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1. Rift Valley Fever Uveitis

Author

Agarwal, Aniruddha, Kumar, Aman, Khairallah, Moncef, Abboud, Emad, Gupta, Vishali, editor, Nguyen, Quan Dong, editor, LeHoang, Phuc, editor, and Agarwal, Aniruddha, editor

Published
2020
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5. Full-Thickness Macular Hole Secondary to High-Power Handheld Blue Laser: Natural History and Management Outcomes

Author

Arevalo, J. Fernando, Al Kahtani, Eman, Nowilaty, Sawsan R., Al Rashaed, Saba, Al-Dhibi, Hassan A., Al-Zahrani, Yahya A., Kozak, Igor, Al-Sulaiman, Sulaiman, Al-Abdullah, Abdulelah, Al-Bar, Ahmad, Al Dhafiri, Yousef, Al Qahtani, Abdullah, Al Rubaie, Khalid, Al Shahrani, Saeed, Al Shehri, Maha, Al Ahmadi, Badr, Al Hadlaq, Abdulaziz, Al Harbi, Majed, Al Oreany, Abdulaziz, Alsulaiman, Sulaiman M., Alrushood, Abdulaziz Adel, Almasaud, Jluwi, Alkharashi, Abdullah S., Alzahrani, Yahya, Abboud, Emad B., Al-Amry, Mohammad, Alrashaed, Saba, and Ghazi, Nicola G.

Published
2015
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7. Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial

Author

Ghazi, Nicola G., Abboud, Emad B., Nowilaty, Sawsan R., Alkuraya, Hisham, Alhommadi, Abdulrahman, Cai, Huimin, Hou, Rui, Deng, Wen-Tao, Boye, Sanford L., Almaghamsi, Abdulrahman, Al Saikhan, Fahad, Al-Dhibi, Hassan, Birch, David, Chung, Christopher, Colak, Dilek, LaVail, Matthew M., Vollrath, Douglas, Erger, Kirsten, Wang, Wenqiu, Conlon, Thomas, Zhang, Kang, Hauswirth, William, and Alkuraya, Fowzan S.

Published
2016
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8. Exome-based case–control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy

Author

Shtir, Corina, Aldahmesh, Mohammed A., Al-Dahmash, Saad, Abboud, Emad, Alkuraya, Hisham, Abouammoh, Marwan A., Nowailaty, Sawsan R., Al-Thubaiti, Ghazai, Naim, E. A., ALYounes, B., Binhumaid, F. S., ALOtaibi, A. B., Altamimi, A. S., Alamer, F. H., Hashem, Mais, Abouelhoda, Mohamed, Monies, Dorota, and Alkuraya, Fowzan S.

Published
2016
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12. Medulloepithelioma of the ciliary body

Author

Al-Torbak Abdullah, Abboud Emad, Al-Sharif Abdulrahman, and El-Okda Mohamad

Subjects
Ciliary body tumours, nonteratoid, medulloepithelioma, congenital tumours, diktyoma, Ophthalmology, RE1-994
Abstract

A rare case of medulloepithelioma of the ciliary body is described. The tumour necessitated enucleation of the eye; histopathological diagnosis was benign nonteratoid medulloepithelioma of the ciliary body

Published
2002

16. Front Cover

Author

Alkuraya, Hisham, primary, Patel, Nisha, additional, Ibrahim, Niema, additional, Al Ghamdi, Bandar, additional, Alsulaiman, Sulaiman M., additional, Nowilaty, Sawsan R., additional, Abboud, Emad, additional, Alturki, Ramadan, additional, Alkharashi, Abdullah, additional, Eyaid, Wafaa, additional, Almasseri, Zainab, additional, Alzaidan, Hamad, additional, Alotaibi, Mohammed D., additional, Abu El‐Asrar, Ahmed M., additional, Alamro, Bandar, additional, Helaby, Rana, additional, Elshaer, Amani, additional, Almontashiri, Naif A.M., additional, Al‐Hussaini, Abdulrahman A., additional, and Alkuraya, Fowzan S., additional

Published
2020
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17. Phenotypic delineation of the retinal arterial macroaneurysms with supravalvular pulmonic stenosis syndrome

