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399 results on '"Abdel-Mageed, Asim B."'

1. Batf-Dependent Th17 cells act through IL23R pathway to promote prostate adenocarcinoma initiation and progression

Author

Liu, Sen, primary, Rivero, Seleste L, additional, Zhang, Bing, additional, Shen, Keyi, additional, Li, Zixuan, additional, Niu, Tianhua, additional, Rowan, Brian G, additional, Jazwinski, S Michal, additional, Abdel−Mageed, Asim B, additional, Steele, Chad, additional, Wang, Alun R, additional, Sartor, Oliver, additional, and Zhang, Qiuyang, additional

Published
2024
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3. The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research

Author

Das, Saumya, Consortium, The Extracellular RNA Communication, Abdel-Mageed, Asim B, Adamidi, Catherine, Adelson, P David, Akat, Kemal M, Alsop, Eric, Ansel, K Mark, Arango, Jorge, Aronin, Neil, Avsaroglu, Seda Kilinc, Azizian, Azadeh, Balaj, Leonora, Ben-Dov, Iddo Z, Bertram, Karl, Bitzer, Markus, Blelloch, Robert, Bogardus, Kimberly A, Breakefield, Xandra Owens, Calin, George A, Carter, Bob S, Charest, Al, Chen, Clark C, Chitnis, Tanuja, Coffey, Robert J, Courtright-Lim, Amanda, Datta, Amrita, DeHoff, Peter, Diacovo, Thomas G, Erle, David J, Etheridge, Alton, Ferrer, Marc, Franklin, Jeffrey L, Freedman, Jane E, Galas, David J, Galeev, Timur, Gandhi, Roopali, Garcia, Aitor, Gerstein, Mark Bender, Ghai, Vikas, Ghiran, Ionita Calin, Giraldez, Maria D, Goga, Andrei, Gogakos, Tasos, Goilav, Beatrice, Gould, Stephen J, Guo, Peixuan, Gupta, Mihir, Hochberg, Fred, Huang, Bo, Huentelman, Matt, Hunter, Craig, Hutchins, Elizabeth, Jackson, Andrew R, Kalani, M Yashar S, Kanlikilicer, Pinar, Karaszti, Reka Agnes, Van Keuren-Jensen, Kendall, Khvorova, Anastasia, Kim, Yong, Kim, Hogyoung, Kim, Taek Kyun, Kitchen, Robert, Kraig, Richard P, Krichevsky, Anna M, Kwong, Raymond Y, Laurent, Louise C, Lee, Minyoung, L’Etoile, Noelle, Levy, Shawn E, Li, Feng, Li, Jenny, Li, Xin, Lopez-Berestein, Gabriel, Lucero, Rocco, Mateescu, Bogdan, Matin, AC, Max, Klaas EA, McManus, Michael T, Mempel, Thorsten R, Meyer, Cindy, Milosavljevic, Aleksandar, Mondal, Debasis, Mukamal, Kenneth Jay, Murillo, Oscar D, Muthukumar, Thangamani, Nickerson, Deborah A, O’Donnell, Christopher J, Patel, Dinshaw J, Patel, Tushar, Patton, James G, Paul, Anu, Peskind, Elaine R, Phelps, Mitch A, Putterman, Chaim, Quesenberry, Peter J, Quinn, Joseph F, Raffai, Robert L, and Ranabothu, Saritha

Subjects
Genetics, Biomarkers, Cell-Free Nucleic Acids, Extracellular Vesicles, Humans, Knowledge Bases, MicroRNAs, RNA, Extracellular RNA Communication Consortium, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.

Published
2019

7. Potential functional applications of extracellular vesicles: a report by the NIH Common Fund Extracellular RNA Communication Consortium.

Author

Quesenberry, Peter J, Aliotta, Jason, Camussi, Giovanni, Abdel-Mageed, Asim B, Wen, Sicheng, Goldberg, Laura, Zhang, Huang-Ge, Tetta, Ciro, Franklin, Jeffrey, Coffey, Robert J, Danielson, Kirsty, Subramanya, Vinita, Ghiran, Ionita, Das, Saumya, Chen, Clark C, Pusic, Kae M, Pusic, Aya D, Chatterjee, Devasis, Kraig, Richard P, Balaj, Leonora, and Dooner, Mark

Subjects
cancer, cell fate change, extracellular vesicles, functional effects, pulmonary heart disease, renal, Biochemistry and Cell Biology
Abstract

