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Wound healing, one of the most intricate and dynamic processes of the body, maintains skin integrity following trauma. One of the main issues that still exists is impaired wound healing, particularly for immunosuppressed patients. Recently, natural products from marine environments have been employed in wound-repairing activities. This work investigates the mesenchymal stem cells in the combined capacity of the bone marrow (BMMSC) for wound healing and Cystoseira sp. Algae extract in immunosuppressed rats. High-resolution liquid chromatography / MS investigation of Cystoseira extract revealed the prevalence of fatty acids that have wound-soothing potential. From constructed PPI network for wound healing and further analysis through molecular docking and molecular dynamics (MD) simulation experiments suggested that cystalgerone metabolite may be responsible for the wound healing-promoting effect of Cystoseira extract. According to the CD marker characterization of the BMMSC, 98.21% of them expressed CD90, and 97.1% expressed CD105. Sixteen d after immunity suppression (by 40 mg/kg hydrocortisone daily), an incision was made in the dorsal skin of the rat. The treatments were applied for 16 d and samples were taken from the tested groups on the 8th, 14th, and 16th days. The BMMSCs / Cystoseira group showed significantly improved wound closure, thickness, density of new layers, and skin elasticity than the control group (p < 0.001). The BMMSCs / Cystoseira combination significantly reduced the oxidative indicators, pro-inflammatory cytokines, and immune markers, according to the RT-PCR gene expression study. In order to delve deeper into the complex interconnections among wound healing-related biological targets and pinpoint key factors in this complex process, we engaged in network pharmacology and computational research. Subsequently, we conducted a comprehensive computational analysis, including reverse docking, free energy (ΔG) computation, and molecular dynamics simulations, on the molecular structures of the annotated compounds. The purpose of this investigation was to identify potential new targets for these chemicals as well as any potential interactions they may have with different signaling pathways related to the wound healing process. Our research indicates that the primary compounds of Cystoseira holds potential wound healing therapeutic activity. Although more safety testing and clinical studies are required, the combination has great potential for regenerative medicine and could be a revolutionary advance in the healing of the wounds of immunosuppressed patients.

Background and Objectives: Hepatocellular carcinoma (HCC) is a prevalent form of malignancy that is characterized by high mortality rates and prognosis that remain suboptimal, largely due to treatment resistance mechanisms. Recent studies have implicated cancer stem cells (CSCs), particularly those expressing epithelial cell adhesion molecule (EpCAM), in HCC progression and resistance. In the present study, we sought to assess EpCAM expression in HCC patients and its correlation with various clinicopathological parameters. Materials and Methods: Tissue samples from 42 HCC patients were subjected to immunohistochemical staining to evaluate EpCAM expression. Clinicopathological data were obtained including the size, grade and stage of tumors, vascular invasion status, alpha-fetoprotein levels, and cirrhosis status. The Chi square and Fisher’s exact tests were employed to assess the association between categorical groups. Independent Student-t test or Mann–Whitney U test was used to investigate the association between continuous patient characteristics and survival. Results: Immunohistochemical analysis revealed EpCAM expression in 52.5% of HCC cases. EpCAM-positive tumors exhibited characteristics indicative of aggressive disease, including larger tumor sizes (p = 0.006), greater tumor multiplicity (p = 0.004), higher grades (p = 0.002), more advanced stages (p = 0.003), vascular invasion (p = 0.023), elevated alpha-fetoprotein levels (p = 0.013), and cirrhosis (p = 0.052). Survival analysis demonstrated that EpCAM expression was significantly associated with lower overall rates of survival and higher rates of recurrence in HCC patients. Conclusions: Our findings suggest that EpCAM expression may serve as a prognostic biomarker for HCC with a potential role in patient management. Targeting EpCAM-positive CSCs may represent a promising approach to overcome treatment resistance and improve clinical outcomes in HCC. However, further investigation into the molecular mechanisms underlying EpCAM’s role in HCC progression is warranted to facilitate the development of personalized therapeutic interventions.

