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363 results on '"Abate, Nicola"'

1. Quantification of muscle triglyceride synthesis rate requires an adjustment for total triglyceride content

Author

Asghar, Rabia, Chondronikola, Maria, Dillon, Edgar L, Durham, William J, Porter, Craig, Wu, Zhanpin, Camacho-Hughes, Maria, Andersen, Clark R, Spratt, Heidi, Volpi, Elena, Sheffield-Moore, Melinda, Sidossis, Labros, Wolfe, Robert R, Abate, Nicola, and Tuvdendorj, Demidmaa R

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Artifacts, Female, Healthy Volunteers, Humans, Kinetics, Middle Aged, Muscle, Skeletal, Triglycerides, in vivo muscle triglyceride synthesis, stable isotope tracers, skeletal muscle lipid metabolism, Biochemistry and Cell Biology, Biochemistry & Molecular Biology, Biochemistry and cell biology, Medical biochemistry and metabolomics
Abstract

Intramyocellular triglyceride (imTG) in skeletal muscle plays a significant role in metabolic health, and an infusion of [13C16]palmitate can be used to quantitate the in vivo fractional synthesis rate (FSR) and absolute synthesis rate (ASR) of imTGs. However, the extramyocellular TG (emTG) pool, unless precisely excised, contaminates the imTG pool, diluting the imTG-bound tracer enrichment and leading to underestimation of FSR. Because of the difficulty of excising the emTGs precisely, it would be advantageous to be able to calculate the imTG synthesis rate without dissecting the emTGs from each sample. Here, we tested the hypothesis that the ASR of total TGs (tTGs), a combination of imTGs and emTGs, calculated as "FSR × tTG pool," reasonably represents the imTG synthesis. Muscle lipid parameters were measured in nine healthy women at 90 and 170 min after the start of [13C16]palmitate infusion. While the measurements of tTG content, enrichment, and FSR did not correlate (P > 0.05), those of the tTG ASR were significantly correlated (r = 0.947, P < 0.05). These results demonstrate that when imTGs and emTGs are pooled, the resulting underestimation of imTG FSR is balanced by the overestimation of the imTG content. We conclude that imTG metabolism is reflected by the measurement of the tTG ASR.

Published
2018

2. Palmitoyl-carnitine production by blood cells associates with the concentration of circulating acyl-carnitines in healthy overweight women

Author

Chondronikola, Maria, Asghar, Rabia, Zhang, Xiaojun, Dillon, Edgar L, Durham, William J, Wu, Zhanpin, Porter, Craig, Camacho-Hughes, Maria, Zhao, Yingxin, Brasier, Allan R, Volpi, Elena, Sheffield-Moore, Melinda, Abate, Nicola, Sidossis, Labros, and Tuvdendorj, Demidmaa

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Diabetes, Prevention, Obesity, Nutrition, Metabolic and endocrine, Adult, Aged, Blood Cells, Blood Glucose, Body Mass Index, Carnitine, Diabetes Mellitus, Type 2, Female, Humans, Hyperinsulinism, Insulin, Insulin Resistance, Lipid Metabolism, Middle Aged, Overweight, Oxidation-Reduction, Palmitates, Palmitoylcarnitine, Acyl-carnitines, Blood cells, Stable isotope tracer, Plasma palmitate oxidation, Insulin resistance, Nutrition and Dietetics, Nutrition & Dietetics, Nutrition and dietetics
Abstract

BackgroundCirculating acyl-carnitines (acyl-CNTs) are associated with insulin resistance (IR) and type 2 diabetes (T2D) in both rodents and humans. However, the mechanisms whereby circulating acyl-CNTs are increased in these conditions and their role in whole-body metabolism remains unknown. The purpose of this study was to determine if, in humans, blood cells contribute in production of circulating acyl-CNTs and associate with whole-body fat metabolism.Methods and resultsEight non-diabetic healthy women (age: 47 ± 19 y; BMI: 26 ± 1 kg·m-2) underwent stable isotope tracer infusion and hyperinsulinemic-euglycemic clamp study to determine in vivo whole-body fatty acid flux and insulin sensitivity. Blood samples collected at baseline (0 min) and after 3 h of clamp were used to determine the synthesis rate of palmitoyl-carnitine (palmitoyl-CNT) in vitro. The fractional synthesis rate of palmitoyl-CNT was significantly higher during hyperinsulinemia (0.788 ± 0.084 vs. 0.318 ± 0.012%·hr-1, p = 0.001); however, the absolute synthesis rate (ASR) did not differ between the periods (p = 0.809) due to ∼30% decrease in blood palmitoyl-CNT concentration (p = 0.189) during hyperinsulinemia. The ASR of palmitoyl-CNT significantly correlated with the concentration of acyl-CNTs in basal (r = 0.992, p

Published
2017

4. In vivo triglyceride synthesis in subcutaneous adipose tissue of humans correlates with plasma HDL parameters

Author

Tuvdendorj, Demidmaa, Munoz, Alejandro O, Ruiz-Barros, Viviana, Schwarz, Jean-Marc, Montalto, Giuseppe, Chandalia, Manisha, Sowers, Lawrence C, Rizzo, Manfredi, Murphy, Elizabeth J, and Abate, Nicola

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Cardiovascular, Atherosclerosis, Clinical Research, Diabetes, 2.1 Biological and endogenous factors, Aetiology, Metabolic and endocrine, Aged, Blood Glucose, Cholesterol, HDL, Female, Humans, Insulin Resistance, Lipids, Lipogenesis, Male, Middle Aged, Obesity, Subcutaneous Fat, Abdominal, Triglycerides, Adipocyte, HDL-C metabolism, Stable isotope tracer kinetics, Atheroprotective, Gender-related, Mass spectrometry, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