The NIH Extracellular RNA Communication Program's initiative on clinical utility of extracellular RNAs and therapeutic agents and developing scalable technologies is reviewed here. Background information and details of the projects are presented. The work has focused on modulation of target cell fate by extracellular vesicles (EVs) and RNA. Work on plant-derived vesicles is of intense interest, and non-mammalian sources of vesicles may represent a very promising source for different therapeutic approaches. Retro-viral-like particles are intriguing. Clearly, EVs share pathways with the assembly machinery of several other viruses, including human endogenous retrovirals (HERVs), and this convergence may explain the observation of viral-like particles containing viral proteins and nucleic acid in EVs. Dramatic effect on regeneration of damaged bone marrow, renal, pulmonary and cardiovascular tissue is demonstrated and discussed. These studies show restoration of injured cell function and the importance of heterogeneity of different vesicle populations. The potential for neural regeneration is explored, and the capacity to promote and reverse neoplasia by EV exposure is described. The tremendous clinical potential of EVs underlies many of these projects, and the importance of regulatory issues and the necessity of general manufacturing production (GMP) studies for eventual clinical trials are emphasized. Clinical trials are already being pursued and should expand dramatically in the near future.

Published
2015

8. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium

Author

Laurent, Louise C, Abdel‐Mageed, Asim B, Adelson, P David, Arango, Jorge, Balaj, Leonora, Breakefield, Xandra, Carlson, Elizabeth, Carter, Bob S, Majem, Blanca, Chen, Clark C, Cocucci, Emanuele, Danielson, Kirsty, Courtright, Amanda, Das, Saumya, Elmageed, Zakaria Y Abd, Enderle, Daniel, Ezrin, Alan, Ferrer, Marc, Freedman, Jane, Galas, David, Gandhi, Roopali, Huentelman, Matthew J, Van Keuren‐Jensen, Kendall, Kalani, Yashar, Kim, Yong, Krichevsky, Anna M, Lai, Charles, Lal‐Nag, Madhu, Laurent, Clara D, Leonardo, Trevor, Li, Feng, Malenica, Ivana, Mondal, Debasis, Nejad, Parham, Patel, Tushar, Raffai, Robert L, Rubio, Renee, Skog, Johan, Spetzler, Robert, Sun, Jie, Tanriverdi, Kahraman, Vickers, Kasey, Wang, Liang, Wang, Yaoyu, Wei, Zhiyun, Weiner, Howard L, Wong, David, Yan, Irene K, Yeri, Ashish, and Gould, Stephen

Subjects
Genetics, extracellular RNA, extracellular vesicles, exosomes, microvesicles, RNA sequencing, Biochemistry and Cell Biology
Abstract

Extracellular RNAs (exRNAs) have been identified in all tested biofluids and have been associated with a variety of extracellular vesicles, ribonucleoprotein complexes and lipoprotein complexes. Much of the interest in exRNAs lies in the fact that they may serve as signalling molecules between cells, their potential to serve as biomarkers for prediction and diagnosis of disease and the possibility that exRNAs or the extracellular particles that carry them might be used for therapeutic purposes. Among the most significant bottlenecks to progress in this field is the lack of robust and standardized methods for collection and processing of biofluids, separation of different types of exRNA-containing particles and isolation and analysis of exRNAs. The Sample and Assay Standards Working Group of the Extracellular RNA Communication Consortium is a group of laboratories funded by the U.S. National Institutes of Health to develop such methods. In our first joint endeavour, we held a series of conference calls and in-person meetings to survey the methods used among our members, placed them in the context of the current literature and used our findings to identify areas in which the identification of robust methodologies would promote rapid advancements in the exRNA field.

Published
2015

11. Pioglitazone’s beneficial effects on erectile function preservation after cavernosal nerve injury in the rat are negated by inhibition of the insulin-like growth factor-1 receptor: a preclinical study

Author

Heidenberg, Daniel J., Haney, Nora M., Rezk, Bashir M., Talwar, Sudha, Okpechi, Samuel C., Srivastav, Sudesh K., Honda, Matthew, Song, Bryant, Swan, Kevin, Awadallah, Salah, Anaissie, James, Peak, Taylor, DeLay, Kenneth J., Kadowitz, Phillip J., Sikka, Suresh C., Abdel Mageed, Asim B., and Hellstrom, Wayne J. G.

