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Background: Developmental delay in early childhood is a significant concern with multifaceted causes and implications. The Bayley Scales of Infant and Toddler Development (BSID-III) is widely used for developmental assessment, but its use in Iranian children has been understudied. This study aimed to evaluate the developmental delays of Iranian children aged 1 to 42 months, investigate the association between parental education and these developmental outcomes, and compare developmental outcomes between the BSID-III and the Ages and Stages Questionnaire, Third Edition (ASQ-3). These findings contribute to informing clinical practices, policy makers, and early intervention programs aimed at promoting optimal development for all children. Methods: In this cross-sectional study, 707 Iranian children from Yazd, Iran, with suspected developmental delays were recruited from two health centers. Trained examiners administered the Persian-adapted and validated version of the BSID-III following standardized procedures. We hypothesized differences in BSID-III scores compared to normative samples, considering age, gender, and parental education. Additionally, comparisons between BSID-III scores and the validated Iranian version of ASQ-3 outcomes were explored to gain further insights. Results: The study sample exhibited varying rates of developmental delays across Cognitive (15.8%), Receptive Communication (20.1%), Expressive Communication (18.4%), Fine Motor (13.6%) and Gross Motor (15.7%) domains. Additionally, Age-related differences were observed, particularly in Receptive and Expressive Communication, where older children showed higher rates of delays. Gender differences were also significant in the Language Scale, with females showing slightly higher rates of normal development. Moreover, parental education emerged as a significant factor, with higher levels associated with a reduced occurrence of developmental delays. Furthermore, comparisons between BSID-III results and ASQ-3 outcomes highlighted discrepancies, suggesting an imperfect alignment between measures. The analysis demonstrated fair agreement for Cognitive-Problem Solving and Gross Motor development, but poor agreement for Fine Motor development, highlighting the complexity of developmental assessment and the need for cautious interpretation of test results. Conclusions: This study enhances our understanding of developmental assessment in Iranian children with suspected delays by emphasizing culturally sensitive adaptations for assessment tools alongside recognizing how parental education influences developmental trajectories. Future research with diverse, longitudinal samples is warranted to gain a more comprehensive picture. [ABSTRACT FROM AUTHOR]

Abstract Background Developmental delay in early childhood is a significant concern with multifaceted causes and implications. The Bayley Scales of Infant and Toddler Development (BSID-III) is widely used for developmental assessment, but its use in Iranian children has been understudied. This study aimed to evaluate the developmental delays of Iranian children aged 1 to 42 months, investigate the association between parental education and these developmental outcomes, and compare developmental outcomes between the BSID-III and the Ages and Stages Questionnaire, Third Edition (ASQ-3). These findings contribute to informing clinical practices, policy makers, and early intervention programs aimed at promoting optimal development for all children. Methods In this cross-sectional study, 707 Iranian children from Yazd, Iran, with suspected developmental delays were recruited from two health centers. Trained examiners administered the Persian-adapted and validated version of the BSID-III following standardized procedures. We hypothesized differences in BSID-III scores compared to normative samples, considering age, gender, and parental education. Additionally, comparisons between BSID-III scores and the validated Iranian version of ASQ-3 outcomes were explored to gain further insights. Results The study sample exhibited varying rates of developmental delays across Cognitive (15.8%), Receptive Communication (20.1%), Expressive Communication (18.4%), Fine Motor (13.6%) and Gross Motor (15.7%) domains. Additionally, Age-related differences were observed, particularly in Receptive and Expressive Communication, where older children showed higher rates of delays. Gender differences were also significant in the Language Scale, with females showing slightly higher rates of normal development. Moreover, parental education emerged as a significant factor, with higher levels associated with a reduced occurrence of developmental delays. Furthermore, comparisons between BSID-III results and ASQ-3 outcomes highlighted discrepancies, suggesting an imperfect alignment between measures. The analysis demonstrated fair agreement for Cognitive-Problem Solving and Gross Motor development, but poor agreement for Fine Motor development, highlighting the complexity of developmental assessment and the need for cautious interpretation of test results. Conclusions This study enhances our understanding of developmental assessment in Iranian children with suspected delays by emphasizing culturally sensitive adaptations for assessment tools alongside recognizing how parental education influences developmental trajectories. Future research with diverse, longitudinal samples is warranted to gain a more comprehensive picture.

Background and objectives: Adverse childhood experiences (ACEs) are known to affect physical and mental health outcomes. In this study, we investigated the role of demographical factors and ACEs focusing on family-related factors on behavioral and developmental outcomes in young children exposed to maltreatment in Singapore. Participants and setting: Children suspected of maltreatment and their siblings (

STUDY QUESTION In non-male factor infertile couples, are there any differences in the developmental outcomes between children born through ICSI and conventional IVF (cIVF)? SUMMARY ANSWER In this preliminary study, ICSI and cIVF seem to have a comparable effect on developmental outcomes after 12 months in children born to non-male factor infertile couples. WHAT IS KNOWN ALREADY ICSI, an invasive technique, has raised concerns about potential developmental abnormalities in children. Limited data are available regarding the developmental outcomes of ICSI-conceived infants born to non-male factor infertile couples. STUDY DESIGN, SIZE, DURATION This prospective cohort study involved a follow-up of all children aged 12 months or older who were born from pregnancies resulting from either ICSI or cIVF as part of a previous randomized controlled trial (RCT) (NCT03428919). PARTICIPANTS/MATERIALS, SETTING, METHODS In the original RCT, 1064 women were randomly assigned to the ICSI or cIVF groups (532 women for each group). Follow-up was conducted with 155 couples (195 children) in the ICSI group and 141 couples (185 children) in the cIVF group. The Vietnamese version of the Ages & Stages Third Edition Questionnaires (ASQ-3) and the Development Red Flags questionnaires were completed by the participants. A total of 141 (90.1%) women (177 children) in the ICSI group and 113 (80.1%) women (145 children) in the cIVF group returned fully completed questionnaires. The primary outcomes were the developmental outcomes based on responses to the ASQ-3 and the Red Flags questionnaire. MAIN RESULTS AND THE ROLE OF CHANCE The mean age of children at follow-up was 19.5 ± 5.0 months in the ICSI group and 19.3 ± 5.5 months in the cIVF group. The mean height and weight of children in both groups were similar. The overall proportion of children with any abnormal ASQ-3 score did not differ significantly between the ICSI and cIVF groups (16.9% vs 13.1%, P  = 0.34). The proportion of children with Red Flag signs was also comparable between the two groups (6.2% vs 9.2%, P  = 0.36, ICSI vs cIVF, respectively). LIMITATIONS, REASONS FOR CAUTION Despite a reasonably high follow-up response rate, there is a potential risk of sampling bias, and overall, the number of children with developmental abnormalities was very small. The study relied solely on questionnaires as screening tools, rather than incorporating additional behavioral observations or physical developmental tests; this may have affected the statistical power and the significance of between-group comparisons. WIDER IMPLICATIONS OF THE FINDINGS The current findings contribute to the existing evidence and support the comparative safety of ICSI and cIVF regarding early childhood development. However, more extensive and prolonged follow-up data for these children are needed to draw definitive conclusions. STUDY FUNDING/COMPETING INTEREST(S) No external funding was received for this study, and no authors reported conflicting interests. TRIAL REGISTRATION NUMBER NCT04866524 (clinicaltrials.gov). [ABSTRACT FROM AUTHOR]

Background: In the recent years, a high risk of developmental delay not only in very low birth weight infants and late preterm infants but also in early term infants (37–38 weeks) have increasingly been reported. However, in Japan, there are virtually no studies regarding the development delays in early term infants. Methods: This study used the data from the Japan Environment and Children's Study (JECS), a birth cohort study conducted in Japan. Data were selected for analysis from the records of 104,065 fetal records. The risk of neurodevelopmental delays at 6 months and 12 months after birth was evaluated using multivariate analysis for infants of various gestational ages, using the 40th week of pregnancy as a reference value. Neurodevelopment was evaluated at 6 months and 12 months after birth using the Ages and Stages Questionnaires, Japanese translation (J-ASQ-3). Results: The proportion of infants born at a gestational age of 37 to 38 weeks who did not reach the J-ASQ-3 score cutoff value was significantly higher in all areas at both 6 months and 12 months after birth, when compared to that of infants born at 40 weeks. The odds ratio decreased at 12 months after birth compared to that at 6 months after birth. Conclusion: Early term infants in Japan are at an increased risk of neurodevelopmental delay at 12 months after birth. Significance: What's known on this subject: Early term infants with gestational ages of 37 to 38 weeks and not only premature babies may be at an increased risk of developmental delay. What this study adds: This study was conducted using data from a birth cohort of 104,065 fetal records. Early term infants had an increased risk of developmental delay at 6 months, and while the risk decreased by 12 months after birth, it was still high. [ABSTRACT FROM AUTHOR]

