Search

Study design:Retrospective analysis of research data collected over >18 years at our center.Objectives:Examine results of repeated semen retrievals in men with spinal cord injury (SCI) who were initially found to be azoospermic.Setting:Major university medical center.Methods:Three different groups were analyzed in this study. Group 1 (n=15) consisted of patients who were found to be azoospermic after the first ejaculation obtained by penile vibratory stimulation (PVS) and who had subsequent ejaculates obtained by PVS. Group 2 (n=8) consisted of patients who were found to be azoospermic after the first ejaculation obtained by PVS and who had subsequent ejaculates obtained by electroejaculation (EEJ). Group 3 (n=18) consisted of patients who were found to be azoospermic after the first ejaculation obtained by EEJ and who had subsequent ejaculates obtained by EEJ.Results:In group 1 (PVS-PVS), the second ejaculate contained sperm in none of the 15 patients. In group 2 (PVS-EEJ), the second ejaculate contained sperm in three of eight patients. In group 3 (EEJ-EEJ), the second EEJ resulted in semen with sperm in 6 of 18 patients. In the 388 study subjects, the overall prevalence of azoospermia was 7.0%.Conclusion:In a study of a large group of subjects with SCI, the vast majority had normal sperm concentrations. In the minority who were azoospermic on their first ejaculate, and who were past the acute phase of injury, obtaining a second ejaculate by EEJ versus PVS may be a reasonable step before proceeding to surgical sperm retrieval. [ABSTRACT FROM AUTHOR]

STUDY DESIGN:: Retrospective chart review. OBJECTIVE:: To identify factors in addition to level of injury (LOI) that may predict ejaculation by penile vibratory stimulation (PVS) in spinal cord injured males. SETTING:: Major urban medical school and teaching hospital. MATERIALS AND METHODS:: Presence of a bulbocavernosus response (BCR) and a hip flexor response (HR) before PVS (n=123 patients), and somatic responses during PVS (n=204 trials performed on a subset of 44 patients) were evaluated for their frequency of occurrence on trials with and without ejaculation. RESULTS:: Overall ejaculation success rates for cervical, T1–T6, and T7–T12 LOI were 71%, 73%, and 35%, respectively. Eighty per cent of patients who were positive for both BCR and HR ejaculated with PVS, while only 8% of patients who were negative for both BCR and HR ejaculated with PVS. For cervical injuries, BCR and HR were no more predictive of ejaculation by PVS than LOI alone. T1–T6 patients were more likely to ejaculate when at least one reflex was present. T7–T12 patients with no BCR were unlikely to ejaculate by PVS. Except for abdominal contractions, somatic responses were not present in the majority of PVS trials. When they were present, however, they occurred in a high percentage of ejaculation trials: withdrawal response (hip flexion, knee flexion and thigh adduction) (90%), piloerection (84%), extremity spasms (83%), thigh abduction (80%), and thigh adduction (72%). CONCLUSION:: We recommend that patients with cervical injuries initially undergo PVS. Patients with T1–T6 LOI with at least one reflex present, and patients with T7–T12 LOI with both reflexes, or only BCR present, may undergo PVS. Certain somatic/autonomic responses, when seen, may help in deciding whether to continue with a given trial, or give a repeat trial, of PVS. SPONSORSHIP:: The Miami Project to Cure Paralysis and the State of Florida Specific Appropriations.Spinal Cord... [ABSTRACT FROM AUTHOR]

Purpose: Recent evidence suggests that the seminal plasma of spinal cord injured men contributes to their distinctive semen profile of normal sperm concentration but low sperm motility and viability. This finding indicates that sperm in these men may be normal before exposure to the seminal and prostatic fluids. To investigate this question we compared vas aspirated to ejaculated sperm in 12 men with spinal cord injury and 14 healthy, age matched controls., Materials and Methods: Ejaculate was collected by penile vibratory stimulation or electroejaculation in spinal cord injured men and by masturbation in controls. Sperm was aspirated via microsurgery from 1 hemisectioned vas deferens in spinal cord injured men and during routine elective vasectomy in controls. Ejaculated and aspirated specimens were compared., Results: In men with spinal cord injury mean vas aspirated sperm motility and viability plus or minus standard error of mean were significantly higher than mean ejaculated sperm motility and viability (54.4% +/- 5.0% and 74.1% +/- 5.3% versus 14.1% +/- 2.6% and 26.1% +/- 4.9%, respectively). In controls mean vas aspirated sperm motility and viability were not significantly different from mean ejaculated sperm motility and viability (77.5% +/- 5.2% and 88.9% +/- 2.5% versus 74.3% +/- 5.2% and 85.0% +/- 3.5%, respectively)., Conclusions: In spinal cord injured men sperm motility and viability were significantly higher before contact with seminal fluids. Although aspirated sperm from men with spinal cord injury generally had lower motility and viability than that of controls, implying that epididymal or testicular factors may also have a part, the greatest decrease was observed in the ejaculate. Further study of infertility in these men should focus on prostatic and seminal vesicle factors.

