the ureters is an established principle of ureteral surgery. This can be achieved using conventional double-J (DJ) stents, ureteric catheter or improvised infant feeding tubes. In routine urological practice, our choice is influenced by availability, cost, and the availability of urethrocystoscopic equipment for device retrieval. We described an alternative surgical technique and review the outcomes of this procedure. Patients and Method: This is a 10-year retrospective study from October 2007 to November 2017 of patients who had an alternative to DJ-stenting using infant feeding tube for ureteroneocystostomy following ureteric injury in the urology unit of a tertiary health facility. The records of socio-demographic, clinical and therapeutic characteristics and complications in patients who had alternative to DJ-Stenting inserted for ureteroneocystostomy following ureteric injury were extracted from patient's case notes. Data was analyzed using SPSS version 20. Results: Out of a total of 26 female patients with ureteral injuries who had ureteroneocystostomy with alternative to DJ-stenting, complete records of 12 (46.2%) patients were available. Mean age of patients was 37.42 ± 13.69 years with a range of 20-58 years. Majority of the patients were between the ages of 30 to 39 years (33.3%). The alternative to DJ-stent specific complication was stent dislodgement noted in 12.5% of patients. Conclusion: The alternative to DJ-stenting for ureteroneocystostomy is associated with low procedure-specific complications. It is a useful tool especially for patients from low socio-economic background presenting with ureteral complications after gynecological or obstetric surgeries.
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- 2019
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35. Use of transrectal ultrasound in the management of urologic diseases in a tertiary hospital in North-Western Nigeria
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Muhammad, AbubakarSadiq, primary, Abdulwahab-Ahmed, Abdullahi, additional, Agwu, NgwobiaPeter, additional, Yunusa, Garba, additional, Abdullahi, Khalid, additional, and Mungadi, IsmailaArzika, additional
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- 2018
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36. Safety and efficacy of ultrasound-guided percutaneous suprapubic cystostomy in resource-poor setting: A 7-year review
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Muhammad, AbubakarSadiq, primary, Agwu, NgwobiaPeter, additional, Abdulwahab-Ahmed, Abdullahi, additional, Abdullahi, Khalid, additional, and Mungadi, IsmailaArzika, additional
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- 2018
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37. Management of obstructive nephropathy in a tertiary hospital in North West Nigeria: A five-year review.
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Muhammad, A. Sadiq, Abdulwahab-Ahmed, Abdullahi, Agwu, Peter N., Abdullahi, Khalid, and Mungadi, Ismaila A.
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URETERIC obstruction , *URINARY calculi , *TRANSURETHRAL prostatectomy , *KIDNEY diseases , *BENIGN prostatic hyperplasia , *URINARY diversion - Abstract
Background: Obstructive nephropathy is managed initially with urinary diversion and possibly haemodialysis before definitive therapy. This study was aimed at determining the pattern of presentation, aetiology and management options of obstructive nephropathy in our practice. Methods: This was a five-year retrospective study of the patients managed for obstructive nephropathy at our facility from January 2011-December 2015. Data were collected via a pro forma and analysed using SPSS version 20.0. Results: There were 106 patients managed for obstructive nephropathy with a mean age of 48.3 ± 17. 4 years and age range of 4 months to 85 years. The male: female ratio was 10:1. The most common causes of obstructive nephropathy were bladder cancer (49.1%), benign prostatic hyperplasia (BPH, 22.6%), bilateral ureteric stone (5.7%) and bilateral schistosomal lower ureteric obstruction (4.7%). Urethral or suprapubic catheterisation (22.6%), nephrostomy (2.8%) and dialysis (10.4%) were the initial treatments. Chemoradiation was done for the patients with bladder cancer and 17.9% of the patients had operative interventions, which included ureteroneocystostomy, open prostatectomy or transurethral resection of the prostate, and ureteroscopy + lithotripsy. Fifty-two patients (49.1%) died while awaiting dialysis and four patients (3.8%) developed end-stage renal disease. Conclusions: Bladder carcinomas, BPH, ureteric obstruction are the commonest causes of obstructive nephropathy in our practice. The initial treatment includes urinary diversion and or dialysis before definitive treatment. [ABSTRACT FROM AUTHOR]
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- 2017
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