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233 results on '"Aakalu, Vinay K."'

11. A review of surgical management of progressive myogenic ptosis.

Author

Park, Royce B., Akella, Sruti S., and Aakalu, Vinay K.

Subjects
BLEPHAROPLASTY, MYASTHENIA gravis, SURGICAL complications, MUSCULAR dystrophy, OPERATIVE surgery, AUTHORSHIP
Abstract

Surgical correction of myogenic ptosis is a sophisticated endeavor, as the disease is progressive and the post-operative course is prone to significant complications. We sought to review the literature for repair techniques in different types of myogenic ptosis. A PubMed/MEDLINE literature search of publications pertaining to surgical outcomes of progressive myogenic ptosis repair was performed. Studies included were original retrospective studies with a minimum of four patients. A total of 27 articles were identified and divided by etiology of myogenic ptosis; either chronic progressive external ophthalmoplegia (CPEO), oculopharyngeal muscular dystrophy (OPMD), myasthenia gravis (MG), or mixed. Surgical techniques predominantly involved levator advancement, levator resection, frontalis sling, blepharoplasty, and Fasanella-Servat. Success rates ranged from 60.5% to 100%. Significant postoperative complications included ptosis recurrence, under-correction, over-correction, keratopathy, lagophthalmos, sling exposure, and sling infection. Like surgical repair for other forms of ptosis, correction of progressive myogenic ptosis is guided by levator excursion. However, myogenic ptosis is especially challenging as it is characterized by worsening ptosis and the loss of protective corneal mechanisms. The goals of care with myogenic ptosis involves repairing ptosis just sufficiently to alleviate visual obstruction while avoiding adverse post-operative complications. This intentional under-correction subsequently increases susceptibility for ptosis recurrence. Myogenic ptosis repair therefore requires delicate balancing between function, sustained repair, and corneal protection. [ABSTRACT FROM AUTHOR]

Published
2023
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12. Orbital Radiation for Thyroid Eye Disease

Author

Sobel, Rachel K., primary, Aakalu, Vinay K., additional, Vagefi, M. Reza, additional, Foster, Jill A., additional, Tao, Jeremiah P., additional, Freitag, Suzanne K., additional, Wladis, Edward J., additional, McCulley, Timothy J., additional, and Yen, Michael T., additional

Published
2022
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14. Adjustable Sutures in the Treatment of Strabismus

Author

Heidary, Gena, primary, Aakalu, Vinay K., additional, Binenbaum, Gil, additional, Chang, Melinda Y., additional, Morrison, David G., additional, VanderVeen, Deborah K., additional, Lambert, Scott R., additional, Trivedi, Rupal H., additional, Galvin, Jennifer A., additional, and Pineles, Stacy L., additional

Published
2022
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15. Adjustable Sutures in the Treatment of Strabismus: A Report by the American Academy of Ophthalmology

Author

Heidary, Gena, Aakalu, Vinay K., Binenbaum, Gil, Chang, Melinda Y., Morrison, David G., VanderVeen, Deborah K., Lambert, Scott R., Trivedi, Rupal H., Galvin, Jennifer A., and Pineles, Stacy L.

Subjects
Adult, Vision, Binocular, Technology Assessment, Biomedical, Sutures, Suture Techniques, Academies and Institutes, Ophthalmologic Surgical Procedures, Article, United States, Strabismus, Ophthalmology, Oculomotor Muscles, Humans, Child
Abstract

PURPOSE: To review the scientific literature that evaluates the effectiveness of adjustable sutures in the management of strabismus for adult and pediatric patients. METHODS: Literature searches were performed in the PubMed database through April 2021 with no date limitations and were restricted to publications in English. The searches identified 551 relevant citations, of which 55 were reviewed in full text. Of these, 17 articles met the inclusion criteria and were assigned a level of evidence rating by the panel methodologist. The search included all randomized controlled studies regardless of study size and cohort studies of 100 or more patients comparing the adjustable versus nonadjustable suture technique, with a focus on motor alignment outcomes or reoperation rates. RESULTS: The literature search yielded no level I studies. Of the 17 articles that met the inclusion criteria, 11 were rated level II and 6 were rated level III. Among the 12 studies that focused on motor alignment outcomes, 4 small randomized clinical trials (RCTs) did not find a statistically significant difference between groups, although they were powered to detect only very large differences. Seven of 8 nonrandomized studies found a statistically significant difference in motor alignment success in favor of the adjustable suture technique, both overall and in certain subgroups of patients. Successful motor alignment was seen in both exotropia (in 3 studies that were not limited to children) and esotropia (in 1 study of adults and 2 of children). The majority of included studies that reported on reoperation rates found the rates to be lower in patients who underwent strabismus surgery with adjustable sutures, but this finding was not uniformly demonstrated. CONCLUSIONS: Although there are no level I studies evaluating the effectiveness of adjustable sutures for strabismus surgery, the majority of nonrandomized studies that met the inclusion criteria for this assessment reported an advantage of the adjustable suture technique over the nonadjustable technique with respect to motor alignment outcomes. This finding was not uniformly demonstrated among all studies reviewed and warrants further investigation in the development and analysis of adjustable suture techniques.