Background: With increasing acceptance of universal developmental screening in primary care, it is essential to evaluate the local validity and psychometric properties of commonly used questionnaires like the parent-completed Ages and Stages Questionnaires, 3rd Edition (ASQ-3) in identifying developmental delays. The aim of this study is to assess the convergent validity of the ASQ-3 with the Bayley Scales of Infant Development-3rd edition (Bayley-III) in identifying developmental delay in a low-risk term cohort in Singapore. Methods: ASQ-3 and Bayley-III data was collected prospectively with generation of ASQ-3 cut-off scores using three different criteria: 1-standard deviation (SD) (Criterion-I) or 2-SD (Criterion-II) below the mean, and using a Receiver Operator Curve (ROC) (Criterion-III). Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were calculated. Correlations between the ASQ-3 and Bayley-III domains were evaluated using Pearson coefficients. Results: With all three criteria across different domains ASQ-3 showed high specificity (72–99%) and NPV (69–98%), but lower sensitivity (19–74%) and PPV (11–59%). Criterion-I identified 11–21% of children as “at-risk of developmental delay,” and was the most promising criterion measure, with high specificity (82–91%), NPV (69–74%) and overall agreement of 64–71%. Moderate-strong correlations were seen between ASQ-3 Communication and Bayley-III Language scales (r = 0.44–0.59, p

Background: The COVID-19 pandemic has significantly affected the mental health of pregnant persons. Objective: We aimed to evaluate the impact of maternal mental health and antidepressant use on children's cognitive development. Methods: We followed a cohort of children born during the COVID-19 pandemic. Maternal mental health was self-reported during pregnancy (Edinburgh Postnatal Depression Scale, General Anxiety Disorder-7, stress levels, and antidepressant use). The child's cognitive development was measured using the third edition of the Ages & Stages Questionnaires® (ASQ-3) at 18 months. Multivariate multinomial logistic regression models were built to assess the association between in utero exposure to maternal mental health and ASQ-3 domains: communication, gross motor, fine motor, problem-solving, and personal–social. Results: Overall, 472 children were included in our analyses. After adjusting for potential confounders, a need for further assessment in communication (adjusted odds ratio (aOR) 12.2, 95% confidence interval (CI) (1.60;92.4)), and for improvement in gross motricity (aOR 6.33, 95%CI (2.06;19.4)) were associated with in utero anxiety. The need for improvement in fine motricity (aOR 4.11, 95%CI (1.00; 16.90)) was associated with antidepressant exposure. In utero depression was associated with a decrease in the need for improvement in problem solving (aOR 0.48, 95%CI (0.24; 0.98)). Conclusions: During the COVID-19 pandemic, maternal mental health appears to be associated with some aspects of children's cognitive development. [ABSTRACT FROM AUTHOR]

With increasing acceptance of universal developmental screening in primary care, it is essential to evaluate the local validity and psychometric properties of commonly used questionnaires like the parent-completed Ages and Stages Questionnaires, 3rd Edition (ASQ-3) in identifying developmental delays. The aim of this study is to assess the convergent validity of the ASQ-3 with the Bayley Scales of Infant Development-3rd edition (Bayley-III) in identifying developmental delay in a low-risk term cohort in Singapore. ASQ-3 and Bayley-III data was collected prospectively with generation of ASQ-3 cut-off scores using three different criteria: 1-standard deviation (SD) (Criterion-I) or 2-SD (Criterion-II) below the mean, and using a Receiver Operator Curve (ROC) (Criterion-III). Sensitivity, specificity, positive (PPV) and negative (NPV) predictive values were calculated. Correlations between the ASQ-3 and Bayley-III domains were evaluated using Pearson coefficients. With all three criteria across different domains ASQ-3 showed high specificity (72–99%) and NPV (69–98%), but lower sensitivity (19–74%) and PPV (11–59%). Criterion-I identified 11–21% of children as "at-risk of developmental delay," and was the most promising criterion measure, with high specificity (82–91%), NPV (69–74%) and overall agreement of 64–71%. Moderate-strong correlations were seen between ASQ-3 Communication and Bayley-III Language scales (r = 0.44–0.59, p < 0.01). The lowest sensitivities were seen in the motor domains. ASQ-3 is reliable in low-risk settings in identifying typically developing children not at risk of developmental delay, but it has modest sensitivity. Moderate-strong correlations seen in the communication domain are clinically important for early identification of language delay, which is one of the most prevalent areas of early childhood developmental delay. [ABSTRACT FROM AUTHOR]

Prior studies suggest autism-specific and general developmental screens are complementary for identifying both autism and developmental delay (DD). Parents completed autism and developmental screens before 18-month visits. Children with failed screens for autism (n = 167) and age, gender, and practice-matched children passing screens (n = 241) completed diagnostic evaluations for autism and developmental delay. When referral for autism and/or DD was considered, overall false positives from the autism screens were less frequent than for referral for autism alone. Presence of a failed communication subscale in the developmental screen was a red flag for autism and/or DD. An ordinally-scored autism screen had more favorable characteristics when considering autism and/or DD, yet none of the screens achieved recommended standards at 18 months, reinforcing the need for recurrent screening as autism emerges in early development. [ABSTRACT FROM AUTHOR]

BackgroundAnimal studies have shown that maternal low-fiber diets during pregnancy may impair brain development and function in offspring, but this has not been validated by epidemiological studies. The aim of this study was to investigate the link between maternal dietary fiber intake during pregnancy and neurodevelopmental delay in offspring using a large birth cohort.MethodsA total of 76,207 mother-infant pairs were analyzed using data from the Japan Environment and Children's Study, a nationwide prospective cohort study. Maternal dietary fiber intake was estimated using the food frequency questionnaire in mid-pregnancy. Maternal dietary fiber intake was adjusted for energy and classified into quintiles. Developmental delay was assessed in five domains using the Japanese version of the Ages and Stages Questionnaire, Third Edition at the age of 3 years. The logistic regression analysis was performed to estimate the odds ratio (OR) and 95% confidence interval (CI) for the link between dietary fiber intake during pregnancy and developmental delay at the age of 3 years.ResultsThe lowest intake group of total dietary fiber had a higher risk of delayed communication [adjusted OR (aOR), 1.51; 95% CI, 1.32–1.74], fine motor (aOR, 1.45; 95% CI, 1.32–1.61), problem-solving (aOR, 1.46; 95% CI, 1.32–1.61), and personal-social skills (aOR, 1.30; 95% CI, 1.12–1.50) than did the highest intake group. An analysis that excluded the effects of insufficient folic acid intake during pregnancy also showed a similar trend.ConclusionThis study showed that maternal dietary fiber deficiency during pregnancy might influence an increased risk of neurodevelopmental delay in offspring.