Author

Alkuraya, Hisham, primary, Patel, Nisha, additional, Ibrahim, Niema, additional, Al Ghamdi, Bandar, additional, Alsulaiman, Sulaiman M., additional, Nowilaty, Sawsan R., additional, Abboud, Emad, additional, Alturki, Ramadan, additional, Alkharashi, Abdullah, additional, Eyaid, Wafaa, additional, Almasseri, Zainab, additional, Alzaidan, Hamad, additional, Alotaibi, Mohammed D., additional, Abu El‐Asrar, Ahmed M., additional, Alamro, Bandar, additional, Helaby, Rana, additional, Elshaer, Amani, additional, Almontashiri, Naif A.M., additional, Al‐Hussaini, Abdulrahman A., additional, and Alkuraya, Fowzan S., additional

Published
2019
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20. Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis in the United Arab Emirates.

Author

Khan, Arif O., Pichi, Francesco, Neri, Piergiorgio, and Abboud, Emad B.

Subjects
PULMONARY stenosis, ASYMPTOMATIC patients, GENETIC testing, RETINAL diseases, CONVERGENT strabismus
Abstract

Retinal arteriolar macroaneurysms with supravalvular pulmonic stenosis (RAMSVPS) is a rare syndrome that to date has only been reported in Saudi Arabian families. All tested patients have been homozygous for a single IGFBP7 splice variant (NM_001553.2:c.830-1G>A). We report our experience with RAMSVPS in the United Arab Emirates. Retrospective case series. Five affected individuals (two males and three females) from two unrelated Emirati families were known to our institution (age of first signs 6 months to 10 years of age, with one asymptomatic 6-year-old boy identified by sibling screening examination). Initial ophthalmic diagnoses had been Coats disease or traumatic retinal bleeding. Characteristic retinal arteriolar trunk beading and macroaneurysms led to the actual diagnosis of RAMSVPS. One child with esotropia at 6 months of age seemed to have unilateral Coats disease until retinal signs became apparent in the contralateral eye at 4 years old. One family consented to genetic testing, and both affected siblings were homozygous for the Saudi IGFBP7 splice variant (c.830-1G>A). The three children who underwent echocardiography were all confirmed to have cardiac valvular abnormalities (two supravalvular pulmonic stenosis and one tricuspid stenosis). The distinct ophthalmic phenotype of RAMSVPS is important to recognize because of systemic implications. Retinal findings can be misinterpreted as sequelae of trauma or Coats disease and can seem unilateral in very young children until changes in the contralateral eye become apparent years later. The homozygous IGFBP7 splice variant associated with the disease likely represents an ancestral founder effect for the Arabian Peninsula. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Adjunctive Intravitreal Triamcinolone Acetonide for Exudative Retinal Detachment in Coats Disease

Author

Alsakran, Wael A., Nowilaty, Sawsan R., Ghazi, Nicola G., Alzahrani, Yahya, AlZaid, Abdulrahman, Mura, Marco, Arevalo, J. Fernando, Abboud, Emad B., and Alsulaiman, Sulaiman M.

Abstract

Purpose: This work aims to assess the value of intravitreal triamcinolone acetonide (IVTA) as an adjunctive therapy in advanced Coats disease with exudative retinal detachment (ERD).Methods: A retrospective review was conducted of patients with Coats disease stage 3 or higher who received IVTA to decrease subretinal fluid (SRF), facilitate retinal ablative therapy, and avoid surgical drainage. Primary outcomes were SRF resolution and avoidance of surgical SRF drainage.Results: Seventeen eyes of 17 patients (mean, [SD] age, 3.9 [3.4] years) met the inclusion criteria. ERD configuration was bullous in 7 and shallow in 10 eyes. Following a single IVTA injection, ablative therapy was achieved after a mean (SD) of 2.1 (3.0) weeks. Complete SRF resolution was observed in 13 eyes (76.4%) after a mean of 1.3 IVTA injections and a mean of 2 (SD, 1.27) laser sessions, and none of these eyes required SRF drainage up to last follow-up (mean [SD], 50.5 [26.24] months). In 4 eyes with bullous ERD at presentation, SRF persisted (P= .015) despite additional measures including surgical drainage. Final visual acuity ranged from 20/100 to no light perception. Cataract developed in 12 of the 17 eyes (70.5%). None developed an increase in intraocular pressure at final follow-up.Conclusions: IVTA injection can be a helpful adjunctive modality to address SRF in advanced Coats disease. It may obviate the need to surgically drain SRF to effectively treat the condition, particularly when the ERD is not highly bullous.