Published
2021

17. Interventions for Indirect Traumatic Optic Neuropathy

Author

Wladis, Edward J., primary, Aakalu, Vinay K., additional, Sobel, Rachel K., additional, McCulley, Timothy J., additional, Foster, Jill A., additional, Tao, Jeremiah P., additional, Freitag, Suzanne K., additional, and Yen, Michael T., additional

Published
2021
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21. Homeopathic Agents or Vitamins in Reducing Ecchymosis after Oculofacial Surgery: A Report by the American Academy of Ophthalmology.

Author

Tao, Jeremiah P., Aakalu, Vinay K., Freitag, Suzanne K., Sobel, Rachel K., Foster, Jill A., Wladis, Edward J., McCulley, Timothy J., and Yen, Michael T.

Subjects
*HOMEOPATHIC agents, *ECCHYMOSIS, *VITAMIN K, *REDUCING agents, *DYE lasers
Abstract

To review the published literature to determine the efficacy and safety of homeopathic agents or vitamins in reducing ecchymosis after oculofacial surgery or laser surgery. A literature search was conducted in the PubMed database initially in December 2019 and updated in March 2020 to identify all studies in the English language literature on the use of homeopathic agents or vitamins in oculofacial procedures, including laser surgery. The search yielded 124 citations, and 11 articles met all inclusion criteria for this assessment. A panel methodologist then assigned a level of evidence rating for each study. Eleven studies met inclusion criteria; 9 were rated level I, and 2 were rated level III. The agents studied in the articles identified included oral or topical Arnica montana (AM), oral Melilotus extract, topical vitamin K oxide, and topical AM combined with Rhododendron tomentosum. Metrics to describe ecchymosis varied. In 7 controlled studies, perioperative AM provided no or negligible benefit versus placebo. In 2 studies, vitamin K cream was equivalent to placebo. One study of oral Melilotus extract had less ecchymosis compared with controls in paranasal and eyelid ecchymosis at postoperative day (POD) 7, but not at PODs 1 and 4. A lone cohort study of combined topical AM and R. tomentosum lacked objective metrics and adequate controls. No serious side effects from administration of homeopathic agents or vitamins were identified. The current literature does not support the use of AM, vitamin K oxide, R. tomentosum, or Melilotus extract for reducing ecchymosis after oculofacial surgery or pulsed dye laser surgery. [ABSTRACT FROM AUTHOR]

Published
2022
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22. Electrothermal soft manipulator enabling safe transport and handling of thin cell/tissue sheets and bioelectronic devices

Author

Kim, Byoung Soo, primary, Kim, Min Ku, additional, Cho, Younghak, additional, Hamed, Eman E., additional, Gillette, Martha U., additional, Cha, Hyeongyun, additional, Miljkovic, Nenad, additional, Aakalu, Vinay K., additional, Kang, Kai, additional, Son, Kyung-No, additional, Schachtschneider, Kyle M., additional, Schook, Lawrence B., additional, Hu, Chenfei, additional, Popescu, Gabriel, additional, Park, Yeonsoo, additional, Ballance, William C., additional, Yu, Seunggun, additional, Im, Sung Gap, additional, Lee, Jonghwi, additional, Lee, Chi Hwan, additional, and Kong, Hyunjoon, additional

Published
2020
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26. Binocular Treatment of Amblyopia

Author

Pineles, Stacy L., primary, Aakalu, Vinay K., additional, Hutchinson, Amy K., additional, Galvin, Jennifer A., additional, Heidary, Gena, additional, Binenbaum, Gil, additional, VanderVeen, Deborah K., additional, and Lambert, Scott R., additional

Published
2020
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27. Reply

Author

Lambert, Scott R., primary, Vanderveen, Deborah K., additional, Aakalu, Vinay K., additional, and Kim, Stephen J., additional

Published
2020
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29. Intraocular Lens Implantation during Early Childhood

Author

Lambert, Scott R., primary, Aakalu, Vinay K., additional, Hutchinson, Amy K., additional, Pineles, Stacy L., additional, Galvin, Jennifer A., additional, Heidary, Gena, additional, Binenbaum, Gil, additional, and VanderVeen, Deborah K., additional

Published
2019
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30. Monocanalicular Stents in Eyelid Lacerations

Author

Wladis, Edward J., primary, Aakalu, Vinay K., additional, Tao, Jeremiah P., additional, Sobel, Rachel K., additional, Freitag, Suzanne K., additional, Foster, Jill A., additional, and Mawn, Louise A., additional

Published
2019
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40. 3D printing for low cost, rapid prototyping of eyelid crutches.