Background: Astrocytomas are considered the most prevalent central nervous system [CNS] tumors. Diffuse astrocytomas are evaluated by a three-tiered system [II, III, and IV] according to the 2007 WHO classification. The WHO grading scheme is based on the existence or lack of four histological features: mitosis, nuclear atypia, microvascular proliferation, and necrosis. Pilocytic astrocytoma is classified as WHO grade I in histological grading of localized astrocytic tumors. In many cases of human neoplasms, including astrocytoma, p53, and Ki67, the expression increases, especially in aggressive and high-grade tumors.The Aim of the work: We aimed to validate the p53 and Ki 67 immunohistochemical expression in various grades of astrocytic tumors and correlate this expression with clinicopathologic findings and histopathologic grading.Patients and methods: Immunohistochemical analysis [IHC] of p53 and Ki67 were used to evaluate 45 paraffin-embedded samples, which included different grades of astrocytoma [10 participants of pilocytic astrocytoma, 12 participants of diffuse astrocytoma grade II, 9 participants of anaplastic type, and 14 participants of glioblastoma type]. Tumor tissue blocks and clinical information of the cases were gathered from the files of Pathology Department of Al-Azhar University Hospitals [Al-Hussein & Al-Zahraa] and from the archives of some private laboratories from March 2018 to June 2021.Results: Immunohistochemical [IHC] expression of p53 and Ki 67 had a significant positive association with histopathological grading of astrocytoma. High expressions were detected in high-grade astrocytoma [grade III, IV] versus low-grade types [I, II]. Conclusion: p53 and Ki 67 immunohistochemical expression is up regulated in high-grade astrocytoma. Their overexpression seems to indicate a more malignant phenotype.

- تبین من نتائج قیاس تحلیل مصفوفة السیاسات الزراعیة لمحصولی الدراسة أن معامل الحمایة الأسمی لمستلزمات الإنتاج قد بلغ حوإلی 0.915، 0.915 لکل من القمح والأرز خلال الفترة 2013- 2017، الأمر الذی یشیر إلی عدم وجود دعم لمستلزمات الإنتاج. - کما تبین أن معامل الحمایة الإسمی للنواتج من محصولی القمح والأرز علی الترتیب خلال فترة الدراسة قد بلغ حوإلی 0.771، 0.746، الأمر الذی یوضح إلی عدم وجود سیاسة إنتاجیة عادلة وذلک لقیام الدولة بفرض ضرائب مباشرة وغیر مباشرة علی المنتج وتقدیم دعم للمستهلک. - کما تبین من النتائج إلی وجود میزة نسبیة لمحاصیل الدراسة خلال نفس الفترة ، الأمر الذی یعنی إلی ان معامل المیزة النسبیة أقل من الواحد الصحیح. - کما تبین ان بمقارنة التقییم المإلی والتقییم الاقتصادی لکل من أجور الآلات، ثمن التقاوی، ثمن السماد الکیماوی، ثمن المبیدات، نجد أن التقییم المإلی یقل عن التقییم الاقتصادی لهذه البنود مما یدل على أنها مدعومة من جانب الدولة لمزارعی القمح. - کما تبین ان بمقارنة التقییم المإلی والاقتصادی لکل من إیجار الأرض، أجور الحیوانات، ثمن السماد البلدی، والمصاریف العمومیة یتبین أنهما متساویان مما یدل على عدم تدخل الدولة فی أسعار هذه البنود. - کما تبین ان بمقارنة التقییم المإلی والتقییم الاقتصادی لکل من أجور الآلات، ثمن التقاوی، ثمن السماد الکیماوی، ثمن المبیدات، نجد أن التقییم المإلی یقل عن التقییم الاقتصادی لهذه البنود مما یدل على أنها مدعومة من جانب الدولة لمزارعی الأرز. - کما تبین ان بمقارنة التقییم المإلی والاقتصادی لکل من إیجار الأرض، أجور الحیوانات، ثمن السماد البلدی، والمصاریف العمومیة یتبین أنهما متساویان مما یدل على عدم تدخل الدولة فی أسعار هذه البنود. - کما تبین من النتائج إلی أن قیمة معامل الحمایة الفعال لمحصول القمح بلغت حوإلی 0.756 خلال فترة الدراسة، مما یعنی أن محصول القمح لم یتمتع بحمایة حکومیة خلال تلک الفترة. - کما تبین من النتائج أن قیمة معامل الحمایة الفعال لمحصول الارز بلغت حوإلی 0.723 خلال فترة الدراسة، مما یعنی أن محصول الأرز لم یتمتع بحمایة حکومیة خلال تلک الفترة.

