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3. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis

Author

Ghallab, Ahmed, González, Daniela, Strängberg, Ellen, Hofmann, Ute, Myllys, Maiju, Hassan, Reham, Hobloss, Zaynab, Brackhagen, Lisa, Begher-Tibbe, Brigitte, Duda, Julia C., Drenda, Carolin, Kappenberg, Franziska, Reinders, Joerg, Friebel, Adrian, Vucur, Mihael, Turajski, Monika, Seddek, Abdel-latief, Abbas, Tahany, Abdelmageed, Noha, Morad, Samy A.F., Morad, Walaa, Hamdy, Amira, Albrecht, Wiebke, Kittana, Naim, Assali, Mohyeddin, Vartak, Nachiket, van Thriel, Christoph, Sous, Ansam, Nell, Patrick, Villar-Fernandez, Maria, Cadenas, Cristina, Genc, Erhan, Marchan, Rosemarie, Luedde, Tom, Åkerblad, Peter, Mattsson, Jan, Marschall, Hanns-Ulrich, Hoehme, Stefan, Stirnimann, Guido, Schwab, Matthias, Boor, Peter, Amann, Kerstin, Schmitz, Jessica, Bräsen, Jan H., Rahnenführer, Jörg, Edlund, Karolina, Karpen, Saul J., Simbrunner, Benedikt, Reiberger, Thomas, Mandorfer, Mattias, Trauner, Michael, Dawson, Paul A., Lindström, Erik, and Hengstler, Jan G.

Published
2024
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5. Acaricidal activity of Egyptian crude plant extracts against Haemaphysalis longicornis ticks.

Author

Abdou, Ahmed M., Arifeta, Nanang R., Seddek, Abdel-latif S., Morad, Samy Abdel-Raouf Fahim, Abdelmageed, Noha, Badry, Mohamed O., Umemiya-Shirafuji, Rika, and Nishikawa, Yoshifumi

Subjects
PLANT extracts, TICKS, LIQUID chromatography-mass spectrometry, FLAVONOID glycosides, PHYTOCHEMICALS, NATURAL products
Abstract

Haemaphysalis longicornis is a common Ixodida tick species found in temperate areas of Asian countries. An anti-tick assay was conducted on adult female H. longicornis ticks. Plant extract solutions were prepared at concentrations of 50, 25, and 10 mg/mL. Tick survival and mortality were assessed by counting the number of dead and live ticks at 24 h, 48 h, 72 h, and 96 h posttreatment. Out of 11 plant extracts screened, Artemisia judaica extract exhibited the highest potency with 100% mortality (5/5) at 48 h when applied at high and moderate concentrations (50 and 25 mg/mL). Similar results were observed at 96 h for the 10 mg/mL group compared to the untreated ticks. Cleome droserifolia extract demonstrated partial activity with 60% (3/5) and 20% (1/5) mortality at 96 h posttreatment at concentrations of 50 and 25 mg/mL, respectively. Forsskaolea tenacissima extract showed a weak effect with 100% tick mortality (5/5) only at the highest treatment concentration after 96 h. To confirm the activity of A. judaica, trial 2 was conducted. A. judaica demonstrated potency within 48 h in high dose and 72 h in moderate dose, with 100% mortality (15/15) at 96 h posttreatment compared to untreated ticks. The median lethal time 50 (LT50) values were 30.37 h for the high and 55.08 h for the moderate doses. Liquid chromatography‒mass spectrometry was performed on the most potent candidate (A. judaica) to identify its phytochemical components. The results revealed the presence of 9 compounds identified through manual annotation and 74 compounds from the Global Natural Products Social library. These compounds included terpenoids, steroids, phenylpropanoids, flavonoid glycosides, flavonoids, and benzenoids. Camphor was identified as the major component via both approaches. These findings suggest the potential use of A. judaica extract in the future development of acaricidal therapeutics. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Increased sinusoidal export of drug glucuronides is a compensative mechanism in liver cirrhosis of mice

