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Background: Thyroid disease is one of the most common illnesses in the UAE, which could be linked to vast numbers of people suffering from vitamin D deficiency. This study aimed to explore the association between serum 25(OH)D levels and thyroid function parameters in men and women with diagnosed hypothyroidism. Methods and Results: This cross-sectional observational study included 86 patients (78[90.7%] women and 8[9.3%] men) with diagnosed hypothyroidism. The patients were divided into two groups, male and female. These two groups were compared in terms of age, TSH, free-T4 (FT4), vitamin D, free-T3 (FT3), and body mass index (BMI). In addition, the correlation between levels of vitamin D and TSH was also examined in these two groups. The mean age of the patients was 27.5 years, and BMI was 28.00 kg/m2, indicating overweight. Vitamin D deficiency was found in 61(70.9%) patients and severe vitamin D deficiency in 10(11.6%) patients with hypothyroidism. 25(OH)D levels were significantly low in patients with high TSH levels, showing a weak negative correlation (r=-0.132, P=0.043). A negligible positive correlation was identified between 25(OH)D levels and FT4 r=0.089, P>0.05) and FT3 (r=0.071, P>0.05), and a negligible negative correlation with BMI (r=-0.059, P>0.05). Conclusion: There is a clear indication that vitamin D deficiency is prevalent in hypothyroid patients and that these subjects have lower levels of serum 25(OH)D. Suggesting that lower serum 25(OH)D is related to hypothyroidism and the deficiency in vitamin D plays a role in the development of the disease.

Background: This study aimed to estimate the levels of CRP and PRL in SARS-CoV2 infection and their association with the severity of COVID-19 among patients in Ajman, UAE. Methods and Results: This cross-sectional study was conducted in Thumpay Hospital from 2020 to 2021. The study included 71 patients (55 males and 16 females) with positive SARS-CoV-2 test results. Nasal swab specimens were collected for the COVID-19 test on the day of admission or after one day of admission. COVID-19 diagnoses and severity levels were determined according to the New Coronavirus Pneumonia Prevention and Control Program (7th edition) published by the National Health Commission of China (2020). Serum samples were collected from the patients upon admission. The PRL level was determined using the immune chemiluminescent method by the DXI 800 Beckman Coulter analyzer. The CRP level was determined using the immunoturbidimetric method by the DXC 700 AU chemistry analyzer. Among 71 COVID-19 patients, the great majority were men 55(77.5%), 38(53.5%) being of Indian nationality. In this study, most participants (50.7%) had no history of chronic illnesses. In terms of COVID-19 severity, 24(33.8%) of patients had mild cases, 27(38.0%) had moderate cases, and 20(28.2%) had severe cases. Twenty (28.2%) patients were transferred to the ICU, and 19(26.8%) were intubated. The patients' average age was 47.58±13.63, CRP level - 74.30±71.46 mg/L, and PRL level - 205.1946±168.52 ng/mL. The mean CRP level was highest in severe cases, compared to mild and moderate cases, with a statistically significant difference between mild and severe groups (P=0.000) and mild and moderate groups (P=0.004). The mean PRL level was highest in severe cases compared to mild and moderate cases; however, the differences between the groups were not significant. CRP and PRL levels were greater in the ICU patients than non-ICU patients, with statistically significant differences only for CRP. We found a moderate positive correlation between CRP level and age (r=0.458, P=0.000); a weak positive correlation between PRL level and age was not statistically significant (r=0.201, P=0.093). A moderate positive correlation between CRP level and PRL level (r=0.461, P=0.03) was statistically significant. Conclusion: The current study implies that serum CRP levels might be an important indication of COVID-19 development and severity. A more extensive study with a larger sample size is needed to validate the significance of PRL in disease severity.