Introduction: Preterm birth is the most common cause of neonatal morbidity and mortality. Women with twin pregnancies and a short cervical length are at high risk for preterm birth. Vaginal progesterone and cervical pessary have been proposed as potential strategies to reduce preterm birth in this high‐risk population. Therefore, we aimed to compare the effectiveness of cervical pessary and vaginal progesterone in improving developmental outcomes of children born to women with twin pregnancies and mid‐trimester short cervical length. Material and methods: This was a follow‐up study (NCT04295187) of all children at 24 months of age, born from women treated with cervical pessary or progesterone to prevent preterm birth in a randomized controlled trial (NCT02623881). We used a validated Vietnamese version of Ages & Stages Third Edition Questionnaires (ASQ‐3) and a red flag questionnaire. In surviving children, we compared the mean ASQ‐3 scores, abnormal ASQ‐3 scores, the number of children with any abnormal ASQ‐3 scores and red flag signs between the two groups. We reported the composite outcome of perinatal death or survival with any abnormal ASQ‐3 score in offspring. These outcomes were also calculated in a subgroup of women with a cervical length ≤28 mm (<25th percentile). Results: In the original randomized controlled trial, we randomized 300 women to pessary or progesterone. After counting the number of perinatal deaths and lost to follow‐up, 82.8% parents in the pessary group and 82.5% parents in progesterone group returned the questionnaire. The mean ASQ‐3 scores of the five skills and red flag signs did not differ significantly between the two groups. However, the percentage of children having abnormal ASQ‐3 scores in fine motor skills was significantly lower in the progesterone group (6.1% vs 1.3%, P = 0.01). There were no significant differences in the composite outcome of perinatal death or survival with any abnormal ASQ‐3 score in unselected women and in those with cervical length ≤28 mm. Conclusions: Cervical pessary and vaginal progesterone may have comparable effects on developmental outcomes in children at ≥24 months of age, born to women with twin pregnancies and short cervical length. However, this finding could be likely due to a lack of study power. [ABSTRACT FROM AUTHOR]

Background Optimal child development is needed for adequate learning. Children, particularly toddlers, require iron for brain development, and consequently, overall development. Objective To analyze for an association between iron status and developmental status in children aged 24–36 months. Methods This explorative cross-sectional study was held in Kampung Melayu, Jakarta. Subjects were recruited using a total population sampling method. Data were collected through interview with parents, anthropometric examinations, and blood tests. Developmental status was determined using the Ages and Stages Questionnaire-3 (ASQ-3) and iron status was based on ferritin, high sensitivity C-reactive protein (hs-CRP), and hemoglobin levels. Data analyses included Chi-square/Fisher’s exact, Mann-Whitney, and logistic regression tests. Results Of 80 subjects, 17.5% had developmental delay and 41.3% had deficient iron status. There was no significant association between iron status and developmental status in bivariate analysis, but the logistic regression analysis revealed that iron status (OR=6.9; 95%CI 1.328 to 35.633; P=0.022) and nutritional status (OR=11.75; 95%CI 1.551 to 88.979; P=0.017) contributed to developmental delay. Conclusion Better iron status and nutritional status are associated with better child development of children aged 24–36 months. So efforts are needed to maintain iron status as well as nutritional status.

Background: Developmental delays (DDs) in children are rising and necessitate routine screening for early recognition and management. Objective(s): To estimate the prevalence of developmental delays among children 2-36 months of age in a Primary Health Care (PHC) center in Cairo, Egypt. Methods: This cross-sectional study was conducted in Saraya El-Koba PHC center involving 193 children 2-36 months of age. Data were collected using Ages and Stages Questionnaire (ASQ-3) to assess five domains of development: communication, gross motor, fine motor, problem-solving, and personal-social. Some parents’ characteristics were also included. Results: Frequency of developmental delays was 9.3%. The domains with the most frequent delays were the communication and gross motor (3.1% each) and the least was the fine motor domain (1.04%). Girls scored significantly higher than boys in the problem-solving domain (p=0.037). First to third order of birth had higher communication and social scores (p=0.025, p=0.003 respectively). Highly educated mothers had children with higher fine motor and total developmental scores (p < 0.001 and 0.014 respectively), while highly educated fathers had children with higher communication scores (p=0.009). Duration of breast feeding was positively correlated with gross motor and social scores (p=0.001, p=0.042 respectively). Conclusion: The frequency of DDs was 9.3%. This prevalence is considered high compared to previous studies. It showed several associated factors and recommended early screening of preschool children for prompt recognition and timely intervention.

Identifying children with developmental disabilities is critical in providing early intervention services. This study aimed to evaluate the concurrent validity information of the 24‐, 30‐, and 36‐month Indonesian Ages and Stages Questionnaires third edition (ASQ‐3) with Bayley Scales of Infant and Toddler Development 3rd Edition (BSID‐III) in Indonesian children. Children living in Tanah Tinggi subdistrict, Central Jakarta, within the 24‐, 30‐, or 36‐month age group, were assessed for Indonesian ASQ‐3 concurrently with BSID‐III. Screening test accuracy was measured in sensitivity, specificity, and predictive values for both overall dan specific domains. A total of 131 children were included as study participants. Sensitivity, specificity, positive predictive value, and negative predictive value (NPV) for 24‐, 30‐, and 36‐ month ASQ‐3 questionnaires were 80.6%, 69.5%, 50%, and 90.4%, respectively. Age‐specific sensitivity and specificity were 72.7%–84.6% and 59.4%–79.4%, with accuracy increasing from 65.9% at 24‐month to 77.8% at 36‐month. The accuracy in detecting language delay (88.5%) is higher than cognitive delay (77.9%) and motor delay (64.1%). ASQ‐3 overall and age‐specific sensitivities were good enough, given they were above 70%. The 36‐month questionnaire had the best accuracy. A high NPV supports using the ASQ‐3 Indonesian version to exclude developmental delay. Highlights: Indonesian ASQ‐3 questionnaires can identify children at risk for developmental delay and undergo early intervention.Likelihood ratios calculation revealed findings of developmental delay using Indonesian ASQ‐3 questionnaires increases the probability of developmental delay detection by around 22%.Indonesian ASQ‐3 questionnaires for 24‐, 30‐, and 36‐ month age groups generated good sensitivity and accuracy for developmental screening.Indonesian ASQ‐3 can be used as first‐stage screening following the MCHH surveillance tool, particularly at 24‐, 30‐, and 36‐ months. [ABSTRACT FROM AUTHOR]

Background: The role of polymorphisms in genes regulating alcohol metabolism, particularly those modulating the impact of prenatal alcohol exposure on the neurodevelopment of offspring, remains inconclusive. Herein, we aimed to determine the involvement of ADH1B and ALDH2 gene polymorphisms in maternal alcohol consumption during pregnancy and the risk of developmental delay in offspring in a Japanese population., Methods: We analyzed 1727 mother-child pairs from the Yamanashi Adjunct Study of the Japan Environment and Children's Study. Maternal alcohol consumption during pregnancy was determined through a mid-pregnancy questionnaire and categorized into three groups: never-drinkers, those who quit drinking in early pregnancy, and current drinkers. Developmental delays in children were assessed in five domains using the Japanese version of the Ages and Stages Questionnaire, Third Edition (J-ASQ-3) at 3 years of age. We conducted a logistic regression analysis to explore the relationship between maternal drinking status during pregnancy and developmental delays in offspring with respect to maternal ADH1B (rs1229984) or ALDH2 (rs671) gene polymorphisms., Results: Children born to mothers who continued alcohol consumption during pregnancy had a higher risk of delayed communication skills at 3 years of age compared with children born to mothers who did not drink alcohol (adjusted odds ratio [OR], 5.82; 95% confidence interval, 1.84-18.38). Analysis by ALDH2 gene polymorphism revealed that alcohol consumption by mothers carrying the wild-type ALDH2 (*1/*1) increased the risk of delayed communication skills at 3 years of age, whereas alcohol consumption by mothers carrying a heterozygotic genotype of ALDH2 (*1/*2) enhanced the risk of developmental delay in all five domains of the J-ASQ-3. The impact of ADH1B gene polymorphism could not be clearly elucidated., Conclusions: Our results suggest that alcohol consumption by pregnant females carrying the deficient variant ALDH2*2 genotype may increase the risk of developmental delay in their offspring., (© 2024 The Author(s). Alcohol, Clinical and Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol.)

