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22. Usefulness of the SYNTAX Score II to Predict In-Hospital and Long-Term Mortality in ST-Segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention.

Author

Kocas, Betul Balaban, Cetinkal, Gokhan, Kocas, Cuneyt, Arslan, Sukru, Abaci, Okay, Dalgic, Yalcin, Ser, Ozgur Selim, Batit, Servet, Yildiz, Ahmet, and Dogan, Sait Mesut

Subjects
MYOCARDIAL infarction diagnosis, PERCUTANEOUS coronary intervention, MORTALITY, PROGNOSTIC tests, ACCURACY
Abstract

Objectives: The prognostic significance of SYNTAX Score II (SS-II) is well-known in patients with chronic coronary syndromes. However, its predictive ability for mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (p-PCI) remains unclear. Therefore, we aimed to investigate the prognostic accuracy of SS-II in STEMI patients who underwent p-PCI. Methods: A total of 743 STEMI patients treated with p-PCI were retrospectively analyzed. Study population was divided into three groups according to SS-II and defined as SS-IILOW ≤22.5 (n=245), 22.5 31 (n=255). Inhospital and long-term mortality at long-term follow-up were defined as clinical endpoints of the study. Results: The incidence of in-hospital (15% vs. 0.4% vs. 0.8%, p<0.001) and all-cause mortality (32.2% vs. 6.6% vs. 2.9%, p<0.001) were significantly higher in SS-IIHIGH group compared with the other two groups. In addition, Kaplan--Meier analysis showed statistically significantly increased incidence of death in SS-II > 31 group (P [log-rank] <0.001). SS-II >31 was defined as an independent predictor of all-cause mortality (hazard ratio 5.22 95% confidence interval 2.11--12.87 p<0.001). Area under the curve values derived from ROC analysis to evaluate the predictive accuracy of SS-II, anatomical and clinical SS, modified ACEF score, and Global Registry of Acute Coronary Events risk scores for all-cause mortality were 0.82, 0.71, 0.81, 0.82, and 0.82, respectively (p<0.001). Conclusion: SS-II has an increased predictive ability for in-hospital and long-term mortality in STEMI patients undergoing p-PCI. [ABSTRACT FROM AUTHOR]

Published
2022
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24. Long-Term Follow-Up of Patients With Isolated Side Branch Coronary Artery Disease.

Author

Arslan, Sukru, Yildiz, Ahmet, Abaci, Okay, Jafarov, Urfan, Batit, Servet, Kilicarslan, Onur, Yumuk, Tugay, Dogan, Omer, Kocas, Cuneyt, and Bostan, Cem

Subjects
CEREBROVASCULAR disease risk factors, CARDIOVASCULAR diseases risk factors, GLYCOSYLATED hemoglobin, AGE distribution, MYOCARDIAL ischemia, ANGINA pectoris, RISK assessment, CORONARY angiography, NEUTROPHILS, CORONARY artery disease, DESCRIPTIVE statistics, DISEASE risk factors, DISEASE complications
Abstract

The data with respect to stable coronary artery disease (SCAD) are mainly confined to main vessel disease. However, there is a lack of information and long-term outcomes regarding isolated side branch disease. This study aimed to evaluate long-term major adverse cardiac and cerebrovascular events (MACCEs) in patients with isolated side branch coronary artery disease (CAD). A total of 437 patients with isolated side branch SCAD were included. After a median follow-up of 38 months, the overall MACCE and all-cause mortality rates were 14.6% and 5.9%, respectively. Among angiographic features, 68.2% of patients had diagonal artery and 82.2% had ostial lesions. In 28.8% of patients, the vessel diameter was ≥2.75 mm. According to the American College of Cardiology lesion classification, 84.2% of patients had either class B or C lesions. Age, ostial lesions, glycated hemoglobin A1c, and neutrophil levels were independent predictors of MACCE. On the other hand, side branch location, vessel diameter, and lesion complexity did not affect outcomes. Clinical risk factors seem to have a greater impact on MACCE rather than lesion morphology. Therefore, the treatment of clinical risk factors is of paramount importance in these patients. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Effect of chronic toluene exposure on heart rhythm parameters

Author

Arslan, Şűkrű, primary, Uzunhasan, Isil, additional, Kocas, Betul Balaban, additional, Cetinkal, Gokhan, additional, Arslan, Şeyma, additional, Kocas, Cuneyt, additional, Abaci, Okay, additional, Yildiz, Mustafa, additional, Celiker, Cengiz, additional, and Turkoglu, Cengizhan, additional

Published
2018
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32. Long-Term Mortality of Nonvalvular Atrial Fibrillation

Author

BOSTAN, Cem, ABACI, Okay, KOÇAŞ, Cüneyt, COŞKUN, Uğur, YILDIZ, Ahmet, SARI, Mustafa, and YİĞİT, Zerrin

Subjects
Kapak dışı atriyal fibrilasyon,mortalite, Medicine, Nonvalvular atrial fibrillation,mortality, Tıp
Abstract