Published
2022
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25. Phenotypic delineation of the retinal arterial macroaneurysms with supravalvular pulmonic stenosis syndrome.

Author

Alkuraya, Hisham, Patel, Nisha, Ibrahim, Niema, Al Ghamdi, Bandar, Alsulaiman, Sulaiman M., Nowilaty, Sawsan R., Abboud, Emad, Alturki, Ramadan, Alkharashi, Abdullah, Eyaid, Wafaa, Almasseri, Zainab, Alzaidan, Hamad, Alotaibi, Mohammed D., Abu El‐Asrar, Ahmed M., Alamro, Bandar, Helaby, Rana, Elshaer, Amani, Almontashiri, Naif A.M., Al‐Hussaini, Abdulrahman A., and Alkuraya, Fowzan S.

Subjects
PULMONARY stenosis, RETINAL artery, CEREBRAL hemorrhage, SYNDROMES, EARLY death
Abstract

Retinal arterial macroaneurysms with supravalvular pulmonic stenosis (RAMSVPS), also known as Familial Retinal Arterial Macroaneurysms (FRAM) syndrome, is a very rare multisystem disorder. Here, we present a case series comprising ophthalmologic and systemic evaluation of patients homozygous for RAMSVPS syndrome causative IGFBP7 variant. New clinical details on 22 previously published and 8 previously unpublished patients are described. Age at first presentation ranged from 1 to 34 years. The classical feature of macroaneurysms and vascular beading involving the retinal arteries was universal. Follow up extending up to 14 years after initial diagnosis revealed recurrent episodes of bleeding and leakage from macroaneurysms in 55% and 59% of patients, respectively. The majority of patients who underwent echocardiography (18/23) showed evidence of heart involvement, most characteristically pulmonary (valvular or supravalvular) stenosis, often requiring surgical correction (12/18). Four patients died in the course of the study from complications of pulmonary stenosis, cerebral hemorrhage, and cardiac complications. Liver involvement (usually cirrhosis) was observed in eight patients. Cerebral vascular involvement was observed in one patient, and stroke was observed in two. We conclude that RAMSVPS is a recognizable syndrome characterized by a high burden of ocular and systemic morbidity, and risk of premature death. Recommendations are proposed for early detection and management of these complications. [ABSTRACT FROM AUTHOR]

Published
2020
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26. Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy

Author

Pichi, Francesco, primary, Fragiotta, Serena, additional, Freund, K Bailey, additional, Au, Adrian, additional, Lembo, Andrea, additional, Nucci, Paolo, additional, Sebastiani, Stefano, additional, Gutierrez Hernandez, Juan Carlos, additional, Interlandi, Emanuela, additional, Pellegrini, Francesco, additional, Dolz-Marco, Rosa, additional, Gallego-Pinazo, Roberto, additional, Orellana-Rios, Jorge, additional, Adatia, Feisal A, additional, Munro, Monique, additional, Abboud, Emad B, additional, Ghazi, Nicola, additional, Cunha Souza, Eduardo, additional, Amer, Radgonde, additional, Neri, Piergiorgio, additional, and Sarraf, David, additional

Published
2018
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28. Congenital Retinal Macrovessel and the Association of Retinal Venous Malformations With Venous Malformations of the Brain

Author

Pichi, Francesco, primary, Freund, K. Bailey, additional, Ciardella, Antonio, additional, Morara, Mariachiara, additional, Abboud, Emad B., additional, Ghazi, Nicola, additional, Dackiw, Christine, additional, Choudhry, Netan, additional, Souza, Eduardo Cunha, additional, Cunha, Leonardo Provetti, additional, Arevalo, J. Fernando, additional, Liu, T. Y. Alvin, additional, Wenick, Adam, additional, He, Lingmin, additional, Villarreal, Guadalupe, additional, Neri, Piergiorgio, additional, and Sarraf, David, additional

Published
2018
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31. Cilioretinal artery hypoperfusion and its association with paracentral acute middle maculopathy.