Background: Clinicians and parents should closely monitor the neurodevelopment of very preterm infants. The aim of our study was to compare whether neurodevelopmental assessments completed by parents and those done by specialists yielded similar outcomes. We wanted to check whether the assessments completed by specialists and parents were comparable in outcomes to emphasize the important roles of early assessment of a child and of the parents in their child's treatment and medical care. Another aim was to check whether or not the pull to sit maneuver from the Neonatal Behavioral Assessment Scale (NBAS) is still a parable item in well-known scales of neurodevelopment. Methods: We assessed 18 preterm neonates in the fourth month of corrected age with scales such as the General Movement Assessment (GMA), the Alberta Infant Motor Scale (AIMS), and the pull to sit maneuver from the NBAS. Finally, we asked parents to complete the Ages and Stages Questionnaire, Third Edition (ASQ-3). Results: We found that the respective assessments completed by specialists and parents are comparable in outcomes. We also found that the pull to sit item from the NBAS was still a valid test since it showed similar findings to those from the AIMS, the GMA, and the ASQ-3. Conclusions: The pull to sit item from the NBAS is an important item for assessment of very preterm infants. Specialists should also take into consideration the input and concerns of parents when planning for treatment and intervention. [ABSTRACT FROM AUTHOR]

The present paper evaluates the impact of a home visiting program aimed at training mothers in aspects of stimulation of their 0–3-year-old children in contexts of social vulnerability in the province of Santiago del Estero, Argentina. This program was carried out by the Asociación Civil Haciendo Camino (ACHC) with mothers participating in the program who were trained and supervised by health professionals within the framework of a comprehensive intervention. The evaluation was conducted through a difference-in-differences (DiD) method between a treatment group and a control group and two measurements over time with a six-month lapse of intervention. The measurements were made with the tool Ages & Stages Questionnaires, Third Edition (ASQ-3), which assesses five areas of child development. In addition, sociodemographic, socioeconomic and parenting aspects were surveyed to estimate heterogeneous effects. The results of the present study indicate that the program achieved positive and significant effects in three areas of child development (communication, fine motor skills and problem solving), and positive but not significant effects in two other areas (gross motor skills and personal-social development). Among the positive heterogeneous effects, the increase in the child's age and the mother's age in different dimensions of development under the effects of the reference program stand out. These results add evidence on the relevance of early childhood stimulation programs in contexts of social vulnerability. [ABSTRACT FROM AUTHOR]

Purpose: IVM preceded by a prematuration step (capacitation [CAPA]-IVM) improves the acquisition of oocyte developmental competence and can enhance embryo quality. There is currently no follow-up data on babies born from CAPA-IVM. This study investigated developmental outcomes in children born after CAPA-IVM versus natural conception. Methods: This prospective cohort study was conducted at a fertility clinic in Vietnam in August/September 2019. Children born after CAPA-IVM were propensity score-matched with those born after natural conception. All parents were asked to complete the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) questionnaires. Results: A total of 46 parents (23 in each group) of 55 babies (31 CAPA-IVM and 24 natural conception) were included in the study. Baseline characteristics, including mother's age and body mass index, gestational age at delivery, and birth weight, were comparable. The mean age of children at the end of follow-up was 15 months. The overall proportion of children with any abnormal ASQ-3 score was 6.5% in the CAPA-IVM group and 20.8% in the natural conception group (p = 0.24). The proportion of children with a developmental red flag did not differ significantly between the CAPA-IVM and natural conception groups (9.7% vs. 4.2%; p = 0.80). Conclusions: The use of CAPA-IVM did not have any significant impact on childhood physical and mental development compared with children born as a result of natural conception. [ABSTRACT FROM AUTHOR]

Study Question: Is there any difference in developmental outcomes in children born after capacitation IVM (CAPA IVM) compared with conventional IVF?Summary Answer: Overall development up to 24 months of age was comparable in children born after CAPA IVM compared with IVF.What Is Known Already: IVM has been shown to be a feasible alternative to conventional IVF in women with a high antral follicle count (AFC). In addition to live birth rate, childhood development is also a relevant metric to compare between the two approaches to ART and there are currently no data on this.Study Design, Size, Duration: This study was a follow-up of babies born to women who participated in a randomized controlled trial comparing IVM with a pre-maturation step (CAPA IVM) and IVF. Developmental assessments were performed on 231 children over 24 months of follow-up.Participants/materials, Setting, Methods: Participants in the randomized controlled trial had an indication for ART and a high AFC (≥24 follicles in both ovaries). They were randomized to undergo one cycle of either IVM (n = 273) or IVF (n = 273). Of these, 96 women and 118 women, respectively, had live births. Seventy-six women (94 children, 79.2%) and 104 women (137 children, 88.1%), respectively, completed Ages & Stages Third Edition Questionnaire assessment (ASQ-3), and underwent evaluation of Developmental Red Flags at 6, 12 and 24 months of age.Main Results and the Role Of Chance: Baseline characteristics of participants in the follow-up study between the IVM and IVF groups were comparable. Overall, there were no significant differences in ASQ-3 scores at 6, 12 and 24 months between children born after IVM or IVF. The proportion of children with developmental red flags was low and did not differ between the two groups. Slightly, but significantly, lower ASQ-3 problem solving and personal-social scores in twins from the IVM versus IVF group at 6 months were still within the normal range and had caught up to the IVF group in the 12- and 24-month assessments. The number of children confirmed to have abnormal mental and/or motor development after specialist assessment was four in the IVM group and two in the IVF group (relative risk 2.91, 95% CI 0.54-15.6; P = 0.23).Limitations, Reasons For Caution: This study is an open-label follow-up of participants in a randomized controlled trial, and not all original trial subjects took part in the follow-up. The self-selected nature of the follow-up population could have introduced bias, and the sample size may have been insufficient to detect significant between-group differences in developmental outcomes.Wider Implications Of the Findings: Based on the current findings at 2 years of follow-up, there does not appear to be any significant concern about the effects of IVM on childhood development. These data add to the evidence available to physicians when considering different approaches to fertility treatment, but require validation in larger studies.Study Funding/competing Interest(s): This work was funded by the Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number FWO.106-YS.2017.02. L.N.V. has received speaker and conference fees from Merck, grant, speaker and conference fees from Merck Sharpe and Dohme, and speaker, conference and scientific board fees from Ferring; T.M.H. has received speaker fees from Merck, Merck Sharp and Dohme, and Ferring; R.J.N. has receives grant funding from the National Health and Medical Research Council (NHMRC) of Australia; B.W.M. has acted as a paid consultant to Merck, ObsEva and Guerbet and is the recipient of grant money from an NHMRC Investigator Grant; J.E.J.S. reports lecture fees from Ferring Pharmaceuticals, Biomérieux and Besins Female Healthcare, grants from Fund for Research Flanders (FWO) and is co-inventor on granted patents on CAPA-IVM methodology in the USA (US10392601B2) and Europe (EP3234112B1); T.D.P., M.H.N.N., N.A.N., T.T.L., V.T.T.T., N.T.N., H.L.T.H. and X.T.H.L. have no financial relationships with any organizations that might have an interest in the submitted work in the previous 3 years, and no other relationships or activities that could appear to have influenced the submitted work.Trial Registration Number: NCT04296357 (www.clinicaltrials.gov).Trial Registration Date: 5 March 2020.Date Of First Patient’s Enrolment: 7 March 2020. [ABSTRACT FROM AUTHOR]

Background Optimal child development is needed for adequate learning. Children, particularly toddlers, require iron for brain development, and consequently, overall development. Objective To analyze for an association between iron status and developmental status in children aged 24-36 months. Methods This explorative cross-sectional study was held in Kampung Melayu, Jakarta. Subjects were recruited using a total population sampling method. Data were collected through interview with parents, anthropometric examinations, and blood tests. Developmental status was determined using the Ages and Stages Questionnaire-3 (ASQ-3) and iron status was based on ferritin, high sensitivity C-reactive protein (hs-CRP), and hemoglobin levels. Data analyses included Chi-square/Fisher’s exact, MannWhitney, and logistic regression tests. Results Of 80 subjects, 17.5% had developmental delay and 41.3% had deficient iron status. There was no significant association between iron status and developmental status in bivariate analysis, but the logistic regression analysis revealed that iron status (OR=6.9; 95%CI 1.328 to 35.633; P=0.022) and nutritional status (OR=11.75; 95%CI 1.551 to 88.979; P=0.017) contributed to developmental delay. Conclusion Better iron status and nutritional status are associated with better child development of children aged 24-36 months. So efforts are needed to maintain iron status as well as nutritional status [ABSTRACT FROM AUTHOR]

