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Background: The four muscles that support the humeral head and come from the anterior and posterior sides of the scapula with their tendons situated in the smaller and larger tuberosities are collectively known as the "rotator cuff." The teres minor, supraspinatus, infraspinatus, and subscapularis are among these muscles. Objectives: This study compares dynamic high-resolution ultrasonography to MRI, which was the gold standard to assess the value of each technology in identifying rotator cuff injury. Patients and methods: This was prospective study for fifty patients were sent to the Diagnostic and Interventional Radiology Clinic in Qena City suspected to have rotator cuff injury. . Results: Patients' ages ranged from 19 to 70, with a mean age of 36 years, a standard deviation of 16.35 years. In our study, there were a total of 32 affected males (64%) and 18 affected females (36%) with a male to female ratio of 1.78:1. In identifying complete tears in our patients, in general, we found that USG has 100% overall sensitivity, 92.68% overall specificity, and 94% overall diagnostic accuracy. Positive predictive value was 75%, whereas the negative predictive value was 100%. Conclusion: MRI and ultrasound have similar levels of sensitivity and specificity. When high-resolution imaging is feasible, trained radiologists are on hand, and rotator cuff integrity is the main concern, US may be thought of as the screening method because it is less expensive and more widely available.

Salvia guaranitica is considered one of the most significant medicinal and aromatic herbs in terms of nutritional and medical benefits due to its wealth of important active components. Among these compounds, terpenoids are the most prominent and abundant, particularly monoterpenes (C10), sesquiterpenes (C15), and diterpenes (C20). They are biologically advantageous to plants and perform a multitude of functions. The current study aimed to clone the S. guaranitica gene that encodes for geranyllinalool synthases (SgGES, EC: 4.2.3.144), with consideration for these features. The open reading frame of the 867-amino-acid protein encoded by SgGES consists of 2.721 base pairs. In addition, the SgGES protein has five domains that belong to the terpene synthase family, which are related to the terpene and terpenoid synthase domains. We manipulated and overexpressed the SgGES gene in Nicotiana tabacum to explore its function. When compared to the GUS control, the transgenic N. tabacum plants displayed an increase in leaf production and diameter when compared with the wild-type plants. Finally, analysis of transgenic plants using gas chromatography/mass spectrometry (GC-MS) showed that SgGES is responsible for producing various terpene species, especially diterpenes. [ABSTRACT FROM AUTHOR]

This research aims to provide a systematic scientific picture of the design and production of printed advertising integrated in the daily newspaper where advertising is different in our time is a necessity of life indispensable, as the main process in communication between the advertiser and the recipient, one of the most important marketing and promotional activities of products And services where it contributes to strengthen the personality of the service or product and affirms it in the minds of the masses and affects their purchasing power, and therefore deserves the design and production of printed advertising integrated in the newspaper to pay due attention and attention in terms of keeping pace with development, innovation and trade The hand which would attract the attention of the forum is always to follow the announcement and keep it.The integrated advertising in the newspaper is one of the important advertising areas that must be addressed by study and research, where it is not rarely shed light where it allows the advertisement integrated newspaper newspaper advertisers to address their products by explaining and analyzing and clarify its advantages and influence the target audience in order to benefit the advertiser may not be available in the ad problem The printed advertising in the newspaper is an important part of the policy of advertising campaigns planning, as it is an important communication medium between the advertiser and the forum. Targeted to convey the advertising message in order to change and enhance the views of recipients.The printed advertising integrated in the newspaper is of great importance to both the recipient and the advertiser and the press institutions.The printed advertising integrated in the newspaper is considered one of the most important advertising media because of its wide spread and regular attachment and distribution with newspapers

Background and Aim: Vitamin D has anti-viral, anti-inflammatory, and metabolic effects. The goal of this study was to evaluate the link between vitamin D level and COVID-19 incidence and to identify the result of short-term vitamin D deficiency correction in decrease the risk of COVID-19 infection. Patients and Methods: A prospective open-label controlled trial was carried out on 897 enrolled subjects who had contact with relatives infected by COVID-19 disease randomized into two arms according to baseline vitamin D level; the first arm of which 816 subjects (90.97% vitamin D deficiency) received 200,000 IU cholecalciferol/vitamin D3 every other day with a total of 3 doses, whereas the second arm, 81 subjects (9.03% normal vitamin D) didn't receive vitamin D supplementation. Serum calcium and serum vitamin D were measured at baseline and 2 weeks after treatment. CBC, ESR, CRP, ferritin, and D-dimer were performed in suspected cases. Results: Symptoms compatible with COVID-19 were 17.3% in the second arm and 16.4% in the first arm, Laboratory-confirmed diagnosis were 3.7% in the second arm and 5.4% in the first arm. Hospitalization was 1.2% in the second arm and 0.4% in the first arm. Deficient vitamin D levels increased the risk of symptoms compatible with COVID-19 disease by 1.66 folds.correlation was detected between P300 amplitude with IQ or language age (P > 0.05). Conclusion: Rapid correction of vitamin D deficiency decrease the risk of COVID-19 infection. [ABSTRACT FROM AUTHOR]