Renal ischemia/reperfusion (IR) injury is characterized by an unexpected impairment of blood flow to the kidney. Azilsartan is an angiotensin receptor blocker that is approved for the management of hypertension. The present study aimed to investigate, on molecular basics, the nephroprotective activity of azilsartan on renal IR injury in rats. Rats were assigned into four groups: (1) Sham group, (2) Azilsartan group, (3) IR group, and (4) IR/Azilsartan-treated group. Histological examination and renal function were evaluated. Levels of KIM-1, HMGB1, caspase 3, GPX, SOD, NF-κB, and p53 proteins were investigated using ELISA. mRNA levels of IL-1β, IL6, IL10, TNF-α, NF-κB, p53, and bax were assessed by qRT-PCR. Expression of p38, JNK, and ERK1/2 proteins was investigated by Western blotting. IR injury resulted in tissue damage, elevation of creatinine, BUN, KIM-1, HMGB1, caspase 3, NF-κB, and p53 levels, decreasing GPX and SOD activities, and up-regulation of NF-κB, IL-1β, IL6, TNF-α, p53, and bax genes. Furthermore, it up-regulated the expression of phosphorylated/total ratio of p38, ERK1/2, and JNK proteins. Interestingly, treatment of the injured rats with azilsartan significantly alleviated IR injury-induced histopathological and biochemical changes. It reduced the creatinine, BUN, KIM-1, HMGB1, caspase-3, NF-κB, and p53 levels, elevated GPX and SOD activities, down-regulated the expression of NF-κB, IL-1β, IL6, TNF-α, p53, and bax genes, and up-regulated IL10 gene expression. Furthermore, it decreased the phosphorylated/total ratio of p38, ERK1/2, and JNK proteins. Azilsartan exhibited nephroprotective activity in IR-injured rats via its antioxidant effect, suppression of inflammation, attenuation of apoptosis, and inhibition of HMGB1/NF-κB/p38/ERK1/2/JNK signaling pathway.

Scabies is an invasive skin condition caused by Sarcoptes scabiei mites. The present study investigates the antiscabies potential of coconut seed extract (CSE) in rabbits. GC-MS analysis of the seed oil identified 17 known compounds, while CSE phytochemical investigation afforded 4 known ones. The topical application of seed extract improved all signs of infection, and the improvement started 3 days post application. However, in vitro application of the extract caused 99% mortality of mites 1 day post application. Histopathological examination revealed the absence of inflammatory infiltration and hyperkeratosis of the epidermis, compared with ivermectin-treated groups which revealed less improvement. The mRNA gene expression results revealed a suppression of IL-1β, IL-6, IL-10, MMP-9, VEGF, and MCP-1, and an upregulation of I-CAM-1, KGF as well as TIMP-1. The docking analysis emphasized a strong binding of gondoic acid with IL-1β, IL-6, and VEGF with high binding scores of −5.817, −5.291, and −8.362 kcal/mol, respectively, and a high binding affinity of 3″(1‴-O-β-D-glucopyranosyl)-sucrose with GST with −7.24 kcal/mol. Accordingly, and for the first time, our results highlighted the scabicidal potential of coconut seed extract, which opens the gate for an efficient, cost-effective as well as herbal-based alternative for the control of scabies in rabbits.

