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The Clinical E-Science Framework (CLEF) project was used to extract important information from medical texts by building a system for the purpose of clinical research, evidence-based healthcare and genotype-meets-phenotype informatics. The system is divided into two parts, one part concerns with the identification of relationships between clinically important entities in the text. The full parses and domain-specific grammars had been used to apply many approaches to extract the relationship. In the second part of the system, statistical machine learning (ML) approaches are applied to extract relationship. A corpus of oncology narratives that hand annotated with clinical relationships can be used to train and test a system that has been designed and implemented by supervised machine learning (ML) approaches. Many features can be extracted from these texts that are used to build a model by the classifier. Multiple supervised machine learning algorithms can be applied for relationship extraction. Effects of adding the features, changing the size of the corpus, and changing the type of the algorithm on relationship extraction are examined. Keywords: Text mining; information extraction; NLP; entities; and relations., Comment: 15 pages 13 figures 7 tables