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416 results on '"ASSENMACHER, I."'

1. Design Support of Reaction and Compounding Extruders

Author

Schlüter, M., Stewering, J., Haberstroh, E., Assenmacher, I., Kuhlen, T., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Nagl, Manfred, editor, and Marquardt, Wolfgang, editor

Published
2008
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2. Multimedia and VR Support for Direct Communication of Designers

Author

Schüppen, A., Spaniol, O., Thißen, D., Assenmacher, I., Haberstroh, E., Kuhlen, T., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Nagl, Manfred, editor, and Marquardt, Wolfgang, editor

Published
2008
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8. Temporal cascade of plasma level surges in ACTH, corticosterone, and cytokines in endotoxin-challenged rats

Author

Givalois, L., Dornand, J., Mekaouche, M., Solier, M.D., Bristow, A.F., Ixart, G., Siaud, P., Assenmacher, I., and Barbanel, G.

Subjects
ACTH -- Physiological aspects, Blood plasma -- Research, Corticosterone -- Physiological aspects, Biological sciences
Abstract

Plasma analysis of conscious rats reveals that administration of lipopolysaccharide (LPS), an intra-arterial endotoxin, initiates adrenocorticotropic hormone (ACTH) and corticosterone (Cort) swelling, along with increased hormonal response. This infusion also increases the concentration of three cytokines. Delayed increase of cytokines concentrations in the plasma influences the hypothalamic pituitary-adrenocortical (HPA) activation.

Published
1994

16. Parallel caching for remote visualisation

Author

Ancel, A., Bruno Raffin, Assenmacher, I., Annemie van Hirtum, Yo Fujiso, Nozaki, K., PrograMming and scheduling design fOr Applications in Interactive Simulation (MOAIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), GIPSA - Group aeroacoustics, modeling and application (GIPSA-GAMA), Département Parole et Cognition (GIPSA-DPC), Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Stendhal - Grenoble 3-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS), Osaka University [Osaka], ANR-09-BLAN-0376,PetaFlow,Calculs intensifs, visualisation scientifique et transfert haut débit international pour des données d?échelle peta: application à l?écoulement dans les voies supérieure de l?Homme(2009), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Grenoble Images Parole Signal Automatique (GIPSA-lab), and Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Stendhal - Grenoble 3-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph], ComputingMilieux_MISCELLANEOUS, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience

Published
2013

30. Circadian Variations in the Amplitude of Corticotropin-Releasing Hormone 41 (CRH41) Episodic Release Measured In Vivo in Male Rats: Correlations with Diurnal Fluctuations in Hypothalamic and Median Eminence CRH41 Contents

Author

Ixart, I, Siaud, P., Barbanel, Gérard, Mekaouche, M., Givalois, Laurent, Assenmacher, I., Ixart, G., Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Evening, Corticotropin-Releasing Hormone, Physiology, Hypothalamus, Fluorescent Antibody Technique, Adrenocorticotropic hormone, Rats, Sprague-Dawley, 03 medical and health sciences, Corticotropin-releasing hormone, 0302 clinical medicine, Adrenocorticotropic Hormone, Physiology (medical), Internal medicine, medicine, Animals, Circadian rhythm, Chemistry, Median Eminence, Radioimmunoassay, Immunohistochemistry, Circadian Rhythm, Rats, 030104 developmental biology, Endocrinology, Median eminence, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030217 neurology & neurosurgery, Hormone
Abstract

The possible correlation between the circadian and episodic release of corticotropin-releasing hormone 41 (CRH41) in male rats was explored in a comparative study, including the measurement at 0700 hr and 1700 hr of (1) the quantitative parameters of the episodic release pattern of CRH41 into the push-pull-cannulated median eminence (ME); (2) CRH41 content measured by radioimmunoassay in the hypothalamus, and immunocytochemically in the ME; and (3) plasma adrenocorticotropic hormone (ACTH). The data showed that in early evening, the 3.4-fold rise in plasma ACTH coincided with a doubling of CRH41 content in the hypothalamus and in the ME, and of the CRH41 release from the perfused ME. The immunocytochemical data further indicated that the ME area labeled with CRH41 immunoreactivity, rather than the labeling intensity of CRH41-stained neurons, increased in the evening, which may point to an evening recruitment of additional CRH41-producing neurons as the origin of the evening increment in CRH41 and ACTH releases. Finally, the computerized analysis of the CRH41-releasing pattern with three different algorithms (Pulsar, Ultra, and the Santen and Bardin algorithm) showed for the first time that the evening rise in CRH41 output was associated with correlative increases of three parameters of the episodic pattern—peak amplitude (+ 55% to + 80%), peak duration (+ 20%), and mean absolute peak values (+ 73%)-while the pulse frequency remained at the baseline level of 3 cycles · hr-1. The data suggest the occurrence of a connection between the circadian pacemaker and the machinery generating the episodic release of CRH41.