Laryngeal cancer, particularly the squamous cell carcinoma subtype, is prevalent globally and is characterized by a poor prognosis and high mortality rates. Currently, no definitive prognostic markers exist for predicting the behavior of the tumor. The aim of this study is to examine the correlation between cyclin D1 and E-cadherin expression with some clinicopathological parameters in laryngeal squamous cell carcinoma (LSCC). 60 cases of LSCC were retrospectively studied concerning the clinicopathological features and the potential prognostic role of cyclin D1 and E-cadherin expression in laryngeal carcinoma, using immunohistochemical staining scores on paraffin-embedded cancer tissues from patients who were treated with surgical excision. Reduced Ecadherin expression was significantly correlated with tumor grade (p = 0.0288), T stage (p = 0.041), and lymph node metastasis (p = 0.003). Regarding Cyclin D1, a statistically significant correlation was found with lymph node metastasis (p=0.019). In contrast, cyclin D1 expression was not significantly correlated with TNM stage or tumor grade (p=0.99 and 0.66, respectively). Evaluating expression of cyclin D1 in conjunction with E-cadherin expression in laryngeal squamous cell carcinoma may prove beneficial in identifying patients with lymph node metastasis. Tumor grade, stage, and nodal metastasis can significantly affect E-cadherin expression in patients with LSCC. However, further studies using genetic testing are recommended to assess the role of E-cadherin in tumor progression. [ABSTRACT FROM AUTHOR]

Background and Objectives: Hepatocellular carcinoma (HCC) is a prevalent form of malignancy that is characterized by high mortality rates and prognosis that remain suboptimal, largely due to treatment resistance mechanisms. Recent studies have implicated cancer stem cells (CSCs), particularly those expressing epithelial cell adhesion molecule (EpCAM), in HCC progression and resistance. In the present study, we sought to assess EpCAM expression in HCC patients and its correlation with various clinicopathological parameters. Materials and Methods: Tissue samples from 42 HCC patients were subjected to immunohistochemical staining to evaluate EpCAM expression. Clinicopathological data were obtained including the size, grade and stage of tumors, vascular invasion status, alpha-fetoprotein levels, and cirrhosis status. The Chi square and Fisher's exact tests were employed to assess the association between categorical groups. Independent Student-t test or Mann–Whitney U test was used to investigate the association between continuous patient characteristics and survival. Results: Immunohistochemical analysis revealed EpCAM expression in 52.5% of HCC cases. EpCAM-positive tumors exhibited characteristics indicative of aggressive disease, including larger tumor sizes (p = 0.006), greater tumor multiplicity (p = 0.004), higher grades (p = 0.002), more advanced stages (p = 0.003), vascular invasion (p = 0.023), elevated alpha-fetoprotein levels (p = 0.013), and cirrhosis (p = 0.052). Survival analysis demonstrated that EpCAM expression was significantly associated with lower overall rates of survival and higher rates of recurrence in HCC patients. Conclusions: Our findings suggest that EpCAM expression may serve as a prognostic biomarker for HCC with a potential role in patient management. Targeting EpCAM-positive CSCs may represent a promising approach to overcome treatment resistance and improve clinical outcomes in HCC. However, further investigation into the molecular mechanisms underlying EpCAM's role in HCC progression is warranted to facilitate the development of personalized therapeutic interventions. [ABSTRACT FROM AUTHOR]