Author

Fendt, Rebekka, primary, Ghallab, Ahmed, additional, Myllys, Maiju, additional, Hofmann, Ute, additional, Hassan, Reham, additional, Hobloss, Zaynab, additional, González, Daniela, additional, Brackhagen, Lisa, additional, Marchan, Rosemarie, additional, Edlund, Karolina, additional, Seddek, Abdel-Latif, additional, Abdelmageed, Noha, additional, Blank, Lars M., additional, Schlender, Jan-Frederik, additional, Holland, Christian H., additional, Hengstler, Jan G., additional, and Kuepfer, Lars, additional

Published
2023
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7. Inhibition of the renal apical sodium dependent bile acid transporter prevents cholemic nephropathy in mice with obstructive cholestasis

Author

Ghallab, Ahmed, primary, González, Daniela, additional, Strängberg, Ellen, additional, Hofmann, Ute, additional, Myllys, Maiju, additional, Hassan, Reham, additional, Hobloss, Zaynab, additional, Brackhagen, Lisa, additional, Begher-Tibbe, Brigitte, additional, Duda, Julia C., additional, Drenda, Carolin, additional, Kappenberg, Franziska, additional, Reinders, Joerg, additional, Friebel, Adrian, additional, Vucur, Mihael, additional, Turajski, Monika, additional, Seddek, Abdel-latief, additional, Abbas, Tahany, additional, Abdelmageed, Noha, additional, Morad, Samy A.F., additional, Morad, Walaa, additional, Hamdy, Amira, additional, Albrecht, Wiebke, additional, Kittana, Naim, additional, Assali, Mohyeddin, additional, Vartak, Nachiket, additional, van Thriel, Christoph, additional, Sous, Ansam, additional, Nell, Patrick, additional, Villar-Fernandez, Maria, additional, Cadenas, Cristina, additional, Genc, Erhan, additional, Marchan, Rosemarie, additional, Luedde, Tom, additional, Åkerblad, Peter, additional, Mattsson, Jan, additional, Marschall, Hanns-Ulrich, additional, Hoehme, Stefan, additional, Stirnimann, Guido, additional, Schwab, Matthias, additional, Boor, Peter, additional, Amann, Kerstin, additional, Schmitz, Jessica, additional, Bräsen, Jan H., additional, Rahnenführer, Jörg, additional, Edlund, Karolina, additional, Karpen, Saul J., additional, Simbrunner, Benedikt, additional, Reiberger, Thomas, additional, Mandorfer, Mattias, additional, Trauner, Michael, additional, Dawson, Paul A., additional, Lindström, Erik, additional, and Hengstler, Jan G., additional

Published
2023
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10. Additional file 1 of Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities

Author

Abdou, Ahmed M., Seddek, Abdel-latif S., Abdelmageed, Noha, Badry, Mohamed O., and Nishikawa, Yoshifumi

Subjects
fungi, parasitic diseases, food and beverages
Abstract

Additional file 1: Table S1. The plants used in this study and their reported medicinal uses. Table S2. Chemotherapeutic test of four plant extracts against the growth of Plasmodium yoelii in mice. Figure S1. Sampling map of the plant samples collected in Egypt. Figure S2. Images of the collected plant materials. Figure S3. Effect of wild plant extracts on the growth of plasmodium yoelii in male BALB/c mice. Figure S4. Effect of wild plant extracts on bodyweight change in Plasmodium-infected mice. Figure S5. Effect of wild plant extracts on survival rate of Plasmodium-infected mice.

