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2. Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells

Author

Abderrahim-Ferkoune, Anissa, Bezy, Olivier, Chiellini, Chiara, Grimaldi, Paul, Bonino, Frederic, Chiellini, C., Maffei, M., Moustaid-Moussa, Naima, Pasqualini, Fabio, Mantovani, Alberto, Ailhaud, Gerard, Amri, Ez-Zoubir, Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Dept. Nutrition, Pisa, Italy, Université Pise, Génétique du développement normal et pathologique, Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Dept. Nutrition, Pise, Italy, Dept. Nutrition and Agricultural Experiment Station, Knoxville, The University of Tennessee [Knoxville], Department of Immunology and Cell Biology, and Mario Negri Institute

Subjects
MESH: 3T3 Cells, MESH: Serum Amyloid P-Component, Adipose tissue, Mice, Obese, White adipose tissue, Biochemistry, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, Adipocyte, MESH: Gene Expression Regulation, Developmental, Adipocytes, MESH: Obesity, MESH: Animals, MESH: Mice, Obese, [SDV.BDD]Life Sciences [q-bio]/Development Biology, 0303 health sciences, biology, Gene Expression Regulation, Developmental, Cell Differentiation, PTX3, 3T3 Cells, Cell biology, Serum Amyloid P-Component, C-Reactive Protein, Adipose Tissue, Adipogenesis, 030220 oncology & carcinogenesis, MESH: Adipose Tissue, MESH: Cell Differentiation, medicine.medical_specialty, MESH: Diabetes Mellitus, Adipose tissue macrophages, QD415-436, tumor necrosis factor α, 03 medical and health sciences, Internal medicine, MESH: C-Reactive Protein, medicine, Diabetes Mellitus, Animals, Obesity, RNA, Messenger, adipocyte protein 2, MESH: Mice, MESH: Adipocytes, 030304 developmental biology, MESH: RNA, Messenger, Tumor Necrosis Factor-alpha, 3T3-L1, Cell Biology, cytokines, chemistry, MESH: Tumor Necrosis Factor-alpha, biology.protein
Abstract

International audience; Exposure of preadipocytes to long-chain fatty acids induces the expression of several markers of adipocyte differentiation. In an attempt to identify novel genes and proteins that are regulated by fatty acids in preadipocytes, we performed a substractive hybridization screening and identified PTX3, a protein of the pentraxin family. PTX3 mRNA expression is transient during adipocyte differentiation of clonal cell lines and is absent in fully differentiated cells. Stable overexpression of PTX3 in preadipocytes has no effect on adipocyte differentiation. In line with this, PTX3 mRNA is expressed in the stromal-vascular fraction of adipose tissue, but not in the adipocyte fraction; however, in 3T3-F442A adipocytes, the PTX3 gene can be reinduced by tumor necrosis factor alpha (TNFalpha) in a dose-dependent manner. This effect is accompanied by PTX3 protein secretion from both 3T3-F442A adipocytes and explants of mouse adipose tissue. PTX3 mRNA levels are found to be higher in adipose tissue of genetically obese mice versus control mice, consistent with their increased TNFalpha levels. In conclusion, PTX3 appears as a TNFalpha-induced protein that provides a new link between chronic low-level inflammatory state and obesity.

Published
2003
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3. A French multifactorial prospective study of tumor protein and genetic markers in stage I-III colorectal cancer (CRC): Highlight on molecular characteristics related to mismatch repair (MMR) status.

Author

Milano, Gerard, primary, Chazal, Maurice, additional, Laurent-Puig, Pierre, additional, Olschwang, Sylviane, additional, Gaub, Marie-Pierre, additional, Formento, Jean-Louis, additional, Formento, Patricia, additional, Abderrahim-Ferkoune, Anissa, additional, Benchimol, Daniel, additional, André, Thierry, additional, Houry, Sydney, additional, Faucheron, Jean-Luc, additional, Letoublon, Christian, additional, Gilly, Francois-Noel, additional, Delpero, Jean-Robert, additional, Lasser, Philippe, additional, Pradere, Bernard, additional, Pezet, Denis, additional, and Etienne-Grimaldi, Marie-Christine, additional

Published
2013
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4. Characterization of the long pentraxin PTX3 as a TNFalpha-induced secreted protein of adipose cells.

Author

Abderrahim-Ferkoune A, Bezy O, Chiellini C, Maffei M, Grimaldi P, Bonino F, Moustaid-Moussa N, Pasqualini F, Mantovani A, Ailhaud G, and Amri EZ

Subjects
3T3 Cells, Adipocytes cytology, Adipocytes drug effects, Adipose Tissue cytology, Adipose Tissue drug effects, Animals, C-Reactive Protein metabolism, Cell Differentiation drug effects, Cell Differentiation physiology, Diabetes Mellitus genetics, Gene Expression Regulation, Developmental drug effects, Mice, Mice, Obese, Obesity, RNA, Messenger drug effects, RNA, Messenger genetics, RNA, Messenger metabolism, Serum Amyloid P-Component metabolism, Adipocytes metabolism, Adipose Tissue metabolism, C-Reactive Protein genetics, Serum Amyloid P-Component genetics, Tumor Necrosis Factor-alpha pharmacology
Abstract

Exposure of preadipocytes to long-chain fatty acids induces the expression of several markers of adipocyte differentiation. In an attempt to identify novel genes and proteins that are regulated by fatty acids in preadipocytes, we performed a substractive hybridization screening and identified PTX3, a protein of the pentraxin family. PTX3 mRNA expression is transient during adipocyte differentiation of clonal cell lines and is absent in fully differentiated cells. Stable overexpression of PTX3 in preadipocytes has no effect on adipocyte differentiation. In line with this, PTX3 mRNA is expressed in the stromal-vascular fraction of adipose tissue, but not in the adipocyte fraction; however, in 3T3-F442A adipocytes, the PTX3 gene can be reinduced by tumor necrosis factor alpha (TNFalpha) in a dose-dependent manner. This effect is accompanied by PTX3 protein secretion from both 3T3-F442A adipocytes and explants of mouse adipose tissue. PTX3 mRNA levels are found to be higher in adipose tissue of genetically obese mice versus control mice, consistent with their increased TNFalpha levels. In conclusion, PTX3 appears as a TNFalpha-induced protein that provides a new link between chronic low-level inflammatory state and obesity.

Published
2003
Full Text
View/download PDF

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