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518 results on '"Abbouda, A."'

5. Identifying Meibomian Gland Dysfunction Biomarkers in a Cohort of Patients Affected by DM Type II

Author

Alessandro Abbouda, Antonio Florido, Filippo Avogaro, John Bladen, and Enzo Maria Vingolo

Subjects
mibomian gland dysfunction, diabetes mellitus, hormones, biomarkers, Biology (General), QH301-705.5
Abstract

(1) Background: Meibomian gland dysfunction (MGD) among patients with diabetes mellitus (DM) is a common manifestation of dry eye syndrome (DES). (2) Methods: The purpose of this study is to identify clinical parameters and biomarkers useful to improve the follow-up and the treatment of these patients. We have used an ocular surface disease index (OSDI) questionnaire, Schirmer test I/II, tear film break-up time (TF-BUT), fluorescein plus lissamine green staining, Marx’s line (ML), and meibomian gland (MGs) morphology using Sirius® Topographer (CSO, Costruzione Strumenti Oftalmici, Florence, Italy). Blood sample analysis included glucose, glycated hemoglobin, lipid profile, cortisol, dehydroepiandrosterone sulfate (DHEA-S), androstenedione (ASD) and testosterone. (3) Results: Cortisol and ASD were positively correlated with an increase of MG tortuosity, and an Increased level of triglycerides was associated with a reduction of MGs length. DHEAS levels lowered with age and were associated with ocular surface staining. (4) Conclusions: Future studies, perhaps including meibum lipid analysis and tear cytokine levels, may also further elucidate the connection between these parameters, MG architecture and function.

Published
2023
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12. REP1 deficiency causes systemic dysfunction of lipid metabolism and oxidative stress in choroideremia

Author

Dulce Lima Cunha, Rose Richardson, Dhani Tracey-White, Alessandro Abbouda, Andreas Mitsios, Verena Horneffer-van der Sluis, Panteleimon Takis, Nicholas Owen, Jane Skinner, Ailsa A. Welch, and Mariya Moosajee

Subjects
Metabolism, Ophthalmology, Medicine
Abstract

Choroideremia (CHM) is an X-linked recessive chorioretinal dystrophy caused by mutations in CHM, encoding for Rab escort protein 1 (REP1). Loss of functional REP1 leads to the accumulation of unprenylated Rab proteins and defective intracellular protein trafficking, the putative cause for photoreceptor, retinal pigment epithelium (RPE), and choroidal degeneration. CHM is ubiquitously expressed, but adequate prenylation is considered to be achieved, outside the retina, through the isoform REP2. Recently, the possibility of systemic features in CHM has been debated; therefore, in this study, whole metabolomic analysis of plasma samples from 25 CHM patients versus age- and sex-matched controls was performed. Results showed plasma alterations in oxidative stress–related metabolites, coupled with alterations in tryptophan metabolism, leading to significantly raised serotonin levels. Lipid metabolism was disrupted with decreased branched fatty acids and acylcarnitines, suggestive of dysfunctional lipid oxidation, as well as imbalances of several sphingolipids and glycerophospholipids. Targeted lipidomics of the chmru848 zebrafish provided further evidence for dysfunction, with the use of fenofibrate over simvastatin circumventing the prenylation pathway to improve the lipid profile and increase survival. This study provides strong evidence for systemic manifestations of CHM and proposes potentially novel pathomechanisms and targets for therapeutic consideration.

Published
2021
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13. CXL in Pediatric Age

Author

Abbouda, Alessandro, Estrada, Alfredo Vega, Alió, Jorge L., editor, Azar, Dimitri T., editor, Abbouda, Alessandro, editor, and Aswad, Amr El, editor

Published
2015
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14. Angle-Supported Phakic IOL

Author

Abbouda, Alessandro, Alió, Jorge L., Alió, Jorge L., editor, Azar, Dimitri T., editor, Abbouda, Alessandro, editor, and Aswad, Amr El, editor

Published
2015
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18. Ectasia Post PRK at Delayed Onset

Author

Ayala, Maria Jose, Abbouda, Alessandro, Javaloy, Jaime, Alió, Jorge L., editor, Azar, Dimitri T., editor, Abbouda, Alessandro, editor, and Aswad, Amr El, editor

Published
2015
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27. An Unusual Retinal Vessel Modification in Patients Affected by JIA-Uveitis with a Follow-Up Longer Than 16 Years

Author

Alessandro Abbouda, Irene Abicca, Simone Bruschi, Federico Ricci, Gianluca Aloe, and Maria Pia Paroli

Subjects
Ophthalmology, RE1-994
Abstract

Purpose. To report unusual and rare clinical changes of retinal vessel pattern in a series of patients affected by Juvenile Idiopathic Arthritis (JIA) uveitis with a follow-up longer than 16 years. Methods. A series of three patients with JIA-uveitis followed at the University of Rome “Sapienza” from 1998 to 2014 were reported. The retinal vessels were analyzed with fluorescein angiography using Heidelberg Retinal Angiogram-2 (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany) and the Topcon TRC-50LX retinal camera (Topcon Europe, The Netherlands). A Spectralis Domain OCT (SD-OCT) (Spectralis Family Heidelberg, Germany) was performed to evaluate vessel anatomy. Results. Fundus photography showed sheathed vessels localized around the optic disc in every case. Angiography revealed a normal physiology of vessel walls and flow; no sheathing or leakage of dye was observed. SD-OCT demonstrated reflective vessel walls. Vessel lumen appeared patent, and the normal “hourglass configuration” was blurred, but identifiable. Conclusions. Vessel modifications observed in long-standing JIA-uveitis are not signs of vascular inflammation and are not associated to hypoperfusion. In these cases, ophthalmologists should avoid further invasive investigation and should consider introducing SD-OCT as a routine method to evaluate the vessel changes during the follow-up.

Published
2020
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38. Abnormal Healing

Author

Javaloy, Jaime, Abbouda, Alessandro, Rampone, Angelo, Alió, Jorge L., editor, Azar, Dimitri T., editor, Abbouda, Alessandro, editor, and Aswad, Amr El, editor

Published
2015
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