1. Performance of 18F fluoro-2-désoxy-D-glucose positron emission tomography/computed tomography for the diagnosis of venous thromboembolism
- Author
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Philippe Robin, Abdelmalek Reffad, Bernard Tardy, Grégoire Le Gal, Pierre-Yves Le Roux, Aurélien Delluc, Francis Couturaud, Pierre-Yves Salaun, Ronan Abgral, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Department of Nuclear Medicine, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Département de Médecine Interne et Pneumologie [Brest] (DMIP - Brest), Groupe de recherche sur la thrombose (GRT (EA 3065)), Université Jean Monnet [Saint-Étienne] (UJM), Département des Urgences (Urgences - SAINT ETIENNE), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Service de Médecine Nucléaire [Saint-Etienne], CHU Saint-Etienne-Hôpital Bellevue, Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Ottawa Hospital Research Institute [Ottawa] (OHRI)
- Subjects
Adult ,Male ,medicine.medical_specialty ,pulmonary embolism ,Deep vein ,[SDV]Life Sciences [q-bio] ,Population ,venous thromboembolism ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,030204 cardiovascular system & hematology ,FDG-Positron Emission Tomography ,Scintigraphy ,Multimodal Imaging ,deep vein thrombosis ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Pulmonary angiography ,medicine ,Humans ,Prospective Studies ,education ,Aged ,Ultrasonography ,education.field_of_study ,Lung ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,Hematology ,Middle Aged ,medicine.disease ,Thrombosis ,FDG PET/CT ,3. Good health ,Pulmonary embolism ,Perfusion ,Treatment Outcome ,medicine.anatomical_structure ,inflammation ,Positron-Emission Tomography ,Female ,Radiology ,Tomography, X-Ray Computed ,Nuclear medicine ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
International audience; Thrombosis and inflammation are intimately linked. Inflammatory component of venous thromboembolism (VTE) may allow the use of FDG positron emission tomography / computed tomography (FDG PET/CT) in the detection of thrombotic process. Published studies remain limited and contradictory. We aimed at evaluating the performance of FDG PET/CT in the detection of VTE in a population of patients enrolled in a prospective study evaluating FDG PET/CT for cancer screening in etiological assessment of idiopathic VTE. The first consecutive 100 patients who underwent FDG PET/CT were included. Visual and quantitative analyses of vascular axes was performed and compared with lower limb veins compression ultrasonography, lung scintigraphy and/or computed tomography pulmonary angiography. Out of the 100 patients, 63 presented lobar pulmonary embolism for a total of 217 embolic sites and 62 had a deep vein thrombosis for a total of 143 thrombotic sites. Regarding pulmonary embolism, sensitivity and specificity of FDG PET/CT were 3% (95%CI: 1-6%) and 99% (95%CI: 98-100%). SUV max ratio between pulmonary embolism location and non-pathological contralateral vessel was 1.04±0.18 (p=0.7). Regarding deep vein thrombosis, sensitivity and specificity were 31% (95%CI: 24-39%) and 88% (95%CI: 81-92%). The metabolic activity was significantly higher than in contralateral vessels (p
- Published
- 2014
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