Background: Developmental delays (DDs) in children are rising and necessitate routine screening for early recognition and management. Objective(s): To estimate the prevalence of developmental delays among children 2-36 months of age in a Primary Health Care (PHC) center in Cairo, Egypt. Methods: This cross-sectional study was conducted in Saraya El-Koba PHC center involving 193 children 2-36 months of age. Data were collected using Ages and Stages Questionnaire (ASQ-3) to assess five domains of development: communication, gross motor, fine motor, problem-solving, and personal-social. Some parents' characteristics were also included. Results: Frequency of developmental delays was 9.3%. The domains with the most frequent delays were the communication and gross motor (3.1% each) and the least was the fine motor domain (1.04%). Girls scored significantly higher than boys in the problem-solving domain (p=0.037). First to third order of birth had higher communication and social scores (p=0.025, p=0.003 respectively). Highly educated mothers had children with higher fine motor and total developmental scores (p<0.001 and 0.014 respectively), while highly educated fathers had children with higher communication scores (p=0.009). Duration of breast feeding was positively correlated with gross motor and social scores (p=0.001, p=0.042 respectively). Conclusion: The frequency of DDs was 9.3%. This prevalence is considered high compared to previous studies. It showed several associated factors and recommended early screening of preschool children for prompt recognition and timely intervention. [ABSTRACT FROM AUTHOR]

Objective: Recent studies have shown that inclusion of eggs in young children's diet can help meet nutritional requirements associated with cognitive development. This study aims to investigate the effect of egg consumption on Early Childhood Development (ECD) using Ages and Stages Questionnaire-3(ASQ-3) in Burkina Faso., Design: The study presented here uses data collected during a follow-up of the Un Oeuf -a 3 arm clustered randomized controlled trial (RCT), conducted roughly four months after the end of the RCT., Setting: This research was conducted in 18 rural villages within the Kaya Department of the Sanmatenga Province in Burkina Faso., Participants: Participants of this study include a total of 244 children aged between 18-33 months, with 78 children in the full intervention group, 83 in the partial group, and 83 in the control group., Results: Results show that children with consistent egg consumption (in all months) had a lower odd of falling below the cut-off scores in gross motor ( OR = 0.13, p = 0.02) and personal social skills ( OR = 0.34, p = 0.05). And a dose response was established; for each additional egg/week, a 1.9% increase in scores for problem-solving skills was observed., Conclusions: Findings from this study contribute to a growing body of evidence that increasing egg consumption among children in LMICs can improve growth and development. The study highlights the need for additional research in LMICs to better understand the multifactorial relationship between diet and childhood development.

Background: The COVID-19 pandemic has created new cultural norms with pervasive societal implications. Families have experienced a heightened amount of physical, psychological, emotional, and financial stress. Infants and children living with stress have the potential for delayed developmental milestones, difficulty with emotional regulation, and social or behavioral issues. Purpose: This study aims to determine if the pandemic has affected developmental outcomes in infants and toddlers. Methodology: Prepandemic and postpandemic developmental (ASQ-3) scores were obtained from charts of 1,024 patients (6, 12, 18, 24, and 36 months) from two pediatric practices. Results: There were no significant differences in prepandemic and postpandemic ASQ-3 scores for the overall sample. Age-group analysis showed statistically significant differences in domain scores. Postpandemic problem-solving scores decreased among 6-month-olds while increasing among 24-month-olds. Categorization by score interpretation categories showed a slight decrease in postpandemic scores in the communication domain among 6- and 12-month-olds. Conclusions: The pandemic has the potential to affect childhood development. However, the results of this study are reassuring, showing only slight differences in developmental scores prepandemic versus postpandemic. More studies are needed to establish causation and possible trends in future developmental trajectories. Implications: An increased focus on communication screening and promotion of language and communication skills in young children postpandemic is needed. Education about the importance of parent-child engagement, nurturing relationships, opportunities for free-play and exploration, and caregiver support and stress reduction will continue to be of paramount importance. [ABSTRACT FROM AUTHOR]

Abnormal maternal gestational weight gain (GWG) increases the risk of obstetric-related complications. This investigation examined the impact of GWG on infant neurodevelopmental abnormalities at 12 months of age using the data of a nationwide Japanese cohort study. Questionnaire data were obtained from the ongoing Japan Environment and Children's Study cohort study. Maternal GWG was subdivided as below, within, or above the reference values of the Institution of Medicine pregnancy weight guidelines. The Ages and Stages Questionnaire, third edition (ASQ-3) is a parent-reported developmental screening instrument for children across five domains: communication, gross motor, fine motor, problem-solving, and personal–social. Multiple logistic regression analysis was employed to identify correlations between GWG and developmental delay defined as ASQ-3 scores of less than two standard deviations below the mean. A total of 30,694 mothers with singleton live births and partners who completed the questionnaire were analyzed. The prevalence of mothers below, within, and above the GWG guidelines was 60.4% (18,527), 32.1% (9850), and 7.5% (2317), respectively. We recorded 10,943 infants (35.7%) who were outliers in at least one ASQ-3 domain. After controlling for covariates, GWG below established guidelines was associated with a significantly higher risk of developmental delay for the communication (odds ratio [OR] 1.21, 95% confidence interval [CI] 1.09–1.34), gross motor (OR 1.14, 95% CI 1.05–1.24), fine motor (OR 1.13, 95% CI 1.04–1.24), problem-solving (OR 1.09, 95% CI 1.01–1.18), and personal–social (OR 1.15, 95% CI 1.07–1.24) domains. Conclusion: This large survey revealed a possible deleterious effect of insufficient maternal GWG on infant neurodevelopment. Trial registration: The Japan Environment and Children's Study (JECS) was registered in the UMIN Clinical Trials Registry on January 15, 2018 (number UMIN000030786). What is Known: • Inappropriate maternal gestational weight gain may cause obstetric complications and adverse birth outcomes. • Excess maternal weight gain may result in gestational diabetes, hypertension, eclampsia, caesarean delivery, and macrosomia, while insufficient maternal weight gain has been associated with pre-term birth and small for gestational age. What is New: • This study provides important information on a possible adverse effect of insufficient maternal gestational weight gain on offspring neurodevelopment at 12 months of age. • Our findings indicate a need to reconsider the optimal body mass index and gestational weight gain for women desiring pregnancy. [ABSTRACT FROM AUTHOR]

Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Maternal and Child Health Hospital of Hubei Province. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.

Objective: Thyroid hormones are essential for neurodevelopment in early life. However, the impact of mild alterations in neonatal thyroid hormones on infant neurodevelopment and its sex dimorphism is unclear. We aimed to assess whether mild variations in neonatal thyroid hormones of term-born newborns with maternal euthyroid are related to neurodevelopment in 2-year-old boys and girls.Methods: This study used data from 452 singleton term-born infants of mothers with normal thyroid function in Shanghai, China, and their follow-up measure at the age of 2 years. Cord serum concentrations of free thyroxine (FT4), free triiodothyronine (FT3), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibody (TPOAb) were measured by chemiluminescent microparticle immunoassays and classified into three groups: the low (1st, Q1), middle (2nd−4th, Q2–Q4), and high (5th, Q5) quintiles. Neurodevelopment indices were assessed using the Ages and Stages Questionnaire, third edition (ASQ-3), at 24 months of age.Results: Compared to infants with thyroid hormones in the middle (Q2–Q4), boys with FT4 in the lowest quintile had 5.08 (95% CI: 1.37, 8.78) points lower scores in the communication domain, 3.25 (0.25,6.25) points lower scores in the fine motor domain, and 3.84 (0.04, 7.64) points lower scores in the personal-social domain, respectively. Boys with FT3 in the highest quintile had 4.46 (0.81, 8.11) points increase in the personal-social domain. These associations were not observed in girls. No associations were observed between cord blood serum TSH and ASQ-assessed neurodevelopment in the boys or the girls.Conclusions: Mild alterations in thyroid hormones of newborns were associated adversely with neurodevelopment in boys, suggesting the importance of optimal thyroid hormone status for neurodevelopment in early life.