Published
2019
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15. Supplementary Figure S2 from Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer

Author

Yang, Yijun, primary, Jia, Dingwu, primary, Kim, Hogyoung, primary, Abd Elmageed, Zakaria Y., primary, Datta, Amrita, primary, Davis, Rodney, primary, Srivastav, Sudesh, primary, Moroz, Krzysztof, primary, Crawford, Byron E., primary, Moparty, Krishnarao, primary, Thomas, Raju, primary, Hudson, Robert S., primary, Ambs, Stefan, primary, and Abdel-Mageed, Asim B., primary

Published
2023
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16. Supplementary Methods from Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer

Author

Yang, Yijun, primary, Jia, Dingwu, primary, Kim, Hogyoung, primary, Abd Elmageed, Zakaria Y., primary, Datta, Amrita, primary, Davis, Rodney, primary, Srivastav, Sudesh, primary, Moroz, Krzysztof, primary, Crawford, Byron E., primary, Moparty, Krishnarao, primary, Thomas, Raju, primary, Hudson, Robert S., primary, Ambs, Stefan, primary, and Abdel-Mageed, Asim B., primary

Published
2023
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17. Supplementary Tables S1-4 from Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer

Author

Yang, Yijun, primary, Jia, Dingwu, primary, Kim, Hogyoung, primary, Abd Elmageed, Zakaria Y., primary, Datta, Amrita, primary, Davis, Rodney, primary, Srivastav, Sudesh, primary, Moroz, Krzysztof, primary, Crawford, Byron E., primary, Moparty, Krishnarao, primary, Thomas, Raju, primary, Hudson, Robert S., primary, Ambs, Stefan, primary, and Abdel-Mageed, Asim B., primary

Published
2023
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18. Supplementary Figures S5-6 from Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer

Author

Yang, Yijun, primary, Jia, Dingwu, primary, Kim, Hogyoung, primary, Abd Elmageed, Zakaria Y., primary, Datta, Amrita, primary, Davis, Rodney, primary, Srivastav, Sudesh, primary, Moroz, Krzysztof, primary, Crawford, Byron E., primary, Moparty, Krishnarao, primary, Thomas, Raju, primary, Hudson, Robert S., primary, Ambs, Stefan, primary, and Abdel-Mageed, Asim B., primary

Published
2023
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19. Supplementary Tables S5-7 from Dysregulation of miR-212 Promotes Castration Resistance through hnRNPH1-Mediated Regulation of AR and AR-V7: Implications for Racial Disparity of Prostate Cancer

Author

Yang, Yijun, primary, Jia, Dingwu, primary, Kim, Hogyoung, primary, Abd Elmageed, Zakaria Y., primary, Datta, Amrita, primary, Davis, Rodney, primary, Srivastav, Sudesh, primary, Moroz, Krzysztof, primary, Crawford, Byron E., primary, Moparty, Krishnarao, primary, Thomas, Raju, primary, Hudson, Robert S., primary, Ambs, Stefan, primary, and Abdel-Mageed, Asim B., primary

Published
2023
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20. Data from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

Author

Zhang, Qiuyang, primary, Liu, Sen, primary, Ge, Dongxia, primary, Zhang, Qingsong, primary, Xue, Yun, primary, Xiong, Zhenggang, primary, Abdel-Mageed, Asim B., primary, Myers, Leann, primary, Hill, Steven M., primary, Rowan, Brian G., primary, Sartor, Oliver, primary, Melamed, Jonathan, primary, Chen, Zhenbang, primary, and You, Zongbing, primary

Published
2023
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21. Supplementary Figure 2 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

Author

Zhang, Qiuyang, primary, Liu, Sen, primary, Ge, Dongxia, primary, Zhang, Qingsong, primary, Xue, Yun, primary, Xiong, Zhenggang, primary, Abdel-Mageed, Asim B., primary, Myers, Leann, primary, Hill, Steven M., primary, Rowan, Brian G., primary, Sartor, Oliver, primary, Melamed, Jonathan, primary, Chen, Zhenbang, primary, and You, Zongbing, primary

Published
2023
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22. Supplementary Figure 3 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

Author

Zhang, Qiuyang, primary, Liu, Sen, primary, Ge, Dongxia, primary, Zhang, Qingsong, primary, Xue, Yun, primary, Xiong, Zhenggang, primary, Abdel-Mageed, Asim B., primary, Myers, Leann, primary, Hill, Steven M., primary, Rowan, Brian G., primary, Sartor, Oliver, primary, Melamed, Jonathan, primary, Chen, Zhenbang, primary, and You, Zongbing, primary

Published
2023
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23. Supplementary Table 1 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

Author

Zhang, Qiuyang, primary, Liu, Sen, primary, Ge, Dongxia, primary, Zhang, Qingsong, primary, Xue, Yun, primary, Xiong, Zhenggang, primary, Abdel-Mageed, Asim B., primary, Myers, Leann, primary, Hill, Steven M., primary, Rowan, Brian G., primary, Sartor, Oliver, primary, Melamed, Jonathan, primary, Chen, Zhenbang, primary, and You, Zongbing, primary

