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26 results on '"Abdul Qadir, Muhammad"'

2. Exploring the Potential of New Benzamide-Acetamide Pharmacophore Containing Sulfonamide as Urease Inhibitors: Structure–Activity Relationship, Kinetics Mechanism, and In Silico Studies

Author

Ahmad, Saghir, primary, Abdul Qadir, Muhammad, additional, Ahmed, Mahmood, additional, Imran, Muhammad, additional, Ahmad, Muhammad, additional, Yousaf, Numan, additional, Wani, Tanveer A., additional, Zargar, Seema, additional, Ali, Ijaz, additional, and Muddassar, Muhammad, additional

Published
2023
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7. Curcumin: Synthesis optimization and in silico interaction with cyclin dependent kinase

Author

Ahmed Mahmood, Abdul Qadir Muhammad, Imtiaz Shafiq Muhammad, Muddassar Muhammad, Hameed Abdul, Nadeem Arshad Muhammad, and Asiri Abdullah M.

Subjects
curcumin synthesis, cdks, molecular docking, Pharmaceutical industry, HD9665-9675
Abstract

Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. During synthesis, solvent choice was found to be an important parameter for better curcumin yield and high purity. In a typical reaction, acetyl acetone was treated with boron trioxide, followed by condensation with vanillin in the presence of tri-n-butyl borate as water scavenger and n-butylamine as catalyst at 80 °C in ethyl acetate to afford curcumin. Moreover, curcumin was also extracted from turmeric powder and spectroscopic properties such as IR, MS, 1H NMR and 13C NMR with synthetic curcumin were established to identify any impurity. The purity of synthetic and extracted curcumin was also checked by TLC and HPLC-DAD. To computationally assess its therapeutic potential against cyclin dependent kinases (CDKs), curcumin was docked in different isoforms of CDKs. It was observed that it did not dock at the active sites of CDK2 and CDK6. However, it could enter into weak interactions with CDK4 protein.

Published
2017
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10. SimExact – An Efficient Method to Compute Function Similarity Between Proteins Using Gene Ontology

Author

Ikram Najmul, Abdul Qadir Muhammad, and Tanvir Afzal Muhammad

Subjects
0303 health sciences, Gene ontology, Computer science, Computational biology, Function (mathematics), Biochemistry, 03 medical and health sciences, Computational Mathematics, 0302 clinical medicine, Similarity (network science), Genetics, 030212 general & internal medicine, Molecular Biology, 030304 developmental biology
Abstract

Background: The rapidly growing protein and annotation databases necessitate the development of efficient tools to process this valuable information. Biologists frequently need to find proteins similar to a given protein, for which BLAST tools are commonly used. With the development of biomedical ontologies, e.g. Gene Ontology, methods were designed to measure function (semantic) similarity between two proteins. These methods work well on protein pairs, but are not suitable for protein query processing. Objective: Our aim is to facilitate searching of similar proteins in an acceptable time. Methods: A novel method SimExact for high speed searching of functionally similar proteins has been proposed. Results: The experiments of this study show that SimExact gives correct results required for protein searching. A fully functional prototype of an online tool (www.datafurnish.com/protsem.php) has been provided that generates a ranked list of the proteins similar to a query protein, with a response time of less than 20 seconds in our setup. SimExact was used to search for protein pairs having high disparity between function similarity and sequence similarity. Conclusion: SimExact makes such searches practical, which would not be possible in a reasonable time otherwise.

Published
2020

14. Proximate and Trace Metal Analysis of Pakistani Coal

Author

Muhammad Akbar, Muhammad Akbar, primary, Muhammad Abdul Qadir, Muhammad Abdul Qadir, additional, Ayoub Rashid, Ayoub Rashid, additional, Abrar Hussain, Abrar Hussain, additional, and Khalid Bhatti and Ahmad Adnan, Khalid Bhatti and Ahmad Adnan, additional

Published
2019
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17. A Novel Method for the Synthesis of 99mTc-Ofloxacin Kits Using D-Penicillamine as Coligand and Their Application as Infection Imaging Agent

Author

Abdul Qadir, Muhammad, Shahzad, Shabnam, Rasheed, Rashid, Ahmed, Mahmood, Anwar, Shahzad, and Kiran Shahzadi, Syeda

