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7. Penile fracture with urethral injury: a case report of rare double trouble

Author

Farooq Hameed, Adeel Anwaar, Humayun Saeed, Usman Noor, Abdullah Saleem, and Mamoona Anwar

Subjects
Fractured penis, Urethral trauma, Urethroplasty, Case report, Science
Abstract

Abstract Background A penile fracture occurs when the tunica albuginea of penis tears during erection. Penile fracture is a rare but serious injury that occurs when the erect penis sustains a traumatic force. It is characterized by a sudden snapping or popping sound, followed by immediate pain, swelling, and discoloration. Its association with concomitant urethral injury is very rare. This case study describes such a rare case. Case presentation In this case study, we present the case of a 47-year-old man who experienced sudden pain and lost erection with a popping sound while having sexual intercourse. There was bloody discharge from the urethral opening and showed the distinct sign of an "Eggplant Deformity." This result confirmed the diagnosis. Immediate surgical intervention revealed damage to the left corpora and urethra. The procedure involved repairing the tunica albuginea covering the corpora tissue and reconstructing the damaged urethra. The surgery went smoothly without complications. The patient reported satisfactory erectile function and normal urination on follow-up visit after 2 months. Conclusion Penile fracture with urethral injury is a rare but serious emergency. Prompt detection and surgical intervention are crucial for optimal outcomes and minimal complications. Depending on severity, either catheterization or repair may be necessary.

Published
2023
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15. Differential Expression of LMNA/C and Insulin Receptor Transcript Variants in Peripheral Blood Mononuclear Cells of Leukemia Patients

Author

Khalid Saud Alshaalan, Turki Khalid Albawardi, Mahmoud Zhra, Norah Bin Sulaiman, Osama Yaheia Jnied, Rimah Abdullah Saleem, and Ahmad Aljada

Subjects
mononuclear cells, leukemia, LMNA/C transcript variants, insulin receptor transcript variants, Medicine
Abstract

Background: Recent research has identified alternative transcript variants of LMNA/C (LMNA, LMNC, LMNAΔ10, and LMNAΔ50) and insulin receptors (INSRs) as potential biomarkers for various types of cancer. The objective of this study was to assess the expression of LMNA/C and INSR transcript variants in peripheral blood mononuclear cells (PBMCs) of leukemia patients to investigate their potential as diagnostic biomarkers. Methods: Quantitative TaqMan reverse transcriptase polymerase chain reaction (RT-qPCR) was utilized to quantify the mRNA levels of LMNA/C (LMNA, LMNC, LMNAΔ10, and LMNAΔ50) as well as INSR (IR-A and IR-B) variants in PBMCs obtained from healthy individuals (n = 32) and patients diagnosed with primary leukemias (acute myeloid leukemia (AML): n = 17; acute lymphoblastic leukemia (ALL): n = 8; chronic myeloid leukemia (CML): n = 5; and chronic lymphocytic leukemia (CLL): n = 15). Results: Only LMNA and LMNC transcripts were notably present in PBMCs. Both exhibited significantly decreased expression levels in leukemia patients compared to the healthy control group. Particularly, the LMNC:LMNA ratio was notably higher in AML patients. Interestingly, IR-B expression was not detectable in any of the PBMC samples, precluding the calculation of the IR-A:IR-B ratio as a diagnostic marker. Despite reduced expression across all types of leukemia, IR-A levels remained detectable, indicating its potential involvement in disease progression. Conclusions: This study highlights the distinct expression patterns of LMNA/C and INSR transcript variants in PBMCs of leukemia patients. The LMNC:LMNA ratio shows promise as a potential diagnostic indicator for AML, while further research is necessary to understand the role of IR-A in leukemia pathogenesis and its potential as a therapeutic target.

Published
2024
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