The agricultural sector plays a vital role in the economic, social and environmental development process. It depends on achieving many objectives such as providing food needs and raw materials for industries, as well as providing the necessary foreign exchange to finance economic, social and environmental development programs. The State has been interested in drawing up plans to maximize the use of available and limited resources, such as water resources in Egypt, due to its limitedity. What distinguishes the water system in Egypt is that it is a closed system, i.e. water is reused several times. The most important of these uses is the reuse of treated wastewater to irrigate areas cultivated with trees of different types, For the purpose of producing oils, dyes and entering into paper industries, and also to establish sustainable wood forests for the purpose of wood production to contribute to reduce the gap of foreign trade of wood in Egypt, and this use may work to preserve water resources and to reduce of water streams that receive this type of water and improve environmental and health conditions as well as contributing to the creation of large green spaces improve the atmosphere characteristics and work as windbreaks around the cities that have a desert back ground and reduce temperatures in by forest areas. The findings show that economic indicators of the most important trees planted in the forest showed that the Red gum trees are came first in terms of the yield of the invested pound, which is about 246.41 pounds And in first place in terms of lower cost of production per tonne, amounting to about 2.48 pounds, while the trees come Casuarina sp. second in terms of return Pound, which amounted to 153.70 pounds and the fourth in terms of the cost of production of the ton, which amounted to about 3.93 pounds. Cupressus sp. trees came third in terms of the pound, which amounted to 127.49 pounds and the third place in terms of the cost of production of tons, which amounted to about 3.49 pounds, The yield of the pound for the trees of the Asersus, E.Citriodora, Khayasenegalensis and pine reached 81.95, 65.31, 53.79 and 41.79 respectively, while the production cost per ton was 3.31, 9.48, 6.72 and 9.29 respectively. It is noted that the Red gum trees obtained the highest yield in terms of the pound and the minimum cost of production of tons, and that the increase in investment and expansion of agriculture yields a better return and a good opportunity to invest. The average annual net yield of the most important trees planted in the Sarabum Forest in the Sarabum area was 16155.53 LE / feddan / year, if compared to the net yield of the most important traditional agricultural rotations for some major crops, net annual yield of the period from (20002016) and which corresponds to the age of trees in the forest (area of study) was calculated. It was found that the agricultural rotation of crop (continuous clover + rice) represents the highest average net yield of about 7246.2 pounds / feddan / year. Thus, the average net yield of the most important trees is about 2.23 times that of the counterpart calculated from the traditional agricultural rotations. Therefore, the planting of trees in the forest (area of the study) is considered economical, so the cultivation of the trees should be considered, especially in the desert back ground of the governorates. Without prejudice to traditional crops, as the tendency to plant forests is necessary to improve the environment and a safe way to dispose of treated wastewater so as not to adversely affect the waterways. The results of the economic indicators for the use of the water component in the production of different types of trees planted in the forest were also shown. The price per cubic meter of water (LE / m3) ranged from a minimum of 1.98 (LE / m3) of Cupressus sp. trees to a maximum of 2.78 (LE / m3) for pine trees with an average of about 2.26 (LE / m3). It was found that the value of net return of cubic meters of water ranged between a minimum of about 27.74 (LE / m3) for pine trees and a maximum of 121.87 (LE / m3) for Red gum trees at an average of about LE 56.80 (LE / m3) The yield per cubic meter (tons / m3) was between 0.056 (tons / m3) for Eucalyptus sp. limmine trees and a maximum of about 0.200 (tons / m3) for Red gum trees at an average of 0.121 (tons / m3). As for the return of the pound of irrigation costs per feddan, the value ranged from a minimum of about 149.8 pounds for pine trees and a maximum of about 855.5 pounds for the trees of Red gum with average of about 383.9 pounds. The ratio of irrigation costs to variable costs ranged from a low of about 47.3% for Eucalyptus sp. limestone trees, kaya trees with the same percentage and a maximum of 53.4% for Red gum trees, Casuarina sp. trees with the same percentage, and with averaging of about 50.7%. The results of the economic evaluation of trees planted in the forest showed that Red gum trees are better and more efficient tree species in the forest and there is economic feasibility of expanding their cultivation, and therefore some financial measures were made to study the economic feasibility of planting Red gum trees. The results showed that the Profitability Index (PI) at 25% discount rate, 28% for Red gum trees palms without change in cost and revenue factors and the project lifetime attained about 2.02 and 1.45 respectively, which confirms the feasibility of the project Greater than the correct one, which means that each pound invested in the project achieves a net return of 1.02, 0.45 pounds, respectively. As reported the current net cash flows or net present value (NPV) of the project is toward the 15,240, 66081 pounds, respectively. And the internal rate of return (IRR) of the project is 31.5%. This means that the rate of return is greater than the opportunity cost prevailing in the community at the study, which is the interest rate, is 25%. Accordingly, the Pay-Back period of the project capital is estimated at 3.2 years, which confirms that there is a capital turnover of the capital. From the above, it is clear that the expansion of the cultivation of the trees Red gum is economically feasible.