The impact of parent-childbearing age on child development at 36 months of age is controversial. We used data from a large cohort study with multiple imputation and mediation analyses of variables. A total of 72,606 parent–child pairs from the Japan Environment and Children's Study were included in the study. Parents' ages were categorized into five groups. We used five domains of the Japanese translation of the Ages and Stages Questionnaire, Third Edition (J-ASQ-3). Scores below the cutoff value at 36 months were defined as developmental delays in each domain. We used three logistic analysis models. In Model 3, we analyzed maternal and paternal age using other variables and covariates. The outcome was a developmental delay in the five domains of J-ASQ-3. In Model 3, ORs for the developmental delay scores regarding parental age were significantly associated with all five domains of J-ASQ-3. The mediation analysis showed a significant mediation interaction effect for mothers but localized for fathers. Advanced paternal and maternal ages were associated with developmental delay in children. Awareness of the risks of childbearing at an advanced age is crucial. This manuscript used data from a large cohort study with multiple imputation and mediation analyses. With these analyses, we identified the pure effect of advanced parental age on their children's development at 36 months. • Both advanced paternal and maternal ages were associated with developmental delay in children. • The effects of advanced maternal age on child developmental delay are similar to the paternal one. • Awareness of the risk of childbearing at an advanced parental age is crucial. [ABSTRACT FROM AUTHOR]

Naltrexone is a medication used to treat both opioid and alcohol use disorder with limited experience in pregnant individuals, particularly in comparison to more commonly utilized treatments such as buprenorphine-naloxone. The long-term outcomes of infants exposed to naltrexone has not been previously examined. To compare the neurobehavioral outcomes of naltrexone versus buprenorphine-naloxone exposed infants. Multi-centered prospective cohort study. Pregnant people on prescribed buprenorphine-naloxone or naltrexone were enrolled during pregnancy and the dyad followed until 12 months after delivery. Infants were evaluated at 4–6 weeks corrected gestational age (CGA) using the NICU Neonatal Neurobehavioral Scale (NNNS) and at the 12-month CGA visit using the Ages and Stages Questionnaire, Third Edition (ASQ-3). There were 7 dyads in the naltrexone group and 34 in the buprenorphine-naloxone group. On the NNNS, infants exposed to naltrexone had higher median scores for arousal and excitability, and lower median scores for attention and regulation at 4–6 weeks CGA compared to the buprenorphine-naloxone group. None of the infants in the naltrexone group were monitored for NOWS and had shorter length of hospital stay compared with the buprenorphine-naloxone group. Although no statistically significant differences were observed, more infants in the buprenorphine-naloxone group were identified as at risk for development delays in the communication, problem solving, and personal social domains of the ASQ-3 at 12 months CGA. Results should be interpreted with caution given this study's small sample size and lack of a prospective comparison cohort. In this small cohort, there are differences noted in infant neurobehavior by NNNS at 4–6 weeks of age when comparing the buprenorphine-naloxone and naltrexone groups. At 12 months, ASQ-3 scores were similar but with percentage differences in potential development delay risk observed between the two groups. Larger cohort studies are needed to determine the long-term child outcomes after naltrexone exposure in pregnancy. • Neurobehavior of infants exposed to naltrexone vs buprenorphine-naloxone were compared. • Infants exposed to naltrexone demonstrated differences in neurobehavior at 4–6 weeks. • Infants in the naltrexone group had shorter hospitalizations with no NOWS diagnoses. [ABSTRACT FROM AUTHOR]

We aimed to evaluate the validity of the Ages and Stages Questionnaires Edition 3 (ASQ‐3) and the MacArthur communicative development inventory (CDI) as a screening measure for children at risk of language development delay in western rural China, by comparing them to the Bayley Scales of Infant and Toddler Development (BSID‐III). We administered the BSID‐III on 1,079 children (aged 8–24 months) and administered the ASQ‐3 and the CDI to their caregivers. We found a significant, low‐to‐moderate correlation between the three scales. Further, correlation strength increased with age of the child and was stronger when the mother was the primary caregiver. We also found that the sensitivity and specificity of the ASQ‐3 ranged widely. The overall findings suggest that the ASQ‐3 and the CDI may not be very accurate screening tools for identifying language development delays in children, especially those under 17 months or whose primary caregiver is not their mother. Highlights: We evaluated the accuracy of language sections of three scales (CDI, ASQ‐3 and BSID‐III) for rural children in western China.Multiple methods were utilized and showed a significant, low‐to‐moderate correlation between the three scales.Our findings revealed that both ASQ‐3 and CDI are not accurate screening tools for identifying language development delays in children. [ABSTRACT FROM AUTHOR]

BACKGROUND: Parent-completed tools like the Ages and Stages Questionnaire Third Edition (ASQ-3) are important in developmental screening. As a screening tool, a high negative predictive value (NPV) is critical to avoid missing the diagnosis of developmental delay. This study evaluated the NPV and accuracy of the ASQ-3 in assessing the development of preterm infants. METHODS: Infants born at <32 weeks and/or <1250 grams, presenting to the Neonatal Neurodevelopmental Clinic at the Singapore General Hospital for follow-up from January 2014 to June 2017, at 6, 12, and 18 months corrected age, were included. The ASQ-3 and standardized tests – Peabody Developmental Motor Scale-Second Edition (PDMS-2) and Preschool Language Scale, Fourth Edition UK (PLS-4 UK) – were administered. ASQ-3 gross motor and fine motor scores were compared to PDMS-2 at 6 and 12 months, and ASQ-3 communication scores to PLS-4 UK at 18 months. RESULTS: At 6 months (n = 145), NPV for gross motor and fine motor were 96.4% (accuracy 80.0%) and 95.4% (accuracy 77.2%) respectively. At 12 months (n = 127), NPV for gross motor and fine motor were 88.9% (accuracy 79.8%) and 82.8% (accuracy 74.0%) respectively. At 18 months (n = 113), NPV for language was 56.9% (accuracy 63.7%). CONCLUSIONS: The ASQ-3 showed high NPV and accuracy in screening gross motor and fine motor skills at 6 and 12 months, but not in screening language skills at 18 months. Judicious use of the ASQ-3 may allow for more effective utilization of resources. [ABSTRACT FROM AUTHOR]

Background: The new health supervision guidelines emphasize the importance of surveillance or a formal developmental screening test at 4 years, one of the most used tests is Ages & Stages Questionnaire. Nevertheless, there is still not enough evidence whether these tools will be useful to predict future school performance (SP). Objectives: The objectives of this study were to evaluate the Ages & Stages Questionnaire 3rd edition 48‐month interval (ASQ3‐48) translated to Spanish for predicting the need for school intervention (SI) and poor SP at 8–9 years of age, in late preterm infants (LPIs) and term‐born infants (Terms) and to compare the prevalence of SI and poor SP in the two groups. Methods: Data were collected from a cohort of 75 LPIs and 58 Terms assessed with ASQ3‐48 and with a further assessment of academic results at 8–9 years, through a standardized school test of the Education Department of Catalonia. SI data were obtained through a parent report. Area under the curve (AUC), sensitivity, specificity and predictive values were calculated, and logistic regression analysis was used. Results: The prevalence of poor SP was 12.8%, without statistically significant differences between LPIs and Terms. LPIs had higher SI than Terms (29.3% vs. 10.3%, P = 0.001). AUC for poor SP was 0.73 and for receiving SI was 0.56 without differences between the two groups. The sensitivity of the ASQ3‐48 for poor SP was 41%, for specificity 92%, and for receiving SI 14% and 89%, respectively. Poor SP was related to having positive screening in the ASQ3‐48 (OR 6.5 [95% CI, 1.9–22.2]) while having received SI was related to late prematurity (OR 3.6 [95% CI, 1.3–9.6]). Conclusions: The ASQ3‐48 shows acceptable predictive properties for poor SP but not for receiving SI. No differences were found in SP between LPI and Term cohorts, but LPIs are likelier to require SI. [ABSTRACT FROM AUTHOR]

