1. Interleukin-8 levels in seminal plasma in chronic prostatitis/chronic pelvic pain syndrome and nonspecific urethritis
- Author
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Graz Luzzi, Phillip Hay, Robin J. Shattock, Abbas Khadra, and Patricia S. Fletcher
- Subjects
Adult ,Male ,medicine.medical_specialty ,Urology ,Urinary system ,Prostatitis ,Semen ,Urine ,Pelvic Pain ,Gastroenterology ,Chronic prostatitis/chronic pelvic pain syndrome ,Internal medicine ,medicine ,Humans ,Urethritis ,business.industry ,Pelvic pain ,Interleukin-8 ,Interleukin ,Syndrome ,medicine.disease ,Endocrinology ,Case-Control Studies ,Chronic Disease ,medicine.symptom ,business ,Biomarkers - Abstract
OBJECTIVE To investigate whether a range of cytokines were detectable in the seminal plasma and urine of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and nonspecific urethritis (NSU), and whether cytokine levels correlated with symptom severity in CP/CPPS. PATIENTS AND METHODS In all, 87 men participated, 33 with CP/CPPS, 31 with NSU, and 23 controls. Interleukin (IL)-1β, IL-2, IL-6, IL-8 and IL-10 were measured in seminal plasma and first pass urine, and the results were correlated with scores for pain, urinary symptoms and quality-of-life impact using a validated symptom index, the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI). RESULTS Seminal plasma levels of IL-8 were higher in men with CP/CPPS and NSU than in controls (P
- Published
- 2006
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