Published
1993

45. PetaFlow-An example of communication and computational technologies with social impact

Author

Ancel, A., Assenmacher, I., Baba, K., Cisonni, Julien, Fujiso, Y., Goncalves, P., Imbert, M., Koyamada, K., Neyron, P., Nozaki, K., Ohsaki, H., Orgerie, A., Pelorson, X., Raffin, B., Sakamoto, N., Sakane, E., Shimojo, S., Hirtum, A., Wada, S., Ancel, A., Assenmacher, I., Baba, K., Cisonni, Julien, Fujiso, Y., Goncalves, P., Imbert, M., Koyamada, K., Neyron, P., Nozaki, K., Ohsaki, H., Orgerie, A., Pelorson, X., Raffin, B., Sakamoto, N., Sakane, E., Shimojo, S., Hirtum, A., and Wada, S.

Abstract

The Petaflow project aims to contribute to the use of high performance computational resources to the benefit of society. To this goal the emergence of adequate information and communication technologies with respect to high performance computing-networking-visualisation and their mutual awareness is required. The developed technology and algorithms are presented and applied to a real peta-scale data intensive scientific problem with social importance, i.e. human upper airflow modeling.

Published
2013

46. Serotoninergic and suprachiasmatic nucleus involvement in the corticotropic response to systemic endotoxin challenge in rats

Author

Givalois, Laurent, Givalois, G, Becq, H, Siaud, P, Ixart, G, Assenmacher, I., Barbanel, Gérard, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)

Subjects
Lipopolysaccharides, Male, Serotonin, endocrine system, Indoles, Fenclonine, Hypothalamus, Rats, Rats, Sprague-Dawley, Kinetics, Adrenocorticotropic Hormone, Animals, Suprachiasmatic Nucleus, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Serotonin Antagonists, Corticosterone, hormones, hormone substitutes, and hormone antagonists, Interleukin-1
Abstract

International audience; We have investigated whether the serotonin system participates in the mechanisms underlying the corticotropic response in experimentally infected rats. Intra-arterial injection of lipopolysaccharide (LPS; 25 microg/kg b.w.) resulted in a slight but significant increase in serotonin (5-HT) metabolism, detectable 60 min after the stimulus and lasting more than 480 min. Adrenocorticotropin (ACTH) and corticosterone (CORT) responses in intact rats conformed to earlier reports, increasing as early as 30 min after LPS injection and reaching maximal concentrations in the circulation 60 min after the bacterial endotoxin injection. Plasma concentrations of interleukin-1beta (IL-1beta) increased only after 60 min, reaching maximal levels 120 min after LPS. Depletion of hypothalamic 5-HT (-93%) by pretreatment of the animals with para-chlorophenylalanine (p-CPA), resulted in a halved ACTH response to LPS, despite an overall unchanged secretory pattern. Neither CORT nor IL-1beta secretory patterns were affected in these rats pretreated with p-CPA. Complete bilateral electrochemical lesions of the suprachiasmatic nucleus (SCN), which is innervated by mesencephalic 5-HT, impaired the early phase of the ACTH (-75% at 30 min) and CORT (-40% at 30 min) responses but did not affect the later increases of the corticotropic and the plasma IL-1beta responses following the LPS injection. These results indicate that serotonin pathways and SCN are involved in the earlier mechanisms of corticotropic axis recruitment following systemic LPS endotoxemia.

Published
1999

47. PetaFlow -- An Example of Communication and Computational Technologies with Social Impact

Author

Ancel, A., primary, Assenmacher, I., additional, Baba, K., additional, Cisonni, J., additional, Fujiso, Y., additional, Goncalves, P., additional, Imbert, M., additional, Koyamada, K., additional, Neyron, P., additional, Nozaki, K., additional, Ohsaki, H., additional, Orgerie, A.C., additional, Pelorson, X., additional, Raffin, B., additional, Sakamoto, N., additional, Sakane, E., additional, Shimojo, S., additional, Van Hirtum, A., additional, and Wada, S., additional

Published
2013
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48. [The corticotropic axis response after subcutaneous endotoxin injection is not associated with the increase of plasma interleukin-1 beta]

Author

Givalois, Laurent, Givalois, G, Mekaouche, M, Malaval, F, Gaillet, G, Ixart, G, Szafarczyk, A, Assenmacher, I., Barbanel, Gérard, Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)

Subjects
Lipopolysaccharides, Male, Rats, Sprague-Dawley, Adrenocorticotropic Hormone, Dose-Response Relationship, Drug, Injections, Intra-Arterial, Injections, Subcutaneous, Animals, lipids (amino acids, peptides, and proteins), [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Corticosterone, Interleukin-1, Rats
Abstract