Published
2022
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14. THE EFFECTIVENESS OF USING COMMUNICATIVE LANGUAGE TEACHING APPROACH (CLT) IN DEVELOPING STUDENTS' SPEAKING SKILLS FROM TEACHERS' PERCEPTIONS

Author

Abdelmageed, Noha Abdelmageed Taha and Mohamoud Ali Ahmed

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION
Abstract

The current study mainly aims at investigating the effectiveness of using Communicative Language Teaching (CLT) approach in developing students’ speaking skills at Sudanese secondary school levels from English language teachers’ perceptions. Also, the study seeks to find out the problems that hinder the teachers’ from implementing the CLT approach. To meet these aims and objectives the researcher employed a quantitative approach using a descriptive design. The researcher used the survey to collect data from the participants of the study. The random sampling technique was applied to select the sample out of all English language teachers at Omdurman Locality. Therefore, (100) female and male teachers have participated in this study. The information gained from the surveys was analyzed using the software Statistical Package for Social Sciences (SPSS). The study revealed the following findings: First of all, the majority of participants strongly agree that there is a positive relationship between teachers’ attitudes and effective usage of the communicative approach. The mains statements that gathered the highest level of response are: I think using CLT in my classroom helps my whole teaching process and using CLT in my class helps me share ideas and opinions with my learners. This means that most of the study participants assured that the use of CLT in the classrooms helped them to share the knowledge and facilitated their teaching process. Secondly, the majority of participants agree that there are effective factors that hinder teachers from using communicative approach to develop students speaking skills. The main statements which gathered their highest level of response are the following: Lack of authentic materials hinder the use of CLA in my and classroom size makes using CLT in my classroom more difficult. This clearly shows that the most effective factors that hinder teachers from implementing CLT in their classes are lacking of authentic material and classroom size. Finally, the majority of participants strongly agree that the communicative approach to develop students speaking skills – in general, and the main statements which gathered their highest level of response: Using CLA enhances students speaking skills, and I think using CLT motivates my student to speak accurately inside and outside the classroom. This result indicates that their participants of the study confirmed that using CLT in classroom enhanced their students speaking skill and motivated them to speak fluently.

Published
2020
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16. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergeticsin resistant HL-60 cells

Author

Fabriàs, Gemma [0000-0001-7162-3772], Li-Pin Kao, Morad, Samy A.F., Davis, Traci S., MacDougall, Matthew R., Kassai, Miki, Abdelmageed, Noha, Fox, Todd E., Kester, Mark, Loughran Jr. Thomas P., Abad, José Luis, Fabriàs, Gemma, Faith, David J., Su-Fern Tan, Claxton, David F., Spiegel, Sarah, Fisher-Wellman, Kelsey H., Cabot, Myles C., Fabriàs, Gemma [0000-0001-7162-3772], Li-Pin Kao, Morad, Samy A.F., Davis, Traci S., MacDougall, Matthew R., Kassai, Miki, Abdelmageed, Noha, Fox, Todd E., Kester, Mark, Loughran Jr. Thomas P., Abad, José Luis, Fabriàs, Gemma, Faith, David J., Su-Fern Tan, Claxton, David F., Spiegel, Sarah, Fisher-Wellman, Kelsey H., and Cabot, Myles C.

Abstract

The combination of daunorubicin (dnr) and cytarabine (Ara-C) is a cornerstone of treatment for acute myelogenous leukemia (AML); resistance to these drugs is a major cause of treatment failure. Ceramide, a sphingolipid (SL), plays a critical role in cancer cell apoptosis in response to chemotherapy. Here, we investigated the effects of chemotherapy selection pressure with Ara-C and dnr on SL composition and enzyme activity in the AML cell line HL-60. Resistant cells, those selected for growth in Ara-C- and dnr-containing medium (HL-60/Ara-C and HL-60/dnr, respectively), demonstrated upregulated expression and activity of glucosylceramide synthase, acid ceramidase (AC), and sphingosine kinase 1 (SPHK1); were more resistant to ceramide than parental cells; and displayed sensitivity to inhibitors of SL metabolism. Lipidomic analysis revealed a general ceramide deficit and a profound upswing in levels of sphingosine 1-phosphate (S1P) and ceramide 1-phosphate (C1P) in HL-60/dnr cells versus parental and HL-60/Ara-C cells. Both chemotherapyselected cells also exhibited comprehensive upregulations in mitochondrial biogenesis consistent with heightened reliance on oxidative phosphorylation, a property that was partially reversed by exposure to AC and SPHK1 inhibitors and that supports a role for the phosphorylation system in resistance. In summary, dnr and Ara-C selection pressure induces acute reductions in ceramide levels and large increases in S1P and C1P, concomitant with cell resilience bolstered by enhanced mitochondrial remodeling. Thus, strategic control of ceramide metabolism and further research to define mitochondrial perturbations that accompany the drug-resistant phenotype offer new opportunities for developing therapies that regulate cancer growth.

