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2. Changes in activity of hepatic xenobiotic-metabolizing enzymes of tiger puffer (Takifugu rubripes) exposed to paralytic shellfish poisoning toxins.

Author

Jeon JK, Lee JS, Shim WJ, Aarakawa O, Takatani T, Honda S, and Noguchi T

Subjects
Animals, Cytochrome P-450 CYP1A1 metabolism, Cytochrome-B(5) Reductase metabolism, Diet veterinary, Dose-Response Relationship, Drug, NADPH-Ferrihemoprotein Reductase metabolism, Reference Values, Takifugu growth & development, Time Factors, Weight Gain drug effects, Liver drug effects, Liver enzymology, Marine Toxins toxicity, Shellfish toxicity, Takifugu metabolism, Xenobiotics metabolism
Abstract

Attempts were made to examine the effect of paralytic shellfish poisoning toxins (PSP) on hepatic xenobiotic-metabolizing enzymes (XMEs) of tiger puffer (Takifugu rubripes). Two groups of nontoxic tiger fish were analyzed, and one group was fed with a PSP-containing diet (PSP group), and another with a PSP-free diet (control group). After 60 days of feeding, they were compared to each other mainly in terms of the activity of XMEs. Both groups did not differ from each other significantly in body weight gain, hepatosomatic index, and condition factor Hepatic level of cytochrome P450 was lower in PSP group than control group. NADPH-cytochrome P450 reductase, NADH-cytochrome b5 reductase, and ethoxyresorufin-O-deethylase (EROD) exhibited a reduced activity in PSP group than control group. Statistical analysis found that the activity or concentration of those enzymes correlated with the hepatic level of PSR with r2=0.497-0.611.

Published
2008

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