Author

Sun, Michael G., Rojdamrongratana, Duangmontree, Rosenblatt, Mark I., Aakalu, Vinay K., and Yu, Charles Q.

Subjects
RAPID prototyping, THREE-dimensional printing, EYELIDS, MUSCLE weakness, FACIAL muscles
Abstract

Blepharoptosis or ptosis is a common and potentially debilitating clinical problem. Long-term surgical treatment for ptosis caused by progressive myopathies can be challenging due to potential recurrence and complications associated with facial muscle weakness. When surgical treatment is no longer effective, an eyelid crutch can be used as an alternative intervention. This report demonstrates how 3D printing was used to rapidly design, prototype, and manufacture new custom-fit eyelid crutches at a low cost. [ABSTRACT FROM AUTHOR]

Published
2019
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42. Cerebrospinal Fluid Leak Presenting as Epiphora

Author

Jain, Sachin, primary, Patel, Rakesh M., additional, Hage, Ziad, additional, Lim, Janet, additional, Lee, Samuel, additional, Amin-Hanjani, Sepideh, additional, Setabutr, Pete, additional, and Aakalu, Vinay K., additional

Published
2016
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45. Re

Author

Epstein, Gil, primary, Aakalu, Vinay K., additional, and Putterman, Allen M., additional

Published
2015
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48. Staphylococcus aureus Infection of the Optic Nerve

Author

Osmanovic, Senad, primary, Al-Heeti, Omar M., additional, Lin, Amy Y., additional, Zivin, Sean P., additional, Justo, Julie Ann, additional, Mayer, Stockton M., additional, Aakalu, Vinay K., additional, Moss, Heather E., additional, and Patel, Mahesh C., additional

Published
2015
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50. Evaluation of Accessory Lacrimal Gland in Muller’s Muscle Conjunctival Resection Specimens for Precursor Cell Markers and Biological Markers of Dry Eye Disease.

Author

Ali, Marwan, Shah, Dhara, Pasha, Zeeshan, Jassim, Sarmad H., Jassim Jaboori, Assraa, Setabutr, Pete, and Aakalu, Vinay K.

Subjects
LACRIMAL apparatus, DRY eye syndromes, BIOLOGICAL tags, IMMUNOFLUORESCENCE, CONJUNCTIVA
Abstract

Purpose: The accessory lacrimal glands (ALGs) are an understudied component of the tear functional unit, even though they are important in the development of dry eye syndrome (DES). To advance our understanding of aging changes, regenerative potential, and histologic correlates to human characteristics, we investigated human ALG tissue from surgical samples to determine the presence or absence of progenitor cell markers and lacrimal epithelial markers and to correlate marker expression to relevant patient characteristics. Materials and Methods: ALG tissues obtained from Muller’s muscle conjunctival resection (MMCR) specimens were created using tissue microarrays (TMAs). Immunofluorescence staining of MMCR sections was performed using primary antibodies specific to cell protein markers. Cell marker localization in TMAs was then assessed by two blinded observers using a standardized scoring system. Patient characteristics including age, race, and status of ocular surface health were then compared against expression of stem cell markers. Results: Human ALG expressed a number of epithelial markers, and in particular, histatin-1 was well correlated with the expression of epithelial markers and was present in most acini. In addition, we noted the presence of precursor cell markers nestin, ABCG2, and CD90 in ALG tissue. There was a decrease in precursor cell marker expression with increasing age. Finally, we noted that a negative association was present between histatin-1 expression and DES. Conclusions: Thus, we report for the first time that human ALG tissues contain precursor marker-positive cells and that this marker expression may decrease with increasing age. Moreover, histatin-1 expression may be decreased in DES. Future studies will be performed to use these cell markers to isolate and culture lacrimal epithelial cells from heterogeneous tissues, determine the relevance of histatin-1 expression to DES, and isolate candidate precursor cells from ALG tissue. [ABSTRACT FROM PUBLISHER]

Published
2017
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