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Background Water pollution with heavy metals is a severe dilemma that concerns the whole world related to its risk to natural ecosystems and human health. The main objective was to evaluate the removal efficiency of Cd of various concentrations from contaminated aqueous solution by use of two cyanobacterial strains (Nostoc muscorum and Trichormus variabilis). For this purpose, a specially designed laboratory pilot-scale experiment was conducted using these two cyanobacterial strains on four different initial concentrations of Cd (0, 0.5, 1.0 and 2.0 mg L−1) for 21 days. Results N. muscorum was more efficient than T. variabilis for removing Cd (II), with the optimum value of residual Cd of 0.033 mg L−1 achieved by N. muscorum after 21 days with initial concentration of 0.5 mg L−1, translating to removal efficiency of 93.4%, while the residual Cd (II) achieved by T. variabilis under the same conditions was 0.054 mg L−1 (89.13% removal efficiency). Algal growth parameters and photosynthetic pigments were estimated for both cyanobacterial strains throughout the incubation period. Conclusions High Cd concentration had a more toxic impact on algal growth. The outcomes of this study will help to produce treated water that could be reused in agrarian activities. Validerad;2022;Nivå 2;2022-01-01 (johcin)