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Purpose: To describe the clinical profile of patients with HLA-B27-associated uveitis at 2 Egyptian tertiary eye centers. Methods: A retrospective study reviewing the medical records of all patients with HLA-B27-associated uveitis served at 2 uveitis referral clinics in Egypt between January 2010 and June 2018. Results: The study included a total of 554 patients. Anterior uveitis was the most common type. Ankylosing spondylitis was an important systemic comorbidity in the present study, affecting 27.4% of our patients. Cataract was the most frequent ocular complication. By the conclusion of the study, 6.1% of the affected eyes had a BSCVA poorer than 20/200. Conclusion: The clinical profile of HLA-B27-associated uveitis in our cohort of Egyptian patients is similar to that reported from other regions of the world. In our study, a relatively high rate of cataract was observed. [ABSTRACT FROM AUTHOR]

Purpose: To describe the clinical experience with intermediate uveitis at six Egyptian tertiary eye centers.Methods: A multicenter retrospective chart review of all patients with intermediate uveitis seen at six ocular inflammation referral clinics in Egypt between January 2010 and January 2017.Results: The study included a total of 781 patients with intermediate uveitis. The study cohort comprised of 282 male and 499 female patients. In over half of our cohort (58.77%), no specific cause could be confirmed. The remaining patients had sarcoidosis (16.26%), tuberculosis (14.85%), multiple sclerosis (9.09%), and TINU (1.02%). By the end of our study, 62% of the affected eyes had a BCVA better than 20/40Conclusion: More than 40% of our patients with intermediate uveitis had sarcoidosis, tuberculosis, multiple sclerosis, or TINU as the underlying etiology. Owing to their potential morbidity, these diseases need to be considered in Egyptian patients presenting with intermediate uveitis. [ABSTRACT FROM AUTHOR]

Purpose: The aim of this study was to assess time-course changes of the ocular surface after simultaneous phacoemulsification and limbal relaxing incisions (LRIs) in the early postoperative period. Patients and methods: We prospectively examined 35 eyes of 22 consecutive patients who underwent simultaneous cataract surgery with LRIs both preoperatively and postoperatively (1 week, 1 month, and 3 months). Ocular surface quality was assessed in terms of corneal sensitivity, tear break-up time (BUT), and tear production, both preoperatively and postoperatively. Corneal sensitivity was measured using the Cochet-Bonnet corneal aesthesiometer, and tear volume was determined using Schirmer's I test. Results: Corneal sensitivity was 58.5±3.9mm preoperatively and was 58.3±2.7, 58.9±2.5, and 59.8±0.6mm at 1 week, 1 month, and 3 months postoperatively, respectively [analysis of variance (ANOVA), P=0.13]. The BUT was 9.7±5.6 s preoperatively and was 5.6±3.1, 5.9±4.7, and 4.5±2.6 s at 1 week, 1 month, and 3 months, postoperatively, respectively (ANOVA, P=0.002). Tear volume was 15.2±8.8mm preoperatively and was 12.2±6.9, 12.5±7.3, and 11.8±8.0mm at 1 week, 1 month, and 3 months postoperatively, respectively (ANOVA, P=0.26). Conclusion: Simultaneous phacoemulsification with LRIs induced a significant decrease in BUT postoperatively without significantly affecting tear volume or corneal sensitivity. [ABSTRACT FROM AUTHOR]

Background: Adjustable sutures increase the success rate of strabismus surgery. However, the optimal timing of postoperative suture adjustment remains controversial. This trial was aimed at comparing the surgical outcomes and pain scores of early or 2 - 4 h and delayed or 24 h postoperative suture adjustment in adult patients undergoing strabismus surgery., Methods: An open-label, prospective, randomized, comparative interventional study was performed in consecutive adult patients scheduled for eye muscle surgery. Patients were randomized into two groups: the early group, with suture adjustment 2 - 4 h postoperatively, and the delayed group, with suture adjustment 24 h postoperatively. Subjective pain scores during the adjustment were also analyzed. The angles of misalignment at 1 and 3 months and the success rate at 3 months postoperatively were compared., Results: Forty-five (90%) patients completed the follow-up, including 23 (92%) in the early adjustment group and 22 (88%) in the delayed adjustment group, with a mean (standard deviation) age of 25.6 (9.5) years and a male-to-female ratio of 46.7:53.3. Thirty patients (66.7%) had exotropia, and 15 (33.3%) patients had esotropia. Both groups had comparable baseline characteristics (all P > 0.05). The mean pain scores during adjustment did not differ significantly between groups ( P > 0.05). The postoperative angles of alignment were comparable between the groups before suture adjustment and at the 1- and 3-month follow-ups (all P > 0.05). The success rate in the early adjustment group was slightly higher (87.0% versus 63.6%), but the difference was not statistically significant ( P > 0.05). The success rate was comparable between the groups in patients with esotropia or exotropia (both P > 0.05)., Conclusions: Although the early adjustment group had a slightly higher success rate, the difference was not significant. Both groups had comparable subjective pain scores during adjustment, final motor alignment, or success rate. Future clinical trials should be performed different time intervals for postoperative suture adjustment, and subjective and objective outcomes, such as diplopia and stereopsis, should be compared between patients with a first strabismus surgery and those who underwent reoperation. This could better resolve the persistent controversy related to the optimal time for suture adjustment., Competing Interests: None., (© Author(s).)