Published
2023
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24. Supplementary Figure 1 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models

Author

Zhang, Qiuyang, primary, Liu, Sen, primary, Ge, Dongxia, primary, Zhang, Qingsong, primary, Xue, Yun, primary, Xiong, Zhenggang, primary, Abdel-Mageed, Asim B., primary, Myers, Leann, primary, Hill, Steven M., primary, Rowan, Brian G., primary, Sartor, Oliver, primary, Melamed, Jonathan, primary, Chen, Zhenbang, primary, and You, Zongbing, primary

Published
2023
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25. Circulating Plasma Exosomal Proteins of Either SHIV-Infected Rhesus Macaque or HIV-Infected Patient Indicates a Link to Neuropathogenesis

Author

Chandra, Partha K., primary, Braun, Stephen E., additional, Maity, Sudipa, additional, Castorena-Gonzalez, Jorge A., additional, Kim, Hogyoung, additional, Shaffer, Jeffrey G., additional, Cikic, Sinisa, additional, Rutkai, Ibolya, additional, Fan, Jia, additional, Guidry, Jessie J., additional, Worthylake, David K., additional, Li, Chenzhong, additional, Abdel-Mageed, Asim B., additional, and Busija, David W., additional

Published
2023
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31. Circulating Exosomal Proteins are linked to Neuropathogenesis in SIV‐infected Rhesus Macaque: A Proteomic Approach

Author

Chandra, Partha K., primary, Braun, Stephen E., additional, Baddoo, Melody C., additional, Kim, Hogyoung, additional, Castorena‐Gonzalez, Jorge A., additional, Cikic, Sinisa, additional, Rutkai, Ibolya, additional, Guidry, Jessie J., additional, Worthylake, David K., additional, Flemington, Erik K., additional, Abdel‐Mageed, Asim B., additional, and Busija, David W., additional

Published
2022
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47. Gene transfer of extracellular SOD to the penis reduces [O.sup.-.sub.2]* and improves erectile function in aged rats

Author

Bivalacqua, Trinity J., Armstrong, Jeffrey S., Biggerstaff, John, Abdel-Mageed, Asim B., Kadowitz, Philip J., Hellstrom, Wayne J.G., and Champion, Hunter C.

Subjects
Physiology -- Research, Gene therapy -- Physiological aspects, Aging -- Physiological aspects, Nitric oxide -- Physiological aspects, Impotence -- Physiological aspects, Superoxide -- Physiological aspects, Biological sciences
Abstract

Increased superoxide anion ([O.sup.-.sub.2]*) may contribute to vascular dysfunction in aging. In aged cavernosal tissue, lucigenin-enhanced chemiluminescence demonstrated a threefold increase in superoxide formation, and the oxidative fluorescent probe hydroethidine indicated higher superoxide levels throughout the aged penis. This increase in superoxide was associated with impaired cavernosal nerve-mediated and agonist-induced erectile responses, increased nitrotyrosine staining, and lower cGMP levels, but no compensatory change in cavernosal extracellular (EC)-superoxide dismutase (EC-SOD) mRNA or protein. In vivo adenoviral (Ad) gene transfer of EC-SOD to the penis resulted in higher expression of EC-SOD mRNA, protein, SOD activity, cGMP levels, and lower nitrotyrosine staining. Transfection with AdCMVEC-SOD resulted in a significant increase in erectile response to cavernosal nerve stimulation, ACh, and zaprinast to a magnitude similar to young rats. These data provide evidence in support of the hypothesis that erectile dysfunction associated with aging is related in part to an increase in cavernosal [O.sup.-.sub.2]* formation. Gene-transfer of EC-SOD reduces superoxide formation and restores age-associated erectile function and may represent a novel therapeutic target for the treatment of erectile dysfunction. gene therapy; aging; nitric oxide; erectile dysfunction

Published
2003

50. CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion

Author

Liu, Sen, primary, Liu, Fengli, additional, Zhang, Bing, additional, Yan, Peng, additional, Rowan, Brian G., additional, Abdel‐Mageed, Asim B., additional, Steele, Chad, additional, Jazwinski, S. Michal, additional, Moroz, Krzysztof, additional, Norton, Elizabeth B., additional, Wang, Alun, additional, Myers, Leann, additional, Sartor, Oliver, additional, and Zhang, Qiuyang, additional

Published
2020
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