Author

Pichi, Francesco, Fragiotta, Serena, Bailey Freund, K., Au, Adrian, Lembo, Andrea, Nucci, Paolo, Sebastiani, Stefano, Hernandez, Juan Carlos Gutierrez, Interlandi, Emanuela, Pellegrini, Francesco, Dolz-Marco, Rosa, Gallego-Pinazo, Roberto, Orellana-Rios, Jorge, Adatia, Feisal A., Munro, Monique, Abboud, Emad B., Ghazi, Nicola, Souza, Eduardo Cunha, Amer, Radgonde, and Neri, Piergiorgio

Abstract

Background/aims To study the multimodal imaging findings of a large series of eyes with cilioretinal artery obstruction (CILRAO) and describe the systemic associations. Methods Multicentre, retrospective chart review from 12 different retina clinics worldwide of eyes with CILRAO, defined as acute retinal whitening in the distribution of the cilioretinal artery, were identified. The clinical, systemic information and multimodal retinal imaging findings were collected and analysed. Results A total of 53 eyes of 53 patients with CILRAO were included in the study. In 100% of eyes, fundus photography illustrated deep retinal whitening corresponding to the course of the cilioretinal artery. Twenty-eight patients (52.8%) presented with isolated CILRAO (baseline best-corrected visual acuity (BCVA) 20/50, final BCVA 20/25) associated with nocturnal hypotension, 23 patients (43.4%) with CILRAO secondary to central retinal vein occlusion (CRVO) (baseline BCVA 20/40, final BCVA 20/20) and two patients with CILRAO due to biopsy-proven giant cell arteritis (GCA) (baseline BCVA 20/175, final BCVA 20/75). With spectral domain optical coherence tomography (SD-OCT), a hyper-reflective band involving the inner nuclear layer (ie, paracentral acute middle maculopathy or PAMM) was noted in 51 eyes (28/28 eyes with isolated CILRAO and 23/23 eyes with CILRAO+CRVO) corresponding to the retinal whitening. In the two eyes with CILRAO+GCA, SD-OCT illustrated hyper-reflective ischaemia of both the middle and inner retina. Conclusions Isolated CILRAO and CILRAO secondary to CRVO are the result of hypoperfusion or insufficiency, rather than occlusion, of the cilioretinal artery and are associated with PAMM or selective infarction of the the inner nuclear layer. With GCA, there is complete occlusion of the cilioretinal artery producing ischaemia involving both the middle and inner retina associated with worse visual outcomes. [ABSTRACT FROM AUTHOR]

Published
2019
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32. The outcomes and prognostic factors of vitrectomy in chronic diabetic traction macular detachment

Author

Abu Najma,Muneera, Al-Dhibi,Hassan, Abboud,Emad, Al Zahrani,Yahya, Alharthi,Essam, Alkharashi,Abdullah, Ghazi,Nicola, Abu Najma,Muneera, Al-Dhibi,Hassan, Abboud,Emad, Al Zahrani,Yahya, Alharthi,Essam, Alkharashi,Abdullah, and Ghazi,Nicola

