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9 results on '"Abbasi, Nissa"'

1. Publisher Correction: The DNA sequence and analysis of human chromosome 14

Author

Heilig, Roland, Eckenberg, Ralph, Petit, Jean-Louis, Fonknechten, Núria, Da Silva, Corinne, Cattolico, Laurence, Levy, Michaël, Barbe, Valérie, de Berardinis, Véronique, Ureta-Vidal, Abel, Pelletier, Eric, Vico, Virginie, Anthouard, Véronique, Rowen, Lee, Madan, Anup, Qin, Shizhen, Sun, Hui, Du, Hui, Pepin, Kymberlie, Artiguenave, François, Robert, Catherine, Cruaud, Corinne, Brüls, Thomas, Jaillon, Olivier, Friedlander, Lucie, Samson, Gaelle, Brottier, Philippe, Cure, Susan, Ségurens, Béatrice, Anière, Franck, Samain, Sylvie, Crespeau, Hervé, Abbasi, Nissa, Aiach, Nathalie, Boscus, Didier, Dickhoff, Rachel, Dors, Monica, Dubois, Ivan, Friedman, Cynthia, Gouyvenoux, Michel, James, Rose, Madan, Anuradha, Mairey–Estrada, Barbara, Mangenot, Sophie, Martins, Nathalie, Ménard, Manuela, Oztas, Sophie, Ratcliffe, Amber, Shaffer, Tristan, Trask, Barbara, Vacherie, Benoit, Bellemere, Chadia, Belser, Caroline, Besnard-Gonnet, Marielle, Bartol–Mavel, Delphine, Boutard, Magali, Briez-Silla, Stéphanie, Combette, Stephane, Dufossé-Laurent, Virginie, Ferron, Carolyne, Lechaplais, Christophe, Louesse, Claudine, Muselet, Delphine, Magdelenat, Ghislaine, Pateau, Emilie, Petit, Emmanuelle, Sirvain-Trukniewicz, Peggy, Trybou, Arnaud, Vega-Czarny, Nathalie, Bataille, Elodie, Bluet, Elodie, Bordelais, Isabelle, Dubois, Maria, Dumont, Corinne, Guérin, Thomas, Haffray, Sébastien, Hammadi, Rachid, Muanga, Jacqueline, Pellouin, Virginie, Robert, Dominique, Wunderle, Edith, Gauguet, Gilbert, Roy, Alice, Sainte-Marthe, Laurent, Verdier, Jean, Verdier-Discala, Claude, Hillier, LaDeana, Fulton, Lucinda, McPherson, John, Matsuda, Fumihiko, Wilson, Richard, Scarpelli, Claude, Gyapay, Gábor, Wincker, Patrick, Saurin, William, Quétier, Francis, Waterston, Robert, Hood, Leroy, and Weissenbach, Jean

Published
2023
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2. Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Zody, Michael C., Garber, Manuel, Sharpe, Ted, Young, Sarah K., Rowen, Lee, O'Neill, Keith, Whittaker, Charles A., Kamal, Michael, Chang, Jean L., Cuomo, Christina A., Dewar, Ken, FitzGerald, Michael G., Kodira, Chinnappa D., Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra M., Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark L., Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, III, Lester, Dors, Monica, Eichler, Evan E., Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer L., Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin P., Madan, Anuradha, Munson, Glen, Jaffe, David B., Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome W., Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinead B., Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine M. B., Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina M., Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew R., Birren, Bruce W., Hood, Leroy, Lander, Eric S., and Nusbaum, Chad

Subjects
Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Michael C. Zody (corresponding author) [1]; Manuel Garber [1]; Ted Sharpe [1]; Sarah K. Young [1]; Lee Rowen [2]; Keith O'Neill [1]; Charles A. Whittaker [1, 6]; Michael Kamal [...]

Published
2006
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3. The DNA sequence and analysis of human chromosome 14

