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16. Effects of counselling and spiritual care program on anxiety in patients with chronic diseases: A systematic review and meta-analysis

Author

Salari, Nader, Kazeminia, Mohsen, Abdi, Alireza, Abdolmaleki, Amir, Abdoli, Nasrin, Mohammadi, Masoud, and Shohaimi, Shamarina

Subjects
Pastoral counseling -- Influence -- Psychological aspects -- Health aspects, Chronic diseases -- Complications and side effects -- Psychological aspects, Psychotherapy -- Religious aspects, Anxiety -- Care and treatment -- Demographic aspects -- Risk factors, Psychology and mental health
Abstract

One of the essential non-pharmacological treatments for patients with chronic diseases are psychosocial supports and counselling services such as spiritual psychotherapy. Although several preliminary studies represent the effects of counselling and spiritual psychotherapy on anxiety in patients with chronic diseases, there are various contradictions among the findings. The present meta-analysis aimed to determine the effects of counselling and spiritual care programs on anxiety in patients with chronic diseases. For data collection, various databases were searched regarding no time limitation until May 2021, including SID, MagIran, Embase, ProQuest, Scopus, PubMed, and Web of Science (WoS) using Google Scholar search engine. Inclusion criteria were original research articles, interventional studies, and exclusion criteria were irrelevant assessments, systematic review and meta-analysis studies, case reports, letters to the editor, and duplicate papers. I.sup.2 test was used to calculate heterogeneity of studies, and the Egger's test was applied to examine the publication bias. According to the inclusion criteria, 26 articles were selected among 612 initial papers with a sample size of 1040 individuals. The mean anxiety scores before and after the interventions were 33.02 ± 3.77 and 25.27 ± 3.66, respectively. The significant (P < 0.05) mean difference before and after the interventions was 1.74 ± 0.23. Counselling and psychotherapy can reduce anxiety in patients with chronic diseases., Author(s): Nader Salari [sup.1] [sup.2] , Mohsen Kazeminia [sup.3] , Alireza Abdi [sup.4] , Amir Abdolmaleki [sup.5] , Nasrin Abdoli [sup.6] , Masoud Mohammadi [sup.4] , Shamarina Shohaimi [sup.7] Author [...]

Published
2023
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25. Transplantation of human umbilical cord mesenchymal stem cells optimized with IFN-γ is a potential procedure for modification of motor impairment in multiple sclerosis cases: a preclinical systematic review and meta analysis study.

Author

Esmaeili Araghi, Mohamad Mahdi, Abdolmaleki, Amir, Gouvarchin Ghaleh, Hadi Esmaeili, Kondori, Bahman Jalali, Alvanegh, Akbar Ghorbani, Moghaddam, Mehrdad Moosazadeh, and Nejad Anbaran, Seyed Javad Hosseini

Subjects
*MESENCHYMAL stem cells, *STEM cell transplantation, *UMBILICAL cord, *TREATMENT effectiveness, *STEM cell treatment
Abstract

Stem cells transplantation (SCT) is known as a newfound strategy for multiple sclerosis (MS) treatment. Human umbilical cord mesenchymal stem cells (hUCMSCs) contain various regenerative features. Experimental autoimmune encephalomyelitis (EAE) is a laboratory model of MS. This meta-analysis study was conducted to assess the overall therapeutic effects of hUCMSCs on reduction of clinical score (CS) and restoration of active movement in EAE-induced animals. For comprehensive searching (in various English and Persian databases until May 1, 2024), the main keywords of "Experimental Autoimmune Encephalomyelitis", "Multiple Sclerosis", "Human", "Umbilical Cord", "Mesenchymal", and "Stem Cell" were hired. Collected data were transferred to the citation manager software (EndNote x8) and duplicate papers were merged. Primary and secondary screenings were applied (according to the inclusion and exclusion criteria) and eligible studies were prepared for data collection. CS of two phases of peak and recovery of EAE were extracted as the difference in means and various analyses including heterogeneity, publication bias, funnel plot, and sensitivity index were reported. Metaanalysis was applied by CMA software (v.2), P<0.05 was considered a significant level, and the confidence interval (CI) was determined 95% (95% CI). Six eligible high-quality (approved by ARRIVE checklist) papers were gathered. The difference in means of peak and recovery phases were -0.775 (-1.325 to -0.225; P=0.006; I²=90.417%) and -1.230 (-1.759 to -0.700; P<0.001; I²=93.402%), respectively. The overall therapeutic effects of SCT of hUCMSCs on the EAE cases was -1.011 (95% CI=-1.392 to -0.629; P=0.001). hUCMSCs transplantation through the intravenous route to the animal MS model (EAE) seems a considerably effective procedure for the alleviation of motor defects in both phases of peak and recovery. [ABSTRACT FROM AUTHOR]

Published
2024
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