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1. Assessment of membrane stability, central nervous system depressant, and gut motility effects of Lablab purpureus seeds

Author

Joysree Roy, Sutapa Bhowmik, Md. Giash Uddin, Md. Nazmul Hasan, Abdullah Al Maswood, Sumyya Zahan, Md. Abdul Aziz, Md. Farhad Hossain, Md. Kamrul Hossain, and Mohammad Safiqul Islam

Subjects
lablab purpureus, antidepressant, membrane stability, gastrointestinal motility, Medicine (General), R5-920, Therapeutics. Pharmacology, RM1-950
Abstract

Introduction: Lablab purpureus, under the family of Fabaceae, is a plant with various pharmacological activities. The present study was aimed to investigate the phytoconstituents, membrane stabilizing activity, central nervous system (CNS) depressant potential, and gastrointestinal (GI) motility of the methanol extract of L. purpureus seeds (MELPS).Methods: The methanol plant extract was screened for different phytochemical groups. Mice were classified into four groups for in vivo activities. Group-I was designated as negative control and received distilled water (10 mL/kg body weight); group-II served as positive control and received diazepam (1 mg/kg body weight). Group-III and group-IV both were experimental groups and received plant extract at 200 and 400 mg/kg body weight, respectively.Results: Alkaloids, carbohydrates, saponins, glycosides, tannins, phenols, flavonoids, and proteins were found after phytochemical analysis. On hypotonic solution-induced hemolysis of erythrocyte membrane, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (60.51 ± 0.889), and on heat-induced hemolysis, MELPS9 (9 mg/mL) resulted in the highest percentage of inhibition (33.97 ± 0.21). In the case of the CNS depressant potential experiment, mice that received a sample at a dose of 400 mg/kg body weight showed the highest result (54.40 ± 4.51) compared with the positive control (14.2 ± 3.70) (P < 0.001). Similarly, 400 mg/kg dose sample exhibited the highest percentage of inhibition (60.51 ± 0.889) of hemolysis and GI motility (22.26%).Conclusion: It can be concluded that the MELPS has potential membrane stability, CNS depressant, and antimotility effects.

Published
2022
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2. Comparison of antioxidant role of methanol, acetone and water extracts of Andrographis paniculata Nees

Author

Nor Mohammad, Abdullah-Al-Maswood, Md. Maniruzzaman A. Aziz, Md. Giash Uddin, Monsur Ahmad, Md. Rakibul Islam, Md. Ashraful Alam, and Md. Shahadat Hossain

Subjects
Pharmacology, chemistry.chemical_classification, Antioxidant, ABTS, biology, Traditional medicine, 010405 organic chemistry, DPPH, medicine.medical_treatment, Flavonoid, Pharmaceutical Science, Plant Science, biology.organism_classification, Ascorbic acid, 01 natural sciences, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Complementary and alternative medicine, chemistry, Drug Discovery, Acetone, medicine, Butylated hydroxyanisole, Andrographis paniculata
Abstract

Antioxidant properties of plants can help thwart a plethora of conditions including cancer, bronchitis, asthma, ulcers, coronary heart diseases, scabies, insomnia, senile debility, diabetes, dysentery, etc. In this study, Andrographis paniculata (Family: Acanthaceae) was investigated for antioxidant activity. 1, 1-Diphenyl-2-picryl hydrazyl (DPPH), reducing power assay, total antioxidant capacity, 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), nitric oxide test, total phenolic and flavonoid from methanol, acetone, and water extracts were investigated employing various established in-vitro system. The results divulged that methanol extract had significant activity in quenching of DPPH, reducing power, ABTS, nitric oxide, antioxidant capacity when compared to other extracts. All extracts were correlated with two specific standard antioxidants ascorbic acid and butylated hydroxyanisole. The methanol extract at 500 µg/ml showed the highest scavenging activity of DPPH (91.78 ± 0.02%), ABTS (99.76 ± 0.05%). Total antioxidant capacity was 83.35 ± 0.13 AAE/mg. Reducing the power of methanol extract was significant compared to all other fractions. Nitric oxide scavenging activity was maximum in acetone extract (80.73 ± 0.05%). The quantitative estimation of the extract revealed a considerable amount of flavonoids and conversely, the amount of phenolic compounds was poor. The flavonoid content (592.34 ± 0.13 mg QE/g of dry extract) was maximum in methanol extract but phenolic content of methanol and acetone extract was very similar. This study strongly suggests that methanol extract exhibits more potent antioxidant activity than other extracts of acetone and water. Key words: Andrographis paniculata, antioxidant potential, methanol, acetone, water, DPPH, ABTS

Published
2020
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