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3 results on '"Abdelmotelb, Nashwa"'

1. The Circulating Micro-RNAs (−122, −34a and −99a) as Predictive Biomarkers for Non-Alcoholic Fatty Liver Diseases

Author

Hendy, Olfat M, Rabie, Hatem, El Fouly, Amr, Abdel-Samiee, Mohamed, Abdelmotelb, Nashwa, Elshormilisy, Amr Aly, Allam, Mahmoud, Ali, Samia Taher, Bahaa EL-Deen, Nessren Mohamed, Abdelsattar, Shimaa, and Mohamed, Somia Mokabel

Subjects
simple steatosis, NAFLD, micro-RNA, NASH, nutritional and metabolic diseases, digestive system, digestive system diseases, Original Research
Abstract

Background It remains essential for patient safety to develop non-invasive diagnostic tools to diagnose non-alcoholic fatty liver rather than invasive techniques. Aim Our case-control study was to address the value of circulating miRNAs as a potential non-invasive biomarker for the diagnosis of non-alcoholic fatty acid diseases (NAFLD) and monitoring of disease progression. Methods Routine clinical assessment, laboratory tests, anthropometric study, and liver biopsy results reported for 210 patients with NAFLD (124 patients of simple steatosis (SS) and 86 of non-alcoholic steatohepatitis (NASH)). Apparently matched for age and gender, healthy participants (n= 90) were enrolled as a control group. Serum samples were tested for micro-RNAs (−122, −34a and −99a) by quantitative-PCR. Results By histopathology, 124 of the NAFLD group were of SS and 86 patients were of NASH. Compared with the control subjects, both mi-RNA-122 and −34a levels were increased in NAFLD (p< 001) and at a cut-off = 1.261, mi-RNA-122 had 92% sensitivity, 85% specificity to differentiate NAFLD from healthy controls, while mi-RNA-99a were significantly decreased in NAFLD patients with an observed decrease in disease severity, and at a cut-off = 0.46, miRNA-99a had 94% sensitivity and 96% specificity to discriminate SS from NASH. Conclusion The integration of a circulating mi-RNA panel to diagnose NAFLD cases and to discriminate between SS and NASH. Large-scale study is still needed to verify the other mi-RNA profiles and their role in NAFLD pathogenesis and targeting therapy.

Published
2019

2. The Circulating Micro-RNAs (−122, −34a and −99a) as Predictive Biomarkers for Non-Alcoholic Fatty Liver Diseases

Author

Hendy,Olfat M., Rabie,Hatem, El Fouly,Amr, Abdel-Samiee,Mohamed, Abdelmotelb,Nashwa, Elshormilisy,Amr Aly, Allam,Mahmoud, Ali,Samia Taher, Bahaa EL-Deen,Nessren Mohamed, Abdelsattar,Shimaa, Mohamed,Somia Mokabel, Hendy,Olfat M., Rabie,Hatem, El Fouly,Amr, Abdel-Samiee,Mohamed, Abdelmotelb,Nashwa, Elshormilisy,Amr Aly, Allam,Mahmoud, Ali,Samia Taher, Bahaa EL-Deen,Nessren Mohamed, Abdelsattar,Shimaa, and Mohamed,Somia Mokabel

Abstract

Olfat M Hendy,1 Hatem Rabie,1 Amr El Fouly,2 Mohamed Abdel-Samiee,3 Nashwa Abdelmotelb,1 Amr Aly Elshormilisy,4 Mahmoud Allam,3 Samia Taher Ali,5 Nessren Mohamed Bahaa EL-Deen,6 Shimaa Abdelsattar,7 Somia Mokabel Mohamed8 1Clinical Pathology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt; 2Endemic Medicine Department, Helwan University, Cairo, Egypt; 3Hepatology and Gastroenterology Department, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt; 4Internal Medicine Department, Helwan University, Cairo, Egypt; 5Internal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 6Tropical Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt; 7Department of Clinical Biochemistry, National Liver Institute, Menoufia University, Shebin El-Kom, Egypt; 8Department of Physiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, EgyptCorrespondence: Mohamed Abdel-SamieeNational Liver Institute, Yassin Abdel-Ghafar Street, Shebin El-Kom, Menoufia 32511, EgyptTel +2048 2222740Fax +2048 2234685Email Drmohammed100@yahoo.comBackground: It remains essential for patient safety to develop non-invasive diagnostic tools to diagnose non-alcoholic fatty liver rather than invasive techniques.Aim: Our case-control study was to address the value of circulating miRNAs as a potential non-invasive biomarker for the diagnosis of non-alcoholic fatty acid diseases (NAFLD) and monitoring of disease progression.Methods: Routine clinical assessment, laboratory tests, anthropometric study, and liver biopsy results reported for 210 patients with NAFLD (124 patients of simple steatosis (SS) and 86 of non-alcoholic steatohepatitis (NASH)). Apparently matched for age and gender, healthy participants (n= 90) were enrolled as a control group. Serum samples were tested for micro-RNAs (−122, −34a and −99a) by quantitative-PCR.Results: By histopathology, 124 of

Published
2019

3. The Circulating Micro-RNAs (-122, -34a and -99a) as Predictive Biomarkers for Non-Alcoholic Fatty Liver Diseases.

Author

Hendy OM, Rabie H, El Fouly A, Abdel-Samiee M, Abdelmotelb N, Elshormilisy AA, Allam M, Ali ST, Bahaa El-Deen NM, Abdelsattar S, and Mohamed SM

Abstract

Background: It remains essential for patient safety to develop non-invasive diagnostic tools to diagnose non-alcoholic fatty liver rather than invasive techniques., Aim: Our case-control study was to address the value of circulating miRNAs as a potential non-invasive biomarker for the diagnosis of non-alcoholic fatty acid diseases (NAFLD) and monitoring of disease progression., Methods: Routine clinical assessment, laboratory tests, anthropometric study, and liver biopsy results reported for 210 patients with NAFLD (124 patients of simple steatosis (SS) and 86 of non-alcoholic steatohepatitis (NASH)). Apparently matched for age and gender, healthy participants ( n = 90) were enrolled as a control group. Serum samples were tested for micro-RNAs (-122, -34a and -99a) by quantitative-PCR., Results: By histopathology, 124 of the NAFLD group were of SS and 86 patients were of NASH. Compared with the control subjects, both mi-RNA-122 and -34a levels were increased in NAFLD ( p < 001) and at a cut-off = 1.261, mi-RNA-122 had 92% sensitivity, 85% specificity to differentiate NAFLD from healthy controls, while mi-RNA-99a were significantly decreased in NAFLD patients with an observed decrease in disease severity, and at a cut-off = 0.46, miRNA-99a had 94% sensitivity and 96% specificity to discriminate SS from NASH., Conclusion: The integration of a circulating mi-RNA panel to diagnose NAFLD cases and to discriminate between SS and NASH. Large-scale study is still needed to verify the other mi-RNA profiles and their role in NAFLD pathogenesis and targeting therapy., Competing Interests: The authors report no conflicts of interest in this work., (© 2019 Hendy et al.)

Published
2019
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