Objective: To compare the longer-term development outcomes in children born after freeze-only versus fresh embryo transfer (ET) in women with an ovulatory cycle.Design: Long-term follow-up study (NCT04099784) of babies born alive after the first ET in a randomized controlled trial (RCT) comparing ongoing pregnancy and live birth rates after use of a freeze-only versus fresh ET strategy (NCT02471573).Setting: Private clinic.Patient(s): Of 391 couples randomized to each treatment group in the RCT, 132 (97 singleton/35 twins) and 123 (95 singleton/28 twins) in the freeze-only and fresh ET groups had live birth; 113 parents (86%) from the freeze-only group (147 babies) and 99 (80%) from the fresh ET group (120 babies) returned questionnaires for this follow-up study.Intervention(s): Use of a freeze-only or fresh ET strategy after controlled ovarian hyperstimulation with a follicle-stimulating hormone/gonadotropin-releasing antagonist protocol.Main Outcome Measure(s): Developmental status at ≥2 years after birth, determined using the Developmental Red Flags and Ages & Stages Third Edition (ASQ-3) Questionnaires.Result(s): Mean age of children at the end of follow-up was 37 months. Height (95.0 ± 6.1 vs. 95.7 ± 5.6 cm) and weight (14.9 ± 2.6 vs. 14.8 ± 2.6 kg) were similar in the freeze-only and fresh ET groups (results were similar when singletons and twins were analyzed separately). Overall, ASQ-3 scores for problem solving were significantly better in the freeze-only versus fresh ET group (overall: 53.6 ± 8.4 vs. 51.1 ± 10.2), with no significant between-group difference when singletons (52.3 ± 10.1 vs. 51.0 ± 9.9) and twins (55.0 ± 5.5 vs. 51.4 ± 11.1) were analyzed separately. Fine motor skills scores were numerically higher (with P values approaching statistical significance) in the freeze-only versus fresh ET group in the overall analysis (47.8 ± 11.6 vs. 44.9 ± 12.6) and twins (49.85 ± 8.72 vs. 43.93 ± 12.71), but not singletons (46.0 ± 13.4 vs. 45.4 ± 12.6). The overall proportion of children with abnormal ASQ-3 (6.8% vs. 8.3%) or abnormal Red Flags (5.4% vs. 6.7%) findings in the freeze-only and fresh ET groups was low and did not differ significantly between groups.Conclusion(s): These data provide physicians with additional information on which to base decisions about the relative merits of different approaches to infertility treatment. There do not appear to be any grounds for concern about worse outcomes after use of a freeze-only strategy. However, additional studies comparing childhood development after a freeze-only strategy, fresh ET, and natural cycles are needed before firm conclusions can be drawn. [ABSTRACT FROM AUTHOR]

Autism spectrum disorder (ASD) is a developmental disability in early childhood. Early identification and intervention in children with ASD are essential for children and their families. This study aimed to identify the earliest signs of ASD. Using a large cohort including data from 104,062 fetal records in the Japan Environment and Children’s Study, we examined the Ages and Stages Questionnaires® (ASQ-3TM) scores of children with and without ASD. The ASQ-3 comprises five domains: communication, gross motor, fine motor, problem solving, and personal-social. The ASQ-3 scores were obtained at ages 6 months, 1 year, and 3 years. There were 64,501 children with available ASQ-3 data. The number of children diagnosed with ASD was 188 (0.29%) at 3 years of age. The highest relative risk (RR) for any domain below the monitoring score at 6 months was in the communication (RR 1.90, 95% CI 1.29–2.78, p = 0.0041), followed by fine motor (RR 1.50, 95% CI 1.28–1.76, p < 0.0001) domain. A low ASQ-3 score in the communication domain at 6 months was related to an ASD diagnosis at 3 years of age. The ASQ-3 score at 6 months can contribute to the early identification of and intervention for ASD.

Abstract Background Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (

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Aim: Human parechoviruses (HPeV) are responsible for fever without a source (FWS), sepsis-like illness and encephalitis in neonates and children under 3 months of age. Short-term outcome is generally good, but there is great concern about medium and long- term outcome of infants after HPeV infection. The aim of this study is to assess the medium-term outcome in infants following HPeV infection without encephalitis.Methods: Patients who suffered HPeV infection involving cerebrospinal fluid were evaluated twice using Ages and Stages Questionnaire-3 (ASQ-3). The first evaluation was conducted at least one year after the infection and the second one year later.Results: Sixteen patients were evaluated in the first assessment, and three of them presented mild alterations in motor function domains. Moreover, hypotonia was observed in the neurologic exam in one case, and hemiparesis in another case. In the second assessment fifteen patients were included, and only the patient with hemiparesis continued presenting gross motor disfunction, with complete recovery of the remaining patients.Interpretation: We have observed a good medium-term prognosis in infants after HPeV infections, with improvement of mild motor alterations after at-home intervention. Infants who suffer HPeV infection without encephalitis seem to have a better prognosis than those with encephalitis. [ABSTRACT FROM AUTHOR]

Objetivos. Conocer los niveles de desarrollo infantil y explorar sus relaciones con el nivel socioeconómico y la educación de la madre. Materiales y métodos. Estudio cuantitativo realizado entre marzo y agosto de 2013, que incluyó información sobre 5859 niños de 1 a menos de 24 meses al momento de la entrevista y sus 5723 madres, provenientes de 5620 hogares en zonas rurales. Se aplicó el Age and Stages Questionnaire ASQ-3 adaptado y una encuesta sociodemográfica. Resultados. Los puntajes de las escalas de comunicación y motora fina mostraron que a medida que la edad es mayor, la brecha en los resultados de las escalas aumenta. En general, los niños del cuartil menos pobre en la muestra obtienen puntajes mayores que los niños del cuartil más pobre para las cinco dimensiones evaluadas. Por otro lado, en las cinco escalas y en el puntaje total se registran diferencias entre los puntajes alcanzados por los niños con madres más y menos educadas. Conclusiones. El estudio ha permitido establecer que existen diferencias en el puntaje obtenido en la prueba ASQ-3 según las variables edad, educación de la madre y niveles de riqueza.

Background: The Healthy Child Programme is the universal public health system in England to assess and monitor child health from 0 to 19. Following a review of measures for closer monitoring at age 2 years, the Department of Health for England implemented the Ages & Stages Questionnaires®, Third Edition (ASQ‐3™; Hereon, ASQ‐3). Aim: The aim of this study was to evaluate the acceptability and understanding of the ASQ‐3 in England by health professionals and parents. Method: A mixed‐methods approach was used. This paper reports on the qualitative data drawn from interviews with 40 parents and 12 focus groups with 85 health professionals. The data were analysed using applied thematic analysis. Findings Overall, parents and health professionals found the ASQ‐3 acceptable and understandable and could use it as a measure at age 2 years. The ability to work in partnership was valued. Some limitations included potential to cause anxiety, concerns around the safety of some of the items, and use of Americanized language. Health professional's training in the use the ASQ‐3 was inconsistent. Conclusion: The ASQ‐3 is an acceptable and understandable measure to use as part of the 2‐year assessment with some adaptations to the English context and some standardized training for health professionals. [ABSTRACT FROM AUTHOR]

Evidence supporting the internal structure of an assessment can provide support for its scoring mechanisms. A total of 1,691 young children in the United States were assessed by their parents using the 16-month questionnaire of the Ages and Stages Questionnaires, Third Edition (ASQ-3), and results were used to study the internal structure and dimensionality of the ASQ-3 using item response theory (IRT)/Rasch models. Data were analyzed using IRT including unidimensional and multidimensional Rasch Partial Credit Models to examine four theory-based internal structures. Results supported the hypothesis that the ASQ-3 measures a unidimensional construct—the overall development of children—while preference was given to a more precise multidimensional construct of five interrelated domains. However, concerns emerged regarding the extremely high correlations between items in the fine-motor and problem-solving domains. Findings provide implications for the test developers in terms of item refinement to improve measurement of underlying constructs. [ABSTRACT FROM AUTHOR]