Published
2019

17. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells

Author

Kao, Li-Pin, primary, Morad, Samy A.F., additional, Davis, Traci S., additional, MacDougall, Matthew R., additional, Kassai, Miki, additional, Abdelmageed, Noha, additional, Fox, Todd E., additional, Kester, Mark, additional, Loughran, Thomas P., additional, Abad, Jose' L., additional, Fabrias, Gemma, additional, Tan, Su-Fern, additional, Feith, David J., additional, Claxton, David F., additional, Spiegel, Sarah, additional, Fisher-Wellman, Kelsey H., additional, and Cabot, Myles C., additional

Published
2019
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19. VINPOCETINE-BASED THERAPY IS AN ATTRACTIVE STRATEGY AGAINST OXIDATIVE STRESS-INDUCED HEPATOTOXICITY IN VITRO BY TARGETING NRF2/HO-1 PATHWAY.

Author

Abdelmageed, Noha, Twafik, Wael Ahmed-Anwar, Seddek, Abdel-latif, and Fahim Morad, Samy Abdel-Raouf

Subjects
*KEAP1 (Protein), *NUCLEAR factor E2 related factor, *INDOLE alkaloids, *REACTIVE oxygen species, *LIVER cells, *HEPATOTOXICOLOGY
Abstract

Vinpocetine (Vin), a synthetic-derivative of Vincamine, monoterpenoid indole alkaloid, has been reported to have various medicinal benefits. The purpose of our study was to investigate the pivotal role of “nuclear factor erythroid 2-related factor-2” (Nrf2)-mediated antioxidant protection of Vin against H2O2 and paracetamol (APAP)-induced liver toxicity. For this purpose, a normal human hepatic cell line (L02 cells) was incubated with cytotoxic concentrations of H2O2 or APAP in the presence or absence of Vin. To evaluate the responses, MTS Cell Viability assay, immunoblotting, biochemical assays, and molecular docking approach were used. Viability analysis showed that treatment of L02 cells with Vin prevented the cytotoxicity induced by H2O2 and APAP. It was evidenced by the fact that Vin dumped H2O2- and APAP-cytotoxicity and reactive oxygen species (ROS) generation. The immunoblotting analysis shows that Vin increased Nrf2 expression along with the expression of target protein, heme oxygenase-1 (HO-1), and increased intracellular glutathione (GSH) level. Interestingly, we found that Vin could protect the protein expression-level of Nrf2, which indicated the prospective interaction between Vin and Keap1 protein. Additionally, molecular docking-study revealed that Vin competed with Nrf2 for Keap1-binding site, with hydrogen and stearic interactions. Collectively, Vin effectively protects against H2O2 and APAP-induced cytotoxicity via executing Nrf2-mediated restoration of antioxidative/oxidative balance. Meanwhile, Vin interrupts protein-protein interaction between Nrf2 and Keap1, which might also contribute to decrease Nrf2 degradation and stabilize protein expression. Thus, Vin-based adjuvant therapy may represent a smart drug regimen to mitigate drug-induced oxidative stress and liver injuries. [ABSTRACT FROM AUTHOR]

Published
2021
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