The interesting condition of brown-colored semen has often been observed during assisted ejaculation of men with spinal cord injury (SCI). This condition has not been reported in the literature, and its cause is unknown. To investigate this condition, the present study examined the incidence and quality of brown semen and its relationship to level of SCI, time since SCI, number of successive ejaculations, ejaculation frequency, and ejaculation method in a total of 664 semen specimens from 162 SCI men. In addition, a microscopic evaluation was performed on brown semen specimens from SCI men, not-brown specimens from SCI men, and normally colored specimens from normal men. The results showed that 27% of SCI subjects had brown semen on at least one ejaculation. There was no difference between men producing and men not producing brown semen in age, level of injury, or years postinjury. The duration of an ejaculation, number of successive ejaculations, and frequency of ejaculation were not associated with occurrence of brown semen. Sperm concentration and sperm motility were not significantly different in brown and not-brown specimens. Specimens from subjects who produced brown semen had similar pH but lower volume than specimens from subjects who did not produce brown semen. Brown semen had a thin consistency more often than not-brown semen. Brown specimens contained intact red blood cells (RBCs) and/or heme pigment more often than not-brown specimens; however, one half and one third of the specimens, respectively, contained neither RBCs nor heme pigment. The cause of brown semen is unknown but may relate to seminal-vesicle dysfunction.

Purpose: Recent investigations have indicated that factors within the seminal plasma may contribute to the condition of low sperm motility in men with spinal cord injury. To determine whether the prostate gland functions normally in these men we chose prostate specific antigen (PSA) as a marker of prostatic function, and compared serum and semen concentrations in spinal cord injured and healthy noninjured men., Materials and Methods: The study included 21 spinal cord injured men (mean age 33.3+/-1.2 years) and 22 noninjured normal men (mean age 30.3+/-1.5 years). Blood was obtained from subjects following at least 24 hours of abstinence from ejaculation and serum PSA was determined by modified enzyme immunoassay. Antegrade ejaculates from all subjects were frozen to -80 C, exactly 15 minutes after collection. Seminal plasma PSA was determined using Hybritech Tandem MP assay., Results: Mean serum PSA concentration was 1.20+/-0.19 ng./ml. in spinal cord injured and 0.69+/-0.07 ng./ml. in noninjured men (p<0.02). Mean seminal plasma PSA concentration was 0.59+/-0.11 mg./ml. in spinal cord injured and 1.29+/-0.15 mg./ml. in noninjured men (p<0.001)., Conclusions: Our findings of elevated serum and decreased seminal plasma PSA concentrations indicate that prostatic secretory dysfunction is present in men with spinal cord injury.

Objective: To determine if semen quality of men with spinal cord injury (SCI) undergoes a progressive decline as a function of years postinjury., Design: A retrospective analysis of cross-sectional data., Setting: University-based research center., Subjects: Semen quality was examined in 638 specimens from 125 men with SCI., Intervention: Penile vibratory stimulation, electroejaculation, and masturbation were used as semen retrieval methods. Routine semen analysis was performed to evaluate semen quality., Main Outcome Measures: Sperm concentration, total sperm count, and percent sperm motility were examined at 2-year intervals from men whose injuries had occurred 6 weeks to 26 years earlier., Results: No difference in any semen parameter was found as a function of time postinjury., Conclusions: Semen quality in men with SCI does not progressively decline after the SCI. Men with SCI who are considering biologic fatherhood should be advised that the number of years after injury need not be a determinant in deciding when to start a family.

Purpose: We evaluated ejaculatory response and semen quality in 653 trials of penile vibratory stimulation in 211 men with spinal cord injury, and compared results with low versus high amplitude vibratory stimulation., Materials and Methods: Low and/or high amplitude penile vibratory stimulation was performed 1 to 27 times in each patient, and antegrade and retrograde specimens of those who ejaculated were analyzed., Results: Significantly more patients ejaculated using high (54.5%) versus low (39.9%) amplitude stimulation. Using either amplitude the ejaculatory success rate was highest in men with injuries at C3 to C7, followed by T1 to T5, T6 to T10 and T11 to L3. While high amplitude stimulation increased the ejaculatory success rate in each group, the highest rate occurred in men with injuries at C3 to C7 (65.6%). Ejaculation was reliable, since most men who ejaculated did so during 100% of the trials and within 2 minutes of stimulation onset. Symptoms of autonomic dysreflexia were safely managed with nifedipine. All patients who ejaculated produced antegrade specimens. With the exception of ejaculate volume, which was significantly higher with high versus low amplitude stimulation, semen parameters were similar using both vibrator amplitudes., Conclusions: Ejaculatory success is better while semen quality is similar using high versus low amplitude penile vibratory stimulation in men with spinal cord injury. This method may be considered first line treatment for anejaculation in men with spinal cord injury due to its safety, relative effectiveness, and relatively low investment of time and money.