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According to some estimates, haemorrhoids afflict up to one-quarter of all individuals. There are numerous methods available to manage them, ranging from topical and medicinal medicines to outpatient treatments and surgical techniques to repair or excise. Given the disease's polysymptomaticism, determining which therapy choice is optimal is tough. Hemorrhoid disease treatment is one of the most difficult fields in general surgery, with various approaches utilised to cure this illness. In this research, we contrasted Hemorrhoidectomy verses Rubber Band Ligation results of treatment methods for hemorrhoids. Review the effectiveness and safety of the two most often used conventional treatments for haemorrhoids, rubber band ligation and excisional haemorrhoidectomy, and compare between the clinical results for both procedures. The PubMed database and EBSCO Information Services were utilized to choose the articles. In this review, all pertinent articles related to both our topic and other articles were used. Other articles that have nothing to do with this subject were not included. The group members looked through a certain format in which the data had been extracted. Internal hemorrhoid is a common pathological anorectal appearance, although it is a difficult condition to treat. Internal haemorrhoids symptoms and indicators should be thoroughly explored, as should clinical grading. Individual thinking and clinical considerations should influence the various possibilities for managing internal haemorrhoids and specific therapeutic approaches. At first, lifestyle changes should be made, such as consuming a high-fiber diet, developing sane bathroom routines, and administering phlebotropic drugs. When alternative treatments don't work, surgical methods and outpatient procedures should be used. Therapy management such as Hemorrhoidectomy or Rubber Band Ligation is critical to preventing future consequences from internal haemorrhoids.

Objectives: To describe the outcome of primary meningeal sarcoma (PMS) in a pediatric population. Methods: We conducted a retrospective study on patients harbouring a PMS based on the French registry of paediatric tumours. Questionnaires were sent to all French paediatric oncologists. Data on patient characteristics and treatments were collected. Pathology and imaging were centrally reviewed. Results: Between August 1989 and May 2010, 12 patients from 6 French centres, aged 3 months to 14.5 years (mean: 3.3 years) were treated for a PMS. Mean follow-up was 12 years (range: 3 months to 24 years). Tumour locations were: frontal (3), parieto-occipital (2), parietal (1), temporal (1), occipital (1), thalamic (1), pontocerebellar angle (1), cerebellar tentorium (1), ambient cistern (1). No metastasis was observed. The first-line treatment was surgery in 10 cases, chemotherapy in 2. Resection was total in 6 cases, partial in 6. Central pathology review concluded to: high-grade undifferentiated sarcoma (8), chondrosarcoma (2), fibrosarcoma (1), myxoid desmoplastic tumour (1). Seven tumours were smaller than 5 cm in size. Eleven patients received 2 to 10 courses of chemotherapy (median: 5) but no response was observed. Four out of 6 patients for whom a total resection was performed were still alive at time of study, compared to 2 when only partial resection was possible. Four out of 6 patients who received radiotherapy are still alive, compared to 1 out of 4 patients without radiotherapy. The 5-year Event-Free Survival (EFS) and Overall Survival (OS) rates were 50%. The median EFS in case of total resection was 39 months versus 16 months in case of partial resection. Neither correlation was found between tumour size and location or between age at diagnosis and EFS/OS. Conclusions: We report the first multicentre case series describing clinical, radiological presentation and outcome of PMS in children. In this short series of very rare tumours, age and tumour size did not seem to be prognostic factors. Total resection and radiotherapy seem to be essential. The role of chemotherapy remains unclear.

The feasibility, safety, and high technical success of robotically assisted percutaneous coronary intervention (PCI) for the treatment of both simple and complex coronary disease has been demonstrated. As the current generation robotic platform is limited to a rapid exchange system, orbital or rotational atherectomy cannot be performed robotically. However, excimer laser coronary atherectomy is performed with a rapid exchange catheter but its feasibility during robotically assisted PCI is unknown. We report the successful use of laser atherectomy during two complex robotically assisted PCI procedures using the CorPath GRX robotic system.

