1. Prevalence and global trends of polypharmacy among people living with HIV: a systematic review and meta-analysis
- Author
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Mohammed I. Danjuma, Oyelola A. Adegboye, Ahmed Aboughalia, Nada Soliman, Ruba Almishal, Haseeb Abdul, Mohamad Faisal Hamad Mohamed, Mohamed Nabil Elshafie, Abdulatif AlKhal, Abdelnaser Elzouki, Arwa Al-Saud, Mas Chaponda, and Mubarak Arriyo Bidmos
- Subjects
Therapeutics. Pharmacology ,RM1-950 - Abstract
Background: There has been a rising prevalence of polypharmacy among people living with HIV (PLWH). Uncertainty however remains regarding the exact estimates of polypharmacy among these cohorts of patients. Methods: We conducted a systematic search of PubMed; EMBASE, CROI, Cochrane Database of Systematic Reviews; Science Citation Index and Database of Abstracts of Reviews of Effects for studies between 1 January 2000 and 30 June 2021 that reported on the prevalence of polypharmacy (ingestion of > 5 non-ART medications) among PLWH on antiretroviral therapy regimen (ART). Prevalence of polypharmacy among HIV-positive patients on ART with Clopper–Pearson 95% confidence intervals were presented. The heterogeneity between studies was evaluated using I 2 and τ 2 statistics. Results: One hundred ninety-seven studies were initially identified, 23 met the inclusion criteria enrolling 55,988 PLWH, of which 76.7% [95% confidence interval (CI): 76.4–77.1] were male. The overall pooled prevalence of polypharmacy among PLWH was 33% (95% CI: 25–42%) ( I 2 = 100%, τ 2 = 0.9170, p
- Published
- 2022
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