Abstract

Muneera A Abunajma,1 Hassan Al-Dhibi,1 Emad B Abboud,1 Yahya Al Zahrani,1 Essam Alharthi,2 Abdullah Alkharashi,3 Nicola G Ghazi1,4 1Vitreoretinal Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; 2Al Hokama Eye Center, Riyadh, Saudi Arabia; 3Department of Ophthalmology, College of Medicine, King Saud University Riyadh, Saudi Arabia; 4Department of Ophthalmology, University of Virginia, Charlottesville, VA, USA Purpose: To investigate the outcomes of pars plana vitrectomy (PPV) for chronic diabetic traction macular detachment (CTMD).Methods: Ninety-six eyes that underwent PPV for CTMD of at least 6 months duration were retrospectively analyzed. Retinal reattachment rate, final vision, and prognostic factors for poor visual outcome were the main outcome measures.Results: All eyes had long-standing TMD (median 12, range: 6–70 months). The median postoperative follow-up was 15 (range: 3–65) months. Eighty-seven eyes (90.6%) had their retina and macula reattached after one PPV. At final examination, 84 eyes (87.5%) had stable vision or at least one line improvement, and three had no light perception. Seventeen (17.7%) and 41 (43%) eyes had preoperative visual acuity of ≥20/200 and ≥5/200 as compared to 40 (41.6%; P=0.0005) and 64 (66.7%; P=0.0014) eyes at final follow-up, respectively. Age >50 years (Odds ratio [OR] =5.84, 95% confidence interval [CI] =1.53–22.19, P=0.01), preoperative vision <20/400 (OR =7.012, 95% CI =1.82–26.93, P=0.005), and ischemic macula (OR =14.13, 95% CI =3.61–55.33, P<0.001) were significantly associated with final vision <20/400.Conclusion: PPV for CTMD may be beneficial particularly in patients who are relatively younger and have good baseline vision and no macular ischemia. Keywords: chronic diabetic traction macular detachment, diabetic retinopathy, diabetic traction macular detachment, pars plan

Published
2016

33. Macular hole in Behcet's disease

Author

Al-Dhibi, Hassan, Abouammoh, Marwan, Al-Harthi, Essam, Al-Gaeed, Abdulrahman, Larsson, Jorgen, Abboud, Emad, and Chaudhry, Imtiaz

Subjects
Behcet's disease -- Diagnosis -- Care and treatment -- Research, Prevalence studies (Epidemiology) -- Research, Health
Abstract

Byline: Hassan. Al-Dhibi, Marwan. Abouammoh, Essam. Al-Harthi, Abdulrahman. Al-Gaeed, Jorgen. Larsson, Emad. Abboud, Imtiaz. Chaudhry Objective: To investigate the clinical features, prevalence, role of surgical intervention and the visual prognosis [...]

Published
2011

35. Expanding the clinical, allelic, and locus heterogeneity of retinal dystrophies

Author

Patel, Nisha, primary, Aldahmesh, Mohammed A., additional, Alkuraya, Hisham, additional, Anazi, Shamsa, additional, Alsharif, Hadeel, additional, Khan, Arif O., additional, Sunker, Asma, additional, Al-mohsen, Saleh, additional, Abboud, Emad B., additional, Nowilaty, Sawsan R., additional, Alowain, Mohammed, additional, Al-Zaidan, Hamad, additional, Al-Saud, Bandar, additional, Alasmari, Ali, additional, Abdel-Salam, Ghada M.H., additional, Abouelhoda, Mohamed, additional, Abdulwahab, Firdous M., additional, Ibrahim, Niema, additional, Naim, Ewa, additional, Al-Younes, Banan, additional, E. AlMostafa, Abeer, additional, AlIssa, Abdulelah, additional, Hashem, Mais, additional, Buzovetsky, Olga, additional, Xiong, Yong, additional, Monies, Dorota, additional, Altassan, Nada, additional, Shaheen, Ranad, additional, Al-Hazzaa, Selwa A.F., additional, and Alkuraya, Fowzan S., additional

Published
2016
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36. Exome-based case–control association study using extreme phenotype design reveals novel candidates with protective effect in diabetic retinopathy

Author

Shtir, Corina, primary, Aldahmesh, Mohammed A., additional, Al-Dahmash, Saad, additional, Abboud, Emad, additional, Alkuraya, Hisham, additional, Abouammoh, Marwan A., additional, Nowailaty, Sawsan R., additional, Al-Thubaiti, Ghazai, additional, Naim, E. A., additional, ALYounes, B., additional, Binhumaid, F. S., additional, ALOtaibi, A. B., additional, Altamimi, A. S., additional, Alamer, F. H., additional, Hashem, Mais, additional, Abouelhoda, Mohamed, additional, Monies, Dorota, additional, and Alkuraya, Fowzan S., additional

Published
2015
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37. Fundus autofluorescence imaging in hereditary retinal diseases.

