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This paper presents a multi-layer, multi-objective (MLMO) optimization model for techno-economic-environmental energy management in cooperative multi-Microgrids (MMGs) that incorporates a Demand Response Program (DRP). The proposed MLMO approach simultaneously optimizes operating costs, MMG operator benefits, environmental emissions, and MMG dependency. This paper proposed a new hybrid ε-lexicography-weighted-sum that eliminates the need to normalize or scalarize objectives. The first layer of the model schedules MMG resources with DRP to minimize operating costs (local generation and power transactions with the utility grid) and maximize MMG profit. The second layer achieves the environmental operation of the MMG, while the third layer maximizes MMG reliability. This paper also proposed a new application of a recently developed enhanced equilibrium optimizer (EEO) for solving the three-layer EM problem. In addition, the uncertainties of solar power generation, wind power generation, load demand, and energy prices are considered based on the probabilistic 2m + 1 Point estimation method (PEM) approach. Three case studies are presented to verify the proposed MLMO approach on an MMG test system. In Case I, a deterministic EM is solved to simulate the MMG as a single layer to minimize costs and maximize benefits through DRP, while Case II solves the MLMO optimization problem. Simulation results show that the proposed MLMO technique reduces environmental emissions by 2.45% and 3.5% in its optimization layer and at the final layer, respectively. The independence index is also enhanced by 2.49% and 4.8% in its layer only and as a total increase, respectively. Case III is for the probabilistic EM simulation; due to the uncertain variables effect, the mean value in this case is increased by about 2.6% over Case I., (© 2024. The Author(s).)

With the rapid proliferation of portable and wearable electronics, energy autonomy through efficient energy harvesting has become paramount. Thermoelectric generators (TEGs) stand out as promising candidates due to their silent operation, high reliability, and maintenance-free nature. This paper presents the design, fabrication, and analysis of a micro-scale TEG for powering such devices. A planar configuration was employed for its inherent miniaturization advantages. Finite element analysis using ANSYS reveals that a double-layer device under a 50 K temperature gradient generates an impressive open-circuit voltage of 1417 mV and a power output of 2.4 μW, significantly exceeding its single-layer counterpart (226 mV, 0.12 μW). Validation against the analytical model results yields errors within 2.44% and 2.03% for voltage and power, respectively. Furthermore, a single-layer prototype fabricated using paper shadow masks and sputtering deposition exhibits a voltage of 131 mV for a 50 K temperature difference, thus confirming the feasibility of the proposed design. This work establishes a foundation for developing highly efficient micro-TEGs for powering next-generation portable and wearable electronics., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Abdelkader et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Infectious keratitis (IK) is one of the most common causes of monocular blindness worldwide, especially in developing countries and may account for 5.1%-32.3% of all indications for penetrating keratoplasty (PK). However, performing a therapeutic PK on a "hot eye" is associated with a higher incidence of IK recurrence and graft rejection. Standard treatment includes antimicrobials (ATM) and, once the causative pathogen has been identified, must be continued with targeted treatment, depending on antibiogram sensitivity. However, appearance of multiresistant strains to ATM is progressively increasing at an alarming rate. Besides that, the diversity of the causative microorganisms (bacteria, fungi, parasites, viruses) may hinder the clinical diagnosis and secondarily the proper treatment from the beginning. It is estimated that only 50% of eyes will have a good visual result if the correct therapy is delayed. All these factors make the identification of alternatives to ATM treatment of paramount importance. Due to the ATM properties of photoactivated chromophore (riboflavin, RB) and ultraviolet (UV) light of wavelength (λ) 200-400 nanometers (nm), used in multiple medical and non-medical applications for disinfection, photoactivated chromophore for corneal cross-linking (CXL) of IK (PACK-CXL), as an addition to the therapeutic arsenal for the management of IK has been proposed. It must be differentiated from CXL used for the management of progressive keratoconus (KC). The objective of this review is to update the available evidence on the efficacy and safety of PACK-CXL in IKs., (Copyright © 2022 Sociedad Española de Oftalmología. Published by Elsevier España, S.L.U. All rights reserved.)

Purpose: To investigate the potential predictive factors of the visual change achieved with accelerated epi-on and epi-off corneal collagen crosslinking (CXL) in keratoconus., Methods: This retrospective comparative study analyzed 67 eyes treated with an accelerated epithelium-on (epi-on group) and epithelium-off (epi-off group) CXL. The clinical outcomes were evaluated and compared during a 1-year follow-up. Likewise, the relationship of the change achieved with both CXL techniques in the corrected distance visual acuity (CDVA) with different preoperative data was investigated., Results: The mean CDVA change at 3 months postoperatively was -0.04 ± 0.19 and -0.07 ± 0.25 in the epi-on and epi-off groups, respectively ( p  = 0.809). In the epi-on group, this change was significantly correlated with the preoperative apical ( r  = -0.375, p  = 0.045) and central corneal thickness ( r  = -0.402, p  = 0.031). In the epi-off group, the CDVA change was significantly correlated with not only the preoperative apical ( r  = 0.402, p  = 0.028) and central corneal thickness ( r  = 0.367, p  = 0.046) but also with some topometric and aberrometric indices ( r  ≤ -0.374, p  ≤ 0.042). Furthermore, the change in CDVA in the epi-on group could be predicted from age, preoperative refractive astigmatism J 45 component, anterior corneal asphericity, and posterior corneal high order aberration root mean square ( p  = 0.002, R 2  = 0.503). In the epi-off group, the CDVA change could be predicted from the preoperative minimum corneal thickness and magnitude of the vertical anterior corneal primary coma component ( p  = 0.001, R 2  = 0.446)., Conclusions: Clearly, different predictive factors of the visual change induced with the accelerated epi-on and epi-off CXL techniques are present, suggesting a different mechanism of action for stiffening the cornea and inducing changes in this structure., Competing Interests: The authors declare that they have no conflicts of interest., (Copyright © 2021 Sidi Mohamed Hamida Abdelkader et al.)

Purpose : To review the scientific literature on the comparison of the efficacy of different corneal collagen crosslinking (CXL) protocols for the treatment of progressive keratoconus. Methods: Systematic review of randomized clinical trials (RCTs) on CXL outcomes. A search was carried out using the Cochrane Library, PubMed, EMBASE, Web of Science, Ovid MEDLINE, and Scopus databases. Internal validity was analyzed by applying the filter CASPe (Critical Appraisal Skills Program Spain). Results: The search yielded 1151 articles, and among these, 14 articles met the inclusion and exclusion criteria defined. Conventional (S) crosslinking (CXL) provided better topographic outcomes than transepithelial (TE) CXL, and S-CXL had a better therapeutic effect of corneal flattening than accelerated (A) CXL. The corneal thinning after CXL was lower with hypotonic riboflavin than with riboflavin-dextran. While one study demonstrated a better therapeutic effect of corneal flattening with S-CXL than with A-CXL, another study showed similar results between both techniques. No correlation was found between the depth of the demarcation line and topographic changes, which was not a direct measure of treatment effectiveness. Quality analysis of the literature reviewed yielded a mean score of 8.64, indicating that the RCTs evaluated had an overall acceptable quality. Conclusions: Good-quality RCTs comparing CXL techniques have been conducted, and most of them suggest that epi-off CXL can be considered the standard treatment for progressive keratoconus. TE-CXL and iontophoresis-assisted CXL are mainly indicated in patients with a risk of corneal scarring and patients with pain intolerance, respectively.