Author

Heilig, Roland, Eckenberg, Ralph, Petit, Jean-Louis, Fonknechten, Núria, Da Silva, Corinne, Cattolico, Laurence, Levy, Michaël, Barbe, Valérie, de Berardinis, Véronique, Ureta-Vidal, Abel, Pelletier, Eric, Vico, Virginie, Anthouard, Véronique, Rowen, Lee, Madan, Anup, Qin, Shizhen, Sun, Hui, Du, Hui, Pepin, Kymberlie, Artiguenave, François, Robert, Catherine, Cruaud, Corinne, Brüls, Thomas, Jaillon, Olivier, Friedlander, Lucie, Samson, Gaelle, Brottier, Philippe, Cure, Susan, Ségurens, Béatrice, Anière, Franck, Samain, Sylvie, Crespeau, Hervé, Abbasi, Nissa, Aiach, Nathalie, Boscus, Didier, Dickhoff, Rachel, Dors, Monica, Dubois, Ivan, Friedman, Cynthia, Gouyvenoux, Michel, James, Rose, Madan, Anuradha, Mairey–Estrada, Barbara, Mangenot, Sophie, Martins, Nathalie, Ménard, Manuela, Oztas, Sophie, Ratcliffe, Amber, Shaffer, Tristan, Trask, Barbara, Vacherie, Benoit, Bellemere, Chadia, Belser, Caroline, Besnard-Gonnet, Marielle, Bartol–Mavel, Delphine, Boutard, Magali, Briez-Silla, Stéphanie, Combette, Stephane, Dufossé-Laurent, Virginie, Ferron, Carolyne, Lechaplais, Christophe, Louesse, Claudine, Muselet, Delphine, Magdelenat, Ghislaine, Pateau, Emilie, Petit, Emmanuelle, Sirvain-Trukniewicz, Peggy, Trybou, Arnaud, Vega-Czarny, Nathalie, Bataille, Elodie, Bluet, Elodie, Bordelais, Isabelle, Dubois, Maria, Dumont, Corinne, Guérin, Thomas, Haffray, Sébastien, Hammadi, Rachid, Muanga, Jacqueline, Pellouin, Virginie, Robert, Dominique, Wunderle, Edith, Gauguet, Gilbert, Roy, Alice, Sainte-Marthe, Laurent, Verdier, Jean, Verdier-Discala, Claude, Hillier, LaDeana, Fulton, Lucinda, McPherson, John, Matsuda, Fumihiko, Wilson, Richard, Scarpelli, Claude, Gyapay, Gábor, Wincker, Patrick, Saurin, William, Quétier, Francis, Waterston, Robert, Hood, Leroy, and Weissenbach, Jean

Published
2003
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6. Analysis of the DNA sequence and duplication history of human chromosome 15

Author

Zody, Michael, Garber, Manuel, Sharpe, Ted, Young, Sarah, Rowen, Lee, O'Neill, Keith, Whittaker, Charles, Kamal, Michael, Chang, Jean, Cuomo, Christina, Dewar, Ken, FitzGerald, Michael, Kodira, Chinnappa, Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra, Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark, Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, Lester, Dors, Monica, Eichler, Evan, Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer, Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin, Madan, Anuradha, Munson, Glen, Jaffe, David, Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome, Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinéad, Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine, Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina, Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew, Birren, Bruce, Hood, Leroy, Lander, ic, Nusbaum, Chad, Zody, Michael, Garber, Manuel, Sharpe, Ted, Young, Sarah, Rowen, Lee, O'Neill, Keith, Whittaker, Charles, Kamal, Michael, Chang, Jean, Cuomo, Christina, Dewar, Ken, FitzGerald, Michael, Kodira, Chinnappa, Madan, Anup, Qin, Shizhen, Yang, Xiaoping, Abbasi, Nissa, Abouelleil, Amr, Arachchi, Harindra, Baradarani, Lida, Birditt, Brian, Bloom, Scott, Bloom, Toby, Borowsky, Mark, Burke, Jeremy, Butler, Jonathan, Cook, April, DeArellano, Kurt, DeCaprio, David, Dorris, Lester, Dors, Monica, Eichler, Evan, Engels, Reinhard, Fahey, Jessica, Fleetwood, Peter, Friedman, Cynthia, Gearin, Gary, Hall, Jennifer, Hensley, Grace, Johnson, Ericka, Jones, Charlien, Kamat, Asha, Kaur, Amardeep, Locke, Devin, Madan, Anuradha, Munson, Glen, Jaffe, David, Lui, Annie, Macdonald, Pendexter, Mauceli, Evan, Naylor, Jerome, Nesbitt, Ryan, Nicol, Robert, O'Leary, Sinéad, Ratcliffe, Amber, Rounsley, Steven, She, Xinwei, Sneddon, Katherine, Stewart, Sandra, Sougnez, Carrie, Stone, Sabrina, Topham, Kerri, Vincent, Dascena, Wang, Shunguang, Zimmer, Andrew, Birren, Bruce, Hood, Leroy, Lander, ic, and Nusbaum, Chad

Abstract

Here we present a finished sequence of human chromosome 15, together with a high-quality gene catalogue. As chromosome 15 is one of seven human chromosomes with a high rate of segmental duplication, we have carried out a detailed analysis of the duplication structure of the chromosome. Segmental duplication in chromosome 15 are largely clustered in two regions, on proximal and distal 15q; the proximal region is notable because recombination among the segmental duplications can result in deletions causing Prader-Willi and Angelman syndromes. Sequence analysis shows that the proximal and distal regions of 15q share extensive ancient similarity. Using a simple approach, we have been able to reconstruct many of the events by which the current duplication structure arose. We find that most of the intrachromosomal duplications seem to share a common ancestry. Finally, we demonstrate that some remaining gaps in the genome sequence are probably due to structural polymorphisms between haplotypes; this may explain a significant fraction of the gaps remaining in the human genome.

Published
2006
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8. Gene Expression Patterns in Myelodyplasia Underline the Role of Apoptosis and Differentiation in Disease Initiation and Progression.