Quantify and characterize bacterial contamination of lead aprons in a high-volume catheterization laboratory and evaluate the efficacy of decontamination using an ultraviolet-C (UV-C) radiation system.Bacterial contamination and ineffective disinfection of personal protective equipment in medical centers pose potential health risks to patients and medical staff. The contamination burden of lead aprons and a reliable disinfection strategy are unknown.Ten routinely used, unsterilized lead aprons from a high-volume catheterization laboratory were studied. Standard and bacteria-resistant outer fabrics were included. Swabbings from four locations on each apron (inner thyroid collar, chest, waist, and bottom border) were obtained at baseline and after a 15-minute decontamination cycle using the UV-C based DCab System (Nosocom Solutions). Colony counts, speciation, and antibiotic resistance were obtained from aerobic and anaerobic cultures.Baseline cultures grew ≥1 colony from 25 of 40 samples (62.5%; 310 colonies; 0-100 colonies/sample; 16 organisms), mainly skin and mouth flora without antibiotic resistance. Baseline growth was greatest from the thyroid collar and similar between different fabrics. UV-C reduced subsequent growth (7.8 ± 23.8 colonies overall vs 0.1 ± 0.3 colonies overall; P.001), with all four isolates considered contaminants of laboratory handling. Colony counts were reduced in thyroid collar, chest, waist, nylon fabric, polyurethane fabric, and alternative bacteria-resistant fabric subgroups (all P.05).Routinely used lead aprons in a high-volume catheterization laboratory were contaminated by non-pathogenic skin and mouth flora located predominantly on the thyroid collar. Disinfection using an automated UV-C based system is highly effective across different apron surface locations and fabric types.

Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) continuous to evolve. We sought to provide contemporary outcomes of the PROGRESS CTO registry by analyzing the clinical, angiographic and procedural characteristics of 3,550 CTO interventions performed in 3,483 patients at 21

Introduction: Medulloblastoma (MB) is the most common paediatric malignant brain tumour. Recurrences occur in more than 40% of cases and sequelae are very important due to aggressiveness of the treatments. Cancer stem cells (CSCs) generate tumours through the stem cell patterns of self-renewal and differentiation into multiple tumour cell types and have better DNA repair capability inducing tumour resistance to radiotherapy (RT) and chemotherapy. Neuropilin-1 (NRP1) is involved in the progression of MB and seems to be in relation with the differentiation state of cancer cells. Recent molecular research has provided a better understanding of tumour development for the purpose of more targeted treatments. MR438 is a new sugarbased peptidomimetic targeting NRP-1. Our first results showed that MR438 seemed to induce the differentiation of MB stem cells. The objectives were therefore to demonstrate the effect of MR438 on in vitro and in vivo radiosensitivity. Material and methods: DAOY, D283Med and D341Med cell lines were used for obtaining cancer stem cells by in vitro enrichment. Clonogenic assays were performed on MB stem cells exposed to 0, 2, 4, 6, 10 Gy of RT in combination with MR438. For in vivo experiments, xenografted nude mice with 3 subgroup tumours were treated by RT at 2 Gy x 5 days in combination with MR438 and compared to Tuftsin in 6 groups (control, MR438, Tuftsin, RT, RT +MR438, RT +Tuftsin, n=6). Tumour volume was measured by calliper until a maximum of 45 days post-treatment, and then tumours were removed at the set end-points for clonogenic assay and cell viability. Results and discussions: Inhibition of NRP-1 via MR438 increased radiosensitivity of CSC models especially at the dose of 2 Gy. The DMF2 were 0.74, 0.89 and 0.88 for DAOY, D283-Med and Med-D341 cells respectively. In heterotopic models, a significant improvement of tumours radiosensitivity was also observed in the MR438 +RT group by comparing RT alone or MR438 alone (p