This study aims to study the estimation of production cost functions as it reflects the relationship between total costs and actual production. The main economic indicators that reflect the extent to which the agricultural production units achieved economic efficiency in their use of the productive resources involved in the production process as well as the extent to which they are achieved These units of maximizing the profits of the agricultural product, as well as the study of production costs and the associated indicators are important both on the productivity unit or at the national level, which can be used in the design and analysis of price policies and help the user Farmers in their productive decision-making, which would encourage producers to continue production or stop production. As well as to determine the volume of production that maximizes profits and thus achieve economic efficiency of the use of productive elements.

The drying industry for vegetable crops, especially the onion crop, is one of the most important food industries that achieve quality and safety of food in addition to open the doors of export. Germany is the main importer of Egyptian dried onions by 28.8% of the average total Egyptian onion exports with an average of 3448 tons as an average for the study period (2013-2017) .Followed by the Netherlands in the list of the most important importers of Egyptian dried onions with an average quantity of about 2816 tons, representing 23.5% of the average Egyptian exports of dried onions. Japan accounted for 9.2% of Egypt's total exports of dried onions with an average of 819 tons, followed by Greece, Belgium, Britain and Brazil respectively. The most important variables effecting on Egyptian dried onion were import price of Egyptian dried onion in the foreign markets and export pric es of the competing countries, as well as the average per capita income of importing countries, as well as their population. It was found that the study of external demand functions for the Egyptian dried onions were low price elasticity of demand (inelastic demand) for Japan. where, the increase in the price of Egypt's dried onion exports to Japan by 1% led to a decrease in the quantity of exports by 0.51% ,While the demand of the United Kingdom was elasticity equal with unit , where, the increase in the price of Egypt's dried onion exports to the Kingdom by 1% leads to a decrease in the quantity of exports by the same percentage, while it was found that the demand for Egyptian exports of dried onions is flexible for the countries of the Netherlands - Brazil Belgium, where the price of Egypt exports of dried onions by Ratio of 1% leads to a decline in the amount of exported quantity by 1.36%, 1.7%, 1.8% respectively

The research focuses on the basics of building social media marketing strategy, There are a lot of theories that can be relied on to create a brand digital market plan, PR Smith’s SOSTAC strategy is one of the best models that deals with the most of strategy’s aspects, from the construction stage up till pursuing objectives and applying it, It consists of six steps (Situation Analysis - Objectives - Strategy - Tactics - Actions - and Control). the research also focus on the basics of creating a paid advertisement on Facebook, The practical side of the research focuses on applying the SOSTAC theory on the marketing strategy of Sound Publishing House on Facebook, The researcher made a Paid advertisement on Facebook and compared the results of the campaign to the printed advertisement campaign, Hence, the importance of the social media in increasing the effectiveness of the prints marketing campaigns was concluded.

Wheat crop is considered to be one of the most important grain crops and a major source of food for the Egyptian people. The production and economic indicators of wheat yield were studied in Egypt. It is clear that the total area and production of wheat increased by 71 thousand feddans annually and, 199 thousand tons annually, respectively, at a significant level of 0.01. The coefficient of general trend of area and production were (R2) 0.80 respectively, which means that 87%, 80% of the changes in the total area and production of wheat are due to factors whose effect reflects the time variable. However, the food security factor should be increased to 0.50, as the minimum level of strategic stock security is achieved when the stock meets the needs of the population for at least 6 months. Which is estimate at 6.850 million tons during the period 2000-2015, which is edmivelent storage capacity of wheat, which estimated the average national consumption of wheat during about 13.579 million tons, it is noticed the food security coefficient is low than.