International audience; When injected through an intra-arterial (i. a.) cannula, LPS induced a rapid (15-30 min) and long-lasting (> 300 min) increase in plasma ACTH and corticosterone (CORT) levels. The duration of these responses depended on the LPS dose, and except for very small LPS doses, their amplitudes appeared independent of the dose of endotoxin. ACTH peaks (2,200 pg.ml-1) occurred between 30 and 120 min, whereas CORT always reached maximal levels at 120 min. Plasma Interleukin-1 beta (IL-1 beta) levels were always undetectable during the early phase of corticotropic stimulation, but increased strikingly 120 min after LPS injection. Increasing LPS doses, resulted in enhanced and prolonged IL-1 beta plasma circulating levels (up to 3.0 +/- 0.2 ng.ml-1). By contrast, no sub-cutaneous LPS dose used induced early increases in ACTH and CORT levels, whereas time-course of the hormonal response was evocative of the sustained phase of the corticotropic response to i. a. LPS, with both peaks occurring 120 min post-LPS. Increasing the s. c. LPS bolus 50-fold vs the i. a. dose did not affect the maximal amplitude of the ACTH response, whereas the amplitude of the CORT response, instead, appeared dependent on the LPS dose. On the other hand, even for the largest LPS doses, plasma IL-1 beta levels remained undetectable. Sub-cutaneous injection of LPS therefore appears as a new model for the study of the mechanisms of corticotropic responses to endotoxin without a direct involvement of bloodborne IL-1 beta.

Published
1995

49. A subpopulation of corticotropin-releasing hormone neurosecretory cells in the paraventricular nucleus of the hypothalamus also contain NADPH-diaphorase

Author

Givalois, Laurent, Siaud, I, Mekaouche, M, Ixart, I, Balmefrezol, M, Givalois, G, Barbanel, Gérard, Assenmacher, I., Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), and Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)

Subjects
Male, medicine.medical_specialty, endocrine system, Corticotropin-Releasing Hormone, Central nervous system, Population, Biology, Rats, Sprague-Dawley, 03 medical and health sciences, Corticotropin-releasing hormone, 0302 clinical medicine, Internal medicine, medicine, Animals, education, 030304 developmental biology, Injections, Intraventricular, NADPH dehydrogenase, 0303 health sciences, education.field_of_study, General Neuroscience, NADPH Dehydrogenase, Colocalization, Immunohistochemistry, Rats, Endocrinology, medicine.anatomical_structure, nervous system, Hypothalamus, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuron, Colchicine, Nucleus, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists, Paraventricular Hypothalamic Nucleus
Abstract

International audience; The coexistence of ND with CRH 41 was explored in the parvicellular neurons of the PVN, using dual histochemical and radioimmunocytochemical labelling with the light microscope, in rats treated with colchicine. Even though the ND staining was scarce, a clear colocalization was evidenced in the parvicellular part of the PVN. Under these conditions, the ratio of neurons expressing both markers, ND and CRH, amounted about 15% of the CRH-containing neuron population. This result provides a useful tool to study morphological plastic changes in the PVN in response to environmental variations.

Published
1994

50. Evidence for an age-dependent decrease in the immunoreactive prolactin-containing terminals of the median eminence of male rats

Author

Assenmacher I, Gérard Barbanel, Laurent Givalois, MJ Reymond, P Siaud, M. Balmefrezol, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Mécanismes moléculaires dans les démences neurodégénératives (MMDN), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École pratique des hautes études (EPHE), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)

Subjects
Male, endocrine system, medicine.medical_specialty, Aging, Tyrosine 3-Monooxygenase, Central nervous system, 030204 cardiovascular system & hematology, Biology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Labelling, Male rats, medicine, Animals, Young adult, Rats, Wistar, Nerve Endings, Tyrosine hydroxylase, Median Eminence, General Medicine, Immunohistochemistry, Prolactin, Rats, Endocrinology, medicine.anatomical_structure, Median eminence, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], hormones, hormone substitutes, and hormone antagonists, 030217 neurology & neurosurgery
Abstract

International audience; Labelling patterns of immunoreactive prolactin (IR-PRL)-containing and tyrosine hydroxylase (TH)-containing nerve terminals of the median eminence (ME) were compared in young adult (aged 3 months) and old (aged 24 months) male Wistar rats. In the young rats, IR-PRL- and TH-immunostained fibres extended throughout the external most layer of the ME. In the old rats, a significant decrease in the intensity of labelling of IR-PRL terminals was observed in this layer, with a slight reduction in the extent of labelling. As far as TH terminals were concerned, no difference could be detected between young and old animals.

Published
1993

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