The infection caused by the hepatitis C virus (HCV) is a significant global health concern. The prevailing genotype of HCV in Egypt is 4a, commonly referred to as GT‐4a. A significant proportion exceeding 50% of patients infected with HCV experience extrahepatic manifestations (EHMs), encompassing a diverse range of clinical presentations. These manifestations, including essential mixed cryoglobulinemia (MC), can serve as initial and solitary indicators of the disease. The complete understanding of the pathogenesis of EHM remains unclear, with autoimmune phenomena being recognized as the primary causative factor. In this study, we examined the predictive significance of T‐cell subpopulations in relation to the occurrence and prognosis of cryoglobulinemia in HCV patients. A total of 450 CHC genotype four treatment naïve patients were enrolled in this analytic cross‐sectional study after thorough clinical, laboratory, and radiological examinations. All patients underwent laboratory investigations, including testing for cryoglobulin antibodies and measurements of CD4 and CD8 levels; two groups were described according to their test results: Group 1 consists of patients who have tested positive for cryoglobulin antibodies and Group 2 consists of patients who have tested negative for cryoglobulin antibodies. The exclusion criteria encompassed individuals with HIV infection or chronic HBV infection. Additionally, pelvi‐abdominal ultrasonography was performed. Our study included 450 treatment naïve CHC patients (59% male, mean age 50.8 years). The patients were categorized according to their cryoglobulin antibodys test results into two groups: group A, CHC patients with cryoglobulin antibodies (Abs) negative (364 patients), and group B, CHC patients with cryoglobulin Ab positive (86 patients). Group B demonstrated a higher average age, elevated international normalized ratio, more prolonged duration of HCV infection, lower albumin, higher alanine aminotransferase, higher aspartate aminotransferase, higher bilirubin, lower CD8, lower CD4, and lower CD4:CD8 ratio. In contrast, 27 out of 86 (31.40%) patients in group B had symptoms; 85.8% had purpura and arthralgia, 74.3% had paresthesias, 86.7% had weakness, and 12.2% had non‐Hodgkin's lymphoma. The levels of CD4 and CD8 were found to be decreased in chronic HCV patients with MC. T‐cell subpopulation serves as a reliable indicator for assessing the prevalence and prognosis of MC in individuals with genotype 4 chronic hepatitis C. However, additional research is needed to further understand the development and spread of various emerging infectious diseases. Nevertheless, it is noteworthy that a critical threshold may exist beyond which EHM reaches a point of no return. [ABSTRACT FROM AUTHOR]

Background: Patients who undergo primary percutaneous coronary intervention (PCI), are at great risk of contrast-induced nephropathy (CIN). The PRECISE-DAPT score had been implemented nowadays to determine the best period of dual anti-platelet therapy after PCI. This Study aim To determine the predictive value of the admission PRECISE-DAPT score in the early diagnosis of CIN. Methods: A prospective cohort study carried out in the cardiology department at Zagazig university hospital and national heart institute, Cairo, during the period from January 2020 to August 2020. The study included 200 patients admitted with first acute ST segment elevation myocardial infarction (STEMI) and underwent primary percutaneous coronary intervention. All patients were subjected to complete history taking. General examination for all body systems and local cardiological examination were done. We also did full lab investigations as complete blood count (CBC), Creatine kinase-myocardial band (CK-MB), Troponin, creatinine (at admission and within 72h post PCI) and glomerular filtration rate (GFR). Patient's resting Electrocardiogram (ECG) and transthoracic echocardiography (TTE) were done. PRECISE-DAPT score was calculated for all cases. Coronary angiography and PCI were performed. Results: We detected a high statistically significant increase in precise DAPT score (23.6 ± 10.4) p <0.001 among CIN patients. CKMB, Platelet distribution width (PDW), contrast volume, left anterior descending (LAD) culprit vessel and PREISE-DAPT score are significant predictors for CIN among studied patients. Conclusion: The PRECISE-DAPT score can be a valuable tool to predict acute kidney injury in cases of STEMI undergoing PCI. [ABSTRACT FROM AUTHOR]

Background: Flexor tendon injuries represent a significant per-centage of admissions in emergency departments in Egypt. A bloodless surgical field is important to perform a hand surgery. Traditionally, a tourniquet is used for hemostasis, and the standered anesthetic techniques utilized in hand surgery were general anesthesia, intravenous regional anesthesia, or brachial plexus block. Recently the evolving Wide-Awake Local Anesthesia No Tourniquet (WALANT) technique where patient is operated on under local anesthesia and hemostasis is achieved via adrenaline could be a better choice. Aim of this work is to compare the intraoperative pain scores, induction time, operating time, blood loss, postoperative pain scores, and patient satisfaction with WALANT versus supraclavicular brachial plexus block (SC-BPB ) with tourniquet, in patients under-going flexor tendon repair. Patients and Methods: In the current study 52 patients who underwent flexor tendon intervention were divided randomly into two groups, each group consisting of 26 patients. Group A: Patients in this group received WALANT. Group B: Patients in this group received SC-BPB with a tourniquet applied to the arm. Results: Intraoperative Wong-Baker Faces scale revealed no statistically significant difference in intraoperative pain scores in both groups, except during injection (p = 0.04). Tourniquet-related pain was reported in 23% of patients of SC-BPB group (p = 0.001). Induction time was significantly shorter in WALANT (p < 0.01) but time needed to obtain sufficient hemostasis is sig-nificantly more in WALANT than SC-BPB (p < 0.01) while surgical time was similar in both groups (p = 0.538). Blood loss in spite of being minimal it was statistically significant higher in WALANT (p < 0.01). Conclusion: WALANT anesthesia was found to be better alter-native to SC-BPB in flexor tendon repair surgeries in adults being more simple technique and no need for special skills or ultrasound device, less time consumed in induction and less injection pain also no tourniquet-related pain, intraoperative active motion of the hand is preserved facilitating surgical technique, better effect on postoperative analgesia and more patient and surgeon satisfaction. [ABSTRACT FROM AUTHOR]