Giriş:Kapak dışı atriyal fibrilasyonu (AF) olanhastalarda uzun dönemde gerçekleşen tüm sebeplere bağlı ve kardiyovaskülernedenlere bağlı mortaliteyi belirlemeyi amaçladık. Hastalarve Yöntem: 1995 ile 2010 yıllarıarasında kliniğimize başvuran ve kapak dışı AF tanısı konan 352 hasta (153erkek, 199 kadın; ort. yaş 62; dağılım 34-82) geriye dönük olarak incelendi.Takip süresi 72-176 ay arasında değişmekteydi (ort. 110 ay).Bulgular:Atriyal fibrilasyon etkeni veya ilişkili durumuolarak hipertansiyon (%51.1), koroner kalp hastalığı (%29.9), kalp yetersizliği(%48.8), diabetes mellitus (%11.9), pulmoner hipertansiyon (%9.9) saptandı.İzlem sırasında 72 hastanın (%21) öldüğü belirlendi. Ölümler 30 hastada (%41.7)kardiyovasküler nedenli, 20 hastada (%27.8) inme kaynaklı, altı hastada (%8.3)ani ölüm idi; 16 hastada (%22.2) ölümler diğer nedenlere (malignite, kaza,infeksiyon vb.) bağlandı.Sonuç: Kapak dışı AF’li hastalarda uzun dönemde ana ölüm nedenininkardiyovasküler kaynaklı olduğu görüldü.&nbsp, Introduction:This study sought to determine long-term all-cause mortality and cardiovascularmortality in patients with nonvalvular atrial fibrillation (AF). Patientsand Methods: The study included 352 patients (153 males,199 females; mean age 62 years; range 34 to 82 years) who presented to ourclinic between 1995 and 2010 and were diagnosed with nonvalvular AF. Thefollow-up ranged from 72 to 176 months (mean 110 months).Results: Thecauses or associated conditions of AF were hypertension (51.1%), coronary heartdisease (29.9%), heart failure (48.8%), diabetes mellitus (11.9%), andpulmonary hypertension (9.9%). Seventy-two patients (21%) died during thefollow-up period. Cardiovascular death was noted in 30 patients (41.7%). Suddendeath was seen in six patients (8.3%). Death from stroke occurred in 20patients (27.8%), and 16 patients (22.2%) died of other causes (malignancies,accidents, infectious causes, etc.).Conclusion:The major cause of death was of cardiovascularorigin in patients with nonvalvular AF.

Published
2015

33. Kararlı Anjina Pektorisli Hastalarda Trimetazidin Tedavisinin Lipoprotein İlişkili Fosfolipaz A2 Düzeyi ve Egzersiz Parametreleri Üzerine Etkisi

Author

BOSTAN, Cem, KARACOP, Erdem, KOÇAŞ, Cüneyt, ABACI, Okay, KAYA, Ayşem, and YİĞİT, Zerrin

Subjects
Anjina,kararlı,trimetazidin,lipoprotein ilişkili fosfolipaz A2, Angina,stable,trimetazidine,lipoprotein-associated phospholipase A2, Medicine, lipids (amino acids, peptides, and proteins), Tıp
Abstract

Giriş:Kararlı anjina pektorisli hastalarda, metabolik biranti-iskemik ilaç olan trimetazidin (TMZ) tedavisinin risk faktörü olarak kabuledilen lipoprotein ilişkili fosfolipaz A2 (Lp-PLA2) düzeyi ve egzersiz parametreleri üzerine etkisiaraştırıldı.Hastalarve Yöntem: Egzersiz testi pozitif olankararlı anjina pektorisli 30 hasta (ort. yaş 62.1 ± 8.3; dağılım 47-77)çalışmaya alındı. Trimetazidin tedavisi öncesinde Lp-PLA2 düzeyleri ölçüldü; 12 haftalık TMZ tedavisi sonrasındaegzersiz testi ve Lp-PLA2 ölçümleri tekrarlandı.Bulgular:Trimetazidin tedavisi sonrasında Lp-PLA2 düzeyleri anlamlı düşüş (p= 0.006), egzersiz iş yüküanlamlı artış (p= 0.048) gösterdi.Sonuç: Trimetazidin tedavisi kardiyakmetabolizma değişikliği sonucu serbest oksijen radikal oluşumunu veenflamasyonu azaltarak Lp-PLA2düzeyinde anlamlı düşüş sağlamaktadır. Bu bulgu, egzersiz parametrelerindekiiyileşmelerle birlikte, TMZ tedavisinin kararlı anjina pektorisli hastalarınprognozunda olumlu katkı sağlayabileceğini göstermektedir., Introduction:We examined the clinical effectiveness of trimetazidine(TMZ), a metabolic anti-ischemic agent, on lipoprotein-associated phospholipaseA2 (Lp-PLA2) levels, which is considered a risk factorfor cardiovascular events, and on exercise parameters in patients with stableangina pectoris (SAP).Patientsand Methods: The study included 30 patients (mean age 62.1± 8.3 years; range 47 to 77 years) with SAP and a positive exercise testresult. Serum Lp-PLA2 levels were measured at baseline. Exercisetesting and Lp-PLA2 measurements were repeated after at least 12weeks of TMZ treatment.Results: AfterTMZ treatment, Lp-PLA2 levels decreased significantly (p= 0.006),and workload increased significantly (p= 0.048).Conclusion:Trimetazidine treatment reduces serum Lp-PLA2levels via shifting cardiac metabolism, resulting in decreased production offree oxygen radicals and inflammation. This finding, together with improvementsin exercise test parameters, suggests that TMZ may have a beneficial effect onthe prognosis of patients with SAP.