Author

Pichi, Francesco, Abboud, Emad B., Ghazi, Nicola G., and Khan, Arif O.

Subjects
*RETINAL diseases, *OPTICAL coherence tomography, *RHODOPSIN, *EPITHELIUM, *PHOTORECEPTORS, *FLUOROPHORES
Abstract

Abstract: Fundus autofluorescence (FAF) is a non‐invasive retinal imaging modality used in clinical practice to non‐invasively map changes at the level of the retinal pigment epithelium (RPE)/photoreceptor complex and alterations of macular pigment distribution. This imaging method is based on the visualization of intrinsic fluorophores and may be easily and rapidly used in routine patient care. Excessive accumulation of lipofuscin granules in the lysosomal compartment of RPE cells represents a common downstream pathogenic pathway in various hereditary and complex retinal diseases. The clinical applications of FAF continue to expand. It is now an essential tool for evaluating macular dystrophies and various hereditary retinal disorders. Fundus autofluorescence (FAF) may detect abnormalities beyond those detected on funduscopic examination, fluorescein angiography (FA) or optical coherence tomography (OCT). Fundus autofluorescence (FAF) imaging is particularly helpful for differential diagnosis, detection and extent delineation of involved retinal areas, genotype‐phenotype correlations and monitoring of changes overtime. Given its ease of use, non‐invasive nature and value in characterizing retinal disease, FAF enjoys increasing clinical relevance. This review summarizes basic principles and FAF findings in various hereditary retinal diseases. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Reply

Author

Alsulaiman, Sulaiman M., primary, Almasaud, Jluwi, additional, Alkharashi, Abdullah S., additional, Alzahrani, Yahya, additional, Abboud, Emad B., additional, Nowilaty, Sawsan R., additional, Al-Amry, Mohammad, additional, Alrashaed, Saba, additional, Alrushood, Abdulaziz Adel, additional, Arevalo, J. Fernando, additional, and Ghazi, Nicola G., additional

Published
2015
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39. Full-Thickness Macular Hole Secondary to High-Power Handheld Blue Laser: Natural History and Management Outcomes

Author

Alsulaiman, Sulaiman M., primary, Alrushood, Abdulaziz Adel, additional, Almasaud, Jluwi, additional, Alkharashi, Abdullah S., additional, Alzahrani, Yahya, additional, Abboud, Emad B., additional, Nowilaty, Sawsan R., additional, Arevalo, J. Fernando, additional, Al-Amry, Mohammad, additional, Alrashaed, Saba, additional, Ghazi, Nicola G., additional, Al Kahtani, Eman, additional, Al Rashaed, Saba, additional, Al-Dhibi, Hassan A., additional, Al-Zahrani, Yahya A., additional, Kozak, Igor, additional, Al-Sulaiman, Sulaiman, additional, Al-Abdullah, Abdulelah, additional, Al-Bar, Ahmad, additional, Al Dhafiri, Yousef, additional, Al Qahtani, Abdullah, additional, Al Rubaie, Khalid, additional, Al Shahrani, Saeed, additional, Al Shehri, Maha, additional, Al Ahmadi, Badr, additional, Al Hadlaq, Abdulaziz, additional, Al Harbi, Majed, additional, and Al Oreany, Abdulaziz, additional

Published
2015
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40. High-Power Handheld Blue Laser-Induced Maculopathy

Author

Alsulaiman, Sulaiman M., primary, Alrushood, Abdulaziz Adel, additional, Almasaud, Jluwi, additional, Alzaaidi, Sultan, additional, Alzahrani, Yahya, additional, Arevalo, J. Fernando, additional, Ghazi, Nicola G., additional, Abboud, Emad B., additional, Nowilaty, Sawsan R., additional, Al-Amry, Mohammad, additional, and Al-Rashaed, Saba, additional

Published
2014
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41. Role of Intravitreal Antivascular Endothelial Growth Factor Injections for Choroidal Neovascularization due to Choroidal Osteoma