Subjects
Ofloxacin, Isotope Labeling, Pseudomonas aeruginosa, Escherichia coli, Animals, Humans, Technetium, Tissue Distribution, Rabbits, Radiopharmaceuticals, Salmonella typhi, Escherichia coli Infections, Research Article
Abstract

The employment of radiopharmaceuticals is increasing nowadays for infection imaging and early execution of patients having infectious or inflammatory complaints. The main aim of this study was to discover a novel method for the labeling of ofloxacin with (99m)Tc, optimization of labelling conditions to get higher percent yield, to assess kits radiochemical purity, in vitro stability, partition coefficient, protein binding, and intracellular accumulation in Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli in infected rabbits. Maximum labeling efficiency was achieved when 1.5 mg ofloxacin was labeled with 10-20 mCi sodium pertechnetate in the presence of 3 mg D-penicillamine, 75 μg SnCl₂. In vitro binding and biodistribution in Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli showed good results. This new complex is efficient for the imaging of infections caused by Gram-positive and Gram-negative bacteria.

Published
2015

23. Curcumin: Synthesis optimization and in silicointeraction with cyclin dependent kinase

Author

Ahmed, Mahmood, Abdul Qadir, Muhammad, Imtiaz Shafiq, Muhammad, Muddassar, Muhammad, Hameed, Abdul, Nadeem Arshad, Muhammad, and Asiri, Abdullah M.

Abstract

Curcumin is a natural product with enormous biological potential. In this study, curcumin synthesis was revisited using different reaction solvents, a catalyst (n-butylamine) and a water scavenger [(n-BuO)3B], to develop the optimal procedure for its rapid acquisition. During synthesis, solvent choice was found to be an important parameter for better curcumin yield and high purity. In a typical reaction, acetyl acetone was treated with boron trioxide, followed by condensation with vanillin in the presence of tri-n-butyl borate as water scavenger and n-butylamine as catalyst at 80 °C in ethyl acetate to afford curcumin. Moreover, curcumin was also extracted from turmeric powder and spectroscopic properties such as IR, MS, 1H NMR and 13C NMR with synthetic curcumin were established to identify any impurity. The purity of synthetic and extracted curcumin was also checked by TLC and HPLC-DAD. To computationally assess its therapeutic potential against cyclin dependent kinases (CDKs), curcumin was docked in different isoforms of CDKs. It was observed that it did not dock at the active sites of CDK2 and CDK6. However, it could enter into weak interactions with CDK4 protein.

Published
2017
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26. A Novel Method for the Synthesis of Tc99m-Ofloxacin Kits Using D-Penicillamine as Coligand and Their Application as Infection Imaging Agent.

Author

Abdul Qadir, Muhammad, Shahzad, Shabnam, Rasheed, Rashid, Ahmed, Mahmood, Anwar, Shahzad, and Kiran Shahzadi, Syeda

Subjects
*ANIMAL experimentation, *BIOPHYSICS, *ESCHERICHIA coli, *GRAM-negative bacterial diseases, *HIGH performance liquid chromatography, *RESEARCH methodology, *PENICILLAMINE, *PSEUDOMONAS, *QUINOLONE antibacterial agents, *RABBITS, *RADIONUCLIDE imaging, *RADIOPHARMACEUTICALS, *SALMONELLA, *GRAM-positive bacterial infections, *IN vitro studies
Abstract

The employment of radiopharmaceuticals is increasing nowadays for infection imaging and early execution of patients having infectious or inflammatory complaints. The main aim of this study was to discover a novel method for the labeling of ofloxacin with Tc99m, optimization of labelling conditions to get higher percent yield, to assess kits radiochemical purity, in vitro stability, partition coefficient, protein binding, and intracellular accumulation in Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli in infected rabbits. Maximum labeling efficiency was achieved when 1.5 mg ofloxacin was labeled with 10–20 mCi sodium pertechnetate in the presence of 3 mg D-penicillamine, 75 μg SnCl2. In vitro binding and biodistribution in Pseudomonas aeruginosa, Salmonella typhi, and Escherichia coli showed good results. This new complex is efficient for the imaging of infections caused by Gram-positive and Gram-negative bacteria. [ABSTRACT FROM AUTHOR]

Published
2015
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