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Erysipeloid cutaneous leishmaniasis (ECL) is known as the chronic form of cutaneous leishmaniasis (CL). However, keeping its clinical presentation in view, there is a need to revisit this form of the disease.To describe ECL in view of clinical features and treatment modalities.We include a case series seen in Sfax (Southern Tunisia) from January 2017 to January 2021. All patients clinically suggestive and laboratory confirmed with a diagnosis of CL were registered. Patients of all age groups and of either gender having cutaneous lesions resembling erysipela on the face were included in the study. Different demographic features of the patients and clinical aspects were identified. Descriptive statistics were used for analysis.Of 1300 registered patients with CL, 40 (3%) were diagnosed as ECL. Ages ranged from 15 to 65 years, and duration of lesions varied from 15 to 180 days. All patients had lesions over the face. Clinically, a painful infiltrated inflammatory placard of the central facial area with a butterfly shape was observed in 14 cases, as well as zones of the cheekbone (11 cases), cheekbone and nose (5 cases), cheekbone and eyelid (8 cases), and cheekbone with ear (2 cases). Several therapeutic methods were prescribed with a sufficient result with no recurrence.ECL is a rare presentation that typically occurs on the face, looking like erysipelas, in patients who are native from an endemic region of CL.

Background and Aims Pruritus is a common symptom in chronic hemodialysis patients, its intensity varies from patient to patient and which plays a major role in impairing their quality of life. Its pathophysiology is poorly understood and its management remains a challenge. The main objective of our study is to estimate the frequency of pruritus in our population and its impact on their quality of life. Material and methods This is a cross-sectional study involving 53 patients carried out in the dialysis unit of the CHU Hédi chaker in sfax. The DLQI (Dermatology Life Quality Index), the Pittsburgh Sleep Quality Index (PSQI) and the verbal analogue scale to specify the intensity of pruritus were used to assess the impact of pruritus on quality of life. Results The mean age of our patients was 48 ± 28 years with a predominance of men (60%). The mean duration on hemodialysis was 5.4 years. The prevalence of pruritus was 28% of cases. Pruritus affects 75% of the body surface in 90% of patients, an intensity greater than or equal to 5 in 93.33% of cases on an intensity scale of 0 to 10, the impact was moderate on the quality of life according to the DLQI in 66.66% of the cases, 86.66% of the patients presented a nocturnal recrudescence of the pruritus, and an alteration of the quality of sleep was present in 73.33% of the cases according to the PSQI. The Comparison of the groups with (G1) or without pruritus (G2) showed the predominance of hyperposphoraemia in the first group with averages of 1.92mmol / l and 1.4mmol / l respectively in G1 and G2 Conclusion Pruritus remains the most frequent complaint for hemodialysis patients, which in our patients was linked mainly to hyperposphoraemia requiring optimization of phosphorus chelators and hemodialysis measures.

Background Sweet's syndrome (SS) is a neutrophilic dermatosis characterized by the abrupt onset of cutaneous, systemic and histopathological alterations in response to different stimuli. Objectives The aim of this study was to assess the epidemioclinical, histological, and therapeutic features and outcomes of SS. Methods A retrospective study of all patients diagnosed with SS over a 20-year period (1993–2012) was conducted. Data were analyzed using a level of significance of 5%. Results Ninety patients (mean age: 46.5 years) fulfilled the inclusion criteria. The ratio of women to men was 5. Significant associations emerged between dermohypodermic nodes and location on the lower limbs (P = 0.042), and vesiculobullous lesions and location on the legs (P = 0.030), dorsum of the hand (P = 0.015), and forearms (P = 0.003), and paraneoplastic forms (P = 0.012). The upper extremities were involved in the majority of patients (83.3%). Correlations were found between edema of the superficial dermis and vesiculobullous lesions and between leukocytoclastic vasculitis and atypical targetoid lesions. Sweet's syndrome was associated with cytomegalovirus infection (n = 1), inflammatory bowel disease (n = 4), neoplasm (n = 6), and pregnancy (n = 3). First-line treatment consisted of colchicine. Conclusions To the best of the present authors' knowledge, this is the largest series of SS to be reported. Clinical presentations are similar to those described in the literature. Colchicine was efficient and facilitates the reduced use of corticosteroids. The association between SS and neoplasms should be considered in the context of vesiculobullous lesions.

Background Aplasia cutis congenita (ACC) is a rare malformation characterized by absent or scarred areas of skin at birth. Although most commonly found on the scalp, ACC can also involve other locations. Its etiology and pathogenesis remain unclear. Objective To describe the epidemiologic, clinical, therapeutic, and evolutionary aspects of ACC through a hospital series. Methods We conducted a retrospective study from 1995 to 2012 and reported all cases of ACC. Results We enrolled 22 cases (14 girls and eight boys) of ACC during 18 years. The mean age at diagnosis was 5.7 years. Sixteen ACC involved the scalp, five the trunk, and one the left buttock. ACC was oval-shaped in 20 cases, triangular in one case, and linear in one case. The mean size was 4 cm. ACC was associated with bone defects in two cases, various malformations in eight (37.1%), and with syndromic malformation in three (Adams–Olivier syndrome: two cases; Goltz syndrome: one case). Conservative treatment consisting of wound dressing with vaseline was indicated in six cases. Bone reconstruction was performed in two cases. Regular follow-up and no treatment was recommended in 14 cases. Conclusion Our study emphasizes the frequent association of ACC with malformations (37.1%) and bone defects (9%).

Human papillomavirus (HPV) infection is one of the most common sexually transmitted infections worldwide and causes anal cancer. The incidence of HPV infections in renal transplant recipients is 17% to 45%. Using immunosuppression treatment has been associated with significantly lower risks of de novo malignancies and viral infections after kidney transplantation. We reported the results of switching Tacrolimus to Sirolimus in a kidney transplant recipient who suffered from severe cutaneous warts.

Atopic dermatitis (AD) is a chronic inflammatory skin disease resulting from the interaction between envirommental and genetic factors. Many genes are involved in the etiopathology of AD, such as HLA genes.Study the association between HLA-A, B, DR and DQ genes and the AD.HLA A and B genotyping were practised for 53 atopic dermatitis patients and 76 healthy controls using the microlymphotoxicity complement dependent technique, while HLA DR and DQ genetyping were practised for only 20 patients with AD and all the controls by PCR-SSP method.Allelic frequency of HLA A32 was significantly increased in healthy individuals compared to patients affected with AD (p = 0.02, RR = 0.24). HLA-B, DR and DQ showed no differences in distrubition between patients and controls.Our study suggested that HLA-A32 could be a protective marker against atopic dermatitis for Tunisian patients, in contrast to HLA-B, DR and DQ alleles which seemed to have no importance in AD pathogenis.