Author

Mansour, Ahmad M., primary, Arevalo, J. Fernando, additional, Al Kahtani, Eman, additional, Zegarra, Hernando, additional, Abboud, Emad, additional, Anand, Rajiv, additional, Ahmadieh, Hamid, additional, Sisk, Robert A., additional, Mirza, Salman, additional, Tuncer, Samuray, additional, Navea Tejerina, Amparo, additional, Mataix, Jorge, additional, Ascaso, Francisco J., additional, Pulido, Jose S., additional, Guthoff, Rainer, additional, Goebel, Winfried, additional, Roh, Young Jung, additional, Banker, Alay S., additional, Gentile, Ronald C., additional, Martinez, Isabel Alonso, additional, Morris, Rodney, additional, Panday, Neeraj, additional, Min, Park Jung, additional, Mercé, Emilie, additional, Lai, Timothy Y. Y., additional, Massoud, Vicky, additional, and Ghazi, Nicola G., additional

Published
2014
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42. The outcomes and prognostic factors of vitrectomy in chronic diabetic traction macular detachment.

Author

Abunajma, Muneera A., Al-Dhibi, Hassan, Abboud, Emad B., Al Zahrani, Yahya, Alharthi, Essam, Alkharashi, Abdullah, and Ghazi, Nicola G.

Subjects
VITREOUS body surgery, MACULA lutea, VITRECTOMY, DIABETIC retinopathy, RETINA abnormalities, VISUAL acuity
Abstract

Purpose: To investigate the outcomes of pars plana vitrectomy (PPV) for chronic diabetic traction macular detachment (CTMD). Methods: Ninety-six eyes that underwent PPV for CTMD of at least 6 months duration were retrospectively analyzed. Retinal reattachment rate, final vision, and prognostic factors for poor visual outcome were the main outcome measures. Results: All eyes had long-standing TMD (median 12, range: 6-70 months). The median postoperative follow-up was 15 (range: 3-65) months. Eighty-seven eyes (90.6%) had their retina and macula reattached after one PPV. At final examination, 84 eyes (87.5%) had stable vision or at least one line improvement, and three had no light perception. Seventeen (17.7%) and 41 (43%) eyes had preoperative visual acuity of ⩾20/200 and ⩾5/200 as compared to 40 (41.6%; P=0.0005) and 64 (66.7%; P=0.0014) eyes at final follow-up, respectively. Age >50 years (Odds ratio [OR] =5.84, 95% confidence interval [CI] =1.53-22.19, P=0.01), preoperative vision <20/400 (OR =7.012, 95% CI =1.82-26.93, P=0.005), and ischemic macula (OR =14.13, 95% CI =3.61-55.33, P<0.001) were significantly associated with final vision <20/400. Conclusion: PPV for CTMD may be beneficial particularly in patients who are relatively younger and have good baseline vision and no macular ischemia. [ABSTRACT FROM AUTHOR]

Published
2016
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44. Autozygome-guided exome sequencing in retinal dystrophy patients reveals pathogenetic mutations and novel candidate disease genes

Author

Abu-Safieh, Leen, primary, Alrashed, May, additional, Anazi, Shamsa, additional, Alkuraya, Hisham, additional, Khan, Arif O., additional, Al-Owain, Mohammed, additional, Al-Zahrani, Jawahir, additional, Al-Abdi, Lama, additional, Hashem, Mais, additional, Al-Tarimi, Salwa, additional, Sebai, Mohammed-Adeeb, additional, Shamia, Ahmed, additional, Ray-zack, Mohamed D., additional, Nassan, Malik, additional, Al-Hassnan, Zuhair N., additional, Rahbeeni, Zuhair, additional, Waheeb, Saad, additional, Alkharashi, Abdullah, additional, Abboud, Emad, additional, Al-Hazzaa, Selwa A.F., additional, and Alkuraya, Fowzan S., additional

Published
2012
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45. Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling

Author

Chaki, Moumita, primary, Airik, Rannar, additional, Ghosh, Amiya K., additional, Giles, Rachel H., additional, Chen, Rui, additional, Slaats, Gisela G., additional, Wang, Hui, additional, Hurd, Toby W., additional, Zhou, Weibin, additional, Cluckey, Andrew, additional, Gee, Heon Yung, additional, Ramaswami, Gokul, additional, Hong, Chen-Jei, additional, Hamilton, Bruce A., additional, Červenka, Igor, additional, Ganji, Ranjani Sri, additional, Bryja, Vitezslav, additional, Arts, Heleen H., additional, van Reeuwijk, Jeroen, additional, Oud, Machteld M., additional, Letteboer, Stef J.F., additional, Roepman, Ronald, additional, Husson, Hervé, additional, Ibraghimov-Beskrovnaya, Oxana, additional, Yasunaga, Takayuki, additional, Walz, Gerd, additional, Eley, Lorraine, additional, Sayer, John A., additional, Schermer, Bernhard, additional, Liebau, Max C., additional, Benzing, Thomas, additional, Le Corre, Stephanie, additional, Drummond, Iain, additional, Janssen, Sabine, additional, Allen, Susan J., additional, Natarajan, Sivakumar, additional, O’Toole, John F., additional, Attanasio, Massimo, additional, Saunier, Sophie, additional, Antignac, Corinne, additional, Koenekoop, Robert K., additional, Ren, Huanan, additional, Lopez, Irma, additional, Nayir, Ahmet, additional, Stoetzel, Corinne, additional, Dollfus, Helene, additional, Massoudi, Rustin, additional, Gleeson, Joseph G., additional, Andreoli, Sharon P., additional, Doherty, Dan G., additional, Lindstrad, Anna, additional, Golzio, Christelle, additional, Katsanis, Nicholas, additional, Pape, Lars, additional, Abboud, Emad B., additional, Al-Rajhi, Ali A., additional, Lewis, Richard A., additional, Omran, Heymut, additional, Lee, Eva Y.-H.P., additional, Wang, Shaohui, additional, Sekiguchi, JoAnn M., additional, Saunders, Rudel, additional, Johnson, Colin A., additional, Garner, Elizabeth, additional, Vanselow, Katja, additional, Andersen, Jens S., additional, Shlomai, Joseph, additional, Nurnberg, Gudrun, additional, Nurnberg, Peter, additional, Levy, Shawn, additional, Smogorzewska, Agata, additional, Otto, Edgar A., additional, and Hildebrandt, Friedhelm, additional

Published
2012
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48. Whole-exome sequencing identifiesALMS1, IQCB1, CNGA3, andMYO7Amutations in patients with leber congenital amaurosis

Author

Wang, Xia, primary, Wang, Hui, additional, Cao, Ming, additional, Li, Zhe, additional, Chen, Xianfeng, additional, Patenia, Claire, additional, Gore, Athurva, additional, Abboud, Emad B., additional, Al-Rajhi, Ali A., additional, A. Lewis, Richard, additional, Lupski, James R., additional, Mardon, Graeme, additional, Zhang, Kun, additional, Muzny, Donna, additional, Gibbs, Richard A., additional, and Chen, Rui, additional

Published
2011
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49. Mutation of IGFBP7 Causes Upregulation of BRAF/MEK/ERK Pathway and Familial Retinal Arterial Macroaneurysms

Author

Abu-Safieh, Leen, primary, Abboud, Emad B., additional, Alkuraya, Hisham, additional, Shamseldin, Hanan, additional, Al-Enzi, Shamsa, additional, Al-Abdi, Lama, additional, Hashem, Mais, additional, Colak, Dilek, additional, Jarallah, Abdullah, additional, Ahmad, Hala, additional, Bobis, Steve, additional, Nemer, Georges, additional, Bitar, Fadi, additional, and Alkuraya, Fowzan S., additional

Published
2011
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50. Mutations in SPATA7 Cause Leber Congenital Amaurosis and Juvenile Retinitis Pigmentosa

Author

Wang, Hui, primary, den Hollander, Anneke I., additional, Moayedi, Yalda, additional, Abulimiti, Abuduaini, additional, Li, Yumei, additional, Collin, Rob W.J., additional, Hoyng, Carel B., additional, Lopez, Irma, additional, Abboud, Emad B., additional, Al-Rajhi, Ali A., additional, Bray, Molly, additional, Lewis, Richard Alan, additional, Lupski, James R., additional, Mardon, Graeme, additional, Koenekoop, Robert K., additional, and Chen, Rui, additional

Published
2010
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