Backgrounds and aimsLow concentrations of plasma HDL-C are associated with the development of atherosclerotic cardiovascular diseases and type 2 diabetes. Here we aimed to explore the relationship between the in vivo fractional synthesis of triglycerides (fTG) in subcutaneous (s.q.) abdominal adipose tissue (AT), HDL-C concentrations and HDL particle size composition in non-diabetic humans.MethodsThe fTG in s.q. abdominal AT was measured in 16 non-diabetic volunteers (7 women, 9 men; Age: 49 ± 20 years; BMI: 31 ± 5 kg/m; Fasting Plasma Glucose: 90 ± 10 mg/dl) after (2)H2O labeling. HDL-C concentration and subclasses, large (L-HDL), intermediate (I-HDL) and small (S-HDL) were measured.ResultsLinear regression analyses demonstrated significant associations of fTG with plasma concentration of HDL-C (r = 0.625,p = 0.009) and percent contribution of L-HDL (r = 0.798,p

Published
2016

11. Dentro del viaje constitucional europeo

Author

Abate, Nicola, Ediciones Universidad de Valladolid, Abate, Nicola, and Ediciones Universidad de Valladolid

Abstract

This paper analyzes the European constitutional journey with the Habermasian concepts of solidarity and social integration. An analysis of the concept of constitution and of the European (economic) treaties reveals the lack of social integration as an obstacle to further economic integration. The aim is to link social justice and democracy at European constitutional level on the common basis of equality. From this perspective, the goal is to demonstrate the need for a constitutionalization with a strong democratic and social imprint because of the kind of solidarity which is embodied in the social rights.

Published
2022

12. Inside the European Constitutional Journey

Author

Abate, Nicola and Abate, Nicola

Abstract

This paper analyzes the European constitutional journey with the Habermasian concepts of solidarity and social integration. An analysis of the concept of constitution and of the European (economic) treaties reveals the lack of social integration as an obstacle to further economic integration. The aim is to link social justice and democracy at European constitutional level on the common basis of equality. From this perspective, the goal is to demonstrate the need for a constitutionalization with a strong democratic and social imprint because of the kind of solidarity which is embodied in the social rights., Este trabajo analiza el camino constitucional europeo con los conceptos de Habermas de solidaridad e integración social. Un análisis del concepto de constitución y de los tratados (económicos) europeos revela la falta de integración social como un obstáculo para una mayor integración económica. El objetivo es vincular la justicia social y la democracia a nivel constitucional europeo sobre la base común de la igualdad. Desde esta perspectiva, el objetivo es demostrar la necesidad de una constitucionalización con una fuerte huella democrática y social debido al tipo de solidaridad que se encarna en los derechos sociales.

Published
2022

24. Dose-comparison study of the combination of ezetimibe and simvastatin (Vytorin) versus atorvastatin in patients with hypercholesterolemia: The Vytorin Versus Atorvastatin (VYVA) Study

Author

Ballantyne, Christie M., Abate, Nicola, Yuan, Zhong, King, Thomas R., and Palmisano, Joanne

Subjects
Hypercholesterolemia -- Care and treatment, Simvastatin -- Dosage and administration, Cholesterol, Medical research, Medicine, Experimental, Low density lipoproteins, Health
Abstract

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ahj.2004.11.023 Byline: Christie M. Ballantyne (a), Nicola Abate (b), Zhong Yuan (c), Thomas R. King (c), Joanne Palmisano (c) Abstract: Low-density lipoprotein cholesterol (LDL-C) is the primary therapeutic target in the National Cholesterol Education Program Adult Treatment Panel III (ATP III) guidelines. This study tested the hypothesis that ezetimibe/simvastatin, a lipid-lowering agent that inhibits both intestinal cholesterol absorption and cholesterol synthesis, provides greater LDL-C reductions than atorvastatin across dose ranges. Author Affiliation: (a) Department of Medicine, Baylor College of Medicine, Houston, Tex (b) Division of Endocrinology and Metabolism, University of Texas Southwestern Medical Center, Dallas, Tex (c) Merck & Co Inc, West Point, Pa Article History: Received 13 October 2004; Accepted 30 November 2004 Article Note: (miscellaneous) This study was sponsored by Merck/Schering Plough Pharmaceuticals, North Wales, Pa.

Published
2005

26. Joint Effect of Insulin Signaling Genes on Insulin Secretion and Glucose Homeostasis

Author

Prudente, Sabrina, Morini, Eleonora, Marselli, Lorella, Baratta, Roberto, Copetti, Massimiliano, Mendonca, Christine, Andreozzi, Francesco, Chandalia, Manisha, Pellegrini, Fabio, Bailetti, Diego, Alberico, Federica, Shah, Hetal, Abate, Nicola, Sesti, Giorgio, Frittitta, Lucia, Marchetti, Piero, Doria, Alessandro, and Trischitta, Vincenzo

Published
2013

30. The TRIB3 Q84R Polymorphism and Risk of Early-Onset Type 2 Diabetes

Author

Prudente, Sabrina, Scarpelli, Daniela, Chandalia, Manisha, Zhang, Yuan-Yuan, Morini, Eleonora, Del Guerra, Silvia, Perticone, Francesco, Li, Rong, Powers, Christine, Andreozzi, Francesco, Marchetti, Piero, Dallapiccola, Bruno, Abate, Nicola, Doria, Alessandro, Sesti, Giorgio, and Trischitta, Vincenzo

Published
2009

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