Wound healing, one of the most intricate and dynamic processes of the body, maintains skin integrity following trauma. One of the main issues that still exists is impaired wound healing, particularly for immunosuppressed patients. Recently, natural products from marine environments have been employed in wound-repairing activities. This work investigates the mesenchymal stem cells in the combined capacity of the bone marrow (BMMSC) for wound healing and Cystoseira sp. Algae extract in immunosuppressed rats. High-resolution liquid chromatography / MS investigation of Cystoseira extract revealed the prevalence of fatty acids that have wound-soothing potential. From constructed PPI network for wound healing and further analysis through molecular docking and molecular dynamics (MD) simulation experiments suggested that cystalgerone metabolite may be responsible for the wound healing-promoting effect of Cystoseira extract. According to the CD marker characterization of the BMMSC, 98.21% of them expressed CD90, and 97.1% expressed CD105. Sixteen d after immunity suppression (by 40 mg/kg hydrocortisone daily), an incision was made in the dorsal skin of the rat. The treatments were applied for 16 d and samples were taken from the tested groups on the 8th, 14th, and 16th days. The BMMSCs / Cystoseira group showed significantly improved wound closure, thickness, density of new layers, and skin elasticity than the control group (p < 0.001). The BMMSCs / Cystoseira combination significantly reduced the oxidative indicators, pro-inflammatory cytokines, and immune markers, according to the RT-PCR gene expression study. In order to delve deeper into the complex interconnections among wound healing-related biological targets and pinpoint key factors in this complex process, we engaged in network pharmacology and computational research. Subsequently, we conducted a comprehensive computational analysis, including reverse docking, free energy (ΔG) computation, and molecular dynamics simulations, on the molecular structures of the annotated compounds. The purpose of this investigation was to identify potential new targets for these chemicals as well as any potential interactions they may have with different signaling pathways related to the wound healing process. Our research indicates that the primary compounds of Cystoseira holds potential wound healing therapeutic activity. Although more safety testing and clinical studies are required, the combination has great potential for regenerative medicine and could be a revolutionary advance in the healing of the wounds of immunosuppressed patients. [ABSTRACT FROM AUTHOR]

This research was generally aimed at conducting an economic study to evaluate the Beheira Governorate Rural Development Project Phase II, because of the availability of data necessary to carry out the ordinary economic and financial assessment, As one of the leading rural development projects in Egypt financed by of the Bank and the African Development Fund, where research has been aimed at studying the vulnerabilities to avoid them in the future, and strengths to sustain and develop it and increase its efficiency, and this can only be achieved through a systematic scientific assessment of the project. It was one of the most important findings of the research that the project was characterized by rates of performance exceeding the target of the project in most of its activities. In addition to the feasibility of the project from the point of view of the financial and economic assessment, Despite the fact that the project is an agricultural development and most of its activities are not for profit, Despite the fact that the project is an agricultural development and most of its activities are not for profit, it achieved an internal rate of return of about 12.3% and achieved a positive net present value of about 7.7 million pounds, and The project has succeeded in recovering its capital in about two and a half years. The project has added value to beneficiaries of about 23.6 million pounds while achieving a national added value of about 10.5 million pounds and the social surplus rate is about 10. 2 million pounds, However, it is noted that the project spent a lot of money in the training activity, due to the limited education and lack of expertise among the beneficiaries and the lack of skilled labor, which led the project to pump a large part of the project funding for training activities.

Scabies is an invasive skin condition caused by Sarcoptes scabiei mites. The present study investigates the antiscabies potential of coconut seed extract (CSE) in rabbits. GC-MS analysis of the seed oil identified 17 known compounds, while CSE phytochemical investigation afforded 4 known ones. The topical application of seed extract improved all signs of infection, and the improvement started 3 days post application. However, in vitro application of the extract caused 99% mortality of mites 1 day post application. Histopathological examination revealed the absence of inflammatory infiltration and hyperkeratosis of the epidermis, compared with ivermectin-treated groups which revealed less improvement. The mRNA gene expression results revealed a suppression of IL-1β, IL-6, IL-10, MMP-9, VEGF, and MCP-1, and an upregulation of I-CAM-1, KGF as well as TIMP-1. The docking analysis emphasized a strong binding of gondoic acid with IL-1β, IL-6, and VEGF with high binding scores of −5.817, −5.291, and −8.362 kcal/mol, respectively, and a high binding affinity of 3″(1‴-O-β-D-glucopyranosyl)-sucrose with GST with −7.24 kcal/mol. Accordingly, and for the first time, our results highlighted the scabicidal potential of coconut seed extract, which opens the gate for an efficient, cost-effective as well as herbal-based alternative for the control of scabies in rabbits. [ABSTRACT FROM AUTHOR]