Author

Bar, Merav, Stirewalt, Derek, Pogosova-Agadjanyan, Era, Wagner, Vitas, Gooley, Ted, Abbasi, Nissa, Bhatia, Ravi, Deeg, H. Joachim, and Radich, Jerald

Subjects
MYELODYSPLASTIC syndromes, STEM cells, GENE expression, APOPTOSIS, CD antigens, CANCER genes, CELL differentiation, HEMATOPOIESIS, CANCER research, DISEASES
Abstract

The myelodysplastic syndromes (MDS) are clonal stem cell disorders, characterized by ineffective and dysplastic hematopoiesis. The genetic and epigenetic pathways that determine disease stage and progression are largely unknown. In the current study we used gene expression microarray methodology to examine the gene expression differences between normal hematopoietic cells and hematopoietic cells from patients with MDS at different disease stages, using both unselected and CD34+ selected cells. Significant differences between normal and MDS hematopoietic cells were observed for several genes and pathways. Several genes promoting or opposing apoptosis were dysregulated in MDS cases, most notably MCL1 and EPOR. Progression from RA to RAEB(T) was associated with increased expression of several histone genes. In addition, the RAR-RXR pathway, critical for maintaining a balance between self-renewal and differentiation of hematopoietic stem cells, was found to be deregulated in hematopoietic cells from patients with advanced MDS compared to patients with refractory anemia. These findings provide new insights into the understanding of the pathophysiology and progression of MDS, and may guide to new targets for therapy. Taken together with previous published data, the present results also underscore the considerable complexity of the regulation of gene expression in MDS. [ABSTRACT FROM AUTHOR]

Published
2008
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9. NF-kappaB and FLIP in arsenic trioxide (ATO)-induced apoptosis in myelodysplastic syndromes (MDSs).

Author

Kerbauy DM, Lesnikov V, Abbasi N, Seal S, Scott B, and Deeg HJ

Subjects
Anti-Inflammatory Agents, Non-Steroidal pharmacology, Apoptosis Regulatory Proteins metabolism, Arsenic Trioxide, Blotting, Western, Bone Marrow Cells drug effects, Bone Marrow Cells metabolism, CASP8 and FADD-Like Apoptosis Regulating Protein, Cell Line, Tumor, Dose-Response Relationship, Drug, Electrophoretic Mobility Shift Assay, Enzyme Activation drug effects, Etanercept, Flow Cytometry, Glutathione drug effects, Glutathione metabolism, Humans, Immunoglobulin G pharmacology, Intracellular Signaling Peptides and Proteins metabolism, Membrane Glycoproteins metabolism, Myelodysplastic Syndromes drug therapy, Myelodysplastic Syndromes pathology, NF-kappa B metabolism, Protein Transport drug effects, Receptors, Tumor Necrosis Factor, Reverse Transcriptase Polymerase Chain Reaction, TNF-Related Apoptosis-Inducing Ligand, Tumor Necrosis Factor-alpha metabolism, Apoptosis physiology, Arsenicals pharmacology, Growth Inhibitors pharmacology, Intracellular Signaling Peptides and Proteins drug effects, Myelodysplastic Syndromes metabolism, NF-kappa B drug effects, Oxides pharmacology
Abstract

Tumor necrosis factor (TNF)-alpha, a potent stimulus of nuclear factor-kappaB (NF-kappaB), is up-regulated in myelodysplastic syndrome (MDS). Here, we show that bone marrow mononuclear cells (BMMCs) and purified CD34+ cells from patients with low-grade/early-stage MDS (refractory anemia/refractory anemia with ring sideroblasts [RA/RARS]) have low levels of NF-kappaB activity in nuclear extracts comparable with normal marrow, while patients with RA with excess blasts (RAEB) show significantly increased levels of activity (P = .008). Exogenous TNF-alpha enhanced NF-kappaB nuclear translocation in MDS BMMCs above baseline levels. Treatment with arsenic trioxide (ATO; 2-200 microM) inhibited NF-kappaB activity in normal marrow, primary MDS, and ML1 cells, even in the presence of exogenous TNF-alpha (20 ng/mL), and down-regulated NF-kappaB-dependent antiapoptotic proteins, B-cell leukemia XL (Bcl-XL), Bcl-2, X-linked inhibitor of apoptosis (XIAP), and Fas-associated death domain (FADD)-like interleukin-1beta-converting enzyme (FLICE) inhibitory protein (FLIP), leading to apoptosis. However, overexpression of FLIP resulted in increased NF-kappaB activity and rendered ML1 cells resistant to ATO-induced apoptosis. These data are consistent with the observed up-regulation of FLIP and resistance to apoptosis with advanced MDS, where ATO as a single agent may show only limited efficacy. However, the data also suggest that combinations of ATO with agents that interfere with other pathways, such as FLIP autoamplification via NF-kappaB, may have considerable therapeutic activity.

Published
2005
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