Children commonly use mobile devices at pediatric office visits. This practice may affect patient-provider interaction and undermine accuracy of developmental surveillance. A randomized, provider-blinded, controlled trial examined whether a policy prohibiting mobile device use in a pediatric clinic improved accuracy of pediatricians’ developmental surveillance. Children, aged 18 to 36 months, were randomized to device-prohibited (intervention; n = 58) or device-allowed (control; n = 54) groups. After a 30-minute well-visit, development was evaluated as “normal,” “borderline,” or “delayed” in 5 categories using the Ages and Stages Questionnaire (ASQ-3). ASQ-3 results were compared with providers’ clinical assessment in each category. Provider-ASQ discrepancies were more common for intervention participants (P = .025). Providers “missed” more ASQ-3 “delayed” scores (P = .005) in the intervention group, particularly in the fine motor domain (P = .018). Prohibiting mobile device use at well-visits did not improve accuracy of providers’ developmental surveillance. Mobile devices may entertain children at well-visits, allowing opportunities for parent-provider discussion, or observation of fine motor skills. [ABSTRACT FROM AUTHOR]

Low- and middle-income countries need simple, technically sound developmental screening tools. The Ages and Stages Questionnaires, 3rd edition (ASQ-3) is widely accepted as a scientifically reliable and valid, user-friendly, and easy-to-learn and administer tool. This study documents the cultural adaptation, validation, and standardization of the Georgian ASQ-3 for children 1–66 months. The parents of 2974 children from one to 66 months completed the Georgian ASQ-3. We compared mean domain scores to the US normative sample, and performed multivariate analyses to detect variables associated with ASQ-3 cutoff scores. Cronbach's alpha values for all age groups varied from 0.643 to 0.824 across areas. We found significant differences in cutoff points between the Georgian ASQ-3 and US reference population in most domains across age groups. Child gender was associated with Communication (B, 0.453; p = 0.01), Fine Motor (B, 0.457; p = 0.01) and Personal–Social (B, 0.576; p = 0.001) with scores for girls more frequently distributed above the cutoff. We found administration of the Georgian ASQ-3 was easy after adaptation. We recommend additional research to investigate sensitivity and specificity and gender differences. [ABSTRACT FROM AUTHOR]

Background: Vitamin-D deficiency has been linked with impaired development in animal studies; however, the evidence from human studies is scanty. Evidence as to whether vitamin-D deficiency during early childhood affects growth is also limited and conflicting. We examined the extent to which vitamin-D deficiency (<10 ng/ml) is associated with neurodevelopment and physical growth in young children.Methods: We used data from a randomized controlled trial (RCT) of daily folic acid and/ or vitamin B12 supplementation for six months in children aged 6 to 30 months conducted in Delhi, India. We measured vitamin-D status and  neurodevelopment by the Ages and Stages Questionnaire-3 (ASQ-3) at 12 to 36 months of age. Multiple logistic and linear regressions were used to examine the association between vitamin-D deficiency at baseline and neurodevelopment and growth 6 months follow-up.Results: 25-hydroxy-vitamin-D (25OHD) concentration was measured at baseline for 960 (96%) children. Of these, 331 (34.5%) children were vitamin-D deficient. The total and subscale (except for the Personal social scale) ASQ-3 scores, were not different between the vitamin-D deficient and non-deficient children. Vitamin-D deficiency was also not associated with physical growth at baseline and at follow -up.Conclusion: Our data do not support the hypothesis that vitamin-D deficiency is associated with poor growth and neurodevelopment.Trial Registration: NCT00717730 and CTRI/2010/091/001090 . Date of registration: 08 October, 2010. [ABSTRACT FROM AUTHOR]

Objective The Ages and Stages Questionnaires Edition 3 (ASQ-3) are a well-validated international screen for developmental delays in young children. However, previous studies demonstrate variable scores between children eligible to take the same ASQ-3 interval. This study aimed to determine a relationship between age and ASQ-3 score for each screening interval. Methods This was a baseline exploratory cross-sectional study of infants under 2 years old evaluated for the Peruvian social programme Cuna Más. Participants were included in Cuna Más if they lived in districts with fewer than 2000 inhabitants or 400 homes, indicating a predominantly rural population. The appropriate ASQ-3 screening interval was administered to each subject. Subjects were divided into four 2-week chronological subgroups based on age within each 2-month screening window and aggregated across all 12 screening intervals. Fisher's exact test, analysis of variance and Bonferonni post hoc test were used to compare differences between age subgroups. Linear regression was performed to assess the relationship between ASQ-3 score and both aggregated and disaggregated age subgroup. Results A total of 5850 Peruvian infants were evaluated in 2013. Mean age was 13 ± 6.6 months, 50.7% were male and mean maternal education was 6.6 ± 4.0 years; 34.8% infants were stunted, 7.8% were underweight, 0.9% were wasted and 2% had age adjusted greater than 35 days for prematurity for ASQ-3 interval assignment. Mean total ASQ-3 was 42.2 ± 8.2. The ASQ-3 allocated 49.6% with suspected delay in one or more developmental areas. Before and after adjusting for wealth quintile, maternal education level, infant nutritional status and prematurity adjustment, age subgroup remained significantly associated with total ASQ-3 score ( β = 1.8, CI: 1.7-2.0, P < 0.001), sectional ASQ-3 score (all P < 0.001) and inversely associated with one or more scores indicating suspected developmental delay ( P < 0.001). Conclusions The ASQ-3 may underestimate the sensitivity of child development to small differences in age in this population. [ABSTRACT FROM AUTHOR]

Objectives : The Ages & Stages Questionnaires Third Version (ASQ-3) identifies the risk of developmental delay in children aged 1 to 66 months. The aim of this study was to determine a reliable and valid instrument for the Italian population to enable the screening of children's development. Methods : Data from 2278 Italian children (age range: 1-66 months) were used to evaluate item discrimination power using the corrected item-total correlation. Internal consistency was analyzed by Cronbach's alpha scores and a Confirmative Factor Analysis was conducted to test the factor structure of the test. Data were also collected to examine the ASQ-3 test-retest reliability and concurrent validity, which was investigated using the Griffiths Scales of Child Development, Third Edition, the Peabody Developmental Motor Scale, Second Edition, and the Developmental Profile, Third Edition tools. In order to evaluate discriminant validity, differences between typical development children and several clinical groups have been performed. Finally, two different cut-off scores have been proposed. Results : The results showed that the questionnaires are composed of high-quality items; the original factor structure has been confirmed and strong Pearson product-moment correlation coefficients between the overall and the total for each domain (ranging from 0.73 to 0.88). The Italian version of the ASQ-3 had adequate internal consistency and a strong agreement between observations with two weeks' intervals. Moreover, the test showed a high discriminant validity due to the possibility of fully discriminating between typical development children and several clinical groups. Finally, two different cut-off scores have been identified using ROC curves in order to have a screening and a diagnostic cut-off value. Conclusion : This study evaluated the psychometric properties of the Italian adaptation of ASQ-3 questionnaires. We demonstrated the validity of the ASQ-3 and determined new cut-off scores for Italian children. Early identification and accurate assessment are important starting points to better understand and anticipate the needs of children and their link to services.

Background The Ages and Stages Questionnaire (ASQ-3) is frequently used for screening developmental delay in problem solving, communication, fine- and gross motor skills and personal-social behavior of infants, toddlers and preschool aged children. The adequacy of the ASQ-3 is evaluated for Dutch children by comparing results of the ASQ-3, completed by parents, to results of a standardized, professionally administered developmental assessment of cognition, fine- and gross motor skills and receptive and expressive communication for infants and toddlers: the Bayley-III-NL. Methods The ASQ-3 and Bayley-III-NL were administered to 1244 children aged 1 to 43 months old. Two age cohorts were used: 1) the 2–16 month age-versions; and 2) the 18–42 month age-versions. Cutoff points for all ASQ-3 age-versions were calculated in three ways. Sensitivity and specificity of the ASQ-3 were evaluated with four methods, using different cutoff point combinations of 1 SD or 2 SD below the mean. Results Overall, sensitivity was between 7% and 77% and specificity between 53% and 99%. Sensitivity and specificity values were higher for the older age-cohort than for the younger age-cohort. For the older age-cohort, the best sensitivity (69%) and specificity (92%) was found, using 1 SD for the total ASQ-3 score and 2 SD for the Bayley-III-NL subtests as cutoff points. Conclusions For the oldest age-cohort, the ASQ-3 for now has the best potential as a screener for Dutch children. The ASQ-3 identifies most children without a developmental delay according to the Bayley-III-NL, but sensitivity needs improvement. [ABSTRACT FROM AUTHOR]