Published
2015

36. The value of the Clinical SYNTAX Score in predicting long-term prognosis in patients with ST-segment elevation myocardial infarction who have undergone primary percutaneous coronary intervention

Author

Cetinkal, Gokhan, primary, Dogan, Sait M., additional, Kocas, Cuneyt, additional, Abaci, Okay, additional, Arslan, Sukru, additional, Balaban Kocas, Betul, additional, Karaca, Osman S., additional, Buyuk, Ahmet, additional, Firidin, Nur, additional, and Yildiz, Ahmet, additional

Published
2016
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38. Nitric Oxide Response to Acute Exercise in Patients with Coronary Artery Disease

Author

KAYA, Ayşem, ARAT-ÖZKAN, Alev, KÖNER, Özge, BALCI, Huriye, ABACI, Okay, GÜRMEN, Tevfik, KÜÇÜKOĞLU, Serdar, and YİĞİT, Zerrin

Abstract

Nitric oxide (NO) has been identified as a vasodilatory substance released from the endothelium which decreases in the presence of atherosclerosis. This study aimed to evaluate the systemic NO response to acute exercise in untrained diabetic and nondiabetic patients with atherosclerotic coronary artery disease (CAD). This is a prospective, clinical study consisting of three groups. Group A (n=50) consisted of nondiabetic CAD patients,group B (n=20) consisting of diabetic, CAD patients and group C (n=20) of healthy controls. All patients underwent a standard symptom limited treadmill exercise test according to the modified Bruce protocol after 24 hours low nitrite/ nitrate diet. End products of nitric oxide metabolism (NOx) were determined as the half life of NO is very short. Basal serum NOx levels of both diabetics (24±8.4μmol/L,p

Published
2010

39. The role of media on statin adherence

Author

Kocas, Cuneyt, primary, Abaci, Okay, additional, Kocas, Betul Balaban, additional, Cetinkal, Gokhan, additional, Arslan, Sukru, additional, Yildiz, Ahmet, additional, and Ersanli, Murat, additional

Published
2015
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40. Contrast-Induced Acute Kidney Injury Is Associated With Long-Term Adverse Events in Patients With Acute Coronary syndrome.

Author

Uzunhasan, Isil, Yildiz, Ahmet, Arslan, Sukru, Abaci, Okay, Kocas, Cuneyt, Kocas, Betul Balaban, Cetinkal, Gokhan, Dalgic, Yalcin, Karaca, Osman Sukru, and Dogan, Sait Mesut

Subjects
ACUTE kidney failure, LONGITUDINAL method, TIME, ACUTE coronary syndrome
Abstract

Contrast-induced acute kidney injury (CI-AKI) is associated with increased mortality, morbidity, and prolonged hospitalization. Patients with acute coronary syndrome (ACS) have a 3-fold higher risk of developing CI-AKI. The aim of our study was to evaluate the predictors of CI-AKI and long-term prognosis in patients with ACS who developed CI-AKI (1083 patients were enrolled). Contrast-induced acute kidney injury was defined as an increase of ≥0.5 mg/dL and/or an increase of ≥25% of pre-percutaneous coronary intervention (PCI) to post-PCI serum creatinine levels within 48 to 72 hours after the procedure. Primary end point was defined as all-cause mortality, myocardial infarction, and cerebrovascular event at long-term follow-up (36 ± 12 months). Contrast-induced acute kidney injury occurred in 178 (16.4%) of the 1083 patients. The primary end points were significantly high in patients with ACS who developed CI-AKI (P < .001). The occurrence of CI-AKI was identified as an independent predictor of primary end point. Risk of CI-AKI development was more frequently seen in patients with ACS. Also, patients who developed CI-AKI have worse prognosis at long-term follow-up. Additional preventive treatment strategies need to be developed in this group of patients. [ABSTRACT FROM AUTHOR]

Published
2017
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49. Relationship Between Increased Serum Resistin Level and Severity of Coronary Artery Disease

Author

Sinan, Umit Yasar, primary, Canbolat, Ismail Polat, additional, Baydar, Onur, additional, Oktay, Veysel, additional, Imre, Gurkan, additional, Kocas, Cuneyt, additional, Abaci, Okay, additional, Coskun, Ugur, additional, Bostan, Cem, additional, Kilickesmez, Kadriye Orta, additional, Yildiz, Ahmet, additional, Kaya, Aysem, additional, Gurmen, Tevfik, additional, and Yigit, Zerrin, additional

Published
2013
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